| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 6,299,929 | 7,701,476 | +1,401,547 | 0.05 | 0.05 | +0.01 | buy |
| VIKING GLOBAL INVESTORS LP | 46,294 | 940,850 | +894,556 | 0.02 | 0.35 | +0.33 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 614,297 | +614,297 | 0.00 | 0.05 | +0.05 | buy |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 68,509 | 501,897 | +433,388 | 0.01 | 0.06 | +0.05 | buy |
| UBS Group AG | 122,981 | 529,053 | +406,072 | 0.00 | 0.01 | +0.01 | buy |
| Capital International Investors | 1,021,132 | 1,415,566 | +394,434 | 0.02 | 0.03 | +0.01 | buy |
| Logos Global Management LP | 0 | 300,000 | +300,000 | 0.00 | 4.00 | +4.00 | buy |
| MACQUARIE GROUP LTD | 37,263 | 235,045 | +197,782 | 0.00 | 0.03 | +0.03 | buy |
| GOLDMAN SACHS GROUP INC | 30,344 | 200,470 | +170,126 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 225,992 | 385,668 | +159,676 | 0.05 | 0.08 | +0.03 | buy |
| MILLENNIUM MANAGEMENT LLC | 24,095 | 171,310 | +147,215 | 0.00 | 0.02 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 3,384 | 136,786 | +133,402 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 123,657 | +123,657 | 0.00 | 0.24 | +0.24 | buy |
| JANE STREET GROUP, LLC | 41,130 | 133,602 | +92,472 | 0.01 | 0.02 | +0.02 | buy |
| CITADEL ADVISORS LLC | 38,904 | 127,431 | +88,527 | 0.00 | 0.01 | +0.01 | buy |
| CenterBook Partners LP | 119,462 | 194,118 | +74,656 | 0.87 | 1.32 | +0.45 | buy |
| MORGAN STANLEY | 675,916 | 743,383 | +67,467 | 0.01 | 0.01 | +0.00 | buy |
| BRAIDWELL LP | 247,750 | 309,865 | +62,115 | 0.83 | 1.05 | +0.21 | buy |
| STEMPOINT CAPITAL LP | 0 | 61,403 | +61,403 | 0.00 | 1.75 | +1.75 | buy |
| Bank Julius Baer & Co. Ltd, Zurich | 0 | 56,680 | +56,680 | 0.00 | 0.02 | +0.02 | buy |
| T. Rowe Price Investment Management, Inc. | 0 | 53,336 | +53,336 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 134,036 | 187,355 | +53,319 | 0.00 | 0.00 | +0.00 | buy |
| Allianz Asset Management GmbH | 32,800 | 83,605 | +50,805 | 0.01 | 0.01 | +0.01 | buy |
| GROUP ONE TRADING LLC | 15,457 | 66,072 | +50,615 | 0.07 | 0.26 | +0.18 | buy |
| Integral Health Asset Management, LLC | 50,000 | 100,000 | +50,000 | 0.70 | 1.01 | +0.31 | buy |
| FLOSSBACH VON STORCH SE | 4,359,607 | 4,406,843 | +47,236 | 2.03 | 2.00 | -0.03 | buy |
| APG Asset Management N.V. | 0 | 46,900 | +46,900 | 0.00 | 0.01 | +0.01 | buy |
| BAKER BROS. ADVISORS LP | 0 | 45,031 | +45,031 | 0.00 | 0.05 | +0.05 | buy |
| Squarepoint Ops LLC | 324,699 | 369,639 | +44,940 | 0.13 | 0.11 | -0.02 | buy |
| Decheng Capital LLC | 0 | 40,000 | +40,000 | 0.00 | 0.98 | +0.98 | buy |
| MARSHALL WACE, LLP | 112,980 | 150,157 | +37,177 | 0.02 | 0.02 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 184,334 | 221,080 | +36,746 | 0.01 | 0.01 | +0.00 | buy |
