| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | 6,652,013 | 6,652,013 | 0 | 5.11 | 8.00 | +2.89 | hold |
| FMR LLC | 2,936,684 | 5,322,885 | +2,386,201 | 0.00 | 0.01 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 3,191,824 | 4,977,523 | +1,785,699 | 0.02 | 0.05 | +0.03 | buy |
| NEA Management Company, LLC | 3,614,486 | 3,614,486 | 0 | 6.13 | 12.56 | +6.43 | hold |
| ORBIMED ADVISORS LLC | 3,637,887 | 3,428,736 | -209,151 | 2.37 | 3.58 | +1.22 | sell |
| BlackRock, Inc. | 2,941,406 | 3,323,672 | +382,266 | 0.00 | 0.00 | +0.00 | buy |
| Paradigm Biocapital Advisors LP | 0 | 2,508,015 | +2,508,015 | 0.00 | 2.59 | +2.59 | buy |
| NVP Associates, LLC | 2,136,335 | 2,136,335 | 0 | 36.20 | 35.93 | -0.26 | hold |
| Deep Track Capital, LP | 2,757,569 | 1,732,569 | -1,025,000 | 1.70 | 1.41 | -0.29 | sell |
| Polar Capital Holdings Plc | 1,622,186 | 1,608,514 | -13,672 | 0.21 | 0.25 | +0.04 | sell |
| Aaron Wealth Advisors LLC | 1,168,176 | 1,167,799 | -377 | 2.01 | 3.27 | +1.26 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,018,212 | 1,056,579 | +38,367 | 0.22 | 0.34 | +0.11 | buy |
| Kynam Capital Management, LP | 934,799 | 934,799 | 0 | 1.77 | 2.85 | +1.08 | hold |
| Woodline Partners LP | 900,063 | 900,092 | +29 | 0.10 | 0.15 | +0.05 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 890,000 | 873,492 | -16,508 | 0.44 | 0.64 | +0.20 | sell |
| STATE STREET CORP | 787,208 | 864,466 | +77,258 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,029,007 | 814,807 | -214,200 | 0.00 | 0.00 | +0.00 | sell |
| Parkman Healthcare Partners LLC | 800,037 | 800,173 | +136 | 2.48 | 4.54 | +2.06 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 670,385 | 773,072 | +102,687 | 0.00 | 0.00 | +0.00 | buy |
| BRAIDWELL LP | 1,492,467 | 710,880 | -781,587 | 1.49 | 1.45 | -0.03 | sell |
| TCG Crossover Management, LLC | 650,000 | 650,000 | 0 | 0.56 | 0.86 | +0.31 | hold |
| Cormorant Asset Management, LP | 1,120,000 | 550,000 | -570,000 | 1.69 | 1.56 | -0.13 | sell |
| Soleus Capital Management, L.P. | 178,897 | 515,279 | +336,382 | 0.22 | 0.98 | +0.76 | buy |
| GOLDMAN SACHS GROUP INC | 457,945 | 459,005 | +1,060 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 62,703 | 401,885 | +339,182 | 0.00 | 0.02 | +0.02 | buy |
| EcoR1 Capital, LLC | 777,000 | 388,500 | -388,500 | 0.99 | 1.06 | +0.07 | sell |
| BANK OF AMERICA CORP /DE/ | 28,750 | 298,927 | +270,177 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 287,967 | 298,218 | +10,251 | 0.51 | 0.80 | +0.30 | buy |
| Candriam S.C.A. | 294,374 | 289,893 | -4,481 | 0.05 | 0.07 | +0.03 | sell |
| UBS Group AG | 346,914 | 272,747 | -74,167 | 0.00 | 0.00 | +0.00 | sell |
| Opaleye Management Inc. | 260,000 | 260,000 | 0 | 1.02 | 1.30 | +0.28 | hold |
| FRANKLIN RESOURCES INC | 0 | 252,665 | +252,665 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 123,814 | 248,670 | +124,856 | 0.03 | 0.07 | +0.04 | buy |
| MORGAN STANLEY | 0 | 248,558 | +248,558 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 210,575 | 246,678 | +36,103 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 46,753 | 233,700 | +186,947 | 0.00 | 0.00 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 233,095 | +233,095 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 214,908 | 233,095 | +18,187 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 564,415 | 226,151 | -338,264 | 0.01 | 0.01 | -0.00 | sell |
| TFG Asset Management GP Ltd | 145,480 | 203,543 | +58,063 | 0.85 | 1.83 | +0.98 | buy |
| Caligan Partners LP | 848,590 | 200,000 | -648,590 | 1.79 | 0.53 | -1.26 | sell |
| D. E. Shaw & Co., Inc. | 288,889 | 182,767 | -106,122 | 0.01 | 0.01 | -0.00 | sell |
| JPMORGAN CHASE & CO | 147,057 | 139,611 | -7,446 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 115,075 | 113,475 | -1,600 | 0.00 | 0.00 | +0.00 | sell |
| Burkehill Global Management, LP | 100,000 | 100,000 | 0 | 0.15 | 0.20 | +0.05 | hold |
| Nuveen, LLC | 81,792 | 98,733 | +16,941 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 115,998 | 95,598 | -20,400 | 0.00 | 0.00 | +0.00 | sell |
| Bank of New York Mellon Corp | 80,222 | 88,927 | +8,705 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 88,045 | +88,045 | 0.00 | 0.01 | +0.01 | buy |
