| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MILLENNIUM MANAGEMENT LLC | 0 | 213,561 | +213,561 | 0.00 | 0.00 | +0.00 | buy |
| RBF Capital, LLC | 0 | 200,000 | +200,000 | 0.00 | 0.01 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 14,400 | 121,000 | +106,600 | 0.00 | 0.00 | +0.00 | buy |
| Stonepine Capital Management, LLC | 0 | 106,175 | +106,175 | 0.00 | 0.11 | +0.11 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 55,242 | +55,242 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0 | 50,500 | +50,500 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 34,427 | 70,304 | +35,877 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 27,509 | +27,509 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 21,542 | +21,542 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 18,399 | +18,399 | 0.00 | 0.00 | +0.00 | buy |
| Abel Hall, LLC | 0 | 14,399 | +14,399 | 0.00 | 0.01 | +0.01 | buy |
| XTX Topco Ltd | 25,917 | 40,064 | +14,147 | 0.00 | 0.00 | -0.00 | buy |
| Sio Capital Management, LLC | 162,058 | 163,679 | +1,621 | 0.07 | 0.07 | -0.01 | buy |
| Almitas Capital LLC | 234,378 | 235,505 | +1,127 | 0.12 | 0.06 | -0.06 | buy |
| Clearstead Advisors, LLC | 0 | 24 | +24 | 0.00 | 0.00 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 678,574 | 678,574 | 0 | 0.80 | 0.45 | -0.35 | hold |
| CITADEL ADVISORS LLC | 830,936 | 830,936 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Alyeska Investment Group, L.P. | 300,000 | 300,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ensign Peak Advisors, Inc | 187,500 | 187,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Nextech Invest, Ltd. | 1,228,069 | 1,228,069 | 0 | 0.43 | 0.23 | -0.20 | hold |
| Walleye Capital LLC | 39,624 | 39,624 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 556,233 | 556,233 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EverSource Wealth Advisors, LLC | 3 | 2 | -1 | 0.00 | 0.00 | -0.00 | sell |
| True Wealth Design, LLC | 5 | 0 | -5 | 0.00 | 0.00 | -0.00 | sell |
| Sterling Capital Management LLC | 119 | 0 | -119 | 0.00 | 0.00 | -0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 208 | 0 | -208 | 0.00 | 0.00 | -0.00 | sell |
| AMALGAMATED BANK | 218 | 0 | -218 | 0.00 | 0.00 | 0.00 | sell |
| Russell Investments Group, Ltd. | 265 | 0 | -265 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 6,418 | 6,072 | -346 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 430 | 0 | -430 | 0.00 | 0.00 | -0.00 | sell |
| Ameritas Investment Partners, Inc. | 618 | 0 | -618 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,309 | 0 | -1,309 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 1,449 | 0 | -1,449 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 8,257 | 0 | -8,257 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 22,087 | 13,753 | -8,334 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 11,870 | 2,551 | -9,319 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 9,398 | 0 | -9,398 | 0.00 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 11,809 | 0 | -11,809 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 12,231 | 0 | -12,231 | 0.00 | 0.00 | -0.00 | sell |
| O'SHAUGHNESSY ASSET MANAGEMENT, LLC | 12,272 | 0 | -12,272 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 15,360 | 0 | -15,360 | 0.00 | 0.00 | -0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 16,624 | 0 | -16,624 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 18,893 | 1,970 | -16,923 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 17,855 | 2 | -17,853 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 22,100 | 0 | -22,100 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 48,186 | 15,962 | -32,224 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 3,157,772 | 3,125,103 | -32,669 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 40,458 | 0 | -40,458 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 586,440 | 481,267 | -105,173 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 315,365 | 207,500 | -107,865 | 0.00 | 0.00 | -0.00 | sell |
| Redmile Group, LLC | 725,204 | 589,034 | -136,170 | 0.10 | 0.06 | -0.04 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 247,143 | 58,903 | -188,240 | 0.00 | 0.00 | -0.00 | sell |
| PFM Health Sciences, LP | 240,513 | 0 | -240,513 | 0.03 | 0.00 | -0.03 | sell |
| Boxer Capital Management, LLC | 250,000 | 0 | -250,000 | 0.11 | 0.00 | -0.11 | sell |
| BlackRock, Inc. | 628,197 | 64,258 | -563,939 | 0.00 | 0.00 | -0.00 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 2,180,631 | 0 | -2,180,631 | 0.05 | 0.00 | -0.05 | sell |
| Nuveen, LLC | 3,958,413 | 0 | -3,958,413 | 0.12 | 0.00 | -0.12 | sell |