| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ExodusPoint Capital Management, LP | 100,000 | 215,567 | +115,567 | 0.02 | 0.01 | -0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 123,350 | 234,663 | +111,313 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 0 | 110,634 | +110,634 | 0.00 | 0.00 | +0.00 | buy |
| NORGES BANK | 70,000 | 157,211 | +87,211 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 3,263,268 | 3,338,180 | +74,912 | 0.00 | 0.00 | -0.00 | buy |
| Alyeska Investment Group, L.P. | 250,000 | 300,000 | +50,000 | 0.02 | 0.01 | -0.02 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 45,383 | +45,383 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 40,539 | +40,539 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 60,000 | 93,723 | +33,723 | 0.00 | 0.00 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 22,100 | +22,100 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 0 | 21,265 | +21,265 | 0.00 | 0.00 | +0.00 | buy |
| Sio Capital Management, LLC | 143,000 | 162,058 | +19,058 | 0.71 | 0.24 | -0.47 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 14,649 | +14,649 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 17,000 | 28,616 | +11,616 | 0.00 | 0.00 | -0.00 | buy |
| Point72 (DIFC) Ltd | 12,684 | 20,238 | +7,554 | 0.01 | 0.01 | -0.01 | buy |
| RHUMBLINE ADVISERS | 0 | 6,228 | +6,228 | 0.00 | 0.00 | +0.00 | buy |
| Ovata Capital Management Ltd | 20,000 | 25,000 | +5,000 | 0.15 | 0.05 | -0.10 | buy |
| Tower Research Capital LLC (TRC) | 0 | 3,273 | +3,273 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 15,000 | 17,476 | +2,476 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 0 | 1,406 | +1,406 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 618 | +618 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 520 | +520 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 500 | +500 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 457 | +457 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 0 | 218 | +218 | 0.00 | 0.00 | +0.00 | buy |
| Avior Wealth Management, LLC | 0 | 122 | +122 | 0.00 | 0.00 | +0.00 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 2,180,631 | 2,180,631 | 0 | 0.40 | 0.11 | -0.28 | hold |
| PFM Health Sciences, LP | 140,513 | 140,513 | 0 | 0.10 | 0.03 | -0.07 | hold |
| Squarepoint Ops LLC | 31,250 | 31,250 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Sandia Investment Management LP | 7,500 | 7,500 | 0 | 0.11 | 0.04 | -0.07 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| FNY Investment Advisers, LLC | 660 | 0 | -660 | 0.01 | 0.00 | -0.01 | sell |
| Ensign Peak Advisors, Inc | 375,000 | 364,686 | -10,314 | 0.01 | 0.00 | -0.01 | sell |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 14,920 | 0 | -14,920 | 0.00 | 0.00 | -0.00 | sell |
| SOROS FUND MANAGEMENT LLC | 20,000 | 0 | -20,000 | 0.01 | 0.00 | -0.01 | sell |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 20,000 | 0 | -20,000 | 0.00 | 0.00 | -0.00 | sell |
| Weiss Asset Management LP | 22,500 | 0 | -22,500 | 0.02 | 0.00 | -0.02 | sell |
| ROYAL BANK OF CANADA | 24,633 | 0 | -24,633 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 30,000 | 0 | -30,000 | 0.00 | 0.00 | -0.00 | sell |
| Blackstone Inc. | 30,000 | 0 | -30,000 | 0.00 | 0.00 | -0.00 | sell |
| Monashee Investment Management LLC | 31,250 | 0 | -31,250 | 0.05 | 0.00 | -0.05 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 41,650 | 0 | -41,650 | 0.02 | 0.00 | -0.02 | sell |
| NewGen Asset Management Ltd | 50,000 | 0 | -50,000 | 0.38 | 0.00 | -0.38 | sell |
| READYSTATE ASSET MANAGEMENT LP | 50,000 | 0 | -50,000 | 0.03 | 0.00 | -0.03 | sell |
| HBK INVESTMENTS L P | 51,500 | 0 | -51,500 | 0.02 | 0.00 | -0.02 | sell |
| Point72 Asset Management, L.P. | 59,000 | 0 | -59,000 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 64,421 | 0 | -64,421 | 0.01 | 0.00 | -0.01 | sell |
| Redmile Group, LLC | 1,114,034 | 1,034,583 | -79,451 | 0.58 | 0.24 | -0.34 | sell |
| Logos Global Management LP | 200,000 | 117,806 | -82,194 | 0.30 | 0.05 | -0.25 | sell |
| LMR Partners LLP | 89,249 | 0 | -89,249 | 0.03 | 0.00 | -0.03 | sell |
| Altium Capital Management LLC | 200,000 | 83,149 | -116,851 | 1.27 | 0.13 | -1.14 | sell |
| CITADEL ADVISORS LLC | 854,804 | 718,527 | -136,277 | 0.01 | 0.00 | -0.01 | sell |
| SECTORAL ASSET MANAGEMENT INC | 855,875 | 682,274 | -173,601 | 4.79 | 1.07 | -3.72 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 1,171,973 | 948,402 | -223,571 | 0.00 | 0.00 | -0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 312,500 | 0 | -312,500 | 1.25 | 0.00 | -1.25 | sell |
| FEDERATED HERMES, INC. | 375,000 | 0 | -375,000 | 0.01 | 0.00 | -0.01 | sell |