| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MILLENNIUM MANAGEMENT LLC | 512,973 | 2,195,801 | +1,682,828 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 4,608,493 | 5,908,687 | +1,300,194 | 0.00 | 0.00 | +0.00 | buy |
| PFM Health Sciences, LP | 1,244,139 | 1,883,337 | +639,198 | 0.23 | 0.46 | +0.23 | buy |
| VANGUARD GROUP INC | 9,167,585 | 9,797,084 | +629,499 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 353,328 | 684,194 | +330,866 | 0.02 | 0.03 | +0.01 | buy |
| ArrowMark Colorado Holdings LLC | 468,749 | 685,125 | +216,376 | 0.02 | 0.03 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 614,642 | 830,292 | +215,650 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,047,588 | 2,253,836 | +206,248 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 108,340 | 307,420 | +199,080 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 26,836 | 177,000 | +150,164 | 0.00 | 0.01 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 51,083 | 197,386 | +146,303 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 205,567 | 350,614 | +145,047 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 592,963 | 733,402 | +140,439 | 0.00 | 0.00 | +0.00 | buy |
| Corient Private Wealth LLC | 282,860 | 413,360 | +130,500 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 324,882 | 437,614 | +112,732 | 0.01 | 0.01 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 194,869 | 295,100 | +100,231 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 402,394 | 481,790 | +79,396 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 832,607 | 886,973 | +54,366 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 215,231 | 263,477 | +48,246 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 145,370 | 189,900 | +44,530 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 0 | 41,432 | +41,432 | 0.00 | 0.00 | +0.00 | buy |
| ADVISORY RESEARCH INC | 0 | 40,179 | +40,179 | 0.00 | 0.03 | +0.03 | buy |
| ROYAL BANK OF CANADA | 0 | 31,488 | +31,488 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 3,311 | 34,107 | +30,796 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 30,282 | +30,282 | 0.00 | 0.03 | +0.03 | buy |
| Man Group plc | 0 | 29,800 | +29,800 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 0 | 27,500 | +27,500 | 0.00 | 0.00 | +0.00 | buy |
| SHERBROOKE PARK ADVISERS LLC | 0 | 27,061 | +27,061 | 0.00 | 0.05 | +0.05 | buy |
| SG Americas Securities, LLC | 0 | 24,370 | +24,370 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 24,317 | +24,317 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 0 | 23,203 | +23,203 | 0.00 | 0.06 | +0.06 | buy |
| China Universal Asset Management Co., Ltd. | 5,047 | 22,800 | +17,753 | 0.01 | 0.02 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 731,316 | 748,835 | +17,519 | 0.00 | 0.00 | -0.00 | buy |
| PROFUND ADVISORS LLC | 55,314 | 70,703 | +15,389 | 0.01 | 0.01 | +0.00 | buy |
| Vident Advisory, LLC | 10,246 | 25,170 | +14,924 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 13,340 | +13,340 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 1,177,332 | 1,190,634 | +13,302 | 0.00 | 0.00 | -0.00 | buy |
| Employees Retirement System of Texas | 0 | 12,996 | +12,996 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 12,530 | +12,530 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 7,167 | 18,080 | +10,913 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 104,915 | 113,394 | +8,479 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 57,595 | 65,283 | +7,688 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 11,606 | 18,527 | +6,921 | 0.00 | 0.01 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 96,733 | 103,427 | +6,694 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management Co., Ltd. | 16,688 | 23,361 | +6,673 | 0.00 | 0.01 | +0.00 | buy |
| Swiss National Bank | 187,500 | 194,100 | +6,600 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 11,442 | 16,257 | +4,815 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 24,990 | 28,480 | +3,490 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 24,536 | 27,527 | +2,991 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 20,325 | 22,475 | +2,150 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 38,482 | 40,564 | +2,082 | 0.00 | 0.00 | +0.00 | buy |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 200 | 2,200 | +2,000 | 0.00 | 0.00 | +0.00 | buy |
