| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 12,785,536 | 12,929,249 | +143,713 | 0.05 | 0.03 | -0.02 | buy |
| VANGUARD GROUP INC | 9,011,332 | 9,101,536 | +90,204 | 0.01 | 0.01 | -0.00 | buy |
| BAILLIE GIFFORD & CO | 7,919,976 | 7,424,766 | -495,210 | 0.35 | 0.22 | -0.13 | sell |
| ARK Investment Management LLC | 4,041,287 | 6,283,812 | +2,242,525 | 1.34 | 1.63 | +0.29 | buy |
| MORGAN STANLEY | 4,179,415 | 5,164,507 | +985,092 | 0.02 | 0.02 | -0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,104,174 | 3,657,227 | +553,053 | 0.02 | 0.02 | -0.01 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 2,283,530 | 3,621,778 | +1,338,248 | 0.09 | 0.09 | -0.00 | buy |
| Nikko Asset Management Americas, Inc. | 2,283,530 | 3,621,778 | +1,338,248 | 1.23 | 1.35 | +0.12 | buy |
| SANDS CAPITAL MANAGEMENT, LLC | 3,590,145 | 3,383,141 | -207,004 | 0.61 | 0.36 | -0.26 | sell |
| BROWN CAPITAL MANAGEMENT LLC | 3,527,297 | 2,674,847 | -852,450 | 2.96 | 1.78 | -1.19 | sell |
| T. Rowe Price Investment Management, Inc. | 1,141,044 | 2,204,430 | +1,063,386 | 0.04 | 0.05 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,587,815 | 1,643,153 | +55,338 | 0.01 | 0.01 | -0.00 | buy |
| STATE STREET CORP | 1,559,228 | 1,585,702 | +26,474 | 0.00 | 0.00 | -0.00 | buy |
| RTW INVESTMENTS, LP | 1,549,951 | 1,554,856 | +4,905 | 1.35 | 0.86 | -0.49 | buy |
| SVB WEALTH LLC | 1,446,552 | 1,440,560 | -5,992 | 1.97 | 1.21 | -0.76 | sell |
| GENERATION INVESTMENT MANAGEMENT LLP | 1,531,392 | 1,414,124 | -117,268 | 0.39 | 0.24 | -0.15 | sell |
| MILLENNIUM MANAGEMENT LLC | 275,135 | 1,132,428 | +857,293 | 0.01 | 0.04 | +0.02 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 924,832 | 944,357 | +19,525 | 0.01 | 0.01 | -0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 536,721 | 901,745 | +365,024 | 0.12 | 0.12 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 527,577 | 881,164 | +353,587 | 0.01 | 0.01 | -0.00 | buy |
| NORGES BANK | 647,996 | 874,991 | +226,995 | 0.01 | 0.01 | -0.00 | buy |
| Bank of New York Mellon Corp | 947,393 | 850,815 | -96,578 | 0.01 | 0.01 | -0.00 | sell |
| Capital World Investors | 793,300 | 793,300 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Freshford Capital Management, LLC | 305,798 | 783,238 | +477,440 | 2.98 | 5.05 | +2.07 | buy |
| Alyeska Investment Group, L.P. | 708,849 | 706,492 | -2,357 | 0.27 | 0.17 | -0.10 | sell |
| Southpoint Capital Advisors LP | 0 | 700,000 | +700,000 | 0.00 | 0.52 | +0.52 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 642,915 | 656,709 | +13,794 | 0.05 | 0.03 | -0.02 | buy |
| BANK OF AMERICA CORP /DE/ | 268,948 | 639,832 | +370,884 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 469,635 | 591,862 | +122,227 | 0.00 | 0.00 | -0.00 | buy |
| FIRST TRUST ADVISORS LP | 14,352 | 579,884 | +565,532 | 0.00 | 0.02 | +0.02 | buy |
| Squarepoint Ops LLC | 239,375 | 510,163 | +270,788 | 0.05 | 0.08 | +0.02 | buy |
| Granite Investment Partners, LLC | 0 | 509,033 | +509,033 | 0.00 | 0.73 | +0.73 | buy |
