| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Paradigm Biocapital Advisors LP | 0 | 2,508,015 | +2,508,015 | 0.00 | 2.59 | +2.59 | buy |
| FMR LLC | 2,936,684 | 5,322,885 | +2,386,201 | 0.00 | 0.01 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 3,191,824 | 4,977,523 | +1,785,699 | 0.02 | 0.05 | +0.03 | buy |
| BlackRock, Inc. | 2,941,406 | 3,323,672 | +382,266 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 62,703 | 401,885 | +339,182 | 0.00 | 0.02 | +0.02 | buy |
| Soleus Capital Management, L.P. | 178,897 | 515,279 | +336,382 | 0.22 | 0.98 | +0.76 | buy |
| BANK OF AMERICA CORP /DE/ | 28,750 | 298,927 | +270,177 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 0 | 252,665 | +252,665 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 0 | 248,558 | +248,558 | 0.00 | 0.00 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 233,095 | +233,095 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 46,753 | 233,700 | +186,947 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 123,814 | 248,670 | +124,856 | 0.03 | 0.07 | +0.04 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 670,385 | 773,072 | +102,687 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 88,045 | +88,045 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 787,208 | 864,466 | +77,258 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 11,838 | 87,854 | +76,016 | 0.00 | 0.00 | +0.00 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 0 | 64,893 | +64,893 | 0.00 | 0.08 | +0.08 | buy |
| Rhenman & Partners Asset Management AB | 0 | 62,000 | +62,000 | 0.00 | 0.32 | +0.32 | buy |
| TFG Asset Management GP Ltd | 145,480 | 203,543 | +58,063 | 0.85 | 1.83 | +0.98 | buy |
| Ensign Peak Advisors, Inc | 0 | 42,156 | +42,156 | 0.00 | 0.00 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,018,212 | 1,056,579 | +38,367 | 0.22 | 0.34 | +0.11 | buy |
| NORTHERN TRUST CORP | 210,575 | 246,678 | +36,103 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 26,684 | +26,684 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 26,132 | +26,132 | 0.00 | 0.00 | +0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0 | 25,800 | +25,800 | 0.00 | 0.00 | +0.00 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 0 | 25,377 | +25,377 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 27,525 | 50,678 | +23,153 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 214,908 | 233,095 | +18,187 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 10,762 | 28,313 | +17,551 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 81,792 | 98,733 | +16,941 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 7,238 | 21,344 | +14,106 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 8,726 | 22,680 | +13,954 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 3,856 | 16,991 | +13,135 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 13,499 | 25,122 | +11,623 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 36,550 | 48,012 | +11,462 | 0.01 | 0.01 | +0.01 | buy |
| Rock Springs Capital Management LP | 287,967 | 298,218 | +10,251 | 0.51 | 0.80 | +0.30 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 9,877 | +9,877 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 0 | 9,777 | +9,777 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 22,950 | 31,693 | +8,743 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 80,222 | 88,927 | +8,705 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 8,602 | +8,602 | 0.00 | 0.01 | +0.01 | buy |
| DnB Asset Management AS | 0 | 7,793 | +7,793 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 0 | 7,757 | +7,757 | 0.00 | 0.05 | +0.05 | buy |
| Quantinno Capital Management LP | 0 | 6,497 | +6,497 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 0 | 6,410 | +6,410 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 36,020 | 42,070 | +6,050 | 0.02 | 0.03 | +0.01 | buy |
| Arizona State Retirement System | 0 | 5,899 | +5,899 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 0 | 5,622 | +5,622 | 0.00 | 0.00 | +0.00 | buy |
| Blackstone Inc. | 0 | 5,533 | +5,533 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 0 | 4,098 | +4,098 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 0 | 3,855 | +3,855 | 0.00 | 0.01 | +0.01 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 3,800 | +3,800 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 35,970 | 39,524 | +3,554 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 33,871 | 37,196 | +3,325 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 3,386 | 6,245 | +2,859 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,411 | 3,651 | +2,240 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 16,018 | 18,250 | +2,232 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 19,358 | 21,583 | +2,225 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 9,000 | 11,000 | +2,000 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 7,520 | 9,154 | +1,634 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 470 | 2,086 | +1,616 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 7,968 | 9,175 | +1,207 | 0.02 | 0.03 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 457,945 | 459,005 | +1,060 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 0 | 1,055 | +1,055 | 0.00 | 0.01 | +0.01 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 13,325 | 14,292 | +967 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 22,765 | 23,376 | +611 | 0.00 | 0.00 | +0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 0 | 553 | +553 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,312 | 2,817 | +505 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 30,500 | 31,000 | +500 | 0.00 | 0.00 | -0.00 | buy |
| PROFUND ADVISORS LLC | 8,388 | 8,812 | +424 | 0.01 | 0.01 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 1,592 | 2,013 | +421 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 1,600 | 2,000 | +400 | 0.00 | 0.00 | +0.00 | buy |
| Kemnay Advisory Services Inc. | 0 | 321 | +321 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 279 | +279 | 0.00 | 0.00 | +0.00 | buy |
| Aster Capital Management (DIFC) Ltd | 0 | 172 | +172 | 0.00 | 0.00 | +0.00 | buy |
| Integrated Wealth Concepts LLC | 0 | 171 | +171 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 11,472 | 11,634 | +162 | 0.09 | 0.15 | +0.05 | buy |
| Parkman Healthcare Partners LLC | 800,037 | 800,173 | +136 | 2.48 | 4.54 | +2.06 | buy |
| J.Safra Asset Management Corp | 0 | 85 | +85 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 9,131 | 9,215 | +84 | 0.08 | 0.12 | +0.04 | buy |
| Bare Financial Services, Inc | 0 | 34 | +34 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 900,063 | 900,092 | +29 | 0.10 | 0.15 | +0.05 | buy |
| EverSource Wealth Advisors, LLC | 25 | 48 | +23 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 1,307 | 1,327 | +20 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 61 | 79 | +18 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 18 | +18 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 24 | 39 | +15 | 0.00 | 0.00 | +0.00 | buy |
| Physician Wealth Advisors, Inc. | 109 | 121 | +12 | 0.00 | 0.00 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 0 | 11 | +11 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 3 | 10 | +7 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 299 | 304 | +5 | 0.00 | 0.00 | +0.00 | buy |
| SJS Investment Consulting Inc. | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |
| Hughes Financial Services, LLC | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 43,597 | 43,597 | 0 | 0.33 | 0.59 | +0.26 | hold |
| KBC Group NV | 810 | 810 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEA Management Company, LLC | 3,614,486 | 3,614,486 | 0 | 6.13 | 12.56 | +6.43 | hold |
| NVP Associates, LLC | 2,136,335 | 2,136,335 | 0 | 36.20 | 35.93 | -0.26 | hold |
| Opaleye Management Inc. | 260,000 | 260,000 | 0 | 1.02 | 1.30 | +0.28 | hold |
| KLP KAPITALFORVALTNING AS | 4,900 | 4,900 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Larson Financial Group LLC | 49 | 49 | 0 | 0.00 | 0.00 | +0.00 | hold |