| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ARCH Venture Management, LLC | 0 | 2,694,095 | +2,694,095 | 0.00 | 0.61 | +0.61 | buy |
| TANG CAPITAL MANAGEMENT LLC | 0 | 2,559,875 | +2,559,875 | 0.00 | 0.29 | +0.29 | buy |
| ADAR1 Capital Management, LLC | 0 | 1,968,216 | +1,968,216 | 0.00 | 0.23 | +0.23 | buy |
| Cormorant Asset Management, LP | 0 | 1,000,000 | +1,000,000 | 0.00 | 0.13 | +0.13 | buy |
| MILLENNIUM MANAGEMENT LLC | 99,875 | 478,639 | +378,764 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 0 | 250,000 | +250,000 | 0.00 | 0.03 | +0.03 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 12,610 | 146,757 | +134,147 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 116,288 | +116,288 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 83,998 | +83,998 | 0.00 | 0.02 | +0.02 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 50,500 | 128,000 | +77,500 | 0.00 | 0.01 | +0.00 | buy |
| Rangeley Capital, LLC | 0 | 74,000 | +74,000 | 0.00 | 0.17 | +0.17 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 399,000 | 471,570 | +72,570 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 64,323 | +64,323 | 0.00 | 0.00 | +0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 55,356 | +55,356 | 0.00 | 0.09 | +0.09 | buy |
| NORTHERN TRUST CORP | 0 | 34,824 | +34,824 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 70,675 | 88,495 | +17,820 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 16,900 | +16,900 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 3 | 10,443 | +10,440 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 17,492 | 20,207 | +2,715 | 0.00 | 0.00 | +0.00 | buy |
| Financial Management Professionals, Inc. | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 1 | 2 | +1 | 0.00 | 0.00 | +0.00 | buy |
| RBF Capital, LLC | 200,000 | 200,000 | 0 | 0.01 | 0.02 | +0.01 | hold |
| Alyeska Investment Group, L.P. | 300,000 | 300,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Pure Financial Advisors, LLC | 10,100 | 10,100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 556,233 | 556,233 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE STREET CORP | 15,962 | 15,962 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 178 | 176 | -2 | 0.00 | 0.00 | +0.00 | sell |
| Optiver Holding B.V. | 168 | 0 | -168 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 34,671 | 33,361 | -1,310 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 2,371 | 348 | -2,023 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 8,837 | 0 | -8,837 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 127,576 | 116,736 | -10,840 | 0.00 | 0.00 | +0.00 | sell |
| Squarepoint Ops LLC | 16,374 | 0 | -16,374 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 96,824 | 72,353 | -24,471 | 0.01 | 0.01 | +0.00 | sell |
| Ensign Peak Advisors, Inc | 187,500 | 159,835 | -27,665 | 0.00 | 0.00 | +0.00 | sell |
| Walleye Capital LLC | 39,624 | 0 | -39,624 | 0.00 | 0.00 | -0.00 | sell |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 85,792 | 0 | -85,792 | 0.01 | 0.00 | -0.01 | sell |
| FMR LLC | 2,695,455 | 2,581,055 | -114,400 | 0.00 | 0.00 | +0.00 | sell |
| Sio Capital Management, LLC | 163,679 | 0 | -163,679 | 0.03 | 0.00 | -0.03 | sell |
| Stonepine Capital Management, LLC | 597,682 | 154,595 | -443,087 | 0.58 | 0.29 | -0.28 | sell |
| SECTORAL ASSET MANAGEMENT INC | 678,574 | 0 | -678,574 | 0.62 | 0.00 | -0.62 | sell |
| CITADEL ADVISORS LLC | 1,342,131 | 145,049 | -1,197,082 | 0.00 | 0.00 | -0.00 | sell |