| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 701,739 | 6,299,929 | +5,598,190 | 0.00 | 0.05 | +0.04 | buy |
| Capital International, Inc./CA/ | 198,890 | 930,474 | +731,584 | 0.21 | 1.39 | +1.18 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 500,844 | +500,844 | 0.00 | 0.29 | +0.29 | buy |
| Candriam S.C.A. | 578,998 | 927,164 | +348,166 | 0.28 | 0.63 | +0.35 | buy |
| Capital International Investors | 743,077 | 1,021,132 | +278,055 | 0.01 | 0.02 | +0.01 | buy |
| TANG CAPITAL MANAGEMENT LLC | 0 | 270,000 | +270,000 | 0.00 | 2.29 | +2.29 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 52,202 | 318,869 | +266,667 | 0.00 | 0.00 | +0.00 | buy |
| LBP AM SA | 0 | 247,833 | +247,833 | 0.00 | 0.44 | +0.44 | buy |
| BRAIDWELL LP | 0 | 247,750 | +247,750 | 0.00 | 0.83 | +0.83 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 39,086 | 218,067 | +178,981 | 0.00 | 0.04 | +0.03 | buy |
| Aberdeen Group plc | 52,023 | 225,992 | +173,969 | 0.01 | 0.05 | +0.04 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 455,918 | 620,466 | +164,548 | 0.09 | 0.19 | +0.09 | buy |
| Redmile Group, LLC | 0 | 154,456 | +154,456 | 0.00 | 1.08 | +1.08 | buy |
| Avidity Partners Management LP | 0 | 145,000 | +145,000 | 0.00 | 0.88 | +0.88 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 269,857 | 400,306 | +130,449 | 0.08 | 0.17 | +0.09 | buy |
| Polar Asset Management Partners Inc. | 0 | 124,900 | +124,900 | 0.00 | 0.36 | +0.36 | buy |
| BANK OF AMERICA CORP /DE/ | 91,988 | 213,654 | +121,666 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 0 | 103,000 | +103,000 | 0.00 | 0.22 | +0.22 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 6,363 | 105,009 | +98,646 | 0.00 | 0.02 | +0.02 | buy |
| Carmignac Gestion | 93,322 | 187,670 | +94,348 | 0.13 | 0.37 | +0.24 | buy |
| Amundi | 273,846 | 366,671 | +92,825 | 0.01 | 0.02 | +0.01 | buy |
| MARSHALL WACE, LLP | 35,985 | 112,980 | +76,995 | 0.00 | 0.02 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 59,917 | 134,036 | +74,119 | 0.00 | 0.00 | +0.00 | buy |
| Lodestone Wealth Management LLC | 0 | 70,500 | +70,500 | 0.00 | 0.00 | +0.00 | buy |
| SCOTIA CAPITAL INC. | 80,208 | 145,081 | +64,873 | 0.04 | 0.09 | +0.05 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 57,500 | +57,500 | 0.00 | 0.01 | +0.01 | buy |
| Twin Tree Management, LP | 320 | 54,679 | +54,359 | 0.00 | 0.15 | +0.15 | buy |
| DekaBank Deutsche Girozentrale | 427,597 | 481,397 | +53,800 | 0.06 | 0.11 | +0.04 | buy |
| Rhenman & Partners Asset Management AB | 0 | 51,000 | +51,000 | 0.00 | 0.49 | +0.49 | buy |
| Integral Health Asset Management, LLC | 0 | 50,000 | +50,000 | 0.00 | 0.70 | +0.70 | buy |
| TWO SIGMA SECURITIES, LLC | 3,562 | 51,725 | +48,163 | 0.01 | 0.48 | +0.47 | buy |
| VIKING GLOBAL INVESTORS LP | 0 | 46,294 | +46,294 | 0.00 | 0.02 | +0.02 | buy |
