| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Redmile Group, LLC | 15,666,731 | 15,666,731 | 0 | 6.10 | 4.07 | -2.02 | hold |
| TCG Crossover Management, LLC | 1,390,175 | 11,390,175 | +10,000,000 | 0.27 | 1.33 | +1.06 | buy |
| Prosight Management, LP | 7,472,303 | 8,477,338 | +1,005,035 | 7.18 | 6.18 | -0.99 | buy |
| ORBIMED ADVISORS LLC | 5,907,351 | 5,822,854 | -84,497 | 0.57 | 0.42 | -0.15 | sell |
| Nantahala Capital Management, LLC | 2,266,289 | 5,475,433 | +3,209,144 | 0.56 | 1.15 | +0.59 | buy |
| BlackRock, Inc. | 4,511,699 | 5,427,309 | +915,610 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 8,135,651 | 5,014,617 | -3,121,034 | 0.07 | 0.03 | -0.04 | sell |
| MORGAN STANLEY | 3,669,067 | 3,769,743 | +100,676 | 0.00 | 0.00 | -0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 3,364,067 | +3,364,067 | 0.00 | 0.19 | +0.19 | buy |
| GOLDMAN SACHS GROUP INC | 1,594,434 | 1,640,872 | +46,438 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 1,295,941 | 1,407,325 | +111,384 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 1,361,290 | 1,298,584 | -62,706 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 593,954 | 1,129,587 | +535,633 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 862,934 | 996,523 | +133,589 | 0.00 | 0.00 | -0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 1,156,721 | 990,778 | -165,943 | 0.30 | 0.81 | +0.51 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 688,471 | 830,903 | +142,432 | 0.00 | 0.00 | -0.00 | buy |
| Blue Owl Capital Holdings LP | 733,568 | 733,568 | 0 | 0.91 | 0.91 | -0.01 | hold |
| Vantage Consulting Group Inc | 682,998 | 682,998 | 0 | 24.36 | 12.23 | -12.13 | hold |
| PANAGORA ASSET MANAGEMENT INC | 544,261 | 594,256 | +49,995 | 0.01 | 0.01 | -0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 227,500 | 528,965 | +301,465 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 283,286 | 502,570 | +219,284 | 0.23 | 0.30 | +0.08 | buy |
| JPMORGAN CHASE & CO | 330,597 | 471,693 | +141,096 | 0.00 | 0.00 | +0.00 | buy |
| Voleon Capital Management LP | 70,311 | 464,159 | +393,848 | 0.01 | 0.04 | +0.03 | buy |
| NORTHERN TRUST CORP | 417,567 | 437,551 | +19,984 | 0.00 | 0.00 | -0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 418,782 | +418,782 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 701,619 | 328,429 | -373,190 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 69,501 | 320,048 | +250,547 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 820,715 | 298,218 | -522,497 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 0 | 263,071 | +263,071 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 262,261 | 215,212 | -47,049 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 250,084 | 212,915 | -37,169 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 182,012 | 212,668 | +30,656 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 145,252 | 206,576 | +61,324 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 487,868 | 199,764 | -288,104 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 174,943 | 173,867 | -1,076 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 158,694 | 172,987 | +14,293 | 0.00 | 0.00 | -0.00 | buy |
| Jump Financial, LLC | 11,591 | 162,250 | +150,659 | 0.00 | 0.01 | +0.01 | buy |
| BARCLAYS PLC | 130,460 | 161,386 | +30,926 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 133,427 | 133,797 | +370 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 120,567 | +120,567 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 45,458 | 119,461 | +74,003 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 171,230 | 118,915 | -52,315 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 113,369 | +113,369 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 106,651 | 113,247 | +6,596 | 0.00 | 0.00 | -0.00 | buy |
| Florida Trust Wealth Management Co | 113,000 | 113,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| KINGSWOOD WEALTH ADVISORS, LLC | 0 | 105,000 | +105,000 | 0.00 | 0.02 | +0.02 | buy |
| CANTOR FITZGERALD, L. P. | 0 | 100,000 | +100,000 | 0.00 | 0.01 | +0.01 | buy |
| Wilmington Savings Fund Society, FSB | 100,000 | 100,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| RHUMBLINE ADVISERS | 100,474 | 90,683 | -9,791 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 91,579 | 82,871 | -8,708 | 0.02 | 0.01 | -0.01 | sell |
