| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 0 | 4,316,824 | +4,316,824 | 0.00 | 0.27 | +0.27 | buy |
| Prosight Management, LP | 7,050,300 | 9,570,000 | +2,519,700 | 8.81 | 9.04 | +0.23 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 0 | 1,296,153 | +1,296,153 | 0.00 | 0.17 | +0.17 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 501,222 | 1,768,770 | +1,267,548 | 0.63 | 1.38 | +0.75 | buy |
| Artal Group S.A. | 0 | 1,018,461 | +1,018,461 | 0.00 | 0.08 | +0.08 | buy |
| STATE STREET CORP | 0 | 991,296 | +991,296 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 0 | 824,717 | +824,717 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 685,547 | +685,547 | 0.00 | 0.35 | +0.35 | buy |
| Affinity Asset Advisors, LLC | 0 | 474,744 | +474,744 | 0.00 | 0.24 | +0.24 | buy |
| VANGUARD GROUP INC | 0 | 404,229 | +404,229 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 0 | 322,289 | +322,289 | 0.00 | 0.10 | +0.10 | buy |
| TWO SIGMA INVESTMENTS, LP | 54,913 | 328,764 | +273,851 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 2,720,395 | 2,965,229 | +244,834 | 0.00 | 0.00 | -0.00 | buy |
| D. E. Shaw & Co., Inc. | 26,921 | 263,712 | +236,791 | 0.00 | 0.00 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 0 | 228,102 | +228,102 | 0.00 | 0.29 | +0.29 | buy |
| Bank of New York Mellon Corp | 0 | 205,221 | +205,221 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 0 | 204,081 | +204,081 | 0.00 | 0.15 | +0.15 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 175,462 | +175,462 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 0 | 85,977 | +85,977 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 54,126 | +54,126 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 39,750 | +39,750 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 36,076 | +36,076 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 35,600 | +35,600 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 33,849 | +33,849 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 0 | 32,959 | +32,959 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 24,829 | 56,863 | +32,034 | 0.02 | 0.02 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 26,938 | +26,938 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 25,704 | +25,704 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 24,120 | +24,120 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 0 | 23,014 | +23,014 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 1,193,847 | 1,216,418 | +22,571 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 22,476 | +22,476 | 0.00 | 0.00 | 0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 22,020 | +22,020 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 18,810 | +18,810 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 16,454 | +16,454 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 0 | 15,925 | +15,925 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 0 | 15,423 | +15,423 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 18,817 | 32,600 | +13,783 | 0.00 | 0.00 | +0.00 | buy |
| Palumbo Wealth Management LLC | 0 | 13,270 | +13,270 | 0.00 | 0.02 | +0.02 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 10,355 | +10,355 | 0.00 | 0.00 | +0.00 | buy |
| NOMURA HOLDINGS INC | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| Florida Trust Wealth Management Co | 103,000 | 113,000 | +10,000 | 0.02 | 0.01 | -0.00 | buy |
| Legal & General Group Plc | 0 | 7,085 | +7,085 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 6,859 | +6,859 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 0 | 6,221 | +6,221 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 5,073 | +5,073 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 8,000 | 10,872 | +2,872 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 0 | 2,422 | +2,422 | 0.00 | 0.00 | +0.00 | buy |
| Saxony Capital Management, LLC | 20,623 | 22,238 | +1,615 | 0.11 | 0.08 | -0.03 | buy |
| Global Retirement Partners, LLC | 0 | 200 | +200 | 0.00 | 0.00 | +0.00 | buy |
| HARBOUR INVESTMENTS, INC. | 0 | 20 | +20 | 0.00 | 0.00 | +0.00 | buy |
| Gradient Investments LLC | 0 | 11 | +11 | 0.00 | 0.00 | +0.00 | buy |
| Magnetar Financial LLC | 55,762 | 55,762 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Redmile Group, LLC | 15,269,217 | 15,269,217 | 0 | 2.52 | 2.92 | +0.40 | hold |
| Miracle Mile Advisors, LLC | 84,496 | 84,496 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Vantage Consulting Group Inc | 850,737 | 850,737 | 0 | 2.43 | 2.00 | -0.43 | hold |
| Blue Owl Capital Holdings LP | 733,568 | 733,568 | 0 | 0.66 | 0.64 | -0.01 | hold |
| Eagle Bay Advisors LLC | 670 | 670 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GCM Grosvenor Holdings, LLC | 410,888 | 410,888 | 0 | 0.28 | 0.19 | -0.09 | hold |
| DLK Investment Management, LLC | 33,155 | 33,155 | 0 | 0.06 | 0.04 | -0.02 | hold |
| Federation des caisses Desjardins du Quebec | 20 | 20 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| AVISO WEALTH MANAGEMENT | 10,468 | 10,343 | -125 | 0.03 | 0.02 | -0.01 | sell |
| GROUP ONE TRADING LLC | 4,787 | 0 | -4,787 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 14,755 | 1,938 | -12,817 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 1,540,509 | 1,524,717 | -15,792 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 23,765 | 0 | -23,765 | 0.00 | 0.00 | -0.00 | sell |
| Hennion & Walsh Asset Management, Inc. | 70,636 | 0 | -70,636 | 0.02 | 0.00 | -0.02 | sell |
| Cubist Systematic Strategies, LLC | 120,775 | 0 | -120,775 | 0.01 | 0.00 | -0.01 | sell |
| MILLENNIUM MANAGEMENT LLC | 1,010,437 | 816,456 | -193,981 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 243,243 | 0 | -243,243 | 0.00 | 0.00 | -0.00 | sell |
| Monashee Investment Management LLC | 500,000 | 0 | -500,000 | 0.27 | 0.00 | -0.27 | sell |
| CITADEL ADVISORS LLC | 952,464 | 41,433 | -911,031 | 0.00 | 0.00 | -0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,000,000 | 0 | -1,000,000 | 0.01 | 0.00 | -0.01 | sell |