| Squarepoint Ops LLC | 278,672 | 324,699 | +46,027 | 0.08 | 0.13 | +0.04 | buy |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 24,226 | 68,509 | +44,283 | 0.00 | 0.01 | +0.01 | buy |
| FIRST TRUST ADVISORS LP | 409,053 | 451,192 | +42,139 | 0.03 | 0.05 | +0.02 | buy |
| GTS SECURITIES LLC | 11,154 | 51,185 | +40,031 | 0.02 | 0.12 | +0.10 | buy |
| SECTOR GAMMA AS | 0 | 40,000 | +40,000 | 0.00 | 1.44 | +1.44 | buy |
| TD ASSET MANAGEMENT INC | 7,590 | 44,140 | +36,550 | 0.00 | 0.00 | +0.00 | buy |
| EDMOND DE ROTHSCHILD HOLDING S.A. | 38,560 | 74,300 | +35,740 | 0.05 | 0.14 | +0.09 | buy |
| Exome Asset Management LLC | 0 | 34,552 | +34,552 | 0.00 | 2.77 | +2.77 | buy |
| BAILLIE GIFFORD & CO | 8,276,298 | 8,308,071 | +31,773 | 0.52 | 0.74 | +0.22 | buy |
| Point72 Europe (London) LLP | 0 | 27,231 | +27,231 | 0.00 | 0.27 | +0.27 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 26,083 | +26,083 | 0.00 | 0.70 | +0.70 | buy |
| Palo Alto Investors LP | 0 | 25,206 | +25,206 | 0.00 | 0.39 | +0.39 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 20,929 | +20,929 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 38,451 | 56,948 | +18,497 | 0.00 | 0.01 | +0.00 | buy |
| INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC | 0 | 17,934 | +17,934 | 0.00 | 0.00 | +0.00 | buy |
| BIT Capital GmbH | 0 | 17,110 | +17,110 | 0.00 | 0.20 | +0.20 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 0 | 14,946 | +14,946 | 0.00 | 0.02 | +0.02 | buy |
| SIMPLEX TRADING, LLC | 35,636 | 48,687 | +13,051 | 0.09 | 0.19 | +0.10 | buy |
| MANGROVE PARTNERS IM, LLC | 0 | 10,861 | +10,861 | 0.00 | 0.11 | +0.11 | buy |
| KEYSTONE INVESTORS PTE LTD | 0 | 10,678 | +10,678 | 0.00 | 0.09 | +0.09 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 10,645 | +10,645 | 0.00 | 0.10 | +0.10 | buy |
| ADAR1 Capital Management, LLC | 0 | 10,000 | +10,000 | 0.00 | 0.20 | +0.20 | buy |
| Legal & General Group Plc | 202,931 | 212,067 | +9,136 | 0.00 | 0.01 | +0.00 | buy |
| GROUPAMA ASSET MANAGMENT | 57,952 | 66,731 | +8,779 | 0.06 | 0.17 | +0.10 | buy |
| BAMCO INC /NY/ | 9,850 | 18,574 | +8,724 | 0.00 | 0.01 | +0.00 | buy |
| Bellevue Group AG | 0 | 8,721 | +8,721 | 0.00 | 0.02 | +0.02 | buy |
| DAFNA Capital Management LLC | 0 | 8,500 | +8,500 | 0.00 | 0.24 | +0.24 | buy |
| OPTIMAS CAPITAL Ltd | 0 | 8,400 | +8,400 | 0.00 | 0.95 | +0.95 | buy |
| China Universal Asset Management Co., Ltd. | 11,599 | 18,939 | +7,340 | 0.13 | 0.25 | +0.12 | buy |
| Walleye Trading LLC | 11,240 | 17,904 | +6,664 | 0.02 | 0.05 | +0.03 | buy |
| Vestcor Inc | 0 | 6,600 | +6,600 | 0.00 | 0.02 | +0.02 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 6,541 | +6,541 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 81,511 | 87,758 | +6,247 | 0.00 | 0.00 | +0.00 | buy |
