| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ARK Investment Management LLC | 2,993,460 | 4,041,287 | +1,047,827 | 0.94 | 1.34 | +0.39 | buy |
| SVB WEALTH LLC | 753,130 | 1,446,552 | +693,422 | 0.68 | 1.97 | +1.29 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 1,718,471 | 2,283,530 | +565,059 | 0.06 | 0.09 | +0.04 | buy |
| Nikko Asset Management Americas, Inc. | 1,718,471 | 2,283,530 | +565,059 | 0.85 | 1.23 | +0.38 | buy |
| AMERIPRISE FINANCIAL INC | 14,539 | 515,341 | +500,802 | 0.00 | 0.01 | +0.01 | buy |
| BROWN CAPITAL MANAGEMENT LLC | 3,081,105 | 3,527,297 | +446,192 | 1.95 | 2.96 | +1.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,687,451 | 3,104,174 | +416,723 | 0.02 | 0.02 | +0.01 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 405,183 | +405,183 | 0.00 | 0.12 | +0.12 | buy |
| BANK OF MONTREAL /CAN/ | 6,585 | 405,345 | +398,760 | 0.00 | 0.01 | +0.01 | buy |
| NORGES BANK | 287,498 | 647,996 | +360,498 | 0.00 | 0.01 | +0.00 | buy |
| Freshford Capital Management, LLC | 0 | 305,798 | +305,798 | 0.00 | 2.98 | +2.98 | buy |
| BARCLAYS PLC | 22,199 | 266,298 | +244,099 | 0.00 | 0.01 | +0.01 | buy |
| JPMORGAN CHASE & CO | 1,232,147 | 1,475,286 | +243,139 | 0.01 | 0.01 | +0.00 | buy |
| Man Group plc | 0 | 227,167 | +227,167 | 0.05 | 0.04 | -0.02 | buy |
| Blue Water Life Science Advisors, LP | 0 | 194,500 | +194,500 | 0.00 | 9.53 | +9.53 | buy |
| Granahan Investment Management, LLC | 0 | 185,054 | +185,054 | 0.00 | 0.34 | +0.34 | buy |
| T. Rowe Price Investment Management, Inc. | 996,665 | 1,141,044 | +144,379 | 0.03 | 0.04 | +0.01 | buy |
| FMR LLC | 12,666,998 | 12,785,536 | +118,538 | 0.05 | 0.05 | +0.01 | buy |
| Invesco Ltd. | 2,226,466 | 2,334,938 | +108,472 | 0.02 | 0.03 | +0.01 | buy |
| VANGUARD GROUP INC | 8,903,517 | 9,011,332 | +107,815 | 0.01 | 0.01 | +0.00 | buy |
| CITADEL ADVISORS LLC | 15,305 | 114,225 | +98,920 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 1,460,637 | 1,559,228 | +98,591 | 0.00 | 0.00 | +0.00 | buy |
| ARMISTICE CAPITAL, LLC | 0 | 92,000 | +92,000 | 0.00 | 0.14 | +0.14 | buy |
| Cinctive Capital Management LP | 0 | 90,520 | +90,520 | 0.00 | 0.35 | +0.35 | buy |
| Vestmark Advisory Solutions, Inc. | 0 | 77,409 | +77,409 | 0.00 | 0.22 | +0.22 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,519,044 | 1,587,815 | +68,771 | 0.01 | 0.01 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 63,498 | 123,364 | +59,866 | 0.03 | 0.09 | +0.05 | buy |
| JANE STREET GROUP, LLC | 20,903 | 71,451 | +50,548 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 14,283 | 63,892 | +49,609 | 0.01 | 0.05 | +0.04 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 10,877 | 52,054 | +41,177 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 40,050 | +40,050 | 0.00 | 0.02 | +0.02 | buy |
| ORBIMED ADVISORS LLC | 0 | 39,800 | +39,800 | 0.00 | 0.04 | +0.04 | buy |
| MILLENNIUM MANAGEMENT LLC | 235,562 | 275,135 | +39,573 | 0.01 | 0.01 | +0.00 | buy |
| CITIGROUP INC | 10,951 | 49,238 | +38,287 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 10,961 | 48,525 | +37,564 | 0.00 | 0.01 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 238,364 | 275,164 | +36,800 | 0.01 | 0.02 | +0.00 | buy |
| Quantinno Capital Management LP | 9,413 | 43,315 | +33,902 | 0.02 | 0.08 | +0.07 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 892,123 | 924,832 | +32,709 | 0.01 | 0.01 | +0.00 | buy |
| RTW INVESTMENTS, LP | 1,519,956 | 1,549,951 | +29,995 | 1.32 | 1.35 | +0.03 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 21,745 | +21,745 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 21,650 | +21,650 | 0.00 | 0.01 | +0.01 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 41,308 | 60,558 | +19,250 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 92,947 | 111,024 | +18,077 | 0.48 | 0.69 | +0.20 | buy |
| Brevan Howard Capital Management LP | 0 | 17,651 | +17,651 | 0.00 | 0.10 | +0.10 | buy |
| Assenagon Asset Management S.A. | 0 | 17,586 | +17,586 | 0.00 | 0.00 | +0.00 | buy |
| BAMCO INC /NY/ | 180,926 | 197,562 | +16,636 | 0.02 | 0.03 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 98,027 | 114,046 | +16,019 | 0.00 | 0.00 | +0.00 | buy |
| Choate Investment Advisors | 0 | 15,692 | +15,692 | 0.00 | 0.03 | +0.03 | buy |
| Cerity Partners LLC | 0 | 14,497 | +14,497 | 0.00 | 0.00 | +0.00 | buy |
