| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| CITADEL ADVISORS LLC | 876,412 | 1,353,904 | +477,492 | 0.00 | 0.00 | +0.00 | buy |
| Stonepine Capital Management, LLC | 413,453 | 710,071 | +296,618 | 0.41 | 0.67 | +0.26 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 0 | 127,626 | +127,626 | 0.00 | 0.01 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 223,562 | 341,400 | +117,838 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 569,657 | 662,757 | +93,100 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 62,476 | +62,476 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 0 | 25,073 | +25,073 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 29,081 | 39,577 | +10,496 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,593 | 5,803 | +3,210 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 65,374 | 67,048 | +1,674 | 0.00 | 0.00 | -0.00 | buy |
| Qube Research & Technologies Ltd | 18,047 | 18,707 | +660 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 50,500 | 50,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RBF Capital, LLC | 200,000 | 200,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| SECTORAL ASSET MANAGEMENT INC | 678,574 | 678,574 | 0 | 0.52 | 0.65 | +0.14 | hold |
| Alyeska Investment Group, L.P. | 300,000 | 300,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ensign Peak Advisors, Inc | 187,500 | 187,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Sio Capital Management, LLC | 163,679 | 163,679 | 0 | 0.05 | 0.03 | -0.02 | hold |
| Walleye Capital LLC | 39,624 | 39,624 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Optiver Holding B.V. | 168 | 168 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BARCLAYS PLC | 2 | 2 | 0 | 0.00 | 0.00 | +0.00 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 556,233 | 556,233 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STATE STREET CORP | 15,962 | 15,962 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Abel Hall, LLC | 12,925 | 12,865 | -60 | 0.01 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 349 | 176 | -173 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 13,753 | 12,610 | -1,143 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 190,801 | 189,475 | -1,326 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 102,268 | 94,098 | -8,170 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 164,091 | 135,410 | -28,681 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 50,771 | 0 | -50,771 | 0.00 | 0.00 | -0.00 | sell |
| Almitas Capital LLC | 86,808 | 0 | -86,808 | 0.02 | 0.00 | -0.02 | sell |
| Redmile Group, LLC | 245,458 | 0 | -245,458 | 0.03 | 0.00 | -0.03 | sell |
| FMR LLC | 3,098,071 | 2,684,022 | -414,049 | 0.00 | 0.00 | -0.00 | sell |
| Nextech Invest, Ltd. | 1,228,069 | 0 | -1,228,069 | 0.23 | 0.00 | -0.23 | sell |