| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Woodline Partners LP | 0 | 1,933,751 | +1,933,751 | 0.00 | 0.03 | +0.03 | buy |
| ORBIMED ADVISORS LLC | 4,533,801 | 5,968,451 | +1,434,650 | 0.26 | 0.25 | -0.01 | buy |
| MORGAN STANLEY | 3,040,794 | 3,956,172 | +915,378 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 0 | 884,518 | +884,518 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 716,668 | +716,668 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 4,399,134 | 5,011,857 | +612,723 | 0.00 | 0.00 | -0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 1,444,516 | 1,612,556 | +168,040 | 0.21 | 0.19 | -0.02 | buy |
| VANGUARD GROUP INC | 539,359 | 644,618 | +105,259 | 0.00 | 0.00 | -0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 168,557 | 253,342 | +84,785 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 1,106,011 | 1,188,194 | +82,183 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 53,042 | 127,019 | +73,977 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 29,276 | 65,267 | +35,991 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 75,392 | 107,231 | +31,839 | 0.00 | 0.00 | -0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 12,998 | 38,435 | +25,437 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 0 | 25,000 | +25,000 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 0 | 22,989 | +22,989 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 204,081 | 224,081 | +20,000 | 0.15 | 0.11 | -0.04 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 17,430 | +17,430 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 22,107 | 39,362 | +17,255 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 39,845 | 56,062 | +16,217 | 0.00 | 0.00 | -0.00 | buy |
| HRT FINANCIAL LP | 0 | 15,073 | +15,073 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 15,048 | +15,048 | 0.00 | 0.01 | +0.01 | buy |
| RHUMBLINE ADVISERS | 95,189 | 110,037 | +14,848 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 127,739 | 141,495 | +13,756 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 29,998 | 41,832 | +11,834 | 0.00 | 0.00 | -0.00 | buy |
| Kestra Advisory Services, LLC | 0 | 10,002 | +10,002 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 953,171 | 963,109 | +9,938 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 162,243 | 171,993 | +9,750 | 0.00 | 0.00 | -0.00 | buy |
| SG Americas Securities, LLC | 26,657 | 36,140 | +9,483 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 7,546 | 16,794 | +9,248 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 0 | 8,267 | +8,267 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 38,274 | 46,520 | +8,246 | 0.00 | 0.00 | -0.00 | buy |
| ProShare Advisors LLC | 15,366 | 22,901 | +7,535 | 0.00 | 0.00 | -0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 0 | 5,818 | +5,818 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 58,902 | 64,139 | +5,237 | 0.00 | 0.00 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 2,413 | 5,291 | +2,878 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 25,831 | 28,588 | +2,757 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 32,669 | 34,369 | +1,700 | 0.00 | 0.00 | -0.00 | buy |
| Sterling Capital Management LLC | 132 | 1,132 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 4,646 | 5,597 | +951 | 0.00 | 0.00 | -0.00 | buy |
| Creative Planning | 0 | 475 | +475 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 77 | +77 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 115 | 185 | +70 | 0.00 | 0.00 | -0.00 | buy |
| Saxony Capital Management, LLC | 22,238 | 22,288 | +50 | 0.06 | 0.04 | -0.03 | buy |
| Ameritas Investment Partners, Inc. | 6,859 | 6,859 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 5,994 | 5,994 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 22,020 | 22,020 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Magnetar Financial LLC | 55,762 | 55,762 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Florida Trust Wealth Management Co | 113,000 | 113,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Vantage Consulting Group Inc | 850,737 | 850,737 | 0 | 23.47 | 16.14 | -7.34 | hold |
| Blue Owl Capital Holdings LP | 733,568 | 733,568 | 0 | 0.45 | 0.34 | -0.11 | hold |
| Eagle Bay Advisors LLC | 670 | 670 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AVISO WEALTH MANAGEMENT | 10,343 | 10,343 | 0 | 0.02 | 0.01 | -0.01 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Legal & General Group Plc | 8,537 | 8,537 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 28,831 | 28,831 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HARBOUR INVESTMENTS, INC. | 20 | 20 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 9,100 | 9,100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 194,258 | 194,258 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Wilmington Savings Fund Society, FSB | 100,000 | 100,000 | 0 | 0.01 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 2,422 | 2,422 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CWM, LLC | 24 | 20 | -4 | 0.00 | 0.00 | 0.00 | sell |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 36 | 0 | -36 | 0.00 | 0.00 | -0.00 | sell |
| Cornerstone Planning Group LLC | 276 | 0 | -276 | 0.00 | 0.00 | -0.00 | sell |
| COMMONWEALTH EQUITY SERVICES, LLC | 40,413 | 39,611 | -802 | 0.00 | 0.00 | -0.00 | sell |
| READYSTATE ASSET MANAGEMENT LP | 17,039 | 15,620 | -1,419 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 25,399 | 23,786 | -1,613 | 0.00 | 0.00 | -0.00 | sell |
| Redmile Group, LLC | 15,669,217 | 15,666,731 | -2,486 | 2.91 | 2.17 | -0.73 | sell |
| Corebridge Financial, Inc. | 43,481 | 40,430 | -3,051 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 481,037 | 476,193 | -4,844 | 0.00 | 0.00 | -0.00 | sell |
| DLK Investment Management, LLC | 33,155 | 25,805 | -7,350 | 0.04 | 0.02 | -0.02 | sell |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 10,355 | 0 | -10,355 | 0.00 | 0.00 | -0.00 | sell |
| OSAIC HOLDINGS, INC. | 11,872 | 0 | -11,872 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 43,089 | 31,117 | -11,972 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 1,688,594 | 1,673,177 | -15,417 | 0.00 | 0.00 | -0.00 | sell |
| SECTORAL ASSET MANAGEMENT INC | 36,214 | 0 | -36,214 | 0.07 | 0.00 | -0.07 | sell |
| JPMORGAN CHASE & CO | 78,813 | 37,021 | -41,792 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 245,253 | 183,231 | -62,022 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 115,073 | 0 | -115,073 | 0.03 | 0.00 | -0.03 | sell |
| Prosight Management, LP | 9,636,237 | 9,515,000 | -121,237 | 7.70 | 5.30 | -2.39 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 205,036 | 0 | -205,036 | 0.11 | 0.00 | -0.11 | sell |
| D. E. Shaw & Co., Inc. | 284,243 | 0 | -284,243 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 712,401 | 411,124 | -301,277 | 0.00 | 0.00 | -0.00 | sell |
| GCM Grosvenor Holdings, LLC | 410,888 | 0 | -410,888 | 0.20 | 0.00 | -0.20 | sell |
| Siren, L.L.C. | 1,163,461 | 0 | -1,163,461 | 0.18 | 0.00 | -0.18 | sell |
| BANK OF AMERICA CORP /DE/ | 2,497,940 | 1,291,244 | -1,206,696 | 0.00 | 0.00 | -0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,795,080 | 0 | -1,795,080 | 1.27 | 0.00 | -1.27 | sell |