| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 86,154 | 3,598,472 | +3,512,318 | 0.01 | 0.24 | +0.24 | buy |
| Aberdeen Group plc | 385,668 | 721,928 | +336,260 | 0.07 | 0.13 | +0.06 | buy |
| BAKER BROS. ADVISORS LP | 45,031 | 368,923 | +323,892 | 0.05 | 0.38 | +0.34 | buy |
| CenterBook Partners LP | 109,417 | 215,944 | +106,527 | 0.63 | 1.28 | +0.64 | buy |
| Susquehanna Portfolio Strategies, LLC | 6,047 | 92,636 | +86,589 | 0.24 | 0.22 | -0.02 | buy |
| BIT Capital GmbH | 10,586 | 96,089 | +85,503 | 0.08 | 0.59 | +0.51 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 1,195,470 | 1,275,475 | +80,005 | 0.09 | 0.11 | 0.00 | buy |
| Legal & General Group Plc | 253,460 | 315,748 | +62,288 | 0.01 | 0.01 | +0.00 | buy |
| Long Focus Capital Management, LLC | 159,000 | 207,903 | +48,903 | 0.48 | 0.84 | +0.35 | buy |
| Bellevue Group AG | 7,964 | 35,039 | +27,075 | 0.02 | 0.08 | +0.07 | buy |
| GROUPAMA ASSET MANAGMENT | 196,544 | 223,225 | +26,681 | 0.37 | 0.39 | +0.02 | buy |
| GILDER GAGNON HOWE & CO LLC | 649,284 | 667,635 | +18,351 | 0.77 | 0.75 | -0.02 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 177,839 | 192,789 | +14,950 | 0.02 | 0.02 | 0.00 | buy |
| FIRST TRUST ADVISORS LP | 316,935 | 331,360 | +14,425 | 0.03 | 0.03 | 0.00 | buy |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 478,257 | 492,045 | +13,788 | 0.05 | 0.05 | +0.00 | buy |
| EDMOND DE ROTHSCHILD HOLDING S.A. | 82,310 | 92,310 | +10,000 | 0.13 | 0.16 | +0.02 | buy |
| Baader Bank Aktiengesellschaft | 142,822 | 151,862 | +9,040 | 0.97 | 1.15 | +0.18 | buy |
| SECTOR GAMMA AS | 30,000 | 37,470 | +7,470 | 0.88 | 1.30 | +0.43 | buy |
| Erste Asset Management GmbH | 42,000 | 47,700 | +5,700 | 0.05 | 0.04 | -0.01 | buy |
| SHELL ASSET MANAGEMENT CO | 35,212 | 40,610 | +5,398 | 0.15 | 0.15 | 0.00 | buy |
| ALLIANZ SE | 800 | 5,880 | +5,080 | 0.00 | 0.01 | +0.01 | buy |
| APG Asset Management N.V. | 49,600 | 53,100 | +3,500 | 0.01 | 0.01 | +0.00 | buy |
| Bank Julius Baer & Co. Ltd, Zurich | 61,230 | 64,712 | +3,482 | 0.02 | 0.02 | +0.00 | buy |
| Aristides Capital LLC | 14,533 | 17,359 | +2,826 | 0.39 | 0.37 | -0.02 | buy |
| Allianz Asset Management GmbH | 120,680 | 123,495 | +2,815 | 0.02 | 0.02 | +0.00 | buy |
| Swedbank AB | 37,500 | 39,900 | +2,400 | 0.00 | 0.00 | +0.00 | buy |
| Generali Investments CEE, investicni spolecnost, a.s. | 1,200 | 3,200 | +2,000 | 0.01 | 0.03 | +0.02 | buy |
| GUGGENHEIM CAPITAL LLC | 13,785 | 11,922 | +1,863 | 0.01 | 0.01 | 0.00 | sell |
| Beacon Pointe Advisors, LLC | 89,516 | 88,041 | +1,475 | 0.09 | 0.10 | 0.00 | sell |
| Virtus Investment Advisers, LLC | 2,976 | 4,236 | +1,260 | 0.07 | 0.15 | +0.08 | buy |
| BAROMETER CAPITAL MANAGEMENT INC. | 3,160 | 3,960 | +800 | 0.11 | 0.12 | +0.01 | buy |
| Prosperity Wealth Management, Inc. | 3,300 | 4,085 | +785 | 0.14 | 0.16 | +0.02 | buy |
| Raiffeisen Bank International AG | 10,000 | 10,500 | +500 | 0.02 | 0.02 | +0.00 | buy |
| HANTZ FINANCIAL SERVICES, INC. | 100 | 572 | +472 | 0.00 | 0.00 | +0.00 | buy |
| LBP AM SA | 305,221 | 305,470 | +249 | 0.43 | 0.46 | +0.03 | buy |
