| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MPM BioImpact LLC | 0 | 2,671,480 | +2,671,480 | 0.00 | 1.22 | +1.22 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 526,917 | 1,923,639 | +1,396,722 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 133,530 | 1,432,475 | +1,298,945 | 0.03 | 0.43 | +0.40 | buy |
| GREAT POINT PARTNERS LLC | 0 | 979,534 | +979,534 | 0.00 | 1.27 | +1.27 | buy |
| Point72 Asset Management, L.P. | 0 | 716,680 | +716,680 | 0.00 | 0.00 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 600,946 | +600,946 | 0.00 | 0.02 | +0.02 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 434,837 | 932,247 | +497,410 | 0.21 | 0.78 | +0.57 | buy |
| TWO SIGMA INVESTMENTS, LP | 112,681 | 566,712 | +454,031 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 142,450 | 445,342 | +302,892 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 239,043 | +239,043 | 0.00 | 0.00 | +0.00 | buy |
| 683 Capital Management, LLC | 0 | 201,652 | +201,652 | 0.00 | 0.07 | +0.07 | buy |
| JANE STREET GROUP, LLC | 0 | 187,403 | +187,403 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 89,400 | 246,200 | +156,800 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 73,715 | 224,883 | +151,168 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 139,529 | +139,529 | 0.00 | 0.00 | +0.00 | buy |
| ArchPoint Investors | 0 | 121,400 | +121,400 | 0.00 | 0.12 | +0.12 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 38,900 | 140,617 | +101,717 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 85,466 | +85,466 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 229,889 | 304,015 | +74,126 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 109,300 | 159,300 | +50,000 | 0.00 | 0.01 | +0.01 | buy |
| Hudson Bay Capital Management LP | 0 | 48,736 | +48,736 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 80,900 | 124,700 | +43,800 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 24,753 | 61,853 | +37,100 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 103,100 | 128,900 | +25,800 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,315,811 | 1,340,504 | +24,693 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 14,236 | +14,236 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 11,944 | 24,744 | +12,800 | 0.00 | 0.00 | +0.00 | buy |
| BLAIR WILLIAM & CO/IL | 0 | 11,000 | +11,000 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 10,655 | +10,655 | 0.00 | 0.00 | +0.00 | buy |
| Scientech Research LLC | 0 | 10,428 | +10,428 | 0.00 | 0.03 | +0.03 | buy |
| XTX Topco Ltd | 29,184 | 34,852 | +5,668 | 0.00 | 0.00 | +0.00 | buy |
| Peapod Lane Capital LLC | 561,866 | 565,992 | +4,126 | 1.01 | 1.93 | +0.92 | buy |
| Chicago Partners Investment Group LLC | 10,332 | 10,962 | +630 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 1,300,000 | 1,300,000 | 0 | 0.24 | 0.37 | +0.13 | hold |
| NAN FUNG TRINITY (HK) Ltd | 463,654 | 463,654 | 0 | 0.09 | 0.15 | +0.05 | hold |
| Kynam Capital Management, LP | 1,028,341 | 1,028,341 | 0 | 0.15 | 0.27 | +0.11 | hold |
| HARBOUR INVESTMENTS, INC. | 2,000 | 2,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 573 | 573 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DEUTSCHE BANK AG\ | 1 | 1 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SBI Securities Co., Ltd. | 13 | 0 | -13 | 0.00 | 0.00 | -0.00 | sell |
| Advisory Services Network, LLC | 32 | 0 | -32 | 0.00 | 0.00 | -0.00 | sell |
| Arax Advisory Partners | 53 | 0 | -53 | 0.00 | 0.00 | -0.00 | sell |
| EverSource Wealth Advisors, LLC | 224 | 0 | -224 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 125,423 | 124,670 | -753 | 0.00 | 0.00 | +0.00 | sell |
| FMR LLC | 7,142 | 6,349 | -793 | 0.00 | 0.00 | +0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 311,721 | 310,756 | -965 | 0.00 | 0.00 | +0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 1,854 | 513 | -1,341 | 0.00 | 0.00 | -0.00 | sell |
| GF FUND MANAGEMENT CO. LTD. | 1,458 | 0 | -1,458 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 36,602 | 34,596 | -2,006 | 0.00 | 0.00 | +0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 2,620 | 0 | -2,620 | 0.00 | 0.00 | -0.00 | sell |
| Vanguard Personalized Indexing Management, LLC | 14,546 | 11,127 | -3,419 | 0.00 | 0.00 | +0.00 | sell |
| FEDERATED HERMES, INC. | 4,420 | 0 | -4,420 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 13,244 | 3,357 | -9,887 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 11,878 | 0 | -11,878 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 15,000 | 0 | -15,000 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 17,699 | 0 | -17,699 | 0.00 | 0.00 | -0.00 | sell |
| CITIZENS FINANCIAL GROUP INC/RI | 46,000 | 28,168 | -17,832 | 0.00 | 0.00 | +0.00 | sell |
| Susquehanna Portfolio Strategies, LLC | 18,272 | 0 | -18,272 | 0.00 | 0.00 | -0.00 | sell |
| Persistent Asset Partners Ltd | 28,221 | 9,228 | -18,993 | 0.04 | 0.02 | -0.02 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 40,718 | 19,918 | -20,800 | 0.01 | 0.01 | -0.00 | sell |
| BLUEFIN CAPITAL MANAGEMENT, LLC | 59,985 | 0 | -59,985 | 0.05 | 0.00 | -0.05 | sell |
| DIADEMA PARTNERS LP | 136,488 | 0 | -136,488 | 0.19 | 0.00 | -0.19 | sell |
| Shay Capital LLC | 150,000 | 0 | -150,000 | 0.05 | 0.00 | -0.05 | sell |
| MILLENNIUM MANAGEMENT LLC | 471,704 | 296,314 | -175,390 | 0.00 | 0.00 | +0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 537,100 | 320,600 | -216,500 | 0.00 | 0.00 | +0.00 | sell |
| CITIGROUP INC | 329,548 | 10,331 | -319,217 | 0.00 | 0.00 | -0.00 | sell |
| BlackRock, Inc. | 735,503 | 389,309 | -346,194 | 0.00 | 0.00 | +0.00 | sell |
| UBS Group AG | 405,404 | 0 | -405,404 | 0.00 | 0.00 | -0.00 | sell |
| Alyeska Investment Group, L.P. | 485,364 | 0 | -485,364 | 0.00 | 0.00 | -0.00 | sell |
| Deep Track Capital, LP | 509,789 | 0 | -509,789 | 0.03 | 0.00 | -0.03 | sell |
| CANTOR FITZGERALD, L. P. | 547,173 | 0 | -547,173 | 0.02 | 0.00 | -0.02 | sell |
| TANG CAPITAL MANAGEMENT LLC | 1,000,000 | 0 | -1,000,000 | 0.08 | 0.00 | -0.08 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 31,419,267 | 11,293,828 | -20,125,439 | 0.78 | 0.80 | +0.02 | sell |