| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Stonepine Capital Management, LLC | 106,175 | 413,453 | +307,278 | 0.11 | 0.41 | +0.31 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 121,000 | 223,562 | +102,562 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 481,267 | 569,657 | +88,390 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 830,936 | 876,412 | +45,476 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 58,903 | 102,268 | +43,365 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 18,399 | 50,771 | +32,372 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 64,258 | 65,374 | +1,116 | 0.00 | 0.00 | +0.00 | buy |
| Optiver Holding B.V. | 0 | 168 | +168 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 50,500 | 50,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RBF Capital, LLC | 200,000 | 200,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| SECTORAL ASSET MANAGEMENT INC | 678,574 | 678,574 | 0 | 0.45 | 0.52 | +0.06 | hold |
| Alyeska Investment Group, L.P. | 300,000 | 300,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ensign Peak Advisors, Inc | 187,500 | 187,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Sio Capital Management, LLC | 163,679 | 163,679 | 0 | 0.07 | 0.05 | -0.02 | hold |
| Nextech Invest, Ltd. | 1,228,069 | 1,228,069 | 0 | 0.23 | 0.23 | -0.00 | hold |
| Walleye Capital LLC | 39,624 | 39,624 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BARCLAYS PLC | 2 | 2 | 0 | 0.00 | 0.00 | -0.00 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 556,233 | 556,233 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ACADIAN ASSET MANAGEMENT LLC | 13,753 | 13,753 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE STREET CORP | 15,962 | 15,962 | 0 | 0.00 | 0.00 | +0.00 | hold |
| EverSource Wealth Advisors, LLC | 2 | 0 | -2 | 0.00 | 0.00 | -0.00 | sell |
| Clearstead Advisors, LLC | 24 | 0 | -24 | 0.00 | 0.00 | -0.00 | sell |
| Abel Hall, LLC | 14,399 | 12,925 | -1,474 | 0.01 | 0.01 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 1,970 | 349 | -1,621 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 2,551 | 0 | -2,551 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 6,072 | 2,593 | -3,479 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 21,542 | 18,047 | -3,495 | 0.00 | 0.00 | +0.00 | sell |
| XTX Topco Ltd | 40,064 | 29,081 | -10,983 | 0.00 | 0.00 | +0.00 | sell |
| NORTHERN TRUST CORP | 207,500 | 190,801 | -16,699 | 0.00 | 0.00 | +0.00 | sell |
| FMR LLC | 3,125,103 | 3,098,071 | -27,032 | 0.00 | 0.00 | +0.00 | sell |
| HRT FINANCIAL LP | 27,509 | 0 | -27,509 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 213,561 | 164,091 | -49,470 | 0.00 | 0.00 | -0.00 | sell |
| Y-Intercept (Hong Kong) Ltd | 55,242 | 0 | -55,242 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 70,304 | 0 | -70,304 | 0.00 | 0.00 | -0.00 | sell |
| Almitas Capital LLC | 235,505 | 86,808 | -148,697 | 0.06 | 0.02 | -0.04 | sell |
| Redmile Group, LLC | 589,034 | 245,458 | -343,576 | 0.06 | 0.03 | -0.03 | sell |