| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | 6,652,013 | 6,652,013 | 0 | 5.64 | 5.11 | -0.53 | hold |
| ORBIMED ADVISORS LLC | 3,935,203 | 3,637,887 | -297,316 | 2.54 | 2.37 | -0.17 | sell |
| NEA Management Company, LLC | 3,614,486 | 3,614,486 | 0 | 5.81 | 6.13 | +0.32 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 3,349,961 | 3,191,824 | -158,137 | 0.02 | 0.02 | -0.00 | sell |
| BlackRock, Inc. | 2,919,756 | 2,941,406 | +21,650 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 15,746 | 2,936,684 | +2,920,938 | 0.00 | 0.00 | +0.00 | buy |
| Deep Track Capital, LP | 3,249,790 | 2,757,569 | -492,221 | 2.34 | 1.70 | -0.64 | sell |
| NVP Associates, LLC | 2,136,335 | 2,136,335 | 0 | 26.40 | 36.20 | +9.80 | hold |
| Polar Capital Holdings Plc | 0 | 1,622,186 | +1,622,186 | 0.00 | 0.21 | +0.21 | buy |
| BRAIDWELL LP | 1,018,600 | 1,492,467 | +473,867 | 1.03 | 1.49 | +0.46 | buy |
| Aaron Wealth Advisors LLC | 70,000 | 1,168,176 | +1,098,176 | 0.12 | 2.01 | +1.89 | buy |
| Cormorant Asset Management, LP | 1,120,000 | 1,120,000 | 0 | 2.00 | 1.69 | -0.32 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 840,506 | 1,029,007 | +188,501 | 0.00 | 0.00 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,408,159 | 1,018,212 | -389,947 | 0.30 | 0.22 | -0.08 | sell |
| Kynam Capital Management, LP | 934,799 | 934,799 | 0 | 1.92 | 1.77 | -0.15 | hold |
| CITADEL ADVISORS LLC | 809,857 | 932,833 | +122,976 | 0.02 | 0.02 | +0.00 | buy |
| Woodline Partners LP | 1,000,063 | 900,063 | -100,000 | 0.12 | 0.10 | -0.02 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 890,000 | 890,000 | 0 | 0.44 | 0.44 | +0.00 | hold |
| Caligan Partners LP | 0 | 848,590 | +848,590 | 0.00 | 1.79 | +1.79 | buy |
| Parkman Healthcare Partners LLC | 885,639 | 800,037 | -85,602 | 2.66 | 2.48 | -0.18 | sell |
| STATE STREET CORP | 672,740 | 787,208 | +114,468 | 0.00 | 0.00 | +0.00 | buy |
| EcoR1 Capital, LLC | 2,123,604 | 777,000 | -1,346,604 | 3.06 | 0.99 | -2.07 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 649,391 | 670,385 | +20,994 | 0.00 | 0.00 | -0.00 | buy |
| TCG Crossover Management, LLC | 650,000 | 650,000 | 0 | 0.68 | 0.56 | -0.12 | hold |
| MILLENNIUM MANAGEMENT LLC | 462,049 | 564,415 | +102,366 | 0.01 | 0.01 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 78,553 | 499,469 | +420,916 | 0.43 | 2.87 | +2.44 | buy |
| GOLDMAN SACHS GROUP INC | 331,938 | 457,945 | +126,007 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 281,212 | 346,914 | +65,702 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 0 | 294,374 | +294,374 | 0.00 | 0.05 | +0.05 | buy |
| D. E. Shaw & Co., Inc. | 671,838 | 288,889 | -382,949 | 0.02 | 0.01 | -0.01 | sell |
| Rock Springs Capital Management LP | 282,624 | 287,967 | +5,343 | 0.46 | 0.51 | +0.05 | buy |
| Opaleye Management Inc. | 260,000 | 260,000 | 0 | 1.08 | 1.02 | -0.06 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 222,180 | 214,908 | -7,272 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 190,881 | 210,575 | +19,694 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 208,049 | +208,049 | 0.00 | 0.14 | +0.14 | buy |
| Soleus Capital Management, L.P. | 408,900 | 178,897 | -230,003 | 0.55 | 0.22 | -0.33 | sell |
| DAFNA Capital Management LLC | 165,265 | 175,465 | +10,200 | 1.21 | 1.19 | -0.02 | buy |
| Goelzer Investment Management, Inc. | 221,672 | 164,172 | -57,500 | 0.32 | 0.24 | -0.09 | sell |
| Affinity Asset Advisors, LLC | 250,000 | 150,000 | -100,000 | 0.57 | 0.26 | -0.30 | sell |
| JPMORGAN CHASE & CO | 14,645 | 147,057 | +132,412 | 0.00 | 0.00 | +0.00 | buy |
| TFG Asset Management GP Ltd | 143,327 | 145,480 | +2,153 | 0.95 | 0.85 | -0.10 | buy |
| Schonfeld Strategic Advisors LLC | 167,125 | 123,814 | -43,311 | 0.03 | 0.03 | +0.00 | sell |
| TD ASSET MANAGEMENT INC | 101,450 | 115,998 | +14,548 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 138,571 | 115,075 | -23,496 | 0.01 | 0.00 | -0.00 | sell |
| Burkehill Global Management, LP | 100,000 | 100,000 | 0 | 0.21 | 0.15 | -0.06 | hold |
| Squarepoint Ops LLC | 46,702 | 97,215 | +50,513 | 0.00 | 0.01 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 69,551 | 90,634 | +21,083 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 75,565 | 81,792 | +6,227 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 75,262 | 80,222 | +4,960 | 0.00 | 0.00 | +0.00 | buy |
