| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAILLIE GIFFORD & CO | 8,276,298 | 8,308,071 | +31,773 | 0.52 | 0.74 | +0.22 | buy |
| FMR LLC | 701,739 | 6,299,929 | +5,598,190 | 0.00 | 0.05 | +0.04 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 4,789,518 | 4,516,518 | -273,000 | 0.28 | 0.39 | +0.12 | sell |
| FLOSSBACH VON STORCH SE | 4,379,483 | 4,359,607 | -19,876 | 1.48 | 2.03 | +0.56 | sell |
| Temasek Holdings (Private) Ltd | 1,807,232 | 1,807,232 | 0 | 0.67 | 0.87 | +0.19 | hold |
| Capital International Investors | 743,077 | 1,021,132 | +278,055 | 0.01 | 0.02 | +0.01 | buy |
| Capital International, Inc./CA/ | 198,890 | 930,474 | +731,584 | 0.21 | 1.39 | +1.18 | buy |
| Candriam S.C.A. | 578,998 | 927,164 | +348,166 | 0.28 | 0.63 | +0.35 | buy |
| MORGAN STANLEY | 1,147,797 | 675,916 | -471,881 | 0.01 | 0.01 | -0.00 | sell |
| ALTRINSIC GLOBAL ADVISORS LLC | 676,219 | 652,706 | -23,513 | 2.42 | 3.30 | +0.87 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 455,918 | 620,466 | +164,548 | 0.09 | 0.19 | +0.09 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 500,844 | +500,844 | 0.00 | 0.29 | +0.29 | buy |
| DekaBank Deutsche Girozentrale | 427,597 | 481,397 | +53,800 | 0.06 | 0.11 | +0.04 | buy |
| FIRST TRUST ADVISORS LP | 409,053 | 451,192 | +42,139 | 0.03 | 0.05 | +0.02 | buy |
| Quinn Opportunity Partners LLC | 683,287 | 404,500 | -278,787 | 6.36 | 4.79 | -1.57 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 269,857 | 400,306 | +130,449 | 0.08 | 0.17 | +0.09 | buy |
| Amundi | 273,846 | 366,671 | +92,825 | 0.01 | 0.02 | +0.01 | buy |
| Point72 Asset Management, L.P. | 461,711 | 361,993 | -99,718 | 0.12 | 0.15 | +0.03 | sell |
| Squarepoint Ops LLC | 278,672 | 324,699 | +46,027 | 0.08 | 0.13 | +0.04 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 52,202 | 318,869 | +266,667 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 350,554 | 297,751 | -52,803 | 0.01 | 0.01 | +0.00 | sell |
| GILDER GAGNON HOWE & CO LLC | 277,298 | 275,831 | -1,467 | 0.28 | 0.39 | +0.11 | sell |
| TANG CAPITAL MANAGEMENT LLC | 0 | 270,000 | +270,000 | 0.00 | 2.29 | +2.29 | buy |
| LBP AM SA | 0 | 247,833 | +247,833 | 0.00 | 0.44 | +0.44 | buy |
| BRAIDWELL LP | 0 | 247,750 | +247,750 | 0.00 | 0.83 | +0.83 | buy |
| Aberdeen Group plc | 52,023 | 225,992 | +173,969 | 0.01 | 0.05 | +0.04 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 39,086 | 218,067 | +178,981 | 0.00 | 0.04 | +0.03 | buy |
| BANK OF AMERICA CORP /DE/ | 91,988 | 213,654 | +121,666 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 202,931 | 212,067 | +9,136 | 0.00 | 0.01 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 198,596 | 202,322 | +3,726 | 0.02 | 0.02 | +0.01 | buy |
| Mitsubishi UFJ Trust & Banking Corp | 195,680 | 190,542 | -5,138 | 0.04 | 0.05 | +0.01 | sell |
