| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| GOLDMAN SACHS GROUP INC | 626,196 | 1,778,032 | +1,151,836 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 1,022,193 | +1,022,193 | 0.00 | 0.02 | +0.02 | buy |
| FRANKLIN RESOURCES INC | 994,504 | 1,970,828 | +976,324 | 0.00 | 0.00 | +0.00 | buy |
| GW&K Investment Management, LLC | 1,421,109 | 2,166,838 | +745,729 | 0.14 | 0.18 | +0.04 | buy |
| HSBC HOLDINGS PLC | 0 | 709,695 | +709,695 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 4,061,996 | 4,525,129 | +463,133 | 0.00 | 0.00 | -0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 419,094 | +419,094 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 212,706 | +212,706 | 0.00 | 0.00 | +0.00 | buy |
| Propel Bio Management, LLC | 841,272 | 1,050,358 | +209,086 | 5.90 | 5.96 | +0.07 | buy |
| MORGAN STANLEY | 0 | 199,909 | +199,909 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 1,386,890 | 1,586,323 | +199,433 | 0.00 | 0.00 | -0.00 | buy |
| Opaleye Management Inc. | 0 | 185,589 | +185,589 | 0.00 | 0.18 | +0.18 | buy |
| Hennion & Walsh Asset Management, Inc. | 145,932 | 327,278 | +181,346 | 0.05 | 0.10 | +0.05 | buy |
| Jump Financial, LLC | 26,445 | 191,866 | +165,421 | 0.00 | 0.02 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 46,113 | 152,002 | +105,889 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 101,745 | +101,745 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 55,468 | 134,901 | +79,433 | 0.00 | 0.00 | +0.00 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 77,316 | +77,316 | 0.00 | 0.00 | +0.00 | buy |
| DIADEMA PARTNERS LP | 54,650 | 129,950 | +75,300 | 0.25 | 0.50 | +0.25 | buy |
| Virtus Investment Advisers, LLC | 57,986 | 112,139 | +54,153 | 0.18 | 0.28 | +0.11 | buy |
| Pale Fire Capital SE | 0 | 49,713 | +49,713 | 0.00 | 0.04 | +0.04 | buy |
| Engineers Gate Manager LP | 73,848 | 118,257 | +44,409 | 0.01 | 0.02 | +0.01 | buy |
| NORTHERN TRUST CORP | 414,956 | 458,301 | +43,345 | 0.00 | 0.00 | -0.00 | buy |
| Quantbot Technologies LP | 0 | 42,755 | +42,755 | 0.00 | 0.02 | +0.02 | buy |
| NOMURA HOLDINGS INC | 0 | 40,000 | +40,000 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 39,845 | +39,845 | 0.00 | 0.01 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 254,219 | 293,979 | +39,760 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 482,136 | 519,076 | +36,940 | 0.00 | 0.00 | -0.00 | buy |
| Stonepine Capital Management, LLC | 50,010 | 85,010 | +35,000 | 0.49 | 0.70 | +0.21 | buy |
| Bank of New York Mellon Corp | 124,018 | 152,313 | +28,295 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 29,369 | 52,945 | +23,576 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 26,328 | 48,024 | +21,696 | 0.00 | 0.00 | +0.00 | buy |
| NewEdge Advisors, LLC | 183,000 | 203,962 | +20,962 | 0.01 | 0.01 | -0.00 | buy |
| Persistent Asset Partners Ltd | 26,766 | 47,663 | +20,897 | 0.12 | 0.16 | +0.05 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 111,752 | 132,284 | +20,532 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 0 | 18,731 | +18,731 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 30,352 | 48,679 | +18,327 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 44,004 | 62,283 | +18,279 | 0.00 | 0.00 | +0.00 | buy |
| FIDUCIARY TRUST CO | 18,067 | 35,731 | +17,664 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 25,357 | 41,777 | +16,420 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 36,459 | 50,205 | +13,746 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 52,453 | 65,722 | +13,269 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 85,683 | 98,923 | +13,240 | 0.00 | 0.00 | -0.00 | buy |
| Rafferty Asset Management, LLC | 0 | 12,756 | +12,756 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 4,936 | 17,639 | +12,703 | 0.01 | 0.02 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 40,222 | 51,787 | +11,565 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 409,015 | 419,094 | +10,079 | 0.00 | 0.00 | -0.00 | buy |
| Nuveen, LLC | 117,301 | 127,127 | +9,826 | 0.00 | 0.00 | -0.00 | buy |
| Campbell & CO Investment Adviser LLC | 62,023 | 68,759 | +6,736 | 0.04 | 0.04 | -0.00 | buy |
