| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Caligan Partners LP | 756,538 | 3,374,791 | +2,618,253 | 0.37 | 1.32 | +0.94 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 378,269 | 1,379,352 | +1,001,083 | 0.02 | 0.07 | +0.05 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 244,875 | +244,875 | 0.00 | 0.00 | +0.00 | buy |
| Frazier Financial Advisors, LLC | 375 | 515 | +140 | 0.00 | 0.00 | +0.00 | buy |
| Temasek Holdings (Private) Ltd | 566,650 | 566,650 | 0 | 0.01 | 0.00 | -0.00 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 63,800 | 63,800 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 34,347 | 34,347 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Mariner, LLC | 31,535 | 31,535 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Alberta Investment Management Corp | 74,723 | 74,723 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Donald L. Hagan, LLC | 30,000 | 30,000 | 0 | 0.03 | 0.03 | -0.00 | hold |
| Aberdeen Group plc | 162,580 | 162,580 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HHLR ADVISORS, LTD. | 6,909,220 | 6,909,220 | 0 | 0.28 | 0.28 | +0.01 | hold |
| GAMMA Investing LLC | 63 | 63 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 1,191 | 1,191 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CITIGROUP INC | 50 | 50 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RHUMBLINE ADVISERS | 1,371 | 1,367 | -4 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 84 | 0 | -84 | 0.00 | 0.00 | 0.00 | sell |
| Qube Research & Technologies Ltd | 4,065 | 2,565 | -1,500 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 60,407 | 58,358 | -2,049 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 110,373 | 102,961 | -7,412 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 38,552 | 30,370 | -8,182 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 30,485 | 17,876 | -12,609 | 0.01 | 0.00 | -0.01 | sell |
| Invesco Ltd. | 85,144 | 57,933 | -27,211 | 0.00 | 0.00 | -0.00 | sell |
| Atom Investors LP | 29,612 | 0 | -29,612 | 0.01 | 0.00 | -0.01 | sell |
| TWO SIGMA ADVISERS, LP | 617,100 | 576,600 | -40,500 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 93,508 | 40,308 | -53,200 | 0.00 | 0.00 | -0.00 | sell |
| Exome Asset Management LLC | 325,762 | 271,400 | -54,362 | 0.52 | 0.40 | -0.12 | sell |
| MARSHALL WACE, LLP | 71,088 | 14,064 | -57,024 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 84,941 | 15,750 | -69,191 | 0.00 | 0.00 | -0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 81,262 | 0 | -81,262 | 0.01 | 0.00 | -0.01 | sell |
| TWO SIGMA INVESTMENTS, LP | 575,580 | 478,442 | -97,138 | 0.00 | 0.00 | -0.00 | sell |
| Man Group plc | 134,977 | 0 | -134,977 | 0.00 | 0.00 | -0.00 | sell |
| Catalyst Funds Management Pty Ltd | 146,290 | 90 | -146,200 | 0.08 | 0.00 | -0.08 | sell |
| GSA CAPITAL PARTNERS LLP | 432,621 | 272,193 | -160,428 | 0.06 | 0.03 | -0.03 | sell |