| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 144,739 | 711,712 | +566,973 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 220,454 | 493,076 | +272,622 | 0.01 | 0.02 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 126,540 | 277,325 | +150,785 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 17,250 | 117,561 | +100,311 | 0.00 | 0.00 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 85,681 | +85,681 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 20,862 | 82,451 | +61,589 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 577,109 | 629,739 | +52,630 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 468,794 | 507,257 | +38,463 | 0.01 | 0.01 | -0.00 | buy |
| ALPS ADVISORS INC | 0 | 33,932 | +33,932 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 59,610 | 85,681 | +26,071 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 0 | 23,944 | +23,944 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 17,744 | +17,744 | 0.00 | 0.09 | +0.09 | buy |
| Nuveen, LLC | 0 | 14,649 | +14,649 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 0 | 11,844 | +11,844 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 10,962 | +10,962 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 9,852 | +9,852 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 6,986 | +6,986 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 5,400 | +5,400 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 5,190 | +5,190 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 5,103 | +5,103 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 0 | 3,268 | +3,268 | 0.00 | 0.00 | +0.00 | buy |
| Vestal Point Capital, LP | 666,760 | 670,000 | +3,240 | 0.48 | 0.35 | -0.13 | buy |
| STRS OHIO | 0 | 2,200 | +2,200 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 140 | 2,209 | +2,069 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 2,016 | +2,016 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 0 | 1,497 | +1,497 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 44,477 | 45,668 | +1,191 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 0 | 1,087 | +1,087 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 1,006 | +1,006 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 750 | +750 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 11,870 | 12,504 | +634 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 153 | +153 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 0 | 97 | +97 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 10 | +10 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 550,000 | 550,000 | 0 | 0.17 | 0.13 | -0.04 | hold |
| TD ASSET MANAGEMENT INC | 47,580 | 47,580 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 8,021,117 | 8,021,117 | 0 | 2.20 | 1.55 | -0.65 | hold |
| Alyeska Investment Group, L.P. | 57,000 | 57,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEA Management Company, LLC | 7,392,301 | 7,392,301 | 0 | 10.89 | 10.36 | -0.53 | hold |
| Samsara BioCapital, LLC | 2,109,953 | 2,109,953 | 0 | 5.31 | 3.86 | -1.45 | hold |
| Sands Capital Alternatives, LLC | 2,500,012 | 2,500,012 | 0 | 15.38 | 9.07 | -6.31 | hold |
| Squarepoint Ops LLC | 7,811 | 0 | -7,811 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 19,283 | 0 | -19,283 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 28,020 | 0 | -28,020 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 29,348 | 0 | -29,348 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 704,440 | 674,143 | -30,297 | 0.00 | 0.00 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 300,000 | 233,412 | -66,588 | 0.00 | 0.00 | -0.00 | sell |
| Monashee Investment Management LLC | 95,000 | 0 | -95,000 | 1.34 | 0.00 | -1.34 | sell |
| Affinity Asset Advisors, LLC | 250,000 | 131,586 | -118,414 | 0.38 | 0.14 | -0.24 | sell |
| First Light Asset Management, LLC | 375,000 | 0 | -375,000 | 0.87 | 0.00 | -0.87 | sell |