| Swiss National Bank | 92,600 | 98,800 | +6,200 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 55,439 | 60,346 | +4,907 | 0.00 | 0.00 | -0.00 | buy |
| Fulcrum Asset Management LLP | 0 | 4,458 | +4,458 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 11,925 | 16,148 | +4,223 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 25,845 | 28,107 | +2,262 | 0.00 | 0.00 | -0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 0 | 1,337 | +1,337 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 7,025 | 8,230 | +1,205 | 0.00 | 0.00 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 3,527 | 4,463 | +936 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 21,732 | 22,647 | +915 | 0.00 | 0.00 | -0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 24,992 | 25,838 | +846 | 0.00 | 0.00 | -0.00 | buy |
| PROFUND ADVISORS LLC | 16,484 | 17,277 | +793 | 0.01 | 0.01 | -0.00 | buy |
| Arizona State Retirement System | 12,857 | 13,589 | +732 | 0.00 | 0.00 | -0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 3,526 | 4,250 | +724 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 12,908 | 13,631 | +723 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 32,037 | 32,738 | +701 | 0.00 | 0.00 | -0.00 | buy |
| Aster Capital Management (DIFC) Ltd | 0 | 508 | +508 | 0.00 | 0.00 | +0.00 | buy |
| FIFTH THIRD BANCORP | 0 | 218 | +218 | 0.00 | 0.00 | +0.00 | buy |
| ALLSTATE CORP | 32,687 | 32,875 | +188 | 0.00 | 0.00 | -0.00 | buy |
| Quarry LP | 0 | 127 | +127 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,588 | 1,669 | +81 | 0.00 | 0.00 | -0.00 | buy |
| Arax Advisory Partners | 0 | 42 | +42 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 11,348 | 11,388 | +40 | 0.00 | 0.00 | -0.00 | buy |
| Covestor Ltd | 8 | 29 | +21 | 0.00 | 0.00 | 0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 889 | 896 | +7 | 0.00 | 0.00 | -0.00 | buy |
| Clearstead Advisors, LLC | 0 | 5 | +5 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 6,818 | 6,818 | 0 | 0.00 | 0.00 | -0.00 | hold |
| LAZARD ASSET MANAGEMENT LLC | 14,671 | 14,671 | 0 | 0.00 | 0.00 | -0.00 | hold |
| 683 Capital Management, LLC | 1,850,000 | 1,850,000 | 0 | 1.91 | 1.85 | -0.06 | hold |
| KBC Group NV | 77,139 | 77,139 | 0 | 0.00 | 0.00 | -0.00 | hold |
| StepStone Group LP | 422,085 | 422,085 | 0 | 2.26 | 0.21 | -2.05 | hold |
| NEA Management Company, LLC | 1,960,169 | 1,960,169 | 0 | 1.24 | 1.34 | +0.10 | hold |
| Carlyle Group Inc. | 3,496,808 | 3,496,808 | 0 | 0.37 | 0.38 | +0.01 | hold |
| Private Advisor Group, LLC | 10,180 | 10,180 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EcoR1 Capital, LLC | 625,000 | 625,000 | 0 | 0.30 | 0.34 | +0.04 | hold |
| Stratos Wealth Partners, LTD. | 100,000 | 100,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Summit Financial Wealth Advisors, LLC | 22,143 | 22,143 | 0 | 0.03 | 0.03 | -0.00 | hold |
| INSPIRION WEALTH ADVISORS, LLC | 19,914 | 19,914 | 0 | 0.03 | 0.02 | -0.00 | hold |
| Parallel Advisors, LLC | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Stone House Investment Management, LLC | 8 | 8 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Medicxi Ventures Management (Jersey) Ltd | 7,464,572 | 7,464,572 | 0 | 8.45 | 45.65 | +37.20 | hold |
| KLP KAPITALFORVALTNING AS | 14,000 | 14,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Truvestments Capital LLC | 225 | 225 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Woodline Partners LP | 369,052 | 369,052 | 0 | 0.02 | 0.01 | -0.00 | hold |
| Frazier Life Sciences Management, L.P. | 12,466,489 | 12,466,489 | 0 | 3.56 | 2.95 | -0.62 | hold |
| ADAR1 Capital Management, LLC | 42,900 | 42,900 | 0 | 0.03 | 0.02 | -0.01 | hold |
| True Wealth Design, LLC | 88 | 88 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ELEVATION WEALTH PARTNERS, LLC | 20 | 20 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Catalys Pacific, LLC | 1,493,854 | 1,493,854 | 0 | 7.19 | 7.06 | -0.13 | hold |
| Pathstone Holdings, LLC | 15,000 | 15,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Kera Capital Partners, Inc. | 26,826 | 26,826 | 0 | 0.04 | 0.03 | -0.01 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 10,770 | 10,770 | 0 | 0.00 | 0.00 | -0.00 | hold |