| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Point72 Asset Management, L.P. | 110,482 | 973,787 | +863,305 | 0.00 | 0.03 | +0.02 | buy |
| MILLENNIUM MANAGEMENT LLC | 170,440 | 766,840 | +596,400 | 0.00 | 0.01 | +0.01 | buy |
| Parkman Healthcare Partners LLC | 328,323 | 871,933 | +543,610 | 0.29 | 1.15 | +0.86 | buy |
| Schonfeld Strategic Advisors LLC | 200,642 | 631,413 | +430,771 | 0.01 | 0.05 | +0.04 | buy |
| VANGUARD GROUP INC | 665,563 | 1,043,684 | +378,121 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,100,916 | 1,346,910 | +245,994 | 0.00 | 0.00 | +0.00 | buy |
| Sio Capital Management, LLC | 0 | 241,000 | +241,000 | 0.00 | 1.10 | +1.10 | buy |
| BlackRock, Inc. | 783,042 | 1,011,546 | +228,504 | 0.00 | 0.00 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 0 | 191,825 | +191,825 | 0.00 | 1.45 | +1.45 | buy |
| MPM BioImpact LLC | 1,132,950 | 1,294,416 | +161,466 | 1.44 | 2.56 | +1.12 | buy |
| FRANKLIN RESOURCES INC | 369,315 | 494,852 | +125,537 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 177,220 | 265,119 | +87,899 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 274,458 | 348,447 | +73,989 | 0.00 | 0.00 | +0.00 | buy |
| Resolute Capital Asset Partners LLC | 0 | 49,670 | +49,670 | 0.00 | 0.30 | +0.30 | buy |
| BARCLAYS PLC | 11,818 | 58,541 | +46,723 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 96,615 | 141,021 | +44,406 | 0.23 | 0.52 | +0.29 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 42,387 | +42,387 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 32,490 | 70,333 | +37,843 | 0.00 | 0.01 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 50,110 | 87,097 | +36,987 | 0.00 | 0.00 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 0 | 34,135 | +34,135 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0 | 29,200 | +29,200 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 27,632 | +27,632 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 877,461 | 901,103 | +23,642 | 0.04 | 0.05 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 151,504 | 171,304 | +19,800 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 96,507 | 115,594 | +19,087 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 18,001 | +18,001 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 44,240 | 61,333 | +17,093 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 8,712 | 23,662 | +14,950 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 23,910 | 38,032 | +14,122 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 94,546 | 107,483 | +12,937 | 0.00 | 0.00 | +0.00 | buy |
| Koa Wealth Management, LLC | 19,396 | 31,752 | +12,356 | 0.12 | 0.29 | +0.17 | buy |
| XTX Topco Ltd | 0 | 11,861 | +11,861 | 0.00 | 0.01 | +0.01 | buy |
| MetLife Investment Management, LLC | 0 | 11,018 | +11,018 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 10,500 | +10,500 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 8,000 | +8,000 | 0.00 | 0.02 | +0.02 | buy |
| Nuveen, LLC | 14,471 | 22,143 | +7,672 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 5,977 | 10,943 | +4,966 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 10,728 | 14,271 | +3,543 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 6,647 | 9,329 | +2,682 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 137 | 1,802 | +1,665 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 1,592 | +1,592 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 8,006 | 8,772 | +766 | 0.02 | 0.03 | +0.02 | buy |
| Tower Research Capital LLC (TRC) | 1,365 | 2,110 | +745 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 1,107 | 1,551 | +444 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 411 | +411 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 91 | 460 | +369 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 20 | 299 | +279 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 832 | 1,064 | +232 | 0.00 | 0.00 | +0.00 | buy |
