| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 0 | 3,263,268 | +3,263,268 | 0.00 | 0.00 | +0.00 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 2,180,631 | +2,180,631 | 0.00 | 0.40 | +0.40 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 1,171,973 | +1,171,973 | 0.00 | 0.00 | +0.00 | buy |
| Redmile Group, LLC | 0 | 1,114,034 | +1,114,034 | 0.00 | 0.58 | +0.58 | buy |
| SECTORAL ASSET MANAGEMENT INC | 0 | 855,875 | +855,875 | 0.00 | 4.79 | +4.79 | buy |
| CITADEL ADVISORS LLC | 0 | 854,804 | +854,804 | 0.00 | 0.01 | +0.01 | buy |
| FEDERATED HERMES, INC. | 0 | 375,000 | +375,000 | 0.00 | 0.01 | +0.01 | buy |
| Ensign Peak Advisors, Inc | 0 | 375,000 | +375,000 | 0.00 | 0.01 | +0.01 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 312,500 | +312,500 | 0.00 | 1.25 | +1.25 | buy |
| Alyeska Investment Group, L.P. | 0 | 250,000 | +250,000 | 0.00 | 0.02 | +0.02 | buy |
| Altium Capital Management LLC | 0 | 200,000 | +200,000 | 0.00 | 1.27 | +1.27 | buy |
| Logos Global Management LP | 0 | 200,000 | +200,000 | 0.00 | 0.30 | +0.30 | buy |
| Sio Capital Management, LLC | 0 | 143,000 | +143,000 | 0.00 | 0.71 | +0.71 | buy |
| PFM Health Sciences, LP | 0 | 140,513 | +140,513 | 0.00 | 0.10 | +0.10 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 123,350 | +123,350 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 100,000 | +100,000 | 0.00 | 0.02 | +0.02 | buy |
| LMR Partners LLP | 0 | 89,249 | +89,249 | 0.00 | 0.03 | +0.03 | buy |
| NORGES BANK | 0 | 70,000 | +70,000 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 64,421 | +64,421 | 0.00 | 0.01 | +0.01 | buy |
| VANGUARD GROUP INC | 0 | 60,000 | +60,000 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 59,000 | +59,000 | 0.00 | 0.00 | +0.00 | buy |
| HBK INVESTMENTS L P | 0 | 51,500 | +51,500 | 0.00 | 0.02 | +0.02 | buy |
| NewGen Asset Management Ltd | 0 | 50,000 | +50,000 | 0.00 | 0.38 | +0.38 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 50,000 | +50,000 | 0.00 | 0.03 | +0.03 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 0 | 41,650 | +41,650 | 0.00 | 0.02 | +0.02 | buy |
| Monashee Investment Management LLC | 0 | 31,250 | +31,250 | 0.00 | 0.05 | +0.05 | buy |
| Squarepoint Ops LLC | 0 | 31,250 | +31,250 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 30,000 | +30,000 | 0.00 | 0.00 | +0.00 | buy |
| Blackstone Inc. | 0 | 30,000 | +30,000 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 24,633 | +24,633 | 0.00 | 0.00 | +0.00 | buy |
| Weiss Asset Management LP | 0 | 22,500 | +22,500 | 0.00 | 0.02 | +0.02 | buy |
| SOROS FUND MANAGEMENT LLC | 0 | 20,000 | +20,000 | 0.00 | 0.01 | +0.01 | buy |
| Ovata Capital Management Ltd | 0 | 20,000 | +20,000 | 0.00 | 0.15 | +0.15 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 0 | 20,000 | +20,000 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 17,000 | +17,000 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 15,000 | +15,000 | 0.00 | 0.00 | +0.00 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 0 | 14,920 | +14,920 | 0.00 | 0.00 | +0.00 | buy |
| Sandia Investment Management LP | 0 | 7,500 | +7,500 | 0.00 | 0.11 | +0.11 | buy |
| FNY Investment Advisers, LLC | 0 | 660 | +660 | 0.00 | 0.01 | +0.01 | buy |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |