| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 22,042,537 | 27,170,226 | +5,127,689 | 0.01 | 0.01 | -0.01 | buy |
| VANGUARD GROUP INC | 12,155,173 | 12,878,680 | +723,507 | 0.00 | 0.00 | -0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 616,587 | +616,587 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,416,518 | 2,890,425 | +473,907 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 548,027 | 910,167 | +362,140 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 89,800 | 413,510 | +323,710 | 0.00 | 0.01 | +0.00 | buy |
| Corient Private Wealth LLC | 337,463 | 607,000 | +269,537 | 0.01 | 0.01 | -0.00 | buy |
| Qube Research & Technologies Ltd | 55,415 | 288,552 | +233,137 | 0.00 | 0.00 | +0.00 | buy |
| Integral Health Asset Management, LLC | 980,000 | 1,200,000 | +220,000 | 0.96 | 0.65 | -0.31 | buy |
| Zimmer Partners, LP | 202,500 | 368,700 | +166,200 | 0.04 | 0.04 | -0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 83,347 | 247,076 | +163,729 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 146,456 | 303,195 | +156,739 | 0.00 | 0.00 | -0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 36,208 | 184,728 | +148,520 | 0.03 | 0.07 | +0.04 | buy |
| MILLENNIUM MANAGEMENT LLC | 12,338 | 158,048 | +145,710 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 1,489,680 | 1,618,341 | +128,661 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 823,510 | 942,464 | +118,954 | 0.00 | 0.00 | -0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 105,325 | +105,325 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 0 | 96,876 | +96,876 | 0.00 | 0.02 | +0.02 | buy |
| Squarepoint Ops LLC | 30,224 | 126,572 | +96,348 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 341,321 | 431,744 | +90,423 | 0.00 | 0.00 | -0.00 | buy |
| Ensign Peak Advisors, Inc | 0 | 68,050 | +68,050 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 194,100 | 260,200 | +66,100 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 31,921 | 90,320 | +58,399 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 51,974 | +51,974 | 0.00 | 0.00 | +0.00 | buy |
| SHERBROOKE PARK ADVISERS LLC | 0 | 48,339 | +48,339 | 0.00 | 0.05 | +0.05 | buy |
| Brevan Howard Capital Management LP | 0 | 46,296 | +46,296 | 0.00 | 0.02 | +0.02 | buy |
| ALLIANCEBERNSTEIN L.P. | 125,325 | 170,075 | +44,750 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 107,647 | 151,504 | +43,857 | 0.00 | 0.00 | -0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 35,600 | +35,600 | 0.00 | 0.00 | +0.00 | buy |
| Alpine Global Management, LLC | 0 | 34,181 | +34,181 | 0.00 | 0.03 | +0.03 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 98,279 | 129,276 | +30,997 | 0.00 | 0.00 | -0.00 | buy |
| Trexquant Investment LP | 0 | 30,178 | +30,178 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 48,321 | 77,610 | +29,289 | 0.00 | 0.00 | -0.00 | buy |
| JANUS HENDERSON GROUP PLC | 30,177 | 56,760 | +26,583 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 435,040 | 461,613 | +26,573 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 156,847 | 181,903 | +25,056 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 116,011 | 140,731 | +24,720 | 0.00 | 0.00 | -0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 102,680 | 127,176 | +24,496 | 0.00 | 0.00 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 30,861 | 54,309 | +23,448 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 288,874 | 312,031 | +23,157 | 0.00 | 0.00 | -0.00 | buy |
| Focus Partners Wealth | 19,643 | 41,952 | +22,309 | 0.00 | 0.00 | -0.00 | buy |
| EntryPoint Capital, LLC | 1,757 | 22,332 | +20,575 | 0.02 | 0.06 | +0.04 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 19,100 | +19,100 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 18,249 | +18,249 | 0.00 | 0.01 | +0.01 | buy |
| Tower Research Capital LLC (TRC) | 1,222 | 18,589 | +17,367 | 0.00 | 0.00 | +0.00 | buy |
| Clarius Group, LLC | 46,825 | 63,184 | +16,359 | 0.03 | 0.02 | -0.01 | buy |
| Cetera Investment Advisers | 0 | 14,856 | +14,856 | 0.00 | 0.00 | +0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 12,884 | 27,314 | +14,430 | 0.02 | 0.03 | +0.01 | buy |
| D.A. DAVIDSON & CO. | 22,200 | 35,580 | +13,380 | 0.00 | 0.00 | -0.00 | buy |