| BANCO BILBAO VIZCAYA ARGENTARIA, S.A. | 7,467 | 7,653 | +186 | 0.01 | 0.01 | +0.00 | buy |
| PROFUND ADVISORS LLC | 4,160 | 4,309 | +149 | 0.02 | 0.02 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 16,295 | 16,422 | +127 | 0.04 | 0.04 | +0.01 | buy |
| Rhenman & Partners Asset Management AB | 35,750 | 35,870 | +120 | 0.37 | 0.48 | +0.11 | buy |
| Rakuten Securities, Inc. | 280 | 362 | +82 | 0.01 | 0.02 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 20,036 | 20,065 | +29 | 0.17 | 0.20 | +0.03 | buy |
| Perigon Wealth Management, LLC | 5,966 | 5,954 | -12 | 0.01 | 0.01 | +0.00 | sell |
| Midwest Professional Planners, LTD. | 3,930 | 3,906 | -24 | 0.11 | 0.11 | -0.00 | sell |
| Quintet Private Bank (Europe) S.A. | 785 | 760 | -25 | 0.00 | 0.00 | +0.00 | sell |
| BANQUE PICTET & CIE SA | 5,499 | 5,114 | -385 | 0.00 | 0.00 | -0.00 | sell |
| SECTORAL ASSET MANAGEMENT INC | 17,175 | 16,160 | -1,015 | 1.22 | 1.14 | -0.08 | sell |
| BAMCO INC /NY/ | 7,675 | 5,276 | -2,399 | 0.00 | 0.00 | -0.00 | sell |
| Slow Capital, Inc. | 48,761 | 45,346 | -3,415 | 0.59 | 0.59 | -0.00 | sell |
| DAFNA Capital Management LLC | 10,500 | 7,000 | -3,500 | 0.27 | 0.21 | -0.07 | sell |
| Carmignac Gestion | 185,877 | 176,351 | -9,526 | 0.28 | 0.29 | +0.01 | sell |
| TB Alternative Assets Ltd. | 38,996 | 28,917 | -10,079 | 0.82 | 0.57 | -0.25 | sell |
| B. Metzler seel. Sohn & Co. AG | 16,066 | 3,742 | -12,324 | 0.02 | 0.00 | -0.01 | sell |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 145,687 | 131,522 | -14,165 | 0.19 | 0.38 | +0.19 | sell |
| Krensavage Asset Management, LLC | 87,563 | 73,382 | -14,181 | 4.41 | 4.14 | -0.27 | sell |
| Employees Retirement System of Texas | 30,388 | 15,826 | -14,562 | 0.03 | 0.01 | -0.01 | sell |
| Woodline Partners LP | 117,498 | 95,498 | -22,000 | 0.07 | 0.05 | -0.02 | sell |
| FLOSSBACH VON STORCH SE | 4,259,631 | 4,230,098 | -29,533 | 1.68 | 1.84 | +0.16 | sell |
| Lingohr Asset Management GmbH | 43,031 | 6,822 | -36,209 | 0.98 | 1.32 | +0.33 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 4,046,425 | 4,001,466 | -44,959 | 0.30 | 0.34 | +0.03 | sell |
| FRED ALGER MANAGEMENT, LLC | 61,930 | 13,839 | -48,091 | 0.03 | 0.01 | -0.03 | sell |
| Robeco Institutional Asset Management B.V. | 77,535 | 20,619 | -56,916 | 0.01 | 0.00 | -0.01 | sell |
| Candriam S.C.A. | 670,955 | 586,736 | -84,219 | 0.38 | 0.36 | -0.02 | sell |
| SCOTIA CAPITAL INC. | 110,081 | 25,081 | -85,000 | 0.05 | 0.01 | -0.04 | sell |
| BAILLIE GIFFORD & CO | 8,159,682 | 8,038,872 | -120,810 | 0.65 | 0.64 | -0.01 | sell |
| ALTRINSIC GLOBAL ADVISORS LLC | 620,766 | 496,771 | -123,995 | 2.79 | 1.91 | -0.88 | sell |
| Capital International, Inc./CA/ | 638,099 | 470,017 | -168,082 | 0.70 | 0.49 | -0.22 | sell |
| Quinn Opportunity Partners LLC | 197,946 | 25,075 | -172,871 | 1.24 | 0.22 | -1.01 | sell |
| Capital International Investors | 1,428,441 | 1,133,473 | -294,968 | 0.03 | 0.02 | -0.00 | sell |
| Temasek Holdings (Private) Ltd | 1,807,232 | 1,506,027 | -301,205 | 0.66 | 0.61 | -0.05 | sell |