| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 31,609,175 | 33,490,218 | +1,881,043 | 0.01 | 0.00 | -0.00 | buy |
| Flagship Pioneering Inc. | 25,001,856 | 25,001,856 | 0 | 17.57 | 12.19 | -5.38 | hold |
| BlackRock, Inc. | 11,817,295 | 11,933,076 | +115,781 | 0.00 | 0.00 | -0.00 | buy |
| VANGUARD GROUP INC | 13,183,552 | 10,747,760 | -2,435,792 | 0.00 | 0.00 | -0.00 | sell |
| BAILLIE GIFFORD & CO | 10,278,084 | 10,233,573 | -44,511 | 0.03 | 0.01 | -0.02 | sell |
| CANADA PENSION PLAN INVESTMENT BOARD | 10,175,000 | 10,175,000 | 0 | 0.04 | 0.02 | -0.02 | hold |
| STATE STREET CORP | 6,627,320 | 6,709,661 | +82,341 | 0.00 | 0.00 | -0.00 | buy |
| Capital World Investors | 5,449,035 | 5,449,035 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 3,166,480 | 3,193,081 | +26,601 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,889,119 | 3,108,617 | +219,498 | 0.00 | 0.00 | -0.00 | buy |
| Crestline Management, LP | 3,085,624 | 2,860,937 | -224,687 | 0.73 | 0.16 | -0.57 | sell |
| Alphabet Inc. | 2,812,500 | 2,812,500 | 0 | 0.64 | 0.27 | -0.37 | hold |
| BAKER BROS. ADVISORS LP | 2,380,949 | 2,380,949 | 0 | 0.10 | 0.04 | -0.06 | hold |
| Integral Health Asset Management, LLC | 1,800,000 | 2,000,000 | +200,000 | 0.88 | 0.29 | -0.59 | buy |
| MORGAN STANLEY | 1,903,065 | 1,910,219 | +7,154 | 0.00 | 0.00 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,078,900 | 1,557,496 | +478,596 | 0.00 | 0.00 | -0.00 | buy |
| CITADEL ADVISORS LLC | 179,294 | 1,205,537 | +1,026,243 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 1,128,342 | 1,188,346 | +60,004 | 0.00 | 0.00 | -0.00 | buy |
| Corient Private Wealth LLC | 452,000 | 1,182,699 | +730,699 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 1,016,466 | 1,131,813 | +115,347 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,047,846 | 1,056,512 | +8,666 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 849,998 | 1,004,651 | +154,653 | 0.00 | 0.00 | -0.00 | buy |
| Omega Fund Management, LLC | 843,750 | 843,750 | 0 | 2.19 | 0.89 | -1.30 | hold |
| JPMORGAN CHASE & CO | 917,173 | 806,635 | -110,538 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 53,420 | 728,901 | +675,481 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 687,821 | 690,141 | +2,320 | 0.02 | 0.01 | -0.02 | buy |
| ArrowMark Colorado Holdings LLC | 685,125 | 685,125 | 0 | 0.04 | 0.02 | -0.02 | hold |
| TWO SIGMA INVESTMENTS, LP | 146,256 | 480,298 | +334,042 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 304,738 | 448,853 | +144,115 | 0.00 | 0.00 | -0.00 | buy |
| Capital International Investors | 430,000 | 430,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TD ASSET MANAGEMENT INC | 404,348 | 404,348 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AQR CAPITAL MANAGEMENT LLC | 71,408 | 382,663 | +311,255 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 94,993 | 367,855 | +272,862 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 0 | 365,000 | +365,000 | 0.00 | 0.17 | +0.17 | buy |
| Point72 Asset Management, L.P. | 0 | 363,618 | +363,618 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 427,113 | 354,700 | -72,413 | 0.00 | 0.00 | -0.00 | sell |
| Zimmer Partners, LP | 348,700 | 348,700 | 0 | 0.03 | 0.01 | -0.02 | hold |
| Bank of New York Mellon Corp | 326,923 | 336,828 | +9,905 | 0.00 | 0.00 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 16,500 | 319,818 | +303,318 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 318,910 | 318,483 | -427 | 0.00 | 0.00 | -0.00 | sell |
| Rafferty Asset Management, LLC | 324,531 | 313,851 | -10,680 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 310,115 | 308,222 | -1,893 | 0.00 | 0.00 | -0.00 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 449,821 | 293,159 | -156,662 | 0.01 | 0.00 | -0.01 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 274,118 | 280,731 | +6,613 | 0.00 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 253,899 | 279,282 | +25,383 | 0.00 | 0.00 | -0.00 | buy |
| ExodusPoint Capital Management, LP | 99,466 | 272,908 | +173,442 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 105,145 | 267,510 | +162,365 | 0.00 | 0.00 | +0.00 | buy |
| Compass Rose Asset Management, LP | 100,000 | 250,000 | +150,000 | 0.45 | 0.20 | -0.25 | buy |