| GILDER GAGNON HOWE & CO LLC | 502,471 | 504,174 | +1,703 | 0.39 | 0.24 | -0.15 | buy |
| Meritech Capital Associates V L.L.C. | 494,236 | 494,236 | 0 | 6.73 | 6.20 | -0.53 | hold |
| Sands Capital Alternatives, LLC | 481,770 | 481,770 | 0 | 7.50 | 4.36 | -3.14 | hold |
| DIMENSIONAL FUND ADVISORS LP | 501,414 | 476,237 | -25,177 | 0.01 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 515,341 | 466,354 | -48,987 | 0.01 | 0.00 | -0.00 | sell |
| FRED ALGER MANAGEMENT, LLC | 405,183 | 445,567 | +40,384 | 0.12 | 0.08 | -0.04 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 60,558 | 414,245 | +353,687 | 0.00 | 0.02 | +0.01 | buy |
| Qube Research & Technologies Ltd | 0 | 383,704 | +383,704 | 0.00 | 0.03 | +0.03 | buy |
| TD ASSET MANAGEMENT INC | 275,164 | 379,564 | +104,400 | 0.02 | 0.01 | -0.00 | buy |
| Cubist Systematic Strategies, LLC | 123,364 | 365,322 | +241,958 | 0.09 | 0.16 | +0.07 | buy |
| Trexquant Investment LP | 101,344 | 362,419 | +261,075 | 0.13 | 0.27 | +0.14 | buy |
| Mirae Asset Global Investments Co., Ltd. | 87,590 | 319,287 | +231,697 | 0.01 | 0.03 | +0.02 | buy |
| BAMCO INC /NY/ | 197,562 | 314,862 | +117,300 | 0.03 | 0.03 | +0.00 | buy |
| Bellevue Group AG | 293,173 | 308,311 | +15,138 | 0.25 | 0.18 | -0.07 | buy |
| GOLDMAN SACHS GROUP INC | 372,873 | 286,146 | -86,727 | 0.00 | 0.00 | -0.00 | sell |
| ORBIMED ADVISORS LLC | 39,800 | 225,200 | +185,400 | 0.04 | 0.16 | +0.11 | buy |
| Decheng Capital LLC | 359,554 | 195,835 | -163,719 | 5.62 | 0.99 | -4.64 | sell |
| Blue Water Life Science Advisors, LP | 194,500 | 194,500 | 0 | 9.53 | 6.87 | -2.67 | hold |
| Granahan Investment Management, LLC | 185,054 | 178,893 | -6,161 | 0.34 | 0.24 | -0.11 | sell |
| Swiss National Bank | 173,200 | 174,700 | +1,500 | 0.01 | 0.00 | -0.00 | buy |
| HARVARD MANAGEMENT CO INC | 170,000 | 170,000 | 0 | 0.80 | 0.40 | -0.40 | hold |
| AMERICAN CENTURY COMPANIES INC | 173,570 | 168,230 | -5,340 | 0.01 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 0 | 165,732 | +165,732 | 0.00 | 0.08 | +0.08 | buy |
| ARMISTICE CAPITAL, LLC | 92,000 | 158,286 | +66,286 | 0.14 | 0.16 | +0.02 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 114,046 | 156,915 | +42,869 | 0.00 | 0.01 | +0.00 | buy |
| Vestmark Advisory Solutions, Inc. | 77,409 | 156,043 | +78,634 | 0.22 | 0.25 | +0.03 | buy |
| LINCOLN NATIONAL CORP | 150,208 | 150,205 | -3 | 0.15 | 0.09 | -0.06 | sell |
| Russell Investments Group, Ltd. | 11,846 | 146,444 | +134,598 | 0.00 | 0.01 | +0.01 | buy |
| Eagle Health Investments LP | 0 | 135,059 | +135,059 | 0.00 | 0.97 | +0.97 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 132,964 | 134,681 | +1,717 | 0.00 | 0.00 | -0.00 | buy |
| IEQ CAPITAL, LLC | 128,124 | 131,241 | +3,117 | 0.12 | 0.07 | -0.05 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 129,112 | 121,217 | -7,895 | 0.01 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 121,882 | 106,907 | -14,975 | 0.01 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 31,803 | 106,546 | +74,743 | 0.06 | 0.11 | +0.05 | buy |
