| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | 5,985,347 | 6,652,013 | +666,666 | 2.73 | 3.49 | +0.76 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 2,266,628 | 4,823,336 | +2,556,708 | 0.00 | 0.01 | +0.01 | buy |
| ORBIMED ADVISORS LLC | 4,002,887 | 4,002,887 | 0 | 1.15 | 1.68 | +0.53 | hold |
| NEA Management Company, LLC | 3,614,486 | 3,614,486 | 0 | 3.10 | 3.47 | +0.37 | hold |
| Deep Track Capital, LP | 2,188,592 | 3,150,000 | +961,408 | 0.80 | 1.54 | +0.74 | buy |
| NVP Associates, LLC | 2,136,335 | 2,136,335 | 0 | 13.24 | 22.51 | +9.28 | hold |
| EcoR1 Capital, LLC | 1,149,794 | 2,123,604 | +973,810 | 0.78 | 1.78 | +1.01 | buy |
| Kynam Capital Management, LP | 0 | 2,000,000 | +2,000,000 | 0.00 | 2.61 | +2.61 | buy |
| BlackRock, Inc. | 1,011,546 | 1,957,461 | +945,915 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,043,684 | 1,677,362 | +633,678 | 0.00 | 0.00 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,571,906 | 1,539,639 | -32,267 | 0.14 | 0.19 | +0.05 | sell |
| FRANKLIN RESOURCES INC | 494,852 | 1,307,288 | +812,436 | 0.00 | 0.01 | +0.00 | buy |
| Cormorant Asset Management, LP | 700,000 | 1,225,000 | +525,000 | 0.59 | 1.48 | +0.88 | buy |
| Woodline Partners LP | 901,103 | 1,201,150 | +300,047 | 0.05 | 0.10 | +0.04 | buy |
| CITADEL ADVISORS LLC | 0 | 996,083 | +996,083 | 0.00 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,346,910 | 954,726 | -392,184 | 0.00 | 0.00 | +0.00 | sell |
| Parkman Healthcare Partners LLC | 871,933 | 773,304 | -98,629 | 1.15 | 1.49 | +0.34 | sell |
| MILLENNIUM MANAGEMENT LLC | 766,840 | 655,416 | -111,424 | 0.01 | 0.01 | +0.00 | sell |
| TCG Crossover Management, LLC | 650,000 | 650,000 | 0 | 0.85 | 0.56 | -0.29 | hold |
| Point72 Asset Management, L.P. | 973,787 | 627,667 | -346,120 | 0.03 | 0.02 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 348,447 | 473,932 | +125,485 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 358,121 | +358,121 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 265,119 | 319,274 | +54,155 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 631,413 | 282,677 | -348,736 | 0.05 | 0.03 | -0.02 | sell |
| Rock Springs Capital Management LP | 0 | 282,624 | +282,624 | 0.00 | 0.29 | +0.29 | buy |
| BAKER BROS. ADVISORS LP | 0 | 277,777 | +277,777 | 0.00 | 0.04 | +0.04 | buy |
| Soleus Capital Management, L.P. | 0 | 275,000 | +275,000 | 0.00 | 0.26 | +0.26 | buy |
| Opaleye Management Inc. | 239,319 | 253,000 | +13,681 | 0.55 | 0.63 | +0.07 | buy |
| Longaeva Partners L.P. | 0 | 224,433 | +224,433 | 0.00 | 0.84 | +0.84 | buy |
| PFM Health Sciences, LP | 0 | 221,505 | +221,505 | 0.00 | 0.33 | +0.33 | buy |
| SECTORAL ASSET MANAGEMENT INC | 191,825 | 194,898 | +3,073 | 1.45 | 2.11 | +0.66 | buy |
| TFG Asset Management GP Ltd | 0 | 177,840 | +177,840 | 0.00 | 0.45 | +0.45 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 107,483 | 170,006 | +62,523 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 0 | 165,000 | +165,000 | 0.00 | 0.27 | +0.27 | buy |
| NORTHERN TRUST CORP | 115,594 | 133,265 | +17,671 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 171,304 | 118,792 | -52,512 | 0.00 | 0.00 | +0.00 | sell |
| ExodusPoint Capital Management, LP | 0 | 100,000 | +100,000 | 0.00 | 0.02 | +0.02 | buy |
| Burkehill Global Management, LP | 0 | 100,000 | +100,000 | 0.00 | 0.10 | +0.10 | buy |
| DAFNA Capital Management LLC | 0 | 85,000 | +85,000 | 0.00 | 0.37 | +0.37 | buy |
| Hudson Bay Capital Management LP | 0 | 85,000 | +85,000 | 0.00 | 0.01 | +0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 83,766 | +83,766 | 0.00 | 0.00 | +0.00 | buy |
| Murchinson Ltd. | 0 | 80,000 | +80,000 | 0.00 | 0.27 | +0.27 | buy |
| STEMPOINT CAPITAL LP | 141,021 | 75,000 | -66,021 | 0.52 | 0.26 | -0.25 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 112,743 | 69,428 | -43,315 | 0.09 | 0.08 | -0.01 | sell |
| FMR LLC | 61,333 | 68,976 | +7,643 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 87,097 | 68,376 | -18,721 | 0.00 | 0.00 | +0.00 | sell |
| UBS Group AG | 0 | 60,725 | +60,725 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 63,076 | 52,402 | -10,674 | 0.59 | 0.61 | +0.01 | sell |
| Aaron Wealth Advisors LLC | 50,000 | 50,000 | 0 | 0.06 | 0.05 | -0.01 | hold |
