| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PRICE T ROWE ASSOCIATES INC /MD/ | 112,708 | 1,422,935 | +1,310,227 | 0.00 | 0.01 | +0.00 | buy |
| Paradigm Biocapital Advisors LP | 0 | 685,852 | +685,852 | 0.00 | 0.46 | +0.46 | buy |
| FMR LLC | 204,501 | 823,556 | +619,055 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 339,116 | 852,150 | +513,034 | 0.00 | 0.00 | +0.00 | buy |
| Capital World Investors | 0 | 415,730 | +415,730 | 0.00 | 0.00 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 136,818 | +136,818 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 128,841 | +128,841 | 0.00 | 0.00 | +0.00 | buy |
| Boxer Capital Management, LLC | 0 | 75,000 | +75,000 | 0.00 | 0.20 | +0.20 | buy |
| Trexquant Investment LP | 0 | 63,792 | +63,792 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 54,464 | +54,464 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 51,983 | +51,983 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 0 | 45,551 | +45,551 | 0.00 | 0.02 | +0.02 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0 | 35,000 | +35,000 | 0.00 | 0.02 | +0.02 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 37,301 | 70,484 | +33,183 | 0.00 | 0.00 | +0.00 | buy |
| Weiss Asset Management LP | 0 | 33,094 | +33,094 | 0.00 | 0.01 | +0.01 | buy |
| CITADEL ADVISORS LLC | 0 | 25,751 | +25,751 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 25,222 | +25,222 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 960 | 17,051 | +16,091 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 10,261 | 24,919 | +14,658 | 0.00 | 0.01 | +0.01 | buy |
| Rafferty Asset Management, LLC | 0 | 13,853 | +13,853 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 11,791 | +11,791 | 0.00 | 0.10 | +0.10 | buy |
| Quantinno Capital Management LP | 0 | 11,339 | +11,339 | 0.00 | 0.00 | +0.00 | buy |
| MA Private Wealth | 0 | 10,389 | +10,389 | 0.00 | 0.06 | +0.06 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 7,470 | +7,470 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 5,789 | 12,975 | +7,186 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 7,040 | +7,040 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 0 | 6,956 | +6,956 | 0.00 | 0.01 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 6,937 | +6,937 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 100,000 | 106,906 | +6,906 | 0.39 | 0.66 | +0.27 | buy |
| TD ASSET MANAGEMENT INC | 47,768 | 54,526 | +6,758 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 0 | 6,455 | +6,455 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 1,337 | 7,267 | +5,930 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 5,800 | +5,800 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 46,208 | 51,917 | +5,709 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 7,163 | 9,419 | +2,256 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 3,986 | 5,491 | +1,505 | 0.00 | 0.00 | +0.00 | buy |
| Aster Capital Management (DIFC) Ltd | 0 | 1,480 | +1,480 | 0.00 | 0.01 | +0.01 | buy |
| Pinnacle Wealth Planning Services, Inc. | 0 | 1,265 | +1,265 | 0.00 | 0.00 | +0.00 | buy |
| Penserra Capital Management LLC | 0 | 1,088 | +1,088 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 557 | 1,160 | +603 | 0.00 | 0.00 | +0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 0 | 590 | +590 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 550 | +550 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 538 | +538 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 400 | +400 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 0 | 361 | +361 | 0.00 | 0.00 | +0.00 | buy |
| Pacer Advisors, Inc. | 0 | 231 | +231 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,928 | 1,996 | +68 | 0.00 | 0.00 | +0.00 | buy |
| Global Retirement Partners, LLC | 0 | 63 | +63 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 94 | 123 | +29 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 5 | 33 | +28 | 0.00 | 0.00 | +0.00 | buy |
