| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 33,833,306 | 37,431,365 | +3,598,059 | 0.01 | 0.01 | +0.00 | buy |
| Flagship Pioneering Inc. | 25,001,856 | 25,001,856 | 0 | 25.42 | 30.33 | +4.91 | hold |
| BAILLIE GIFFORD & CO | 10,064,728 | 11,436,503 | +1,371,775 | 0.02 | 0.03 | +0.01 | buy |
| BlackRock, Inc. | 10,858,900 | 11,226,136 | +367,236 | 0.00 | 0.00 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 10,175,000 | 10,175,000 | 0 | 0.02 | 0.03 | +0.00 | hold |
| VANGUARD GROUP INC | 7,611,499 | 9,128,973 | +1,517,474 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 2,860,124 | 6,680,541 | +3,820,417 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 2,955,047 | 6,551,977 | +3,596,930 | 0.01 | 0.02 | +0.01 | buy |
| Marex Group plc | 3,817,780 | 3,822,780 | +5,000 | 0.20 | 0.17 | -0.03 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,279,791 | 3,423,532 | +143,741 | 0.00 | 0.00 | +0.00 | buy |
| Alphabet Inc. | 2,812,500 | 2,812,500 | 0 | 0.36 | 0.41 | +0.05 | hold |
| JPMORGAN CHASE & CO | 760,415 | 2,135,444 | +1,375,029 | 0.00 | 0.00 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 2,030,949 | 2,030,949 | 0 | 0.05 | 0.05 | -0.00 | hold |
| Integral Health Asset Management, LLC | 1,500,000 | 2,000,000 | +500,000 | 0.38 | 0.52 | +0.14 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 203,712 | 1,992,500 | +1,788,788 | 0.00 | 0.01 | +0.01 | buy |
| Crestline Management, LP | 2,420,937 | 1,820,937 | -600,000 | 10.56 | 11.13 | +0.56 | sell |
| MILLENNIUM MANAGEMENT LLC | 797,577 | 1,620,000 | +822,423 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 1,145,435 | 1,443,986 | +298,551 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 781,222 | 1,378,236 | +597,014 | 0.01 | 0.02 | +0.01 | buy |
| NORTHERN TRUST CORP | 1,154,314 | 1,318,496 | +164,182 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,086,175 | 1,272,563 | +186,388 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 1,356,363 | 1,181,782 | -174,581 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 884,828 | 917,642 | +32,814 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 1,479,795 | 876,505 | -603,290 | 0.00 | 0.00 | -0.00 | sell |
| Omega Fund Management, LLC | 843,750 | 843,750 | 0 | 1.49 | 1.35 | -0.14 | hold |
| Corient Private Wealth LLC | 1,136,000 | 817,000 | -319,000 | 0.00 | 0.00 | +0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 994,805 | 778,126 | -216,679 | 0.00 | 0.00 | -0.00 | sell |
| GREAT POINT PARTNERS LLC | 0 | 700,000 | +700,000 | 0.00 | 1.04 | +1.04 | buy |
| ArrowMark Colorado Holdings LLC | 685,125 | 685,125 | 0 | 0.03 | 0.05 | +0.01 | hold |
| GOLDMAN SACHS GROUP INC | 303,234 | 682,092 | +378,858 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 611,791 | 610,128 | -1,663 | 0.00 | 0.00 | +0.00 | sell |
| ROYAL BANK OF CANADA | 471,607 | 585,978 | +114,371 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 532,132 | 543,313 | +11,181 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 494,415 | 525,856 | +31,441 | 0.00 | 0.00 | +0.00 | buy |
| Clearline Capital LP | 410,535 | 524,547 | +114,012 | 0.10 | 0.16 | +0.06 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 251,748 | 513,521 | +261,773 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 272,981 | 452,757 | +179,776 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 394,990 | 405,661 | +10,671 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 304,029 | 304,029 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Rafferty Asset Management, LLC | 0 | 267,985 | +267,985 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 0 | 262,300 | +262,300 | 0.00 | 0.00 | +0.00 | buy |
| LMR Partners LLP | 0 | 242,553 | +242,553 | 0.00 | 0.01 | +0.01 | buy |
| IEQ CAPITAL, LLC | 239,649 | 239,875 | +226 | 0.00 | 0.00 | -0.00 | buy |
| JANE STREET GROUP, LLC | 142,863 | 230,620 | +87,757 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 90,998 | 222,322 | +131,324 | 0.00 | 0.00 | +0.00 | buy |
| Clarius Group, LLC | 212,500 | 212,500 | 0 | 0.03 | 0.04 | +0.01 | hold |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 198,179 | +198,179 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 196,745 | 196,745 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RHUMBLINE ADVISERS | 203,283 | 195,706 | -7,577 | 0.00 | 0.00 | +0.00 | sell |
