| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 12,929,249 | 13,010,509 | +81,260 | 0.03 | 0.02 | -0.02 | buy |
| VANGUARD GROUP INC | 9,101,536 | 10,189,257 | +1,087,721 | 0.01 | 0.00 | -0.00 | buy |
| ARK Investment Management LLC | 6,283,812 | 9,313,763 | +3,029,951 | 1.63 | 1.61 | -0.03 | buy |
| Nikko Asset Management Americas, Inc. | 3,621,778 | 6,148,252 | +2,526,474 | 1.35 | 1.38 | +0.03 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 3,621,778 | 6,143,067 | +2,521,289 | 0.09 | 0.09 | -0.01 | buy |
| MORGAN STANLEY | 5,164,507 | 5,773,868 | +609,361 | 0.02 | 0.01 | -0.01 | buy |
| GENERATION INVESTMENT MANAGEMENT LLP | 1,414,124 | 2,884,661 | +1,470,537 | 0.24 | 0.27 | +0.03 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,657,227 | 2,873,952 | -783,275 | 0.02 | 0.01 | -0.01 | sell |
| BAILLIE GIFFORD & CO | 7,424,766 | 2,742,153 | -4,682,613 | 0.22 | 0.04 | -0.18 | sell |
| BROWN CAPITAL MANAGEMENT LLC | 2,674,847 | 2,483,705 | -191,142 | 1.78 | 0.98 | -0.80 | sell |
| SANDS CAPITAL MANAGEMENT, LLC | 3,383,141 | 2,334,901 | -1,048,240 | 0.36 | 0.13 | -0.22 | sell |
| T. Rowe Price Investment Management, Inc. | 2,204,430 | 2,162,979 | -41,451 | 0.05 | 0.03 | -0.02 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 134,681 | 1,926,483 | +1,791,802 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,643,153 | 1,772,933 | +129,780 | 0.01 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 1,585,702 | 1,634,109 | +48,407 | 0.00 | 0.00 | -0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 901,745 | 1,440,042 | +538,297 | 0.12 | 0.10 | -0.02 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,132,428 | 1,360,751 | +228,323 | 0.04 | 0.02 | -0.01 | buy |
| NORGES BANK | 874,991 | 991,051 | +116,060 | 0.01 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 944,357 | 964,682 | +20,325 | 0.01 | 0.00 | -0.00 | buy |
| Capital World Investors | 793,300 | 793,300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BANK OF AMERICA CORP /DE/ | 639,832 | 736,498 | +96,666 | 0.00 | 0.00 | -0.00 | buy |
| Soleus Capital Management, L.P. | 0 | 719,000 | +719,000 | 0.00 | 1.23 | +1.23 | buy |
| NORTHERN TRUST CORP | 591,862 | 648,810 | +56,948 | 0.00 | 0.00 | -0.00 | buy |
| Qube Research & Technologies Ltd | 383,704 | 620,002 | +236,298 | 0.03 | 0.02 | -0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 597,000 | +597,000 | 0.00 | 0.19 | +0.19 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 656,709 | 565,138 | -91,571 | 0.03 | 0.01 | -0.02 | sell |
| SVB WEALTH LLC | 1,440,560 | 525,044 | -915,516 | 1.21 | 0.25 | -0.95 | sell |
| BARCLAYS PLC | 57,736 | 521,957 | +464,221 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 510,163 | 515,883 | +5,720 | 0.08 | 0.04 | -0.04 | buy |
| SRS Investment Management, LLC | 0 | 504,257 | +504,257 | 0.00 | 0.13 | +0.13 | buy |
| RTW INVESTMENTS, LP | 1,554,856 | 502,856 | -1,052,000 | 0.86 | 0.15 | -0.71 | sell |
| Meritech Capital Associates V L.L.C. | 494,236 | 494,236 | 0 | 6.20 | 3.30 | -2.91 | hold |