| PFM Health Sciences, LP | 79,310 | 71,894 | -7,416 | 0.25 | 0.23 | -0.03 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 71,028 | +71,028 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 62,703 | +62,703 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 73,736 | 57,322 | -16,414 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 20,139 | 53,210 | +33,071 | 0.02 | 0.03 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 46,753 | +46,753 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 0 | 44,400 | +44,400 | 0.00 | 0.00 | +0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 43,597 | 43,597 | 0 | 0.32 | 0.33 | +0.01 | hold |
| ALPS ADVISORS INC | 36,872 | 36,550 | -322 | 0.01 | 0.01 | -0.00 | sell |
| ALGERT GLOBAL LLC | 0 | 36,020 | +36,020 | 0.00 | 0.02 | +0.02 | buy |
| Creative Planning | 33,651 | 35,970 | +2,319 | 0.00 | 0.00 | -0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 0 | 34,264 | +34,264 | 0.00 | 0.01 | +0.01 | buy |
| RHUMBLINE ADVISERS | 33,420 | 33,871 | +451 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 27,900 | 30,500 | +2,600 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 37,894 | 28,750 | -9,144 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 57,005 | 28,087 | -28,918 | 0.02 | 0.01 | -0.01 | sell |
| Invesco Ltd. | 21,203 | 27,525 | +6,322 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 31,409 | 27,387 | -4,022 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 20,027 | 22,950 | +2,923 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,754 | 22,765 | +21,011 | 0.00 | 0.00 | +0.00 | buy |
| Cerity Partners LLC | 21,323 | 21,163 | -160 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 2,539 | 19,358 | +16,819 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 19,262 | +19,262 | 0.00 | 0.00 | +0.00 | buy |
| Koa Wealth Management, LLC | 18,413 | 17,913 | -500 | 0.40 | 0.39 | -0.01 | sell |
| Engineers Gate Manager LP | 0 | 17,380 | +17,380 | 0.00 | 0.01 | +0.01 | buy |
| Qube Research & Technologies Ltd | 23,213 | 17,187 | -6,026 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 16,018 | 16,018 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Optimize Financial Inc | 0 | 14,508 | +14,508 | 0.00 | 0.21 | +0.21 | buy |
| CITIGROUP INC | 16,391 | 13,499 | -2,892 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 13,258 | 13,325 | +67 | 0.00 | 0.00 | -0.00 | buy |
| Jump Financial, LLC | 0 | 12,700 | +12,700 | 0.00 | 0.01 | +0.01 | buy |
| BARCLAYS PLC | 52,691 | 11,838 | -40,853 | 0.00 | 0.00 | -0.00 | sell |
| HighVista Strategies LLC | 0 | 11,472 | +11,472 | 0.00 | 0.09 | +0.09 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 11,600 | 10,900 | -700 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 31,931 | 10,762 | -21,169 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 6,784 | 10,384 | +3,600 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 10,300 | +10,300 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 57,575 | 10,222 | -47,353 | 0.01 | 0.00 | -0.01 | sell |
| Aquatic Capital Management LLC | 0 | 10,155 | +10,155 | 0.00 | 0.01 | +0.01 | buy |
| Virtus Investment Advisers, LLC | 8,910 | 9,131 | +221 | 0.08 | 0.08 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 4,300 | 9,000 | +4,700 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 7,657 | 8,989 | +1,332 | 0.00 | 0.00 | +0.00 | buy |
| Tidal Investments LLC | 0 | 8,877 | +8,877 | 0.00 | 0.00 | +0.00 | buy |
| TEMA ETFS LLC | 0 | 8,877 | +8,877 | 0.00 | 0.02 | +0.02 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 48,614 | 8,823 | -39,791 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 12,236 | 8,726 | -3,510 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 9,214 | 8,388 | -826 | 0.01 | 0.01 | +0.00 | sell |
| China Universal Asset Management Co., Ltd. | 15,317 | 7,968 | -7,349 | 0.04 | 0.02 | -0.02 | sell |
| Orion Porfolio Solutions, LLC | 0 | 7,951 | +7,951 | 0.00 | 0.00 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 0 | 7,673 | +7,673 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 7,520 | 7,520 | 0 | 0.00 | 0.00 | -0.00 | hold |