| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | 6,652,013 | 6,652,013 | 0 | 3.49 | 5.64 | +2.15 | hold |
| ORBIMED ADVISORS LLC | 4,002,887 | 3,935,203 | -67,684 | 1.68 | 2.54 | +0.86 | sell |
| NEA Management Company, LLC | 3,614,486 | 3,614,486 | 0 | 3.47 | 5.81 | +2.34 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 4,823,336 | 3,349,961 | -1,473,375 | 0.01 | 0.02 | +0.00 | sell |
| Deep Track Capital, LP | 3,150,000 | 3,249,790 | +99,790 | 1.54 | 2.34 | +0.80 | buy |
| BlackRock, Inc. | 1,957,461 | 2,919,756 | +962,295 | 0.00 | 0.00 | +0.00 | buy |
| NVP Associates, LLC | 2,136,335 | 2,136,335 | 0 | 22.51 | 26.40 | +3.89 | hold |
| EcoR1 Capital, LLC | 2,123,604 | 2,123,604 | 0 | 1.78 | 3.06 | +1.27 | hold |
| VANGUARD GROUP INC | 1,677,362 | 1,817,811 | +140,449 | 0.00 | 0.00 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,539,639 | 1,408,159 | -131,480 | 0.19 | 0.30 | +0.11 | sell |
| Cormorant Asset Management, LP | 1,225,000 | 1,120,000 | -105,000 | 1.48 | 2.00 | +0.52 | sell |
| BRAIDWELL LP | 0 | 1,018,600 | +1,018,600 | 0.00 | 1.03 | +1.03 | buy |
| Woodline Partners LP | 1,201,150 | 1,000,063 | -201,087 | 0.10 | 0.12 | +0.02 | sell |
| Kynam Capital Management, LP | 2,000,000 | 934,799 | -1,065,201 | 2.61 | 1.92 | -0.69 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 890,000 | +890,000 | 0.00 | 0.44 | +0.44 | buy |
| Parkman Healthcare Partners LLC | 773,304 | 885,639 | +112,335 | 1.49 | 2.66 | +1.17 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 954,726 | 840,506 | -114,220 | 0.00 | 0.00 | +0.00 | sell |
| CITADEL ADVISORS LLC | 996,083 | 809,857 | -186,226 | 0.01 | 0.02 | +0.00 | sell |
| Point72 Asset Management, L.P. | 627,667 | 680,609 | +52,942 | 0.02 | 0.03 | +0.01 | buy |
| STATE STREET CORP | 319,274 | 672,740 | +353,466 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 0 | 671,838 | +671,838 | 0.00 | 0.02 | +0.02 | buy |
| TCG Crossover Management, LLC | 650,000 | 650,000 | 0 | 0.56 | 0.68 | +0.12 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 473,932 | 649,391 | +175,459 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 655,416 | 462,049 | -193,367 | 0.01 | 0.01 | +0.00 | sell |
| Soleus Capital Management, L.P. | 275,000 | 408,900 | +133,900 | 0.26 | 0.55 | +0.29 | buy |
| GOLDMAN SACHS GROUP INC | 358,121 | 331,938 | -26,183 | 0.00 | 0.00 | +0.00 | sell |
| Rock Springs Capital Management LP | 282,624 | 282,624 | 0 | 0.29 | 0.46 | +0.17 | hold |
| UBS Group AG | 60,725 | 281,212 | +220,487 | 0.00 | 0.00 | +0.00 | buy |
| Opaleye Management Inc. | 253,000 | 260,000 | +7,000 | 0.63 | 1.08 | +0.46 | buy |
| Affinity Asset Advisors, LLC | 165,000 | 250,000 | +85,000 | 0.27 | 0.57 | +0.30 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 170,006 | 222,180 | +52,174 | 0.00 | 0.00 | +0.00 | buy |
| Goelzer Investment Management, Inc. | 0 | 221,672 | +221,672 | 0.00 | 0.32 | +0.32 | buy |
| NORTHERN TRUST CORP | 133,265 | 190,881 | +57,616 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 282,677 | 167,125 | -115,552 | 0.03 | 0.03 | -0.01 | sell |
| DAFNA Capital Management LLC | 85,000 | 165,265 | +80,265 | 0.37 | 1.21 | +0.84 | buy |
| TFG Asset Management GP Ltd | 177,840 | 143,327 | -34,513 | 0.45 | 0.95 | +0.50 | sell |
| TWO SIGMA INVESTMENTS, LP | 13,587 | 138,571 | +124,984 | 0.00 | 0.01 | +0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 25,641 | 119,726 | +94,085 | 0.00 | 0.01 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 118,792 | 101,450 | -17,342 | 0.00 | 0.00 | +0.00 | sell |
| Burkehill Global Management, LP | 100,000 | 100,000 | 0 | 0.10 | 0.21 | +0.11 | hold |
| JANE STREET GROUP, LLC | 0 | 86,581 | +86,581 | 0.00 | 0.00 | +0.00 | buy |
| PFM Health Sciences, LP | 221,505 | 79,310 | -142,195 | 0.33 | 0.25 | -0.08 | sell |
| STEMPOINT CAPITAL LP | 75,000 | 78,553 | +3,553 | 0.26 | 0.43 | +0.16 | buy |
| OSAIC HOLDINGS, INC. | 0 | 77,601 | +77,601 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 76,528 | +76,528 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 22,143 | 75,565 | +53,422 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 47,735 | 75,262 | +27,527 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 83,766 | 73,736 | -10,030 | 0.00 | 0.00 | +0.00 | sell |
