| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Redmile Group, LLC | 15,666,731 | 15,470,502 | -196,229 | 4.07 | 3.84 | -0.23 | sell |
| TCG Crossover Management, LLC | 11,390,175 | 11,390,175 | 0 | 1.33 | 1.22 | -0.11 | hold |
| Prosight Management, LP | 8,477,338 | 8,300,000 | -177,338 | 6.18 | 5.10 | -1.08 | sell |
| BlackRock, Inc. | 5,427,309 | 6,250,747 | +823,438 | 0.00 | 0.00 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 3,364,067 | 5,701,655 | +2,337,588 | 0.19 | 0.35 | +0.17 | buy |
| Nantahala Capital Management, LLC | 5,475,433 | 5,597,433 | +122,000 | 1.15 | 1.31 | +0.16 | buy |
| MORGAN STANLEY | 3,769,743 | 3,812,582 | +42,839 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 5,014,617 | 3,382,129 | -1,632,488 | 0.03 | 0.02 | -0.01 | sell |
| MILLENNIUM MANAGEMENT LLC | 328,429 | 3,119,154 | +2,790,725 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 1,640,872 | 1,653,026 | +12,154 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 1,407,325 | 1,566,662 | +159,337 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 1,298,584 | 1,325,017 | +26,433 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 5,822,854 | 1,318,026 | -4,504,828 | 0.42 | 0.11 | -0.31 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 996,523 | 1,203,756 | +207,233 | 0.00 | 0.00 | +0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 990,778 | 990,778 | 0 | 0.81 | 0.94 | +0.13 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 830,903 | 860,491 | +29,588 | 0.00 | 0.00 | +0.00 | buy |
| Blue Owl Capital Holdings LP | 733,568 | 733,568 | 0 | 0.91 | 0.70 | -0.21 | hold |
| PANAGORA ASSET MANAGEMENT INC | 594,256 | 691,275 | +97,019 | 0.01 | 0.01 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 119,461 | 668,022 | +548,561 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 437,551 | 552,201 | +114,650 | 0.00 | 0.00 | +0.00 | buy |
| Voleon Capital Management LP | 464,159 | 513,831 | +49,672 | 0.04 | 0.04 | +0.01 | buy |
| JPMORGAN CHASE & CO | 471,693 | 489,079 | +17,386 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 215,212 | 458,902 | +243,690 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 528,965 | 449,122 | -79,843 | 0.00 | 0.00 | -0.00 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 418,782 | 418,782 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CITADEL ADVISORS LLC | 298,218 | 399,721 | +101,503 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 299,278 | +299,278 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 320,048 | 262,783 | -57,265 | 0.00 | 0.00 | -0.00 | sell |
| LAZARD ASSET MANAGEMENT LLC | 0 | 262,595 | +262,595 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 24,532 | 254,909 | +230,377 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 263,071 | 243,176 | -19,895 | 0.00 | 0.00 | +0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 206,576 | 237,637 | +31,061 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 212,915 | 231,064 | +18,149 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 212,668 | 224,361 | +11,693 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 172,987 | 202,254 | +29,267 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 133,797 | 172,678 | +38,881 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 173,867 | 156,126 | -17,741 | 0.00 | 0.00 | +0.00 | sell |
| Florida Trust Wealth Management Co | 113,000 | 150,435 | +37,435 | 0.01 | 0.02 | +0.00 | buy |
| Nuveen, LLC | 118,915 | 146,258 | +27,343 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 199,764 | 142,063 | -57,701 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 113,369 | 126,823 | +13,454 | 0.00 | 0.00 | +0.00 | buy |
| KINGSWOOD WEALTH ADVISORS, LLC | 105,000 | 105,107 | +107 | 0.02 | 0.02 | +0.00 | buy |
| RHUMBLINE ADVISERS | 90,683 | 104,051 | +13,368 | 0.00 | 0.00 | +0.00 | buy |