| Legal & General Group Plc | 212,067 | 247,501 | +35,434 | 0.01 | 0.01 | +0.00 | buy |
| Carmignac Gestion | 187,670 | 222,095 | +34,425 | 0.37 | 0.40 | +0.03 | buy |
| SG Americas Securities, LLC | 8,095 | 41,470 | +33,375 | 0.00 | 0.02 | +0.02 | buy |
| PFM Health Sciences, LP | 0 | 33,109 | +33,109 | 0.00 | 0.29 | +0.29 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 30,827 | +30,827 | 0.00 | 0.00 | +0.00 | buy |
| SCOTIA CAPITAL INC. | 145,081 | 175,224 | +30,143 | 0.09 | 0.11 | +0.01 | buy |
| USS Investment Management Ltd | 0 | 27,850 | +27,850 | 0.00 | 0.02 | +0.02 | buy |
| VAN ECK ASSOCIATES CORP | 94,685 | 118,418 | +23,733 | 0.01 | 0.02 | +0.00 | buy |
| EDMOND DE ROTHSCHILD HOLDING S.A. | 74,300 | 97,310 | +23,010 | 0.14 | 0.19 | +0.05 | buy |
| GROUPAMA ASSET MANAGMENT | 66,731 | 86,725 | +19,994 | 0.17 | 0.20 | +0.03 | buy |
| SHELL ASSET MANAGEMENT CO | 0 | 19,440 | +19,440 | 0.00 | 0.10 | +0.10 | buy |
| Verition Fund Management LLC | 0 | 16,951 | +16,951 | 0.00 | 0.01 | +0.01 | buy |
| Parallax Volatility Advisers, L.P. | 8,457 | 23,827 | +15,370 | 0.03 | 0.06 | +0.03 | buy |
| Sivik Global Healthcare LLC | 0 | 15,000 | +15,000 | 0.00 | 0.95 | +0.95 | buy |
| Cinctive Capital Management LP | 0 | 14,760 | +14,760 | 0.00 | 0.09 | +0.09 | buy |
| Bridgewater Associates, LP | 5,673 | 20,277 | +14,604 | 0.00 | 0.01 | +0.01 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 3,856 | 13,820 | +9,964 | 0.01 | 0.03 | +0.02 | buy |
| C2P Capital Advisory Group, LLC d.b.a. Prosperity Capital Advisors | 0 | 9,810 | +9,810 | 0.00 | 0.21 | +0.21 | buy |
| OMERS ADMINISTRATION Corp | 0 | 8,900 | +8,900 | 0.00 | 0.01 | +0.01 | buy |
| Crestline Management, LP | 0 | 8,272 | +8,272 | 0.00 | 0.03 | +0.03 | buy |
| Engineers Gate Manager LP | 0 | 8,153 | +8,153 | 0.00 | 0.02 | +0.02 | buy |
| BANCO BILBAO VIZCAYA ARGENTARIA, S.A. | 0 | 6,969 | +6,969 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 297,751 | 304,500 | +6,749 | 0.01 | 0.01 | -0.00 | buy |
| Twin Tree Management, LP | 54,679 | 61,412 | +6,733 | 0.15 | 0.17 | +0.02 | buy |
| Aristides Capital LLC | 11,900 | 18,010 | +6,110 | 0.59 | 0.64 | +0.05 | buy |
| Mirabaud & Cie SA | 0 | 6,000 | +6,000 | 0.00 | 0.22 | +0.22 | buy |
| SECTORAL ASSET MANAGEMENT INC | 13,155 | 18,950 | +5,795 | 0.92 | 1.44 | +0.52 | buy |
| GILDER GAGNON HOWE & CO LLC | 275,831 | 281,412 | +5,581 | 0.39 | 0.35 | -0.05 | buy |
| LBP AM SA | 247,833 | 252,918 | +5,085 | 0.44 | 0.39 | -0.05 | buy |
| Jefferies Financial Group Inc. | 0 | 5,000 | +5,000 | 0.00 | 0.01 | +0.01 | buy |
| LMR Partners LLP | 0 | 4,777 | +4,777 | 0.00 | 0.01 | +0.01 | buy |
| Vontobel Holding Ltd. | 17,158 | 21,385 | +4,227 | 0.01 | 0.01 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 24,350 | 27,870 | +3,520 | 0.00 | 0.00 | +0.00 | buy |