| Aaron Wealth Advisors LLC | 50,000 | 70,000 | +20,000 | 0.05 | 0.12 | +0.07 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 68,376 | 69,551 | +1,175 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 0 | 59,026 | +59,026 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 57,575 | +57,575 | 0.00 | 0.01 | +0.01 | buy |
| ExodusPoint Capital Management, LP | 100,000 | 57,005 | -42,995 | 0.02 | 0.02 | -0.00 | sell |
| BARCLAYS PLC | 21,626 | 52,691 | +31,065 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 5,009 | 48,614 | +43,605 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 46,702 | +46,702 | 0.00 | 0.00 | +0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 69,428 | 43,597 | -25,831 | 0.08 | 0.32 | +0.24 | sell |
| BANK OF AMERICA CORP /DE/ | 26,616 | 37,894 | +11,278 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 16,840 | 36,872 | +20,032 | 0.00 | 0.01 | +0.01 | buy |
| Creative Planning | 28,732 | 33,651 | +4,919 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 21,821 | 33,420 | +11,599 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 32,644 | +32,644 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 11,755 | 31,931 | +20,176 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 15,764 | 31,409 | +15,645 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 10,500 | 27,900 | +17,400 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 25,663 | +25,663 | 0.00 | 0.02 | +0.02 | buy |
| Trexquant Investment LP | 0 | 24,268 | +24,268 | 0.00 | 0.01 | +0.01 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 23,820 | +23,820 | 0.00 | 0.12 | +0.12 | buy |
| Qube Research & Technologies Ltd | 0 | 23,213 | +23,213 | 0.00 | 0.00 | +0.00 | buy |
| Cerity Partners LLC | 0 | 21,323 | +21,323 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 11,788 | 21,203 | +9,415 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 38,378 | 20,139 | -18,239 | 0.03 | 0.02 | -0.02 | sell |
| DEUTSCHE BANK AG\ | 10,923 | 20,027 | +9,104 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 19,295 | +19,295 | 0.00 | 0.05 | +0.05 | buy |
| Koa Wealth Management, LLC | 26,713 | 18,413 | -8,300 | 0.35 | 0.40 | +0.05 | sell |
| CITIGROUP INC | 178 | 16,391 | +16,213 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 11,018 | 16,018 | +5,000 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 68,976 | 15,746 | -53,230 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 5,000 | 15,317 | +10,317 | 0.01 | 0.04 | +0.03 | buy |
| JPMORGAN CHASE & CO | 6,175 | 14,645 | +8,470 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 7,120 | 13,258 | +6,138 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 12,236 | +12,236 | 0.00 | 0.00 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 11,600 | +11,600 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 0 | 11,254 | +11,254 | 0.00 | 0.01 | +0.01 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 10,360 | +10,360 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 14,200 | 10,000 | -4,200 | 0.01 | 0.01 | +0.00 | sell |
| GROUP ONE TRADING LLC | 0 | 9,428 | +9,428 | 0.00 | 0.01 | +0.01 | buy |
| PROFUND ADVISORS LLC | 0 | 9,214 | +9,214 | 0.00 | 0.01 | +0.01 | buy |
| SIMPLEX TRADING, LLC | 0 | 8,925 | +8,925 | 0.00 | 0.01 | +0.01 | buy |
| Virtus Investment Advisers, LLC | 10,614 | 8,910 | -1,704 | 0.05 | 0.08 | +0.02 | sell |
| Rafferty Asset Management, LLC | 0 | 8,113 | +8,113 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 0 | 7,657 | +7,657 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 4,509 | 7,520 | +3,011 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 0 | 7,187 | +7,187 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 6,858 | +6,858 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 2,896 | 6,784 | +3,888 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 0 | 6,463 | +6,463 | 0.00 | 0.05 | +0.05 | buy |
| SG Americas Securities, LLC | 0 | 4,765 | +4,765 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 4,300 | 4,300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Tower Research Capital LLC (TRC) | 1,267 | 3,416 | +2,149 | 0.00 | 0.00 | +0.00 | buy |