| Sands Capital Alternatives, LLC | 481,770 | 481,770 | 0 | 4.36 | 3.14 | -1.22 | hold |
| Granite Investment Partners, LLC | 509,033 | 461,013 | -48,020 | 0.73 | 0.37 | -0.36 | sell |
| Southpoint Capital Advisors LP | 700,000 | 400,000 | -300,000 | 0.52 | 0.19 | -0.33 | sell |
| CITADEL ADVISORS LLC | 87,159 | 334,393 | +247,234 | 0.00 | 0.01 | +0.00 | buy |
| Granahan Investment Management, LLC | 178,893 | 334,007 | +155,114 | 0.24 | 0.26 | +0.02 | buy |
| Trexquant Investment LP | 362,419 | 328,924 | -33,495 | 0.27 | 0.10 | -0.17 | sell |
| Bank of New York Mellon Corp | 850,815 | 328,181 | -522,634 | 0.01 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 95,235 | 315,180 | +219,945 | 0.01 | 0.01 | +0.00 | buy |
| BAMCO INC /NY/ | 314,862 | 314,862 | 0 | 0.03 | 0.02 | -0.01 | hold |
| Bellevue Group AG | 308,311 | 308,311 | 0 | 0.18 | 0.10 | -0.08 | hold |
| ExodusPoint Capital Management, LP | 165,732 | 289,211 | +123,479 | 0.08 | 0.06 | -0.02 | buy |
| TD ASSET MANAGEMENT INC | 379,564 | 284,564 | -95,000 | 0.01 | 0.01 | -0.01 | sell |
| PDT Partners, LLC | 45,218 | 261,880 | +216,662 | 0.16 | 0.48 | +0.32 | buy |
| GOLDMAN SACHS GROUP INC | 286,146 | 255,363 | -30,783 | 0.00 | 0.00 | -0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 81,612 | 236,130 | +154,518 | 0.04 | 0.05 | +0.01 | buy |
| Blue Water Life Science Advisors, LP | 194,500 | 230,000 | +35,500 | 6.87 | 4.35 | -2.52 | buy |
| TWO SIGMA ADVISERS, LP | 22,500 | 221,300 | +198,800 | 0.00 | 0.01 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 476,237 | 215,092 | -261,145 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 52,400 | 210,200 | +157,800 | 0.00 | 0.01 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 75,619 | 201,671 | +126,052 | 0.13 | 0.09 | -0.04 | buy |
| Magnetar Financial LLC | 90,262 | 195,762 | +105,500 | 0.08 | 0.08 | +0.00 | buy |
| JANE STREET GROUP, LLC | 14,854 | 189,792 | +174,938 | 0.00 | 0.00 | +0.00 | buy |
| Vestmark Advisory Solutions, Inc. | 156,043 | 188,327 | +32,284 | 0.25 | 0.15 | -0.10 | buy |
| Swiss National Bank | 174,700 | 187,100 | +12,400 | 0.00 | 0.00 | -0.00 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 79,400 | 186,800 | +107,400 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 23,762 | 181,148 | +157,386 | 0.00 | 0.01 | +0.01 | buy |
| HARVARD MANAGEMENT CO INC | 170,000 | 170,000 | 0 | 0.40 | 0.20 | -0.20 | hold |
| ARMISTICE CAPITAL, LLC | 158,286 | 154,482 | -3,804 | 0.16 | 0.08 | -0.08 | sell |
| UBS Group AG | 54,267 | 151,557 | +97,290 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 146,444 | 147,465 | +1,021 | 0.01 | 0.00 | -0.00 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 121,217 | 145,667 | +24,450 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 156,915 | 141,823 | -15,092 | 0.01 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 43,352 | 136,777 | +93,425 | 0.00 | 0.01 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 168,230 | 131,683 | -36,547 | 0.00 | 0.00 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 881,164 | 122,304 | -758,860 | 0.01 | 0.00 | -0.01 | sell |