| HOEY INVESTMENTS, INC | 0 | 2,000 | +2,000 | 0.00 | 0.00 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 2,185 | 4,185 | +2,000 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 150,118 | 151,984 | +1,866 | 0.00 | 0.00 | -0.00 | buy |
| D. E. Shaw & Co., Inc. | 252,769 | 254,403 | +1,634 | 0.00 | 0.00 | -0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 46,543 | 47,694 | +1,151 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 37,071 | 38,220 | +1,149 | 0.00 | 0.00 | +0.00 | buy |
| Arlington Trust Co LLC | 0 | 364 | +364 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 332 | +332 | 0.00 | 0.00 | +0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 471 | 792 | +321 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 7,171 | 7,477 | +306 | 0.00 | 0.00 | -0.00 | buy |
| Spire Wealth Management | 0 | 171 | +171 | 0.00 | 0.00 | +0.00 | buy |
| Dunhill Financial, LLC | 0 | 160 | +160 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 129 | +129 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 1,003 | 1,040 | +37 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 14 | +14 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 19 | 29 | +10 | 0.00 | 0.00 | 0.00 | buy |
| Sculptor Capital LP | 19,400 | 19,400 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ameritas Investment Partners, Inc. | 9,266 | 9,266 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TD ASSET MANAGEMENT INC | 362,652 | 362,652 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 126,595 | 126,595 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BAKER BROS. ADVISORS LP | 2,000,000 | 2,000,000 | 0 | 0.04 | 0.09 | +0.05 | hold |
| CANADA PENSION PLAN INVESTMENT BOARD | 10,175,000 | 10,175,000 | 0 | 0.06 | 0.05 | -0.01 | hold |
| NORGES BANK | 249,621 | 249,621 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Flagship Pioneering Inc. | 25,001,856 | 25,001,856 | 0 | 7.02 | 7.70 | +0.67 | hold |
| Capital World Investors | 1,531,307 | 1,531,307 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DekaBank Deutsche Girozentrale | 112,300 | 112,300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 767 | 767 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MetLife Investment Management, LLC | 48,321 | 48,321 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Crestline Management, LP | 3,365,624 | 3,365,624 | 0 | 1.56 | 1.27 | -0.28 | hold |
| Capital International Investors | 432,071 | 432,071 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Omega Fund Management, LLC | 843,750 | 843,750 | 0 | 3.00 | 2.79 | -0.21 | hold |
| Alphabet Inc. | 2,812,500 | 2,812,500 | 0 | 0.70 | 0.53 | -0.17 | hold |
| Clarius Group, LLC | 46,825 | 46,825 | 0 | 0.02 | 0.02 | -0.00 | hold |
| Viewpoint Capital Management LLC | 23,545 | 23,545 | 0 | 0.07 | 0.07 | -0.01 | hold |
| BARTLETT & CO. WEALTH MANAGEMENT LLC | 100 | 100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Kelly Financial Services LLC | 200 | 200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Erste Asset Management GmbH | 40,000 | 40,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA | 156,254 | 156,254 | 0 | 0.08 | 0.08 | +0.00 | hold |
| METROPOLITAN LIFE INSURANCE CO/NY | 5,125 | 5,125 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 89,947 | 89,947 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MARTINGALE ASSET MANAGEMENT L P | 59,703 | 59,703 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 26,678 | 26,678 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JANUS HENDERSON GROUP PLC | 30,178 | 30,167 | -11 | 0.00 | 0.00 | -0.00 | sell |
| Parallel Advisors, LLC | 27 | 0 | -27 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 67 | 0 | -67 | 0.00 | 0.00 | 0.00 | sell |
| TFO Wealth Partners, LLC | 78 | 0 | -78 | 0.00 | 0.00 | -0.00 | sell |
| Red Tortoise LLC | 437 | 0 | -437 | 0.00 | 0.00 | -0.00 | sell |
| AMALGAMATED BANK | 9,223 | 8,338 | -885 | 0.00 | 0.00 | -0.00 | sell |