| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 17,740,972 | 17,629,266 | -111,706 | 0.02 | 0.03 | +0.01 | sell |
| BlackRock, Inc. | 10,079,913 | 10,804,070 | +724,157 | 0.00 | 0.01 | +0.00 | buy |
| ARK Investment Management LLC | 11,717,317 | 10,003,057 | -1,714,260 | 1.93 | 2.49 | +0.56 | sell |
| Quantinno Capital Management LP | 5,411,761 | 5,469,698 | +57,937 | 0.19 | 0.25 | +0.06 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 163,215 | 4,539,007 | +4,375,792 | 0.00 | 0.02 | +0.02 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 5,110,214 | 4,194,627 | -915,587 | 0.07 | 0.09 | +0.02 | sell |
| Nikko Asset Management Americas, Inc. | 5,104,178 | 4,192,517 | -911,661 | 1.53 | 2.07 | +0.54 | sell |
| MORGAN STANLEY | 2,656,353 | 3,351,911 | +695,558 | 0.00 | 0.01 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 3,971,800 | 3,148,859 | -822,941 | 0.01 | 0.01 | +0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 2,904,228 | 3,082,790 | +178,562 | 0.00 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 2,588,795 | 2,801,437 | +212,642 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 743,734 | 2,779,213 | +2,035,479 | 0.01 | 0.06 | +0.05 | buy |
| DIMENSIONAL FUND ADVISORS LP | 2,042,950 | 2,225,284 | +182,334 | 0.01 | 0.02 | +0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 2,538,256 | 2,026,464 | -511,792 | 0.02 | 0.03 | +0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 2,283,424 | 2,019,883 | -263,541 | 0.20 | 0.28 | +0.07 | sell |
| Point72 Asset Management, L.P. | 0 | 1,852,776 | +1,852,776 | 0.00 | 0.11 | +0.11 | buy |
| Capital World Investors | 1,452,300 | 1,493,031 | +40,731 | 0.00 | 0.01 | +0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 1,279,382 | 1,266,954 | -12,428 | 0.02 | 0.03 | +0.01 | sell |
| NORTHERN TRUST CORP | 1,048,005 | 1,144,027 | +96,022 | 0.00 | 0.01 | +0.00 | buy |
| Nuveen, LLC | 625,796 | 1,124,633 | +498,837 | 0.00 | 0.01 | +0.01 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 1,087,150 | +1,087,150 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,127,056 | 1,087,150 | -39,906 | 0.00 | 0.01 | +0.00 | sell |
| Casdin Capital, LLC | 2,275,000 | 1,050,000 | -1,225,000 | 3.66 | 2.02 | -1.64 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 938,408 | 988,320 | +49,912 | 0.05 | 0.07 | +0.03 | buy |
| BANK OF AMERICA CORP /DE/ | 964,579 | 970,774 | +6,195 | 0.00 | 0.00 | +0.00 | buy |
| Anomaly Capital Management, LP | 0 | 867,794 | +867,794 | 0.00 | 1.27 | +1.27 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 1,008,739 | 802,039 | -206,700 | 0.03 | 0.04 | +0.01 | sell |
| JPMORGAN CHASE & CO | 785,505 | 753,045 | -32,460 | 0.00 | 0.00 | +0.00 | sell |
| JANE STREET GROUP, LLC | 0 | 752,999 | +752,999 | 0.00 | 0.02 | +0.02 | buy |
| Blue Water Life Science Advisors, LP | 1,090,000 | 642,000 | -448,000 | 18.56 | 15.50 | -3.05 | sell |
| Freshford Capital Management, LLC | 672,956 | 600,423 | -72,533 | 7.14 | 7.88 | +0.74 | sell |
| CLOUGH CAPITAL PARTNERS L P | 0 | 549,973 | +549,973 | 0.00 | 1.72 | +1.72 | buy |
| Russell Investments Group, Ltd. | 480,619 | 548,897 | +68,278 | 0.01 | 0.02 | +0.01 | buy |
| HSBC HOLDINGS PLC | 285,389 | 537,009 | +251,620 | 0.00 | 0.01 | +0.01 | buy |
| IEQ CAPITAL, LLC | 700,684 | 526,390 | -174,294 | 0.07 | 0.09 | +0.02 | sell |
| SAMLYN CAPITAL, LLC | 0 | 504,048 | +504,048 | 0.00 | 0.32 | +0.32 | buy |
| UBS Group AG | 494,762 | 494,868 | +106 | 0.00 | 0.00 | +0.00 | buy |
| Sands Capital Alternatives, LLC | 481,770 | 481,770 | 0 | 2.43 | 3.01 | +0.58 | hold |
| CAISSE DE DEPOT ET PLACEMENT DU QUEBEC | 165,250 | 445,983 | +280,733 | 0.01 | 0.02 | +0.02 | buy |
| Meridiem Capital Partners LP | 523,998 | 422,219 | -101,779 | 0.73 | 0.74 | +0.01 | sell |
| FIRST TRUST ADVISORS LP | 12,759 | 414,894 | +402,135 | 0.00 | 0.01 | +0.01 | buy |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 542,757 | 404,351 | -138,406 | 0.87 | 0.99 | +0.11 | sell |
| Duquesne Family Office LLC | 0 | 403,100 | +403,100 | 0.00 | 0.35 | +0.35 | buy |
| LORD, ABBETT & CO. LLC | 329,318 | 397,868 | +68,550 | 0.02 | 0.04 | +0.02 | buy |
| Invesco Ltd. | 317,643 | 388,512 | +70,869 | 0.00 | 0.00 | +0.00 | buy |
| Allianz Asset Management GmbH | 320,009 | 368,214 | +48,205 | 0.01 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 347,562 | 363,633 | +16,071 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 292,201 | 322,486 | +30,285 | 0.00 | 0.01 | +0.00 | buy |