| ALGERT GLOBAL LLC | 84,600 | 117,964 | +33,364 | 0.12 | 0.08 | -0.05 | buy |
| RHUMBLINE ADVISERS | 106,907 | 106,972 | +65 | 0.00 | 0.00 | -0.00 | buy |
| Man Group plc | 44,565 | 106,626 | +62,061 | 0.00 | 0.01 | +0.00 | buy |
| Slow Capital, Inc. | 87,765 | 105,526 | +17,761 | 0.53 | 0.33 | -0.20 | buy |
| IEQ CAPITAL, LLC | 131,241 | 103,958 | -27,283 | 0.07 | 0.03 | -0.04 | sell |
| SG Americas Securities, LLC | 14,377 | 101,344 | +86,967 | 0.00 | 0.01 | +0.01 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 97,172 | 101,301 | +4,129 | 0.02 | 0.01 | -0.01 | buy |
| Invesco Ltd. | 83,811 | 100,418 | +16,607 | 0.00 | 0.00 | -0.00 | buy |
| CIBC Asset Management Inc | 72,147 | 95,259 | +23,112 | 0.01 | 0.01 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 88,924 | 93,456 | +4,532 | 0.00 | 0.00 | -0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 91,335 | +91,335 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 37,862 | 91,081 | +53,219 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 93,224 | 89,738 | -3,486 | 0.01 | 0.00 | -0.01 | sell |
| Legal & General Group Plc | 84,957 | 89,316 | +4,359 | 0.00 | 0.00 | -0.00 | buy |
| State of New Jersey Common Pension Fund D | 59,357 | 84,118 | +24,761 | 0.01 | 0.01 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 80,311 | +80,311 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 79,434 | 78,133 | -1,301 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 414,245 | 77,850 | -336,395 | 0.02 | 0.00 | -0.01 | sell |
| Cresset Asset Management, LLC | 58,604 | 76,147 | +17,543 | 0.01 | 0.01 | -0.00 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 68,737 | 68,737 | 0 | 0.02 | 0.01 | -0.01 | hold |
| LAZARD ASSET MANAGEMENT LLC | 74,540 | 68,099 | -6,441 | 0.00 | 0.00 | -0.00 | sell |
| FRED ALGER MANAGEMENT, LLC | 445,567 | 65,973 | -379,594 | 0.08 | 0.01 | -0.08 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 57,668 | 65,415 | +7,747 | 0.01 | 0.00 | -0.00 | buy |
| Mirador Capital Partners LP | 28,825 | 61,967 | +33,142 | 0.21 | 0.23 | +0.02 | buy |
| AMERIPRISE FINANCIAL INC | 466,354 | 60,561 | -405,793 | 0.00 | 0.00 | -0.00 | sell |
| ENVESTNET ASSET MANAGEMENT INC | 43,194 | 56,643 | +13,449 | 0.00 | 0.00 | -0.00 | buy |
| ALLEN OPERATIONS LLC | 56,600 | 56,600 | 0 | 0.40 | 0.22 | -0.19 | hold |
| NORTH STAR ASSET MANAGEMENT INC | 43,635 | 53,149 | +9,514 | 0.08 | 0.05 | -0.03 | buy |
| JANUS HENDERSON GROUP PLC | 38,800 | 49,688 | +10,888 | 0.00 | 0.00 | -0.00 | buy |
| Prosight Management, LP | 30,000 | 49,021 | +19,021 | 0.31 | 0.28 | -0.03 | buy |
| Quantinno Capital Management LP | 23,063 | 48,915 | +25,852 | 0.02 | 0.02 | -0.00 | buy |
| WESTWOOD HOLDINGS GROUP INC | 25,024 | 47,974 | +22,950 | 0.01 | 0.00 | -0.00 | buy |
| Numerai GP LLC | 0 | 46,559 | +46,559 | 0.00 | 0.33 | +0.33 | buy |