| Carmignac Gestion | 93,322 | 187,670 | +94,348 | 0.13 | 0.37 | +0.24 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 231,547 | 184,334 | -47,213 | 0.01 | 0.01 | +0.00 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 594,000 | 174,500 | -419,500 | 0.79 | 0.31 | -0.48 | sell |
| STATE STREET CORP | 152,853 | 155,867 | +3,014 | 0.00 | 0.00 | +0.00 | buy |
| Redmile Group, LLC | 0 | 154,456 | +154,456 | 0.00 | 1.08 | +1.08 | buy |
| SCOTIA CAPITAL INC. | 80,208 | 145,081 | +64,873 | 0.04 | 0.09 | +0.05 | buy |
| Avidity Partners Management LP | 0 | 145,000 | +145,000 | 0.00 | 0.88 | +0.88 | buy |
| Baader Bank Aktiengesellschaft | 140,750 | 144,281 | +3,531 | 0.88 | 1.44 | +0.56 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 59,917 | 134,036 | +74,119 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 346,600 | 130,000 | -216,600 | 0.21 | 0.11 | -0.10 | sell |
| Polar Asset Management Partners Inc. | 0 | 124,900 | +124,900 | 0.00 | 0.36 | +0.36 | buy |
| UBS Group AG | 165,544 | 122,981 | -42,563 | 0.00 | 0.00 | +0.00 | sell |
| CenterBook Partners LP | 206,234 | 119,462 | -86,772 | 1.03 | 0.87 | -0.16 | sell |
| Woodline Partners LP | 112,538 | 117,785 | +5,247 | 0.09 | 0.12 | +0.03 | buy |
| Robeco Institutional Asset Management B.V. | 138,634 | 115,052 | -23,582 | 0.02 | 0.03 | +0.00 | sell |
| MARSHALL WACE, LLP | 35,985 | 112,980 | +76,995 | 0.00 | 0.02 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 6,363 | 105,009 | +98,646 | 0.00 | 0.02 | +0.02 | buy |
| ORBIMED ADVISORS LLC | 0 | 103,000 | +103,000 | 0.00 | 0.22 | +0.22 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 101,499 | 100,652 | -847 | 0.00 | 0.00 | +0.00 | sell |
| VAN ECK ASSOCIATES CORP | 119,901 | 94,685 | -25,216 | 0.01 | 0.01 | -0.00 | sell |
| AXA S.A. | 94,273 | 94,299 | +26 | 0.02 | 0.03 | +0.01 | buy |
| Krensavage Asset Management, LLC | 132,293 | 93,583 | -38,710 | 4.88 | 6.23 | +1.35 | sell |
| Beacon Pointe Advisors, LLC | 85,027 | 88,362 | +3,335 | 0.08 | 0.12 | +0.04 | buy |
| Invesco Ltd. | 81,511 | 87,758 | +6,247 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 88,706 | 83,253 | -5,453 | 0.00 | 0.00 | +0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 86,924 | 75,554 | -11,370 | 0.00 | 0.01 | +0.00 | sell |
| EDMOND DE ROTHSCHILD HOLDING S.A. | 38,560 | 74,300 | +35,740 | 0.05 | 0.14 | +0.09 | buy |
| Lodestone Wealth Management LLC | 0 | 70,500 | +70,500 | 0.00 | 0.00 | +0.00 | buy |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 24,226 | 68,509 | +44,283 | 0.00 | 0.01 | +0.01 | buy |
| GROUPAMA ASSET MANAGMENT | 57,952 | 66,731 | +8,779 | 0.06 | 0.17 | +0.10 | buy |
| CITIGROUP INC | 157,941 | 60,793 | -97,148 | 0.01 | 0.01 | -0.01 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 57,500 | +57,500 | 0.00 | 0.01 | +0.01 | buy |
| SEI INVESTMENTS CO | 38,451 | 56,948 | +18,497 | 0.00 | 0.01 | +0.00 | buy |
| Twin Tree Management, LP | 320 | 54,679 | +54,359 | 0.00 | 0.15 | +0.15 | buy |