| Simplify Asset Management Inc. | 354,703 | 292,938 | -61,765 | 0.12 | 0.16 | +0.04 | sell |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 0 | 286,746 | +286,746 | 0.00 | 0.07 | +0.07 | buy |
| Tao Capital Management LP | 210,862 | 283,469 | +72,607 | 3.77 | 0.56 | -3.21 | buy |
| FRANKLIN RESOURCES INC | 286,398 | 279,205 | -7,193 | 0.00 | 0.00 | +0.00 | sell |
| Trexquant Investment LP | 533,288 | 274,176 | -259,112 | 0.08 | 0.06 | -0.02 | sell |
| Bellevue Group AG | 329,492 | 261,470 | -68,022 | 0.17 | 0.21 | +0.04 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 226,830 | 258,693 | +31,863 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 611,614 | 250,121 | -361,493 | 0.02 | 0.01 | -0.01 | sell |
| WELLS FARGO & COMPANY/MN | 140,116 | 249,644 | +109,528 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 332,524 | 235,766 | -96,758 | 0.00 | 0.00 | +0.00 | sell |
| D. E. Shaw & Co., Inc. | 68,557 | 233,069 | +164,512 | 0.00 | 0.01 | +0.00 | buy |
| Summit Trail Advisors, LLC | 269,768 | 225,390 | -44,378 | 0.08 | 0.11 | +0.03 | sell |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 224,785 | +224,785 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 34,920 | 221,040 | +186,120 | 0.00 | 0.01 | +0.01 | buy |
| ARCH Venture Management, LLC | 217,834 | 217,834 | 0 | 0.68 | 0.76 | +0.08 | hold |
| Hillsdale Investment Management Inc. | 0 | 216,200 | +216,200 | 0.00 | 0.19 | +0.19 | buy |
| Focus Partners Wealth | 224,496 | 214,296 | -10,200 | 0.01 | 0.01 | +0.00 | sell |
| Vestmark Advisory Solutions, Inc. | 251,030 | 212,877 | -38,153 | 0.06 | 0.08 | +0.02 | sell |
| Swiss National Bank | 207,400 | 212,600 | +5,200 | 0.00 | 0.00 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 111,879 | 212,125 | +100,246 | 0.01 | 0.03 | +0.02 | buy |
| Pictet Asset Management Holding SA | 219,049 | 207,256 | -11,793 | 0.00 | 0.01 | +0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 205,537 | 195,465 | -10,072 | 0.00 | 0.00 | +0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 126,332 | 176,954 | +50,622 | 0.00 | 0.01 | +0.00 | buy |
| Corient Private Wealth LLC | 211,270 | 171,288 | -39,982 | 0.01 | 0.01 | +0.00 | sell |
| HARVARD MANAGEMENT CO INC | 170,000 | 170,000 | 0 | 0.20 | 0.15 | -0.05 | hold |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 152,187 | 159,113 | +6,926 | 0.01 | 0.01 | +0.00 | buy |
| LPL Financial LLC | 63,249 | 157,979 | +94,730 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 143,379 | 150,423 | +7,044 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 402,427 | 141,776 | -260,651 | 0.01 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 125,131 | 140,581 | +15,450 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 115,867 | 136,693 | +20,826 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 108,192 | 133,559 | +25,367 | 0.00 | 0.00 | +0.00 | buy |
| FINANCIAL CONSULATE, INC | 156,457 | 126,356 | -30,101 | 0.41 | 0.54 | +0.13 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 113,345 | 122,915 | +9,570 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 123,142 | 122,063 | -1,079 | 0.00 | 0.00 | +0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 2,068,414 | 116,833 | -1,951,581 | 0.03 | 0.00 | -0.03 | sell |
| SG Americas Securities, LLC | 38,134 | 115,208 | +77,074 | 0.00 | 0.00 | +0.00 | buy |
| Cambridge Investment Research Advisors, Inc. | 88,043 | 112,788 | +24,745 | 0.00 | 0.01 | +0.00 | buy |
| Gotham Asset Management, LLC | 114,953 | 110,660 | -4,293 | 0.01 | 0.01 | +0.00 | sell |
| MERCER GLOBAL ADVISORS INC /ADV | 114,972 | 108,692 | -6,280 | 0.00 | 0.01 | +0.00 | sell |
| Creative Planning | 91,311 | 106,351 | +15,040 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 154,194 | 102,629 | -51,565 | 1.93 | 2.43 | +0.50 | sell |
| Campbell & CO Investment Adviser LLC | 0 | 102,568 | +102,568 | 0.00 | 0.21 | +0.21 | buy |
| RAYMOND JAMES FINANCIAL INC | 14,471 | 102,180 | +87,709 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 62,872 | 101,852 | +38,980 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 91,933 | 97,998 | +6,065 | 0.00 | 0.00 | +0.00 | buy |
| Williamson Legacy Group, LLC | 0 | 95,060 | +95,060 | 0.00 | 1.81 | +1.81 | buy |
| LAZARD ASSET MANAGEMENT LLC | 182,984 | 91,873 | -91,111 | 0.01 | 0.01 | -0.00 | sell |
| Arax Advisory Partners | 11,671 | 90,139 | +78,468 | 0.01 | 0.02 | +0.02 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 150,980 | 86,421 | -64,559 | 0.00 | 0.00 | -0.00 | sell |
| J. Goldman & Co LP | 0 | 84,139 | +84,139 | 0.00 | 0.11 | +0.11 | buy |
| Pembroke Management, LTD | 0 | 82,793 | +82,793 | 0.00 | 0.41 | +0.41 | buy |