| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Caligan Partners LP | 3,374,791 | 3,499,330 | +124,539 | 1.32 | 1.38 | +0.06 | buy |
| CITADEL ADVISORS LLC | 0 | 98,389 | +98,389 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 1,379,352 | 1,419,080 | +39,728 | 0.07 | 0.05 | -0.02 | buy |
| XTX Topco Ltd | 17,876 | 43,039 | +25,163 | 0.00 | 0.00 | +0.00 | buy |
| Freestone Capital Holdings, LLC | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 4,015 | +4,015 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 417 | +417 | 0.00 | 0.00 | 0.00 | buy |
| Temasek Holdings (Private) Ltd | 566,650 | 566,650 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 63,800 | 63,800 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RHUMBLINE ADVISERS | 1,367 | 1,367 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Mariner, LLC | 31,535 | 31,535 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Alberta Investment Management Corp | 74,723 | 74,723 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Aberdeen Group plc | 162,580 | 162,580 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HHLR ADVISORS, LTD. | 6,909,220 | 6,909,220 | 0 | 0.28 | 0.19 | -0.10 | hold |
| BARCLAYS PLC | 30,370 | 30,370 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DIMENSIONAL FUND ADVISORS LP | 58,358 | 58,358 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 1,191 | 1,191 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CITIGROUP INC | 50 | 50 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GAMMA Investing LLC | 63 | 0 | -63 | 0.00 | 0.00 | -0.00 | sell |
| Catalyst Funds Management Pty Ltd | 90 | 0 | -90 | 0.00 | 0.00 | -0.00 | sell |
| Frazier Financial Advisors, LLC | 515 | 0 | -515 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 2,565 | 0 | -2,565 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 15,750 | 10,685 | -5,065 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 34,347 | 22,037 | -12,310 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 14,064 | 0 | -14,064 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 40,308 | 11,325 | -28,983 | 0.00 | 0.00 | -0.00 | sell |
| Donald L. Hagan, LLC | 30,000 | 0 | -30,000 | 0.03 | 0.00 | -0.03 | sell |
| Invesco Ltd. | 57,933 | 0 | -57,933 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 478,442 | 408,519 | -69,923 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 576,600 | 499,300 | -77,300 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 102,961 | 0 | -102,961 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF MONTREAL /CAN/ | 244,875 | 0 | -244,875 | 0.00 | 0.00 | -0.00 | sell |
| Exome Asset Management LLC | 271,400 | 0 | -271,400 | 0.40 | 0.00 | -0.40 | sell |
| GSA CAPITAL PARTNERS LLP | 272,193 | 0 | -272,193 | 0.03 | 0.00 | -0.03 | sell |