| TWO SIGMA SECURITIES, LLC | 3,562 | 51,725 | +48,163 | 0.01 | 0.48 | +0.47 | buy |
| Slow Capital, Inc. | 51,080 | 51,680 | +600 | 0.66 | 0.94 | +0.28 | buy |
| GTS SECURITIES LLC | 11,154 | 51,185 | +40,031 | 0.02 | 0.12 | +0.10 | buy |
| Rhenman & Partners Asset Management AB | 0 | 51,000 | +51,000 | 0.00 | 0.49 | +0.49 | buy |
| Integral Health Asset Management, LLC | 0 | 50,000 | +50,000 | 0.00 | 0.70 | +0.70 | buy |
| SIMPLEX TRADING, LLC | 35,636 | 48,687 | +13,051 | 0.09 | 0.19 | +0.10 | buy |
| Pictet Asset Management Holding SA | 51,777 | 48,184 | -3,593 | 0.00 | 0.01 | +0.00 | sell |
| VIKING GLOBAL INVESTORS LP | 0 | 46,294 | +46,294 | 0.00 | 0.02 | +0.02 | buy |
| TD ASSET MANAGEMENT INC | 7,590 | 44,140 | +36,550 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS | 41,706 | 41,706 | 0 | 0.02 | 0.03 | +0.01 | hold |
| JANE STREET GROUP, LLC | 57,183 | 41,130 | -16,053 | 0.00 | 0.01 | +0.00 | sell |
| SECTOR GAMMA AS | 0 | 40,000 | +40,000 | 0.00 | 1.44 | +1.44 | buy |
| CITADEL ADVISORS LLC | 66,212 | 38,904 | -27,308 | 0.01 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 68,547 | 38,345 | -30,202 | 0.01 | 0.01 | -0.00 | sell |
| MACQUARIE GROUP LTD | 37,263 | 37,263 | 0 | 0.00 | 0.00 | +0.00 | hold |
| LPL Financial LLC | 34,821 | 37,060 | +2,239 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 44,271 | 36,252 | -8,019 | 0.01 | 0.01 | +0.00 | sell |
| Exome Asset Management LLC | 0 | 34,552 | +34,552 | 0.00 | 2.77 | +2.77 | buy |
| Allianz Asset Management GmbH | 29,000 | 32,800 | +3,800 | 0.00 | 0.01 | +0.00 | buy |
| IMC-Chicago, LLC | 36,154 | 32,436 | -3,718 | 0.09 | 0.11 | +0.02 | sell |
| DISCOVERY CAPITAL MANAGEMENT, LLC / CT | 30,700 | 30,700 | 0 | 0.33 | 0.44 | +0.12 | hold |
| Employees Retirement System of Texas | 30,388 | 30,388 | 0 | 0.02 | 0.03 | +0.01 | hold |
| GOLDMAN SACHS GROUP INC | 131,621 | 30,344 | -101,277 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 80,082 | 29,720 | -50,362 | 0.00 | 0.00 | -0.00 | sell |
| Crocodile Capital Partners GmbH | 29,586 | 29,586 | 0 | 3.78 | 4.96 | +1.17 | hold |
| AMERIPRISE FINANCIAL INC | 45,485 | 28,730 | -16,755 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Europe (London) LLP | 0 | 27,231 | +27,231 | 0.00 | 0.27 | +0.27 | buy |
| JPMORGAN CHASE & CO | 49,719 | 26,703 | -23,016 | 0.00 | 0.00 | -0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 26,083 | +26,083 | 0.00 | 0.70 | +0.70 | buy |
| Palo Alto Investors LP | 0 | 25,206 | +25,206 | 0.00 | 0.39 | +0.39 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 20,040 | 24,350 | +4,310 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 654,116 | 24,095 | -630,021 | 0.04 | 0.00 | -0.04 | sell |
| MACKENZIE FINANCIAL CORP | 17,066 | 23,273 | +6,207 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 121,181 | 20,953 | -100,228 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 20,929 | +20,929 | 0.00 | 0.00 | +0.00 | buy |