| LMR Partners LLP | 0 | 12,969 | +12,969 | 0.00 | 0.02 | +0.02 | buy |
| TWO SIGMA INVESTMENTS, LP | 30,200 | 41,700 | +11,500 | 0.00 | 0.01 | +0.00 | buy |
| NEW YORK LIFE INVESTMENT MANAGEMENT LLC | 0 | 11,193 | +11,193 | 0.00 | 0.01 | +0.01 | buy |
| ROYAL BANK OF CANADA | 12,642 | 23,777 | +11,135 | 0.00 | 0.00 | +0.00 | buy |
| HAMILTON LANE ADVISORS LLC | 0 | 10,718 | +10,718 | 0.00 | 0.25 | +0.25 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 10,647 | +10,647 | 0.00 | 0.06 | +0.06 | buy |
| Cresset Asset Management, LLC | 50,877 | 61,002 | +10,125 | 0.01 | 0.02 | +0.01 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 9,884 | +9,884 | 0.00 | 0.05 | +0.05 | buy |
| Advisors Asset Management, Inc. | 10,465 | 19,822 | +9,357 | 0.01 | 0.02 | +0.01 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 12,760 | 22,095 | +9,335 | 0.00 | 0.00 | +0.00 | buy |
| Birchview Capital, LP | 21,000 | 30,000 | +9,000 | 0.74 | 1.31 | +0.58 | buy |
| State of New Jersey Common Pension Fund D | 50,377 | 59,357 | +8,980 | 0.01 | 0.01 | +0.00 | buy |
| Capital Impact Advisors, LLC | 14,821 | 23,594 | +8,773 | 1.02 | 1.73 | +0.71 | buy |
| Neuberger Berman Group LLC | 0 | 8,456 | +8,456 | 0.00 | 0.00 | +0.00 | buy |
| Employees Retirement System of Texas | 0 | 8,273 | +8,273 | 0.00 | 0.01 | +0.01 | buy |
| Rockefeller Capital Management L.P. | 10,658 | 18,420 | +7,762 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 7,516 | +7,516 | 0.00 | 0.00 | +0.00 | buy |
| Amundi | 34,767 | 42,281 | +7,514 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 0 | 7,076 | +7,076 | 0.00 | 0.04 | +0.04 | buy |
| STIFEL FINANCIAL CORP | 0 | 5,934 | +5,934 | 0.00 | 0.00 | +0.00 | buy |
| Allianz Asset Management GmbH | 0 | 5,600 | +5,600 | 0.00 | 0.00 | +0.00 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 5,526 | +5,526 | 0.00 | 0.01 | +0.01 | buy |
| Balentine LLC | 0 | 5,198 | +5,198 | 0.00 | 0.01 | +0.01 | buy |
| ALGERT GLOBAL LLC | 20,390 | 25,240 | +4,850 | 0.04 | 0.06 | +0.02 | buy |
| EFG Asset Management (North America) Corp. | 17,413 | 22,153 | +4,740 | 0.17 | 0.24 | +0.06 | buy |
| AMERICAN CENTURY COMPANIES INC | 168,997 | 173,570 | +4,573 | 0.01 | 0.01 | +0.00 | buy |
| M&T BANK CORP | 0 | 4,501 | +4,501 | 0.00 | 0.00 | +0.00 | buy |
| CAPTRUST FINANCIAL ADVISORS | 0 | 4,488 | +4,488 | 0.00 | 0.00 | +0.00 | buy |
| NWF Advisory Services Inc. | 0 | 4,216 | +4,216 | 0.00 | 0.05 | +0.05 | buy |
| Bleakley Financial Group, LLC | 0 | 4,189 | +4,189 | 0.00 | 0.01 | +0.01 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 638,921 | 642,915 | +3,994 | 0.04 | 0.05 | +0.01 | buy |
| GeoWealth Management, LLC | 0 | 3,628 | +3,628 | 0.00 | 0.02 | +0.02 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 3,594 | +3,594 | 0.00 | 0.01 | +0.01 | buy |
| OPPENHEIMER & CO INC | 10,532 | 14,120 | +3,588 | 0.01 | 0.01 | +0.01 | buy |
| Powell Investment Advisors, LLC | 0 | 3,577 | +3,577 | 0.00 | 0.11 | +0.11 | buy |
| GILDER GAGNON HOWE & CO LLC | 499,121 | 502,471 | +3,350 | 0.31 | 0.39 | +0.07 | buy |
| LPL Financial LLC | 7,866 | 11,173 | +3,307 | 0.00 | 0.00 | +0.00 | buy |
| Bayesian Capital Management, LP | 11,800 | 14,500 | +2,700 | 0.06 | 0.09 | +0.03 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 10,223 | 12,738 | +2,515 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 12,743 | 15,212 | +2,469 | 0.00 | 0.00 | +0.00 | buy |
| Perigon Wealth Management, LLC | 7,838 | 9,656 | +1,818 | 0.01 | 0.02 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 371,058 | 372,873 | +1,815 | 0.00 | 0.00 | +0.00 | buy |
| Gotham Asset Management, LLC | 7,019 | 8,686 | +1,667 | 0.01 | 0.01 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 26,933 | 28,481 | +1,548 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 12,732 | 14,200 | +1,468 | 0.02 | 0.02 | +0.01 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 30,100 | 31,400 | +1,300 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 29,386 | 30,634 | +1,248 | 0.00 | 0.00 | +0.00 | buy |
| Harvest Fund Management Co., Ltd | 0 | 1,178 | +1,178 | 0.00 | 0.01 | +0.01 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 37,395 | 38,446 | +1,051 | 0.01 | 0.01 | +0.00 | buy |
| Arizona State Retirement System | 23,749 | 24,562 | +813 | 0.01 | 0.01 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 15,839 | 16,565 | +726 | 0.00 | 0.00 | +0.00 | buy |