| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MPM BioImpact LLC | 0 | 1,132,950 | +1,132,950 | 0.00 | 1.44 | +1.44 | buy |
| Woodline Partners LP | 608,721 | 877,461 | +268,740 | 0.08 | 0.04 | -0.03 | buy |
| Opaleye Management Inc. | 0 | 250,000 | +250,000 | 0.00 | 0.41 | +0.41 | buy |
| JPMORGAN CHASE & CO | 9,106 | 201,235 | +192,129 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 3,812,215 | 4,002,887 | +190,672 | 1.46 | 0.71 | -0.75 | buy |
| Affinity Asset Advisors, LLC | 0 | 175,000 | +175,000 | 0.00 | 0.20 | +0.20 | buy |
| Parkman Healthcare Partners LLC | 170,000 | 328,323 | +158,323 | 0.42 | 0.29 | -0.13 | buy |
| Exome Asset Management LLC | 0 | 133,113 | +133,113 | 0.00 | 0.88 | +0.88 | buy |
| Schonfeld Strategic Advisors LLC | 71,500 | 200,642 | +129,142 | 0.01 | 0.01 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 36,600 | 151,504 | +114,904 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 110,482 | +110,482 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 0 | 96,615 | +96,615 | 0.00 | 0.23 | +0.23 | buy |
| CITIGROUP INC | 8,864 | 97,328 | +88,464 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 25,900 | 111,211 | +85,311 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 727,952 | 783,042 | +55,090 | 0.00 | 0.00 | -0.00 | buy |
| Aaron Wealth Advisors LLC | 0 | 50,000 | +50,000 | 0.00 | 0.04 | +0.04 | buy |
| Shay Capital LLC | 0 | 49,133 | +49,133 | 0.00 | 0.11 | +0.11 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 40,225 | +40,225 | 0.00 | 0.03 | +0.03 | buy |
| STATE STREET CORP | 142,649 | 177,220 | +34,571 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 33,833 | +33,833 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 32,490 | +32,490 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 1,486 | 30,916 | +29,430 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 28,996 | +28,996 | 0.00 | 0.00 | +0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 162,090 | 185,932 | +23,842 | 0.18 | 0.08 | -0.10 | buy |
| Squarepoint Ops LLC | 0 | 20,098 | +20,098 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 19,815 | +19,815 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 24,573 | 44,240 | +19,667 | 0.00 | 0.00 | -0.00 | buy |
| Koa Wealth Management, LLC | 0 | 19,396 | +19,396 | 0.00 | 0.12 | +0.12 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 12,369 | +12,369 | 0.00 | 0.01 | +0.01 | buy |
| WEALTHEDGE INVESTMENT ADVISORS, LLC | 0 | 11,864 | +11,864 | 0.00 | 0.04 | +0.04 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 10,728 | +10,728 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 265,703 | 274,458 | +8,755 | 0.00 | 0.00 | -0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 8,006 | +8,006 | 0.00 | 0.02 | +0.02 | buy |
| NORTHERN TRUST CORP | 90,682 | 96,507 | +5,825 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 4,338 | 8,762 | +4,424 | 0.00 | 0.00 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 4,300 | +4,300 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 93,311 | 94,546 | +1,235 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 803 | 1,365 | +562 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 49,675 | 50,110 | +435 | 0.00 | 0.00 | -0.00 | buy |
| US BANCORP \DE\ | 0 | 330 | +330 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 6,335 | 6,647 | +312 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 0 | 137 | +137 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 5,844 | 5,977 | +133 | 0.00 | 0.00 | -0.00 | buy |
| GAMMA Investing LLC | 0 | 20 | +20 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 369,300 | 369,315 | +15 | 0.00 | 0.00 | -0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 9 | +9 | 0.00 | 0.00 | +0.00 | buy |
| True Wealth Design, LLC | 0 | 3 | +3 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 1,177 | 1,177 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 832 | 832 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 1,511,334 | 1,511,334 | 0 | 0.37 | 0.19 | -0.18 | hold |
| NEA Management Company, LLC | 3,614,486 | 3,614,486 | 0 | 3.76 | 2.05 | -1.71 | hold |
| NVP Associates, LLC | 2,136,335 | 2,136,335 | 0 | 21.06 | 14.05 | -7.01 | hold |
| Cormorant Asset Management, LP | 700,000 | 700,000 | 0 | 0.71 | 0.39 | -0.32 | hold |
| EcoR1 Capital, LLC | 1,259,273 | 1,259,273 | 0 | 0.93 | 0.55 | -0.38 | hold |
| TCG Crossover Management, LLC | 650,000 | 650,000 | 0 | 1.17 | 0.65 | -0.52 | hold |
| Deep Track Capital, LP | 3,018,935 | 3,018,935 | 0 | 2.09 | 0.72 | -1.36 | hold |
| Frazier Life Sciences Management, L.P. | 5,985,347 | 5,985,347 | 0 | 4.58 | 2.02 | -2.56 | hold |
| Police & Firemen's Retirement System of New Jersey | 2,143 | 2,143 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 1,107 | 1,107 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 384 | 384 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Bank of New York Mellon Corp | 23,914 | 23,910 | -4 | 0.00 | 0.00 | -0.00 | sell |
| Sterling Capital Management LLC | 161 | 91 | -70 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 5,593 | 5,511 | -82 | 0.00 | 0.00 | -0.00 | sell |
| R Squared Ltd | 400 | 0 | -400 | 0.01 | 0.00 | -0.01 | sell |
| RHUMBLINE ADVISERS | 9,472 | 8,712 | -760 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 27,020 | 26,034 | -986 | 0.00 | 0.00 | -0.00 | sell |
| STRS OHIO | 2,100 | 700 | -1,400 | 0.00 | 0.00 | -0.00 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,581,760 | 1,579,207 | -2,553 | 0.24 | 0.11 | -0.13 | sell |
| VIRTUS ADVISERS, LLC | 3,468 | 0 | -3,468 | 0.03 | 0.00 | -0.03 | sell |
| Sandia Investment Management LP | 5,000 | 0 | -5,000 | 0.17 | 0.00 | -0.17 | sell |
| VANGUARD GROUP INC | 670,948 | 665,563 | -5,385 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 17,433 | 11,818 | -5,615 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 7,230 | 0 | -7,230 | 0.00 | 0.00 | -0.00 | sell |
| BIT Capital GmbH | 12,743 | 0 | -12,743 | 0.02 | 0.00 | -0.02 | sell |
| Saturn V Capital Management LP | 18,000 | 0 | -18,000 | 0.13 | 0.00 | -0.13 | sell |
| GOLDMAN SACHS GROUP INC | 34,827 | 15,168 | -19,659 | 0.00 | 0.00 | -0.00 | sell |
| NORGES BANK | 25,000 | 0 | -25,000 | 0.00 | 0.00 | -0.00 | sell |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 26,708 | 0 | -26,708 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 45,901 | 0 | -45,901 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,161,527 | 1,100,916 | -60,611 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 333,642 | 170,440 | -163,202 | 0.01 | 0.00 | -0.00 | sell |
| Alyeska Investment Group, L.P. | 174,700 | 0 | -174,700 | 0.01 | 0.00 | -0.01 | sell |
| CITADEL ADVISORS LLC | 220,330 | 0 | -220,330 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 2,909,639 | 2,638,521 | -271,118 | 0.01 | 0.00 | -0.01 | sell |