| ALGERT GLOBAL LLC | 0 | 13,286 | +13,286 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 34,904 | 47,398 | +12,494 | 0.00 | 0.00 | -0.00 | buy |
| Virtu Financial LLC | 0 | 11,093 | +11,093 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 11,301 | 21,325 | +10,024 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 27,088 | 37,028 | +9,940 | 0.00 | 0.00 | -0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 16,978 | 26,678 | +9,700 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 10,216 | 18,797 | +8,581 | 0.00 | 0.00 | -0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 21,939 | 29,049 | +7,110 | 0.00 | 0.00 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 46,516 | 53,288 | +6,772 | 0.01 | 0.01 | -0.00 | buy |
| Invesco Ltd. | 41,084 | 46,284 | +5,200 | 0.00 | 0.00 | -0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 24,768 | 29,858 | +5,090 | 0.00 | 0.00 | -0.00 | buy |
| FRANKLIN RESOURCES INC | 41,469 | 46,412 | +4,943 | 0.00 | 0.00 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 9,266 | 12,952 | +3,686 | 0.00 | 0.00 | -0.00 | buy |
| Vident Advisory, LLC | 27,059 | 28,939 | +1,880 | 0.01 | 0.00 | -0.00 | buy |
| Blue Trust, Inc. | 0 | 975 | +975 | 0.00 | 0.00 | +0.00 | buy |
| Smartleaf Asset Management LLC | 0 | 597 | +597 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 332 | 855 | +523 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 12,115 | 12,440 | +325 | 0.00 | 0.00 | -0.00 | buy |
| AMALGAMATED BANK | 2,972 | 3,279 | +307 | 0.00 | 0.00 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 1,136 | 1,416 | +280 | 0.00 | 0.00 | -0.00 | buy |
| Arax Advisory Partners | 0 | 150 | +150 | 0.00 | 0.00 | +0.00 | buy |
| Optiver Holding B.V. | 0 | 117 | +117 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 15,510 | 15,565 | +55 | 0.00 | 0.00 | -0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 15 | 70 | +55 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 64 | 67 | +3 | 0.00 | 0.00 | -0.00 | buy |
| BAKER BROS. ADVISORS LP | 2,380,949 | 2,380,949 | 0 | 0.30 | 0.17 | -0.13 | hold |
| CANADA PENSION PLAN INVESTMENT BOARD | 10,175,000 | 10,175,000 | 0 | 0.11 | 0.05 | -0.05 | hold |
| CIBC Private Wealth Group LLC | 625 | 625 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NORGES BANK | 249,621 | 249,621 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Employees Retirement System of Texas | 29,456 | 29,456 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Flagship Pioneering Inc. | 25,001,856 | 25,001,856 | 0 | 16.40 | 16.19 | -0.21 | hold |
| Capital World Investors | 5,449,035 | 5,449,035 | 0 | 0.01 | 0.00 | -0.00 | hold |
| SIGNATUREFD, LLC | 243 | 243 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DekaBank Deutsche Girozentrale | 112,300 | 112,300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 767 | 767 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ArrowMark Colorado Holdings LLC | 685,125 | 685,125 | 0 | 0.08 | 0.04 | -0.03 | hold |
| Skandinaviska Enskilda Banken AB (publ) | 583,489 | 583,489 | 0 | 0.03 | 0.02 | -0.01 | hold |
| Capital International Investors | 432,071 | 432,071 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Omega Fund Management, LLC | 843,750 | 843,750 | 0 | 5.44 | 3.41 | -2.03 | hold |
| QUADRANT CAPITAL GROUP LLC | 792 | 792 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Alphabet Inc. | 2,812,500 | 2,812,500 | 0 | 1.12 | 0.78 | -0.34 | hold |
| EverSource Wealth Advisors, LLC | 129 | 129 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HOEY INVESTMENTS, INC | 2,000 | 2,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Viewpoint Capital Management LLC | 23,545 | 23,545 | 0 | 0.15 | 0.08 | -0.07 | hold |
| Covestor Ltd | 15 | 15 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Dunhill Financial, LLC | 160 | 160 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Farther Finance Advisors, LLC | 14 | 14 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Susquehanna Portfolio Strategies, LLC | 81,695 | 81,695 | 0 | 0.02 | 0.02 | -0.00 | hold |
| Arlington Trust Co LLC | 364 | 364 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BARTLETT & CO. WEALTH MANAGEMENT LLC | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Private Wealth Management Group, LLC | 393 | 393 | 0 | 0.00 | 0.00 | -0.00 | hold |