| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 11,917,482 | 17,740,972 | +5,823,490 | 0.01 | 0.02 | +0.01 | buy |
| ARK Investment Management LLC | 12,667,369 | 11,717,317 | -950,052 | 1.37 | 1.93 | +0.56 | sell |
| BlackRock, Inc. | 10,014,462 | 10,079,913 | +65,451 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 4,667,203 | 5,411,761 | +744,558 | 0.15 | 0.19 | +0.04 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 5,492,189 | 5,110,214 | -381,975 | 0.05 | 0.07 | +0.02 | sell |
| Nikko Asset Management Americas, Inc. | 5,486,153 | 5,104,178 | -381,975 | 1.03 | 1.53 | +0.50 | sell |
| GOLDMAN SACHS GROUP INC | 3,087,267 | 3,971,800 | +884,533 | 0.01 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,789,784 | 2,904,228 | +114,444 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 3,196,893 | 2,656,353 | -540,540 | 0.00 | 0.00 | +0.00 | sell |
| STATE STREET CORP | 2,512,519 | 2,588,795 | +76,276 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 2,579,051 | 2,538,256 | -40,795 | 0.02 | 0.02 | +0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 2,639,999 | 2,283,424 | -356,575 | 0.17 | 0.20 | +0.04 | sell |
| Casdin Capital, LLC | 1,400,000 | 2,275,000 | +875,000 | 1.42 | 3.66 | +2.24 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,242,366 | 2,068,414 | +826,048 | 0.01 | 0.03 | +0.02 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,517,581 | 2,042,950 | +525,369 | 0.01 | 0.01 | +0.00 | buy |
| Capital World Investors | 1,452,300 | 1,452,300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| T. Rowe Price Investment Management, Inc. | 1,279,503 | 1,279,382 | -121 | 0.01 | 0.02 | +0.01 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,106,322 | 1,127,056 | +20,734 | 0.00 | 0.00 | +0.00 | buy |
| Blue Water Life Science Advisors, LP | 0 | 1,090,000 | +1,090,000 | 0.00 | 18.56 | +18.56 | buy |
| NORTHERN TRUST CORP | 993,380 | 1,048,005 | +54,625 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 1,550,539 | 1,008,739 | -541,800 | 0.04 | 0.03 | -0.01 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 989,522 | +989,522 | 0.00 | 0.04 | +0.04 | buy |
| BANK OF AMERICA CORP /DE/ | 1,837,520 | 964,579 | -872,941 | 0.00 | 0.00 | -0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 709,579 | 938,408 | +228,829 | 0.03 | 0.05 | +0.02 | buy |
| JPMORGAN CHASE & CO | 928,426 | 785,505 | -142,921 | 0.00 | 0.00 | +0.00 | sell |
| CITADEL ADVISORS LLC | 130,820 | 743,734 | +612,914 | 0.00 | 0.01 | +0.01 | buy |
| IEQ CAPITAL, LLC | 760,096 | 700,684 | -59,412 | 0.04 | 0.07 | +0.03 | sell |
| Freshford Capital Management, LLC | 833,302 | 672,956 | -160,346 | 5.45 | 7.14 | +1.68 | sell |
| Nuveen, LLC | 236,403 | 625,796 | +389,393 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 644,908 | 611,614 | -33,294 | 0.02 | 0.02 | +0.00 | sell |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 632,079 | 542,757 | -89,322 | 0.71 | 0.87 | +0.16 | sell |
| Trexquant Investment LP | 752,634 | 533,288 | -219,346 | 0.11 | 0.08 | -0.03 | sell |
| Meridiem Capital Partners LP | 0 | 523,998 | +523,998 | 0.00 | 0.73 | +0.73 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 1,228,703 | 497,157 | -731,546 | 0.07 | 0.04 | -0.03 | sell |
| UBS Group AG | 861,000 | 494,762 | -366,238 | 0.00 | 0.00 | -0.00 | sell |
| Sands Capital Alternatives, LLC | 481,770 | 481,770 | 0 | 1.52 | 2.43 | +0.91 | hold |
| Russell Investments Group, Ltd. | 533,947 | 480,619 | -53,328 | 0.01 | 0.01 | +0.00 | sell |
| Quantedge Capital Pte Ltd | 203,953 | 416,553 | +212,600 | 1.59 | 4.84 | +3.25 | buy |
| TWO SIGMA INVESTMENTS, LP | 1,155,691 | 402,427 | -753,264 | 0.03 | 0.01 | -0.02 | sell |
| Simplify Asset Management Inc. | 485,977 | 354,703 | -131,274 | 0.13 | 0.12 | -0.01 | sell |
| Bank of New York Mellon Corp | 350,964 | 347,562 | -3,402 | 0.00 | 0.00 | +0.00 | sell |
| AMERIPRISE FINANCIAL INC | 383,169 | 332,524 | -50,645 | 0.00 | 0.00 | +0.00 | sell |
| Bellevue Group AG | 322,060 | 329,492 | +7,432 | 0.10 | 0.17 | +0.07 | buy |
| LORD, ABBETT & CO. LLC | 0 | 329,318 | +329,318 | 0.00 | 0.02 | +0.02 | buy |
| Allianz Asset Management GmbH | 0 | 320,009 | +320,009 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 334,300 | 317,643 | -16,657 | 0.00 | 0.00 | +0.00 | sell |
| JANUS HENDERSON GROUP PLC | 545,826 | 305,268 | -240,558 | 0.00 | 0.00 | -0.00 | sell |
| Susquehanna Portfolio Strategies, LLC | 298,230 | 298,230 | 0 | 0.08 | 0.09 | +0.02 | hold |
