| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | 0 | 5,985,347 | +5,985,347 | 0.00 | 6.23 | +6.23 | buy |
| ORBIMED ADVISORS LLC | 0 | 3,812,215 | +3,812,215 | 0.00 | 1.81 | +1.81 | buy |
| NEA Management Company, LLC | 0 | 3,614,486 | +3,614,486 | 0.00 | 5.12 | +5.12 | buy |
| Deep Track Capital, LP | 0 | 3,018,935 | +3,018,935 | 0.00 | 2.50 | +2.50 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 2,937,853 | +2,937,853 | 0.00 | 0.01 | +0.01 | buy |
| NVP Associates, LLC | 0 | 2,136,335 | +2,136,335 | 0.00 | 31.51 | +31.51 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 1,511,334 | +1,511,334 | 0.00 | 0.45 | +0.45 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 1,192,938 | +1,192,938 | 0.00 | 0.00 | +0.00 | buy |
| EcoR1 Capital, LLC | 0 | 1,175,809 | +1,175,809 | 0.00 | 1.05 | +1.05 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 981,322 | +981,322 | 0.00 | 0.22 | +0.22 | buy |
| Cormorant Asset Management, LP | 0 | 700,000 | +700,000 | 0.00 | 0.96 | +0.96 | buy |
| TCG Crossover Management, LLC | 0 | 650,000 | +650,000 | 0.00 | 1.43 | +1.43 | buy |
| Woodline Partners LP | 0 | 519,675 | +519,675 | 0.00 | 0.11 | +0.11 | buy |
| FRANKLIN RESOURCES INC | 0 | 450,000 | +450,000 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 440,411 | +440,411 | 0.00 | 0.01 | +0.01 | buy |
| Alyeska Investment Group, L.P. | 0 | 225,000 | +225,000 | 0.00 | 0.03 | +0.03 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 0 | 150,000 | +150,000 | 0.00 | 0.18 | +0.18 | buy |
| CITADEL ADVISORS LLC | 0 | 135,608 | +135,608 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 51,000 | +51,000 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 0 | 50,000 | +50,000 | 0.00 | 0.00 | +0.00 | buy |
| Monashee Investment Management LLC | 0 | 50,000 | +50,000 | 0.00 | 0.14 | +0.14 | buy |
| Maven Securities LTD | 0 | 50,000 | +50,000 | 0.00 | 0.15 | +0.15 | buy |
| STEMPOINT CAPITAL LP | 0 | 50,000 | +50,000 | 0.00 | 0.39 | +0.39 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 46,194 | +46,194 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 0 | 44,782 | +44,782 | 0.00 | 0.00 | +0.00 | buy |
| SOROS FUND MANAGEMENT LLC | 0 | 30,000 | +30,000 | 0.00 | 0.02 | +0.02 | buy |
| Ghisallo Capital Management LLC | 0 | 30,000 | +30,000 | 0.00 | 0.04 | +0.04 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 0 | 26,708 | +26,708 | 0.00 | 0.01 | +0.01 | buy |
| JANE STREET GROUP, LLC | 0 | 26,570 | +26,570 | 0.00 | 0.00 | +0.00 | buy |
| NORGES BANK | 0 | 25,000 | +25,000 | 0.00 | 0.00 | +0.00 | buy |
| Point72 (DIFC) Ltd | 0 | 24,011 | +24,011 | 0.00 | 0.05 | +0.05 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 0 | 22,269 | +22,269 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 21,637 | +21,637 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 16,470 | +16,470 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 16,400 | +16,400 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 15,600 | +15,600 | 0.00 | 0.00 | +0.00 | buy |
| Shay Capital LLC | 0 | 15,000 | +15,000 | 0.00 | 0.11 | +0.11 | buy |
| DAVIDSON KEMPNER CAPITAL MANAGEMENT LP | 0 | 13,500 | +13,500 | 0.00 | 0.01 | +0.01 | buy |
| MARSHALL WACE, LLP | 0 | 12,000 | +12,000 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 10,706 | +10,706 | 0.00 | 0.05 | +0.05 | buy |
| Capula Management Ltd | 0 | 8,362 | +8,362 | 0.00 | 0.00 | +0.00 | buy |
| Sandia Investment Management LP | 0 | 5,000 | +5,000 | 0.00 | 0.21 | +0.21 | buy |
| Legal & General Group Plc | 0 | 5,000 | +5,000 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 154 | +154 | 0.00 | 0.00 | +0.00 | buy |