| Qube Research & Technologies Ltd | 577,358 | 238,590 | -338,768 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 237,900 | 237,900 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TWO SIGMA ADVISERS, LP | 26,900 | 209,000 | +182,100 | 0.00 | 0.00 | +0.00 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 583,489 | 189,472 | -394,017 | 0.01 | 0.00 | -0.01 | sell |
| NOMURA HOLDINGS INC | 143,633 | 180,483 | +36,850 | 0.00 | 0.00 | -0.00 | buy |
| Squarepoint Ops LLC | 122,806 | 178,431 | +55,625 | 0.00 | 0.00 | -0.00 | buy |
| XTX Topco Ltd | 0 | 175,167 | +175,167 | 0.00 | 0.02 | +0.02 | buy |
| RHUMBLINE ADVISERS | 171,788 | 172,775 | +987 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 154,380 | 161,177 | +6,797 | 0.00 | 0.00 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 170,075 | 148,385 | -21,690 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 0 | 146,491 | +146,491 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 115,931 | 115,034 | -897 | 0.00 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 114,895 | +114,895 | 0.00 | 0.01 | +0.01 | buy |
| Clarius Group, LLC | 63,184 | 112,500 | +49,316 | 0.02 | 0.01 | -0.01 | buy |
| DekaBank Deutsche Girozentrale | 112,300 | 112,300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 43,342 | 111,412 | +68,070 | 0.01 | 0.00 | -0.00 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 104,442 | 104,442 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Walleye Capital LLC | 0 | 93,383 | +93,383 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 57,698 | 89,930 | +32,232 | 0.00 | 0.00 | -0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 73,626 | +73,626 | 0.00 | 0.00 | +0.00 | buy |
| Lighthouse Investment Partners, LLC | 0 | 70,000 | +70,000 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 70,689 | 65,727 | -4,962 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 41,071 | 62,021 | +20,950 | 0.00 | 0.00 | -0.00 | buy |
| PROFUND ADVISORS LLC | 64,151 | 60,576 | -3,575 | 0.01 | 0.00 | -0.01 | sell |
| JANUS HENDERSON GROUP PLC | 56,760 | 56,760 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Bristlecone Advisors, LLC | 50,000 | 50,000 | 0 | 0.02 | 0.01 | -0.01 | hold |
| Invesco Ltd. | 47,180 | 48,502 | +1,322 | 0.00 | 0.00 | -0.00 | buy |
| ProShare Advisors LLC | 38,129 | 47,808 | +9,679 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 42,787 | 47,341 | +4,554 | 0.02 | 0.01 | -0.01 | buy |
| FRANKLIN RESOURCES INC | 46,573 | 46,637 | +64 | 0.00 | 0.00 | -0.00 | buy |
| LMR Partners LLP | 0 | 45,356 | +45,356 | 0.00 | 0.00 | +0.00 | buy |
| Vident Advisory, LLC | 30,430 | 43,291 | +12,861 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 43,759 | 41,248 | -2,511 | 0.00 | 0.00 | -0.00 | sell |
| Erste Asset Management GmbH | 40,000 | 40,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Blue Trust, Inc. | 13,129 | 39,827 | +26,698 | 0.00 | 0.00 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 38,609 | 38,609 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 30,588 | 36,797 | +6,209 | 0.00 | 0.00 | -0.00 | buy |
| Creative Planning | 0 | 36,596 | +36,596 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 35,080 | 35,440 | +360 | 0.00 | 0.00 | -0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 35,196 | 35,196 | 0 | 0.00 | 0.00 | -0.00 | hold |
| COLDSTREAM CAPITAL MANAGEMENT INC | 0 | 35,172 | +35,172 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 12,890 | 34,849 | +21,959 | 0.03 | 0.02 | -0.00 | buy |
| HSBC HOLDINGS PLC | 13,620 | 32,704 | +19,084 | 0.00 | 0.00 | -0.00 | buy |
| Employees Retirement System of Texas | 29,456 | 29,456 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Engineers Gate Manager LP | 87,168 | 28,352 | -58,816 | 0.01 | 0.00 | -0.01 | sell |
| MetLife Investment Management, LLC | 77,610 | 27,658 | -49,952 | 0.00 | 0.00 | -0.00 | sell |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 26,678 | 26,678 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Viewpoint Capital Management LLC | 23,545 | 23,545 | 0 | 0.06 | 0.02 | -0.04 | hold |
| Point72 (DIFC) Ltd | 0 | 22,926 | +22,926 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management Co., Ltd. | 20,590 | 22,202 | +1,612 | 0.00 | 0.00 | -0.00 | buy |
| Focus Partners Wealth | 0 | 21,376 | +21,376 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 21,325 | 21,325 | 0 | 0.00 | 0.00 | -0.00 | hold |