| Susquehanna Portfolio Strategies, LLC | 170,823 | 167,503 | -3,320 | 0.01 | 0.01 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 164,261 | 165,120 | +859 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 164,931 | +164,931 | 0.00 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,557,825 | 146,117 | -2,411,708 | 0.00 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 140,647 | +140,647 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 46,798 | 129,257 | +82,459 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 9,579 | 128,676 | +119,097 | 0.00 | 0.00 | +0.00 | buy |
| Quinn Opportunity Partners LLC | 120,100 | 120,100 | 0 | 0.03 | 0.03 | +0.00 | hold |
| DekaBank Deutsche Girozentrale | 112,300 | 112,300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Palumbo Wealth Management LLC | 81,093 | 111,288 | +30,195 | 0.07 | 0.13 | +0.06 | buy |
| XTX Topco Ltd | 0 | 106,795 | +106,795 | 0.00 | 0.02 | +0.02 | buy |
| WELLS FARGO & COMPANY/MN | 84,596 | 106,366 | +21,770 | 0.00 | 0.00 | +0.00 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 104,442 | 104,442 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SG Americas Securities, LLC | 82,677 | 100,258 | +17,581 | 0.00 | 0.00 | +0.00 | buy |
| Ovata Capital Management Ltd | 0 | 100,000 | +100,000 | 0.00 | 0.07 | +0.07 | buy |
| NewEdge Advisors, LLC | 34,630 | 97,630 | +63,000 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 93,081 | 93,081 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GILDER GAGNON HOWE & CO LLC | 0 | 91,539 | +91,539 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 86,750 | 85,115 | -1,635 | 0.00 | 0.00 | +0.00 | sell |
| CITIGROUP INC | 161,561 | 84,717 | -76,844 | 0.00 | 0.00 | -0.00 | sell |
| SCS Capital Management LLC | 81,452 | 81,320 | -132 | 0.00 | 0.00 | +0.00 | sell |
| MetLife Investment Management, LLC | 81,505 | 79,006 | -2,499 | 0.00 | 0.00 | +0.00 | sell |
| HSBC HOLDINGS PLC | 25,741 | 78,228 | +52,487 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 77,080 | +77,080 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 108,413 | 72,651 | -35,762 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 22,682 | 72,423 | +49,741 | 0.00 | 0.01 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 15,444 | 67,336 | +51,892 | 0.00 | 0.00 | +0.00 | buy |
| Hilton Capital Management, LLC | 0 | 67,115 | +67,115 | 0.00 | 0.02 | +0.02 | buy |
| Savant Capital, LLC | 62,914 | 66,414 | +3,500 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 61,232 | +61,232 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 60,475 | +60,475 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 58,189 | +58,189 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 0 | 57,720 | +57,720 | 0.00 | 0.01 | +0.01 | buy |
| Creative Planning | 51,458 | 54,177 | +2,719 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 50,849 | 52,872 | +2,023 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 49,430 | +49,430 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 290,411 | 47,517 | -242,894 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 45,302 | 45,347 | +45 | 0.01 | 0.01 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 37,021 | 44,798 | +7,777 | 0.03 | 0.05 | +0.01 | buy |
| Graham Capital Management, L.P. | 0 | 44,570 | +44,570 | 0.00 | 0.01 | +0.01 | buy |
| Cerity Partners LLC | 42,480 | 42,138 | -342 | 0.00 | 0.00 | +0.00 | sell |
| Virtu Financial LLC | 22,626 | 41,224 | +18,598 | 0.00 | 0.01 | +0.00 | buy |
| Arizona State Retirement System | 0 | 39,983 | +39,983 | 0.00 | 0.00 | +0.00 | buy |
| Pallas Capital Advisors LLC | 39,564 | 39,627 | +63 | 0.00 | 0.01 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 38,609 | 38,609 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Police & Firemen's Retirement System of New Jersey | 26,579 | 36,729 | +10,150 | 0.00 | 0.00 | +0.00 | buy |
| Employees Retirement System of Texas | 29,456 | 34,669 | +5,213 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 33,294 | +33,294 | 0.00 | 0.02 | +0.02 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 0 | 32,328 | +32,328 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 49,153 | 32,227 | -16,926 | 0.00 | 0.00 | -0.00 | sell |
| ProShare Advisors LLC | 35,782 | 32,030 | -3,752 | 0.00 | 0.00 | +0.00 | sell |