| MACKENZIE FINANCIAL CORP | 17,066 | 23,273 | +6,207 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 6,046 | +6,046 | 0.00 | 0.04 | +0.04 | buy |
| Bridgewater Associates, LP | 0 | 5,673 | +5,673 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 112,538 | 117,785 | +5,247 | 0.09 | 0.12 | +0.03 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 20,040 | 24,350 | +4,310 | 0.00 | 0.00 | +0.00 | buy |
| Cannell & Spears LLC | 0 | 4,000 | +4,000 | 0.00 | 0.01 | +0.01 | buy |
| XTX Topco Ltd | 0 | 3,862 | +3,862 | 0.00 | 0.03 | +0.03 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 0 | 3,856 | +3,856 | 0.00 | 0.01 | +0.01 | buy |
| Innova Wealth Partners | 0 | 3,807 | +3,807 | 0.00 | 0.37 | +0.37 | buy |
| Allianz Asset Management GmbH | 29,000 | 32,800 | +3,800 | 0.00 | 0.01 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 198,596 | 202,322 | +3,726 | 0.02 | 0.02 | +0.01 | buy |
| Baader Bank Aktiengesellschaft | 140,750 | 144,281 | +3,531 | 0.88 | 1.44 | +0.56 | buy |
| Compound Planning, Inc. | 0 | 3,406 | +3,406 | 0.00 | 0.03 | +0.03 | buy |
| Beacon Pointe Advisors, LLC | 85,027 | 88,362 | +3,335 | 0.08 | 0.12 | +0.04 | buy |
| HRT FINANCIAL LP | 0 | 3,201 | +3,201 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 3,138 | +3,138 | 0.00 | 0.03 | +0.03 | buy |
| OneDigital Investment Advisors LLC | 0 | 3,040 | +3,040 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 152,853 | 155,867 | +3,014 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 2,907 | +2,907 | 0.00 | 0.00 | +0.00 | buy |
| Rathbones Group PLC | 0 | 2,757 | +2,757 | 0.00 | 0.00 | +0.00 | buy |
| Lester Murray Antman dba SimplyRich | 0 | 2,678 | +2,678 | 0.00 | 0.09 | +0.09 | buy |
| Baird Financial Group, Inc. | 13,780 | 16,282 | +2,502 | 0.00 | 0.00 | +0.00 | buy |
| Capital Investment Advisory Services, LLC | 0 | 2,439 | +2,439 | 0.00 | 0.03 | +0.03 | buy |
| Vanguard Personalized Indexing Management, LLC | 0 | 2,287 | +2,287 | 0.00 | 0.00 | +0.00 | buy |
| Herold Advisors, Inc. | 0 | 2,250 | +2,250 | 0.00 | 0.06 | +0.06 | buy |
| LPL Financial LLC | 34,821 | 37,060 | +2,239 | 0.00 | 0.00 | +0.00 | buy |
| BANQUE PICTET & CIE SA | 0 | 2,180 | +2,180 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 0 | 2,067 | +2,067 | 0.00 | 0.01 | +0.01 | buy |
| ELEVATION POINT WEALTH PARTNERS, LLC | 0 | 2,051 | +2,051 | 0.00 | 0.02 | +0.02 | buy |
| Freedom Investment Management, Inc. | 0 | 2,046 | +2,046 | 0.00 | 0.02 | +0.02 | buy |
| Harbor Advisors LLC | 0 | 2,000 | +2,000 | 0.00 | 0.04 | +0.04 | buy |
| Perfromance Wealth Partners, LLC | 0 | 2,000 | +2,000 | 0.00 | 0.01 | +0.01 | buy |
| Corient Private Wealth LLC | 0 | 1,934 | +1,934 | 0.00 | 0.00 | +0.00 | buy |
| Clearbridge Investments, LLC | 0 | 1,900 | +1,900 | 0.00 | 0.00 | +0.00 | buy |
| Howard Capital Management Inc. | 0 | 1,862 | +1,862 | 0.00 | 0.00 | +0.00 | buy |