| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 2,000,000 | 2,380,949 | +380,949 | 0.09 | 0.17 | 0.00 | buy |
| Integral Health Asset Management, LLC | 980,000 | 1,200,000 | +220,000 | 0.91 | 0.62 | -0.29 | buy |
| Zimmer Partners, LP | 202,500 | 368,700 | +166,200 | 0.04 | 0.04 | -0.01 | buy |
| Clarius Group, LLC | 46,825 | 63,184 | +16,359 | 0.03 | 0.02 | -0.01 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 12,884 | 27,314 | +14,430 | 0.02 | 0.03 | +0.01 | buy |
| PROFUND ADVISORS LLC | 77,202 | 63,083 | +14,119 | 0.03 | 0.01 | 0.00 | sell |
| E Fund Management Co., Ltd. | 23,361 | 20,675 | -2,686 | 0.01 | 0.01 | -0.01 | sell |
| MARTINGALE ASSET MANAGEMENT L P | 49,196 | 42,338 | -6,858 | 0.01 | 0.00 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 21,714 | 12,661 | -9,053 | 0.12 | 0.03 | -0.08 | sell |
| China Universal Asset Management Co., Ltd. | 42,400 | 26,023 | -16,377 | 0.05 | 0.02 | -0.03 | sell |
| BAILLIE GIFFORD & CO | 10,656,279 | 10,571,200 | -85,079 | 0.08 | 0.04 | -0.04 | sell |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 134,309 | 43,342 | -90,967 | 0.06 | 0.01 | -0.06 | sell |
| TD ASSET MANAGEMENT INC | 521,112 | 404,348 | -116,764 | 0.00 | 0.00 | -0.00 | sell |
| Crestline Management, LP | 3,365,624 | 3,225,624 | -140,000 | 2.97 | 1.37 | -1.60 | sell |
| Rafferty Asset Management, LLC | 495,932 | 340,430 | -155,502 | 0.02 | 0.01 | -0.01 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 238,831 | 58,801 | -180,030 | 0.00 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 899,050 | 684,194 | -214,856 | 0.08 | 0.04 | -0.05 | sell |
| PFM Health Sciences, LP | 675,000 | 110,834 | -564,166 | 0.32 | 0.03 | -0.29 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,695,459 | 3,117,996 | -577,463 | 0.00 | 0.00 | -0.00 | sell |
| T. Rowe Price Investment Management, Inc. | 4,801,847 | 1,558,229 | -3,243,618 | 0.03 | 0.01 | -0.02 | sell |