| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Flagship Pioneering Inc. | 25,001,856 | 25,001,856 | 0 | 7.70 | 16.40 | +8.70 | hold |
| FMR LLC | 15,751,291 | 22,042,537 | +6,291,246 | 0.00 | 0.01 | +0.01 | buy |
| VANGUARD GROUP INC | 9,797,084 | 12,155,173 | +2,358,089 | 0.00 | 0.00 | +0.00 | buy |
| BAILLIE GIFFORD & CO | 10,150,017 | 10,656,279 | +506,262 | 0.03 | 0.08 | +0.05 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 10,175,000 | 10,175,000 | 0 | 0.05 | 0.11 | +0.05 | hold |
| STATE STREET CORP | 5,908,687 | 6,370,165 | +461,478 | 0.00 | 0.00 | +0.00 | buy |
| Capital World Investors | 1,531,307 | 5,449,035 | +3,917,728 | 0.00 | 0.01 | +0.01 | buy |
| T. Rowe Price Investment Management, Inc. | 0 | 4,801,847 | +4,801,847 | 0.00 | 0.03 | +0.03 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,594,025 | 3,695,459 | +101,434 | 0.00 | 0.00 | +0.00 | buy |
| Crestline Management, LP | 3,365,624 | 3,365,624 | 0 | 1.27 | 3.19 | +1.92 | hold |
| Alphabet Inc. | 2,812,500 | 2,812,500 | 0 | 0.53 | 1.12 | +0.59 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 2,253,836 | 2,416,518 | +162,682 | 0.00 | 0.00 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 2,000,000 | 2,380,949 | +380,949 | 0.09 | 0.30 | +0.21 | buy |
| CITADEL ADVISORS LLC | 39,876 | 1,887,156 | +1,847,280 | 0.00 | 0.02 | +0.02 | buy |
| MORGAN STANLEY | 733,402 | 1,489,680 | +756,278 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 1,190,634 | 1,105,487 | -85,147 | 0.00 | 0.00 | +0.00 | sell |
| Duquesne Family Office LLC | 0 | 984,000 | +984,000 | 0.00 | 0.26 | +0.26 | buy |
| Integral Health Asset Management, LLC | 0 | 980,000 | +980,000 | 0.00 | 0.96 | +0.96 | buy |
| Woodline Partners LP | 684,194 | 899,050 | +214,856 | 0.03 | 0.08 | +0.05 | buy |
| MARSHALL WACE, LLP | 0 | 869,985 | +869,985 | 0.00 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 886,973 | 866,141 | -20,832 | 0.00 | 0.00 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 830,292 | 852,776 | +22,484 | 0.00 | 0.00 | +0.00 | buy |
| Omega Fund Management, LLC | 843,750 | 843,750 | 0 | 2.79 | 5.44 | +2.65 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 748,835 | 823,510 | +74,675 | 0.00 | 0.00 | +0.00 | buy |
| ArrowMark Colorado Holdings LLC | 685,125 | 685,125 | 0 | 0.03 | 0.08 | +0.05 | hold |
| PFM Health Sciences, LP | 1,883,337 | 675,000 | -1,208,337 | 0.46 | 0.34 | -0.13 | sell |
| Skandinaviska Enskilda Banken AB (publ) | 228,000 | 583,489 | +355,489 | 0.01 | 0.03 | +0.02 | buy |
| BANK OF AMERICA CORP /DE/ | 481,790 | 548,027 | +66,237 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 56,287 | 525,007 | +468,720 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 362,652 | 521,112 | +158,460 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 437,614 | 495,932 | +58,318 | 0.01 | 0.02 | +0.01 | buy |
| CITIGROUP INC | 189,900 | 469,670 | +279,770 | 0.00 | 0.01 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 212,154 | 435,040 | +222,886 | 0.00 | 0.00 | +0.00 | buy |
| Capital International Investors | 432,071 | 432,071 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Verition Fund Management LLC | 484,935 | 384,279 | -100,656 | 0.02 | 0.04 | +0.02 | sell |
| UBS Group AG | 307,420 | 373,727 | +66,307 | 0.00 | 0.00 | +0.00 | buy |
| Octagon Capital Advisors LP | 0 | 360,800 | +360,800 | 0.00 | 0.44 | +0.44 | buy |
| Bank of New York Mellon Corp | 363,012 | 341,321 | -21,691 | 0.00 | 0.00 | +0.00 | sell |
| Corient Private Wealth LLC | 413,360 | 337,463 | -75,897 | 0.00 | 0.01 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 263,477 | 288,874 | +25,397 | 0.00 | 0.00 | +0.00 | buy |
| NORGES BANK | 249,621 | 249,621 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 1,053,330 | 238,831 | -814,499 | 0.00 | 0.00 | -0.00 | sell |
| Zimmer Partners, LP | 0 | 202,500 | +202,500 | 0.00 | 0.04 | +0.04 | buy |
| Swiss National Bank | 194,100 | 194,100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 295,100 | 172,900 | -122,200 | 0.00 | 0.00 | +0.00 | sell |
| RHUMBLINE ADVISERS | 151,984 | 156,847 | +4,863 | 0.00 | 0.00 | +0.00 | buy |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA | 156,254 | 156,254 | 0 | 0.08 | 0.45 | +0.37 | hold |
| AQR CAPITAL MANAGEMENT LLC | 24,317 | 155,792 | +131,475 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 146,456 | +146,456 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 134,309 | +134,309 | 0.00 | 0.06 | +0.06 | buy |