| DAFNA Capital Management LLC | 122,081 | 77,081 | -45,000 | 0.12 | 0.06 | -0.06 | sell |
| DEUTSCHE BANK AG\ | 77,524 | 70,774 | -6,750 | 0.00 | 0.00 | -0.00 | sell |
| Susquehanna Portfolio Strategies, LLC | 64,523 | 64,523 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ExodusPoint Capital Management, LP | 45,941 | 56,783 | +10,842 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 30,049 | 49,682 | +19,633 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 37,213 | 46,750 | +9,537 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 49,590 | 41,850 | -7,740 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 38,789 | 40,211 | +1,422 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 34,045 | 40,027 | +5,982 | 0.00 | 0.00 | -0.00 | buy |
| Magnetar Financial LLC | 39,092 | 39,092 | 0 | 0.00 | 0.00 | +0.00 | hold |
| INTECH INVESTMENT MANAGEMENT LLC | 36,181 | 36,940 | +759 | 0.00 | 0.00 | -0.00 | buy |
| DLK Investment Management, LLC | 25,305 | 25,305 | 0 | 0.04 | 0.03 | -0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 23,135 | 24,758 | +1,623 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 32,502 | 24,532 | -7,970 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 0 | 24,448 | +24,448 | 0.00 | 0.00 | +0.00 | buy |
| Callan Family Office, LLC | 0 | 23,842 | +23,842 | 0.00 | 0.00 | +0.00 | buy |
| Saxony Capital Management, LLC | 23,768 | 23,768 | 0 | 0.06 | 0.05 | -0.01 | hold |
| SEI INVESTMENTS CO | 22,989 | 22,989 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Police & Firemen's Retirement System of New Jersey | 22,819 | 22,819 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GSA CAPITAL PARTNERS LLP | 0 | 20,889 | +20,889 | 0.00 | 0.01 | +0.01 | buy |
| Henrickson Nauta Wealth Advisors, Inc. | 0 | 19,411 | +19,411 | 0.00 | 0.01 | +0.01 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 22,810 | 17,809 | -5,001 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 3,444 | 16,109 | +12,665 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 0 | 16,078 | +16,078 | 0.00 | 0.01 | +0.01 | buy |
| IEQ CAPITAL, LLC | 20,598 | 16,067 | -4,531 | 0.00 | 0.00 | -0.00 | sell |
| ProShare Advisors LLC | 12,388 | 15,727 | +3,339 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 13,570 | 14,375 | +805 | 0.00 | 0.00 | -0.00 | buy |
| Ethic Inc. | 15,207 | 12,100 | -3,107 | 0.00 | 0.00 | -0.00 | sell |
| Engineers Gate Manager LP | 0 | 12,071 | +12,071 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 11,597 | 11,722 | +125 | 0.00 | 0.00 | -0.00 | buy |
| Quantinno Capital Management LP | 0 | 10,825 | +10,825 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 10,521 | 10,521 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CWM, LLC | 10,039 | 10,370 | +331 | 0.00 | 0.00 | -0.00 | buy |
| AVISO WEALTH MANAGEMENT | 10,343 | 10,343 | 0 | 0.02 | 0.02 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 9,100 | 9,100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 8,085 | 8,924 | +839 | 0.00 | 0.00 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 6,859 | 6,859 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 5,997 | 5,308 | -689 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 5,609 | 3,995 | -1,614 | 0.00 | 0.00 | -0.00 | sell |
| JONES FINANCIAL COMPANIES LLLP | 3,000 | 3,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 2,422 | 2,710 | +288 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 8,143 | 2,687 | -5,456 | 0.00 | 0.00 | -0.00 | sell |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 1,725 | +1,725 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 947 | 958 | +11 | 0.00 | 0.00 | -0.00 | buy |
| Optiver Holding B.V. | 1,306 | 586 | -720 | 0.00 | 0.00 | -0.00 | sell |
| GAMMA Investing LLC | 0 | 492 | +492 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 176 | 471 | +295 | 0.00 | 0.00 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 165 | 431 | +266 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 370 | 370 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SBI Securities Co., Ltd. | 226 | 222 | -4 | 0.00 | 0.00 | -0.00 | sell |