| CANTOR FITZGERALD, L. P. | 100,000 | 100,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Wilmington Savings Fund Society, FSB | 100,000 | 100,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| DEUTSCHE BANK AG\ | 70,774 | 80,205 | +9,431 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 113,247 | 79,034 | -34,213 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 77,947 | +77,947 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 77,390 | +77,390 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 77,081 | 72,081 | -5,000 | 0.06 | 0.06 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 46,750 | 70,047 | +23,297 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 64,523 | 64,523 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MetLife Investment Management, LLC | 49,682 | 53,690 | +4,008 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 40,027 | 47,910 | +7,883 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 161,386 | 46,335 | -115,051 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 0 | 45,479 | +45,479 | 0.00 | 0.00 | +0.00 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 43,970 | +43,970 | 0.00 | 0.03 | +0.03 | buy |
| ALLIANCEBERNSTEIN L.P. | 41,850 | 41,850 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Invesco Ltd. | 40,211 | 41,630 | +1,419 | 0.00 | 0.00 | +0.00 | buy |
| Magnetar Financial LLC | 39,092 | 39,092 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SEI INVESTMENTS CO | 22,989 | 33,461 | +10,472 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 22,819 | 32,544 | +9,725 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 162,250 | 32,230 | -130,020 | 0.01 | 0.00 | -0.01 | sell |
| CITIGROUP INC | 16,109 | 31,670 | +15,561 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 26,295 | +26,295 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 24,758 | 25,826 | +1,068 | 0.00 | 0.00 | +0.00 | buy |
| DLK Investment Management, LLC | 25,305 | 25,305 | 0 | 0.03 | 0.04 | +0.00 | hold |
| INTECH INVESTMENT MANAGEMENT LLC | 36,940 | 23,988 | -12,952 | 0.00 | 0.00 | -0.00 | sell |
| Saxony Capital Management, LLC | 23,768 | 23,876 | +108 | 0.05 | 0.05 | +0.00 | buy |
| Graham Capital Management, L.P. | 0 | 22,442 | +22,442 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 56,783 | 19,280 | -37,503 | 0.00 | 0.00 | -0.00 | sell |
| COMMONWEALTH EQUITY SERVICES, LLC | 17,809 | 17,769 | -40 | 0.00 | 0.00 | +0.00 | sell |
| XTX Topco Ltd | 82,871 | 17,422 | -65,449 | 0.01 | 0.00 | -0.01 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 14,375 | 17,395 | +3,020 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 0 | 16,718 | +16,718 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 15,727 | 14,799 | -928 | 0.00 | 0.00 | -0.00 | sell |
| Quantinno Capital Management LP | 10,825 | 14,719 | +3,894 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 11,722 | 14,230 | +2,508 | 0.00 | 0.00 | +0.00 | buy |
| Callan Family Office, LLC | 23,842 | 12,873 | -10,969 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 0 | 12,098 | +12,098 | 0.00 | 0.00 | +0.00 | buy |
| Ethic Inc. | 12,100 | 11,755 | -345 | 0.00 | 0.00 | +0.00 | sell |
| HSBC HOLDINGS PLC | 10,521 | 10,577 | +56 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 10,370 | 10,362 | -8 | 0.00 | 0.00 | +0.00 | sell |
| AVISO WEALTH MANAGEMENT | 10,343 | 10,343 | 0 | 0.02 | 0.02 | +0.00 | hold |
| R Squared Ltd | 0 | 10,119 | +10,119 | 0.00 | 0.02 | +0.02 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 9,100 | 9,100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 8,924 | 9,012 | +88 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 3,995 | 7,992 | +3,997 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 6,859 | 6,859 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 5,308 | 5,573 | +265 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 3,000 | 3,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| State of Wyoming | 0 | 2,032 | +2,032 | 0.00 | 0.00 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 431 | 1,488 | +1,057 | 0.00 | 0.00 | +0.00 | buy |
| C M BIDWELL & ASSOCIATES LTD | 0 | 1,119 | +1,119 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 958 | 966 | +8 | 0.00 | 0.00 | -0.00 | buy |
| Optiver Holding B.V. | 586 | 866 | +280 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 492 | 732 | +240 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 471 | 663 | +192 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 370 | 370 | 0 | 0.00 | 0.00 | +0.00 | hold |
| QUADRANT CAPITAL GROUP LLC | 173 | 173 | 0 | 0.00 | 0.00 | +0.00 | hold |