| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 0 | 727,952 | +727,952 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 50,000 | 670,948 | +620,948 | 0.00 | 0.00 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 981,322 | 1,581,760 | +600,438 | 0.22 | 0.24 | +0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 22,269 | 265,703 | +243,434 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 0 | 170,000 | +170,000 | 0.00 | 0.42 | +0.42 | buy |
| STATE STREET CORP | 0 | 142,649 | +142,649 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 93,311 | +93,311 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 0 | 90,682 | +90,682 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 519,675 | 608,721 | +89,046 | 0.11 | 0.08 | -0.04 | buy |
| CITADEL ADVISORS LLC | 135,608 | 220,330 | +84,722 | 0.00 | 0.00 | +0.00 | buy |
| EcoR1 Capital, LLC | 1,175,809 | 1,259,273 | +83,464 | 1.05 | 0.93 | -0.12 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 71,500 | +71,500 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 0 | 45,901 | +45,901 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 0 | 27,020 | +27,020 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 0 | 24,573 | +24,573 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 0 | 23,914 | +23,914 | 0.00 | 0.00 | +0.00 | buy |
| Saturn V Capital Management LP | 0 | 18,000 | +18,000 | 0.00 | 0.13 | +0.13 | buy |
| MARSHALL WACE, LLP | 12,000 | 25,900 | +13,900 | 0.00 | 0.00 | +0.00 | buy |
| BIT Capital GmbH | 0 | 12,743 | +12,743 | 0.00 | 0.02 | +0.02 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 150,000 | 162,090 | +12,090 | 0.18 | 0.18 | -0.00 | buy |
| RHUMBLINE ADVISERS | 0 | 9,472 | +9,472 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 9,106 | +9,106 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 8,864 | +8,864 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 7,230 | +7,230 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 6,335 | +6,335 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 5,844 | +5,844 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 0 | 5,593 | +5,593 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 4,338 | +4,338 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 46,194 | 49,675 | +3,481 | 0.00 | 0.00 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 0 | 3,468 | +3,468 | 0.00 | 0.03 | +0.03 | buy |
| STRS OHIO | 0 | 2,100 | +2,100 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 1,486 | +1,486 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 1,177 | +1,177 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 16,400 | 17,433 | +1,033 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 832 | +832 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 154 | 803 | +649 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 0 | 384 | +384 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 0 | 161 | +161 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 3,812,215 | 3,812,215 | 0 | 1.81 | 1.46 | -0.35 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 1,511,334 | 1,511,334 | 0 | 0.45 | 0.37 | -0.08 | hold |
| NORGES BANK | 25,000 | 25,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEA Management Company, LLC | 3,614,486 | 3,614,486 | 0 | 5.12 | 3.76 | -1.36 | hold |
| NVP Associates, LLC | 2,136,335 | 2,136,335 | 0 | 31.51 | 21.06 | -10.45 | hold |
| Cormorant Asset Management, LP | 700,000 | 700,000 | 0 | 0.96 | 0.71 | -0.26 | hold |
| TCG Crossover Management, LLC | 650,000 | 650,000 | 0 | 1.43 | 1.17 | -0.26 | hold |
| Deep Track Capital, LP | 3,018,935 | 3,018,935 | 0 | 2.50 | 2.09 | -0.42 | hold |
| Sandia Investment Management LP | 5,000 | 5,000 | 0 | 0.21 | 0.17 | -0.04 | hold |
| Frazier Life Sciences Management, L.P. | 5,985,347 | 5,985,347 | 0 | 6.23 | 4.58 | -1.65 | hold |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 26,708 | 26,708 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Aster Capital Management (DIFC) Ltd | 1,810 | 0 | -1,810 | 0.01 | 0.00 | -0.01 | sell |
| Legal & General Group Plc | 5,000 | 1,107 | -3,893 | 0.00 | 0.00 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 44,782 | 36,600 | -8,182 | 0.00 | 0.00 | -0.00 | sell |
| Capula Management Ltd | 8,362 | 0 | -8,362 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asia (Singapore) Pte. Ltd. | 10,706 | 0 | -10,706 | 0.05 | 0.00 | -0.05 | sell |
| DAVIDSON KEMPNER CAPITAL MANAGEMENT LP | 13,500 | 0 | -13,500 | 0.01 | 0.00 | -0.01 | sell |
| Shay Capital LLC | 15,000 | 0 | -15,000 | 0.11 | 0.00 | -0.11 | sell |
| Point72 Asset Management, L.P. | 15,600 | 0 | -15,600 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 51,000 | 34,827 | -16,173 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 16,470 | 0 | -16,470 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 21,637 | 0 | -21,637 | 0.00 | 0.00 | -0.00 | sell |
| Point72 (DIFC) Ltd | 24,011 | 0 | -24,011 | 0.05 | 0.00 | -0.05 | sell |
| JANE STREET GROUP, LLC | 26,570 | 0 | -26,570 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 2,937,853 | 2,909,639 | -28,214 | 0.01 | 0.01 | -0.00 | sell |
| SOROS FUND MANAGEMENT LLC | 30,000 | 0 | -30,000 | 0.02 | 0.00 | -0.02 | sell |
| Ghisallo Capital Management LLC | 30,000 | 0 | -30,000 | 0.04 | 0.00 | -0.04 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,192,938 | 1,161,527 | -31,411 | 0.00 | 0.00 | -0.00 | sell |
| Monashee Investment Management LLC | 50,000 | 0 | -50,000 | 0.14 | 0.00 | -0.14 | sell |
| Maven Securities LTD | 50,000 | 0 | -50,000 | 0.15 | 0.00 | -0.15 | sell |
| STEMPOINT CAPITAL LP | 50,000 | 0 | -50,000 | 0.39 | 0.00 | -0.39 | sell |
| Alyeska Investment Group, L.P. | 225,000 | 174,700 | -50,300 | 0.03 | 0.01 | -0.02 | sell |
| FRANKLIN RESOURCES INC | 450,000 | 369,300 | -80,700 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 440,411 | 333,642 | -106,769 | 0.01 | 0.01 | -0.00 | sell |