| BARCLAYS PLC | 11,838 | 87,854 | +76,016 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 150,000 | 75,000 | -75,000 | 0.26 | 0.20 | -0.06 | sell |
| PFM Health Sciences, LP | 71,894 | 70,971 | -923 | 0.23 | 0.34 | +0.11 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 208,049 | 70,353 | -137,696 | 0.14 | 0.07 | -0.07 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 90,634 | 66,112 | -24,522 | 0.00 | 0.00 | +0.00 | sell |
| MOORE CAPITAL MANAGEMENT, LP | 0 | 64,893 | +64,893 | 0.00 | 0.08 | +0.08 | buy |
| Rhenman & Partners Asset Management AB | 0 | 62,000 | +62,000 | 0.00 | 0.32 | +0.32 | buy |
| Invesco Ltd. | 27,525 | 50,678 | +23,153 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 36,550 | 48,012 | +11,462 | 0.01 | 0.01 | +0.01 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 43,597 | 43,597 | 0 | 0.33 | 0.59 | +0.26 | hold |
| Swiss National Bank | 44,400 | 42,900 | -1,500 | 0.00 | 0.00 | +0.00 | sell |
| Ensign Peak Advisors, Inc | 0 | 42,156 | +42,156 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 36,020 | 42,070 | +6,050 | 0.02 | 0.03 | +0.01 | buy |
| Creative Planning | 35,970 | 39,524 | +3,554 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 33,871 | 37,196 | +3,325 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 22,950 | 31,693 | +8,743 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 30,500 | 31,000 | +500 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 10,762 | 28,313 | +17,551 | 0.00 | 0.00 | +0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 34,264 | 27,421 | -6,843 | 0.01 | 0.01 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 26,684 | +26,684 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 26,132 | +26,132 | 0.00 | 0.00 | +0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0 | 25,800 | +25,800 | 0.00 | 0.00 | +0.00 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 0 | 25,377 | +25,377 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 13,499 | 25,122 | +11,623 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 22,765 | 23,376 | +611 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 8,726 | 22,680 | +13,954 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 27,387 | 22,591 | -4,796 | 0.00 | 0.00 | +0.00 | sell |
| Legal & General Group Plc | 19,358 | 21,583 | +2,225 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 7,238 | 21,344 | +14,106 | 0.00 | 0.00 | +0.00 | buy |
| Cerity Partners LLC | 21,163 | 20,997 | -166 | 0.00 | 0.00 | +0.00 | sell |
| MetLife Investment Management, LLC | 16,018 | 18,250 | +2,232 | 0.00 | 0.00 | +0.00 | buy |
| Koa Wealth Management, LLC | 17,913 | 17,113 | -800 | 0.39 | 0.64 | +0.26 | sell |
| Russell Investments Group, Ltd. | 3,856 | 16,991 | +13,135 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 19,262 | 15,971 | -3,291 | 0.00 | 0.00 | +0.00 | sell |
| Optimize Financial Inc | 14,508 | 14,458 | -50 | 0.21 | 0.29 | +0.07 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 13,325 | 14,292 | +967 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 175,465 | 11,809 | -163,656 | 1.19 | 0.12 | -1.07 | sell |
| HighVista Strategies LLC | 11,472 | 11,634 | +162 | 0.09 | 0.15 | +0.05 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 9,000 | 11,000 | +2,000 | 0.00 | 0.00 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 9,877 | +9,877 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 10,384 | 9,860 | -524 | 0.00 | 0.00 | +0.00 | sell |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 0 | 9,777 | +9,777 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 9,131 | 9,215 | +84 | 0.08 | 0.12 | +0.04 | buy |
| China Universal Asset Management Co., Ltd. | 7,968 | 9,175 | +1,207 | 0.02 | 0.03 | +0.01 | buy |
| Police & Firemen's Retirement System of New Jersey | 7,520 | 9,154 | +1,634 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 8,388 | 8,812 | +424 | 0.01 | 0.01 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 8,602 | +8,602 | 0.00 | 0.01 | +0.01 | buy |
| DnB Asset Management AS | 0 | 7,793 | +7,793 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 0 | 7,757 | +7,757 | 0.00 | 0.05 | +0.05 | buy |
| State of New Jersey Common Pension Fund D | 7,673 | 6,913 | -760 | 0.00 | 0.00 | +0.00 | sell |
| Quantinno Capital Management LP | 0 | 6,497 | +6,497 | 0.00 | 0.00 | +0.00 | buy |