| Ikarian Capital, LLC | 0 | 48,071 | +48,071 | 0.00 | 0.17 | +0.17 | buy |
| Bank of New York Mellon Corp | 38,032 | 47,735 | +9,703 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 39,498 | +39,498 | 0.00 | 0.02 | +0.02 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 38,500 | +38,500 | 0.00 | 0.03 | +0.03 | buy |
| XTX Topco Ltd | 11,861 | 38,378 | +26,517 | 0.01 | 0.03 | +0.03 | buy |
| Ghisallo Capital Management LLC | 0 | 38,250 | +38,250 | 0.00 | 0.02 | +0.02 | buy |
| Weiss Asset Management LP | 0 | 30,823 | +30,823 | 0.00 | 0.01 | +0.01 | buy |
| SummitTX Capital, L.P. | 0 | 29,310 | +29,310 | 0.00 | 0.02 | +0.02 | buy |
| Creative Planning | 0 | 28,732 | +28,732 | 0.00 | 0.00 | +0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0 | 28,461 | +28,461 | 0.00 | 0.00 | +0.00 | buy |
| Koa Wealth Management, LLC | 31,752 | 26,713 | -5,039 | 0.29 | 0.35 | +0.06 | sell |
| BANK OF AMERICA CORP /DE/ | 42,387 | 26,616 | -15,771 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 25,641 | +25,641 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 22,143 | 22,143 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RHUMBLINE ADVISERS | 23,662 | 21,821 | -1,841 | 0.00 | 0.00 | +0.00 | sell |
| BARCLAYS PLC | 58,541 | 21,626 | -36,915 | 0.00 | 0.00 | -0.00 | sell |
| Caption Management, LLC | 0 | 20,000 | +20,000 | 0.00 | 0.02 | +0.02 | buy |
| ALPS ADVISORS INC | 18,048 | 16,840 | -1,208 | 0.00 | 0.00 | +0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 18,001 | 15,764 | -2,237 | 0.00 | 0.00 | +0.00 | sell |
| Walleye Capital LLC | 70,333 | 15,176 | -55,157 | 0.01 | 0.00 | -0.01 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 15,000 | +15,000 | 0.00 | 0.04 | +0.04 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 29,200 | 14,200 | -15,000 | 0.01 | 0.01 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 0 | 13,587 | +13,587 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 0 | 11,788 | +11,788 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 10,943 | 11,755 | +812 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 11,018 | 11,018 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DEUTSCHE BANK AG\ | 8,762 | 10,923 | +2,161 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 8,772 | 10,614 | +1,842 | 0.03 | 0.05 | +0.02 | buy |
| ALLIANCEBERNSTEIN L.P. | 10,500 | 10,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Man Group plc | 0 | 10,225 | +10,225 | 0.00 | 0.00 | +0.00 | buy |
| Symmetry Investments LP | 0 | 10,000 | +10,000 | 0.00 | 0.01 | +0.01 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 9,329 | 7,120 | -2,209 | 0.00 | 0.00 | -0.00 | sell |
| Quarry LP | 8,000 | 6,499 | -1,501 | 0.02 | 0.03 | +0.01 | sell |
| JPMORGAN CHASE & CO | 8,184 | 6,175 | -2,009 | 0.00 | 0.00 | +0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 5,009 | +5,009 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 5,000 | +5,000 | 0.00 | 0.01 | +0.01 | buy |
| Police & Firemen's Retirement System of New Jersey | 2,143 | 4,509 | +2,366 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 4,300 | 4,300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Rockefeller Capital Management L.P. | 34,135 | 3,000 | -31,135 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 1,329 | 2,896 | +1,567 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 1,592 | 1,592 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FNY Investment Advisers, LLC | 0 | 1,575 | +1,575 | 0.00 | 0.01 | +0.01 | buy |
| Russell Investments Group, Ltd. | 35 | 1,481 | +1,446 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 1,802 | 1,384 | -418 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 1,551 | 1,328 | -223 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 2,110 | 1,267 | -843 | 0.00 | 0.00 | -0.00 | sell |
| Ameritas Investment Partners, Inc. | 1,177 | 1,177 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,064 | 1,065 | +1 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 460 | 1,058 | +598 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 700 | 700 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Arax Advisory Partners | 0 | 398 | +398 | 0.00 | 0.00 | +0.00 | buy |