| SJS Investment Consulting Inc. | 0 | 18 | +18 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 0 | 16 | +16 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 6 | 8 | +2 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 6 | 7 | +1 | 0.00 | 0.00 | +0.00 | buy |
| Larson Financial Group LLC | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| Sanofi | 912,041 | 912,041 | 0 | 5.52 | 6.12 | +0.60 | hold |
| BAKER BROS. ADVISORS LP | 364,705 | 364,705 | 0 | 0.04 | 0.07 | +0.02 | hold |
| Novo Holdings A/S | 3,686,622 | 3,686,622 | 0 | 6.07 | 7.67 | +1.60 | hold |
| DAFNA Capital Management LLC | 171,006 | 171,006 | 0 | 0.79 | 1.17 | +0.38 | hold |
| LMR Partners LLP | 10,000 | 10,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Versant Capital Management, Inc | 50 | 50 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MARKET STREET WEALTH MANAGEMENT ADVISORS LLC | 14,124 | 14,124 | 0 | 0.05 | 0.07 | +0.03 | hold |
| Nan Fung Group Holdings Ltd | 971,253 | 971,253 | 0 | 16.28 | 26.47 | +10.19 | hold |
| 5AM Venture Management, LLC | 950,011 | 950,011 | 0 | 5.36 | 11.83 | +6.46 | hold |
| Ghisallo Capital Management LLC | 20,000 | 20,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Velan Capital Investment Management LP | 492,893 | 492,893 | 0 | 6.28 | 10.82 | +4.55 | hold |
| Burkehill Global Management, LP | 75,000 | 75,000 | 0 | 0.08 | 0.10 | +0.02 | hold |
| SEVEN GRAND MANAGERS, LLC | 100,000 | 100,000 | 0 | 0.14 | 0.14 | +0.01 | hold |
| Farther Finance Advisors, LLC | 120 | 120 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Siren, L.L.C. | 450,000 | 450,000 | 0 | 0.25 | 0.33 | +0.07 | hold |
| FCPM III SERVICES B.V. | 3,226,400 | 3,226,400 | 0 | 9.08 | 15.41 | +6.33 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 5,300 | 5,300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Pivotal bioVenture Partners Investment Advisor LLC | 611,447 | 611,446 | -1 | 4.44 | 7.12 | +2.68 | sell |
| True Wealth Design, LLC | 3 | 0 | -3 | 0.00 | 0.00 | -0.00 | sell |
| MAI Capital Management | 12 | 0 | -12 | 0.00 | 0.00 | -0.00 | sell |
| Root Financial Partners, LLC | 28 | 0 | -28 | 0.00 | 0.00 | -0.00 | sell |
| Sterling Capital Management LLC | 370 | 56 | -314 | 0.00 | 0.00 | -0.00 | sell |
| Ameritas Investment Partners, Inc. | 1,371 | 946 | -425 | 0.00 | 0.00 | +0.00 | sell |
| Legal & General Group Plc | 1,805 | 1,033 | -772 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,062 | 144 | -918 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 9,798 | 7,353 | -2,445 | 0.00 | 0.00 | +0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 9,061 | 6,411 | -2,650 | 0.00 | 0.00 | +0.00 | sell |
| STRS OHIO | 3,000 | 0 | -3,000 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 13,679 | 10,326 | -3,353 | 0.00 | 0.00 | +0.00 | sell |
| JPMORGAN CHASE & CO | 7,869 | 4,332 | -3,537 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 20,368 | 15,748 | -4,620 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 14,098 | 8,998 | -5,100 | 0.00 | 0.00 | +0.00 | sell |
| Nuveen, LLC | 23,089 | 17,921 | -5,168 | 0.00 | 0.00 | +0.00 | sell |
| Invesco Ltd. | 12,252 | 5,729 | -6,523 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 39,465 | 30,410 | -9,055 | 0.00 | 0.00 | +0.00 | sell |
| Walleye Capital LLC | 11,572 | 0 | -11,572 | 0.00 | 0.00 | -0.00 | sell |
| T. Rowe Price Investment Management, Inc. | 2,801,937 | 2,781,728 | -20,209 | 0.04 | 0.07 | +0.03 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 161,146 | 136,818 | -24,328 | 0.00 | 0.00 | +0.00 | sell |
| NORTHERN TRUST CORP | 146,172 | 116,652 | -29,520 | 0.00 | 0.00 | +0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 36,740 | 0 | -36,740 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 1,994,873 | 1,948,312 | -46,561 | 0.01 | 0.01 | +0.00 | sell |
| LAZARD ASSET MANAGEMENT LLC | 142,016 | 80,082 | -61,934 | 0.00 | 0.00 | -0.00 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 192,139 | 125,432 | -66,707 | 2.79 | 2.84 | +0.05 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 481,201 | 402,051 | -79,150 | 0.00 | 0.00 | +0.00 | sell |
| BNP Paribas Asset Management Holding S.A. | 267,746 | 170,862 | -96,884 | 0.01 | 0.01 | -0.00 | sell |