| Physician Wealth Advisors, Inc. | 0 | 109 | +109 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 0 | 108 | +108 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 0 | 101 | +101 | 0.00 | 0.00 | +0.00 | buy |
| Rise Advisors, LLC | 0 | 68 | +68 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 35 | +35 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 0 | 25 | +25 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 9 | 29 | +20 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 20 | +20 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 330 | 337 | +7 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 4,002,887 | 4,002,887 | 0 | 0.71 | 1.15 | +0.44 | hold |
| Ameritas Investment Partners, Inc. | 1,177 | 1,177 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEA Management Company, LLC | 3,614,486 | 3,614,486 | 0 | 2.05 | 3.10 | +1.05 | hold |
| NVP Associates, LLC | 2,136,335 | 2,136,335 | 0 | 14.05 | 13.24 | -0.82 | hold |
| Cormorant Asset Management, LP | 700,000 | 700,000 | 0 | 0.39 | 0.59 | +0.20 | hold |
| Aaron Wealth Advisors LLC | 50,000 | 50,000 | 0 | 0.04 | 0.06 | +0.02 | hold |
| TCG Crossover Management, LLC | 650,000 | 650,000 | 0 | 0.65 | 0.85 | +0.19 | hold |
| Frazier Life Sciences Management, L.P. | 5,985,347 | 5,985,347 | 0 | 2.02 | 2.73 | +0.71 | hold |
| Police & Firemen's Retirement System of New Jersey | 2,143 | 2,143 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 4,300 | 4,300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STRS OHIO | 700 | 700 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 384 | 384 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DEUTSCHE BANK AG\ | 8,762 | 8,762 | 0 | 0.00 | 0.00 | +0.00 | hold |
| True Wealth Design, LLC | 3 | 0 | -3 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 5,511 | 0 | -5,511 | 0.00 | 0.00 | -0.00 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,579,207 | 1,571,906 | -7,301 | 0.11 | 0.14 | +0.03 | sell |
| ALPS ADVISORS INC | 26,034 | 18,048 | -7,986 | 0.00 | 0.00 | +0.00 | sell |
| Opaleye Management Inc. | 250,000 | 239,319 | -10,681 | 0.41 | 0.55 | +0.14 | sell |
| WEALTHEDGE INVESTMENT ADVISORS, LLC | 11,864 | 0 | -11,864 | 0.04 | 0.00 | -0.04 | sell |
| GSA CAPITAL PARTNERS LLP | 12,369 | 0 | -12,369 | 0.01 | 0.00 | -0.01 | sell |
| GOLDMAN SACHS GROUP INC | 15,168 | 0 | -15,168 | 0.00 | 0.00 | -0.00 | sell |
| Verition Fund Management LLC | 19,815 | 0 | -19,815 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 20,098 | 0 | -20,098 | 0.00 | 0.00 | -0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 40,225 | 15,617 | -24,608 | 0.03 | 0.02 | -0.01 | sell |
| Jump Financial, LLC | 28,996 | 0 | -28,996 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 30,916 | 1,329 | -29,587 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 33,833 | 0 | -33,833 | 0.00 | 0.00 | -0.00 | sell |
| Shay Capital LLC | 49,133 | 0 | -49,133 | 0.11 | 0.00 | -0.11 | sell |
| Exome Asset Management LLC | 133,113 | 63,076 | -70,037 | 0.88 | 0.59 | -0.29 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 185,932 | 112,743 | -73,189 | 0.08 | 0.09 | +0.01 | sell |
| CITIGROUP INC | 97,328 | 5,723 | -91,605 | 0.00 | 0.00 | -0.00 | sell |
| EcoR1 Capital, LLC | 1,259,273 | 1,149,794 | -109,479 | 0.55 | 0.78 | +0.23 | sell |
| MARSHALL WACE, LLP | 111,211 | 0 | -111,211 | 0.00 | 0.00 | -0.00 | sell |
| Affinity Asset Advisors, LLC | 175,000 | 0 | -175,000 | 0.20 | 0.00 | -0.20 | sell |
| JPMORGAN CHASE & CO | 201,235 | 8,184 | -193,051 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 2,638,521 | 2,266,628 | -371,893 | 0.00 | 0.00 | +0.00 | sell |
| Deep Track Capital, LP | 3,018,935 | 2,188,592 | -830,343 | 0.72 | 0.80 | +0.08 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 1,511,334 | 377,841 | -1,133,493 | 0.19 | 0.07 | -0.11 | sell |