| Woodline Partners LP | 0 | 105,261 | +105,261 | 0.00 | 0.04 | +0.04 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 99,600 | +99,600 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 97,172 | +97,172 | 0.00 | 0.02 | +0.02 | buy |
| AQR CAPITAL MANAGEMENT LLC | 48,525 | 95,235 | +46,710 | 0.01 | 0.01 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 89,738 | 93,224 | +3,486 | 0.01 | 0.01 | +0.00 | buy |
| Magnetar Financial LLC | 0 | 90,262 | +90,262 | 0.00 | 0.08 | +0.08 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 93,503 | 88,924 | -4,579 | 0.01 | 0.00 | -0.00 | sell |
| Slow Capital, Inc. | 64,016 | 87,765 | +23,749 | 0.62 | 0.53 | -0.10 | buy |
| CITADEL ADVISORS LLC | 114,225 | 87,159 | -27,066 | 0.01 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 84,355 | 84,957 | +602 | 0.00 | 0.00 | -0.00 | buy |
| ALGERT GLOBAL LLC | 25,240 | 84,600 | +59,360 | 0.06 | 0.12 | +0.07 | buy |
| Invesco Ltd. | 2,334,938 | 83,811 | -2,251,127 | 0.03 | 0.00 | -0.03 | sell |
| TUDOR INVESTMENT CORP ET AL | 63,892 | 81,612 | +17,720 | 0.05 | 0.04 | -0.01 | buy |
| JPMORGAN CHASE & CO | 1,475,286 | 79,434 | -1,395,852 | 0.01 | 0.00 | -0.01 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 31,400 | 79,400 | +48,000 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 0 | 78,341 | +78,341 | 0.00 | 0.17 | +0.17 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 75,619 | +75,619 | 0.00 | 0.13 | +0.13 | buy |
| LAZARD ASSET MANAGEMENT LLC | 60,568 | 74,540 | +13,972 | 0.00 | 0.00 | -0.00 | buy |
| CIBC Asset Management Inc | 0 | 72,147 | +72,147 | 0.00 | 0.01 | +0.01 | buy |
| Point72 Hong Kong Ltd | 0 | 70,045 | +70,045 | 0.00 | 0.13 | +0.13 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 69,787 | 68,737 | -1,050 | 0.04 | 0.02 | -0.01 | sell |
| D. E. Shaw & Co., Inc. | 4,944 | 64,799 | +59,855 | 0.00 | 0.00 | +0.00 | buy |
| Assenagon Asset Management S.A. | 17,586 | 63,400 | +45,814 | 0.00 | 0.01 | +0.00 | buy |
| Amundi | 42,281 | 62,125 | +19,844 | 0.00 | 0.00 | -0.00 | buy |
| State of New Jersey Common Pension Fund D | 59,357 | 59,357 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Engineers Gate Manager LP | 0 | 58,913 | +58,913 | 0.00 | 0.06 | +0.06 | buy |
| Cresset Asset Management, LLC | 61,002 | 58,604 | -2,398 | 0.02 | 0.01 | -0.01 | sell |
| BARCLAYS PLC | 266,298 | 57,736 | -208,562 | 0.01 | 0.00 | -0.01 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 65,036 | 57,668 | -7,368 | 0.01 | 0.01 | -0.00 | sell |
| ALLEN OPERATIONS LLC | 56,600 | 56,600 | 0 | 0.63 | 0.40 | -0.23 | hold |
| UBS Group AG | 6,229 | 54,267 | +48,038 | 0.00 | 0.00 | +0.00 | buy |
| Dynamic Technology Lab Private Ltd | 10,647 | 53,367 | +42,720 | 0.06 | 0.21 | +0.15 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 52,400 | +52,400 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 36,877 | 51,593 | +14,716 | 0.00 | 0.00 | -0.00 | buy |