| Vestcor Inc | 6,600 | 9,900 | +3,300 | 0.02 | 0.04 | +0.01 | buy |
| Lingohr Asset Management GmbH | 0 | 3,170 | +3,170 | 0.00 | 0.74 | +0.74 | buy |
| CIBC WORLD MARKET INC. | 0 | 3,159 | +3,159 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 4,766 | 7,791 | +3,025 | 0.00 | 0.00 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 0 | 2,614 | +2,614 | 0.00 | 0.00 | +0.00 | buy |
| B. Metzler seel. Sohn & Co. AG | 9,468 | 11,959 | +2,491 | 0.01 | 0.01 | +0.00 | buy |
| Bridgefront Capital, LLC | 0 | 2,488 | +2,488 | 0.00 | 0.10 | +0.10 | buy |
| QRG CAPITAL MANAGEMENT, INC. | 0 | 2,415 | +2,415 | 0.00 | 0.00 | +0.00 | buy |
| BIT Capital GmbH | 17,110 | 19,480 | +2,370 | 0.20 | 0.19 | -0.00 | buy |
| BAMCO INC /NY/ | 18,574 | 20,936 | +2,362 | 0.01 | 0.01 | +0.00 | buy |
| Baird Financial Group, Inc. | 16,282 | 18,589 | +2,307 | 0.00 | 0.00 | +0.00 | buy |
| Retireful, LLC | 0 | 2,278 | +2,278 | 0.00 | 0.15 | +0.15 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 0 | 2,089 | +2,089 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 20,929 | 22,983 | +2,054 | 0.00 | 0.00 | +0.00 | buy |
| KESTRA PRIVATE WEALTH SERVICES, LLC | 0 | 1,981 | +1,981 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 18,939 | 20,899 | +1,960 | 0.25 | 0.22 | -0.03 | buy |
| LPL Financial LLC | 37,060 | 38,860 | +1,800 | 0.00 | 0.00 | -0.00 | buy |
| Rhenman & Partners Asset Management AB | 51,000 | 52,750 | +1,750 | 0.49 | 0.62 | +0.13 | buy |
| Beacon Pointe Advisors, LLC | 88,362 | 90,021 | +1,659 | 0.12 | 0.11 | -0.01 | buy |
| O'SHAUGHNESSY ASSET MANAGEMENT, LLC | 6,227 | 7,600 | +1,373 | 0.01 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 100,652 | 101,715 | +1,063 | 0.00 | 0.00 | -0.00 | buy |
| HRT FINANCIAL LP | 3,201 | 4,074 | +873 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,168 | 1,881 | +713 | 0.00 | 0.00 | +0.00 | buy |
| Quintet Private Bank (Europe) S.A. | 85 | 785 | +700 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 2,287 | 2,646 | +359 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 623 | 923 | +300 | 0.01 | 0.01 | +0.00 | buy |
| Lester Murray Antman dba SimplyRich | 2,678 | 2,926 | +248 | 0.09 | 0.10 | +0.01 | buy |
| JONES FINANCIAL COMPANIES LLLP | 223 | 469 | +246 | 0.00 | 0.00 | +0.00 | buy |
| Compound Planning, Inc. | 3,406 | 3,635 | +229 | 0.03 | 0.02 | -0.00 | buy |
| Perigon Wealth Management, LLC | 5,678 | 5,902 | +224 | 0.02 | 0.02 | -0.00 | buy |
| Midwest Professional Planners, LTD. | 3,829 | 4,051 | +222 | 0.14 | 0.14 | -0.00 | buy |
| MAI Capital Management | 0 | 160 | +160 | 0.00 | 0.00 | +0.00 | buy |
| Probity Advisors, Inc. | 1,816 | 1,970 | +154 | 0.04 | 0.04 | +0.00 | buy |
| Bank of New York Mellon Corp | 3,527 | 3,677 | +150 | 0.00 | 0.00 | -0.00 | buy |
| CoreCap Advisors, LLC | 55 | 184 | +129 | 0.00 | 0.00 | +0.00 | buy |