| ALLIANCEBERNSTEIN L.P. | 126,595 | 125,325 | -1,270 | 0.00 | 0.00 | +0.00 | sell |
| BARCLAYS PLC | 350,614 | 116,011 | -234,603 | 0.00 | 0.00 | -0.00 | sell |
| DekaBank Deutsche Girozentrale | 112,300 | 112,300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 89,947 | 107,647 | +17,700 | 0.00 | 0.00 | +0.00 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 121,442 | 104,442 | -17,000 | 0.00 | 0.01 | +0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 113,875 | 102,680 | -11,195 | 0.00 | 0.00 | +0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 103,427 | 98,279 | -5,148 | 0.00 | 0.00 | +0.00 | sell |
| BOSUN ASSET MANAGEMENT, LLC | 0 | 96,221 | +96,221 | 0.00 | 0.55 | +0.55 | buy |
| TWO SIGMA INVESTMENTS, LP | 74,758 | 89,800 | +15,042 | 0.00 | 0.00 | +0.00 | buy |
| GILDER GAGNON HOWE & CO LLC | 0 | 84,259 | +84,259 | 0.00 | 0.01 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 65,283 | 83,347 | +18,064 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 223,138 | 81,695 | -141,443 | 0.02 | 0.02 | +0.00 | sell |
| PROFUND ADVISORS LLC | 70,703 | 77,202 | +6,499 | 0.01 | 0.03 | +0.02 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 134,638 | 70,245 | -64,393 | 0.00 | 0.00 | +0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 77,316 | 59,397 | -17,919 | 0.00 | 0.00 | +0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 197,386 | 57,535 | -139,851 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 0 | 55,415 | +55,415 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 0 | 54,453 | +54,453 | 0.00 | 0.05 | +0.05 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 52,459 | +52,459 | 0.00 | 0.05 | +0.05 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 59,703 | 49,196 | -10,507 | 0.00 | 0.01 | +0.00 | sell |
| MetLife Investment Management, LLC | 48,321 | 48,321 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMERICAN INTERNATIONAL GROUP, INC. | 47,694 | 47,288 | -406 | 0.00 | 0.00 | +0.00 | sell |
| Clarius Group, LLC | 46,825 | 46,825 | 0 | 0.02 | 0.03 | +0.02 | hold |
| SIMPLEX TRADING, LLC | 18,080 | 46,516 | +28,436 | 0.00 | 0.01 | +0.01 | buy |
| China Universal Asset Management Co., Ltd. | 22,800 | 42,400 | +19,600 | 0.02 | 0.05 | +0.04 | buy |
| FRANKLIN RESOURCES INC | 41,432 | 41,469 | +37 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 113,394 | 41,084 | -72,310 | 0.00 | 0.00 | -0.00 | sell |
| Erste Asset Management GmbH | 40,000 | 40,000 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Jump Financial, LLC | 0 | 39,400 | +39,400 | 0.00 | 0.01 | +0.01 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 39,228 | 36,394 | -2,834 | 0.00 | 0.00 | +0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 168,971 | 36,208 | -132,763 | 0.06 | 0.03 | -0.03 | sell |
| WELLS FARGO & COMPANY/MN | 30,423 | 34,904 | +4,481 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 34,376 | +34,376 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 28,480 | 32,690 | +4,210 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 38,220 | 31,921 | -6,299 | 0.00 | 0.00 | +0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 40,564 | 30,861 | -9,703 | 0.00 | 0.00 | +0.00 | sell |
| Squarepoint Ops LLC | 10,667 | 30,224 | +19,557 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 30,167 | 30,177 | +10 | 0.00 | 0.00 | +0.00 | buy |
| Employees Retirement System of Texas | 12,996 | 29,456 | +16,460 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 27,527 | 27,088 | -439 | 0.00 | 0.00 | +0.00 | sell |
| Vident Advisory, LLC | 25,170 | 27,059 | +1,889 | 0.00 | 0.01 | +0.00 | buy |
| LPL Financial LLC | 22,475 | 24,925 | +2,450 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 16,257 | 24,768 | +8,511 | 0.00 | 0.00 | +0.00 | buy |
| Viewpoint Capital Management LLC | 23,545 | 23,545 | 0 | 0.07 | 0.15 | +0.08 | hold |
| E Fund Management Co., Ltd. | 23,361 | 23,361 | 0 | 0.01 | 0.01 | +0.01 | hold |
| D.A. DAVIDSON & CO. | 0 | 22,200 | +22,200 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 22,226 | 21,939 | -287 | 0.00 | 0.00 | +0.00 | sell |
| VIRTUS ADVISERS, LLC | 23,203 | 21,714 | -1,489 | 0.06 | 0.12 | +0.06 | sell |
| AlphaQuest LLC | 0 | 20,298 | +20,298 | 0.00 | 0.04 | +0.04 | buy |
| Focus Partners Wealth | 0 | 19,643 | +19,643 | 0.00 | 0.00 | +0.00 | buy |