| AMERICAN CENTURY COMPANIES INC | 271,654 | 292,201 | +20,547 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 250,016 | 286,398 | +36,382 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 285,389 | +285,389 | 0.00 | 0.00 | +0.00 | buy |
| Summit Trail Advisors, LLC | 220,386 | 269,768 | +49,382 | 0.06 | 0.08 | +0.02 | buy |
| Man Group plc | 393,064 | 269,264 | -123,800 | 0.01 | 0.01 | -0.00 | sell |
| Vestmark Advisory Solutions, Inc. | 270,668 | 251,030 | -19,638 | 0.06 | 0.06 | -0.00 | sell |
| OSSIAM | 229,300 | 229,300 | 0 | 0.07 | 0.09 | +0.01 | hold |
| PRINCIPAL FINANCIAL GROUP INC | 249,007 | 226,830 | -22,177 | 0.00 | 0.00 | +0.00 | sell |
| Focus Partners Wealth | 189,059 | 224,496 | +35,437 | 0.00 | 0.01 | +0.00 | buy |
| Pictet Asset Management Holding SA | 229,227 | 219,049 | -10,178 | 0.00 | 0.00 | +0.00 | sell |
| ARCH Venture Management, LLC | 737,539 | 217,834 | -519,705 | 1.85 | 0.68 | -1.16 | sell |
| Corient Private Wealth LLC | 149,027 | 211,270 | +62,243 | 0.00 | 0.01 | +0.00 | buy |
| Tao Capital Management LP | 210,862 | 210,862 | 0 | 2.96 | 3.77 | +0.81 | hold |
| Swiss National Bank | 203,000 | 207,400 | +4,400 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 169,589 | 205,537 | +35,948 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 228,745 | 182,984 | -45,761 | 0.01 | 0.01 | +0.00 | sell |
| HARVARD MANAGEMENT CO INC | 170,000 | 170,000 | 0 | 0.13 | 0.20 | +0.07 | hold |
| CAISSE DE DEPOT ET PLACEMENT DU QUEBEC | 0 | 165,250 | +165,250 | 0.00 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 118,371 | 163,215 | +44,844 | 0.00 | 0.00 | +0.00 | buy |
| FINANCIAL CONSULATE, INC | 156,457 | 156,457 | 0 | 0.35 | 0.41 | +0.06 | hold |
| Exome Asset Management LLC | 163,658 | 154,194 | -9,464 | 1.32 | 1.93 | +0.61 | sell |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 118,706 | 152,187 | +33,481 | 0.00 | 0.01 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 53,528 | 150,980 | +97,452 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 390,280 | 147,310 | -242,970 | 0.10 | 0.05 | -0.05 | sell |
| RHUMBLINE ADVISERS | 143,440 | 143,379 | -61 | 0.00 | 0.00 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 344,950 | 140,116 | -204,834 | 0.00 | 0.00 | -0.00 | sell |
| Cerity Partners LLC | 129,251 | 133,827 | +4,576 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 91,983 | 133,038 | +41,055 | 0.11 | 0.22 | +0.11 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 127,250 | 127,250 | 0 | 0.01 | 0.01 | +0.00 | hold |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 121,427 | 126,332 | +4,905 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 126,200 | 125,131 | -1,069 | 0.00 | 0.00 | +0.00 | sell |
| CWM, LLC | 124,970 | 124,804 | -166 | 0.01 | 0.01 | +0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 126,293 | 123,142 | -3,151 | 0.00 | 0.00 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 101,629 | 115,867 | +14,238 | 0.00 | 0.00 | +0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 83,266 | 114,972 | +31,706 | 0.00 | 0.00 | +0.00 | buy |
| Gotham Asset Management, LLC | 94,717 | 114,953 | +20,236 | 0.01 | 0.01 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 113,724 | +113,724 | 0.00 | 0.02 | +0.02 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 35,242 | 113,345 | +78,103 | 0.00 | 0.00 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 101,683 | 111,879 | +10,196 | 0.01 | 0.01 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 61,813 | 108,632 | +46,819 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 108,112 | 108,192 | +80 | 0.00 | 0.00 | +0.00 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 51,499 | 107,216 | +55,717 | 0.06 | 0.14 | +0.09 | buy |
| MARSHALL WACE, LLP | 91,700 | 102,272 | +10,572 | 0.00 | 0.00 | +0.00 | buy |
| Capricorn Fund Managers Ltd | 0 | 101,800 | +101,800 | 0.00 | 0.34 | +0.34 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 108,215 | 96,319 | -11,896 | 0.00 | 0.00 | +0.00 | sell |
| Engineers Gate Manager LP | 93,378 | 92,513 | -865 | 0.02 | 0.02 | +0.01 | sell |
| Legal & General Group Plc | 101,896 | 91,933 | -9,963 | 0.00 | 0.00 | +0.00 | sell |
| Creative Planning | 58,719 | 91,311 | +32,592 | 0.00 | 0.00 | +0.00 | buy |
| Cambridge Investment Research Advisors, Inc. | 80,003 | 88,043 | +8,040 | 0.00 | 0.00 | +0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 89,006 | 85,207 | -3,799 | 0.04 | 0.05 | +0.01 | sell |
| CANADA PENSION PLAN INVESTMENT BOARD | 229,300 | 82,900 | -146,400 | 0.00 | 0.00 | -0.00 | sell |
| PEAK6 LLC | 0 | 81,424 | +81,424 | 0.00 | 0.05 | +0.05 | buy |