| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | 10,109,279 | 10,109,279 | 0 | 4.93 | 4.53 | -0.40 | hold |
| Medicxi Ventures Management (Jersey) Ltd | 3,760,869 | 7,464,572 | +3,703,703 | 11.59 | 17.65 | +6.06 | buy |
| Carlyle Group Inc. | 3,496,808 | 3,496,808 | 0 | 1.54 | 2.34 | +0.80 | hold |
| Invesco Ltd. | 3,167,653 | 3,159,789 | -7,864 | 0.01 | 0.01 | +0.00 | sell |
| TAKEDA PHARMACEUTICAL CO LTD | 7,459,286 | 3,153,217 | -4,306,069 | 23.62 | 11.59 | -12.03 | sell |
| Ensign Peak Advisors, Inc | 2,280,000 | 2,280,000 | 0 | 0.04 | 0.04 | +0.00 | hold |
| VANGUARD GROUP INC | 1,956,429 | 1,979,113 | +22,684 | 0.00 | 0.00 | +0.00 | buy |
| NEA Management Company, LLC | 1,960,169 | 1,960,169 | 0 | 1.19 | 1.29 | +0.10 | hold |
| Avidity Partners Management LP | 1,721,580 | 1,735,000 | +13,420 | 0.60 | 0.65 | +0.05 | buy |
| 683 Capital Management, LLC | 1,280,000 | 1,650,000 | +370,000 | 1.17 | 1.79 | +0.62 | buy |
| JENNISON ASSOCIATES LLC | 0 | 1,647,697 | +1,647,697 | 0.00 | 0.01 | +0.01 | buy |
| GILDER GAGNON HOWE & CO LLC | 1,455,132 | 1,017,617 | -437,515 | 0.18 | 0.14 | -0.05 | sell |
| Propel Bio Management, LLC | 443,047 | 869,927 | +426,880 | 3.35 | 5.38 | +2.02 | buy |
| Decheng Capital LLC | 850,000 | 850,000 | 0 | 2.17 | 1.21 | -0.96 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 735,273 | 751,379 | +16,106 | 0.00 | 0.00 | +0.00 | buy |
| Catalys Pacific, LLC | 721,962 | 721,962 | 0 | 6.18 | 5.18 | -1.00 | hold |
| STATE STREET CORP | 687,837 | 717,201 | +29,364 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 571,976 | 572,336 | +360 | 0.11 | 0.13 | +0.01 | buy |
| GW&K Investment Management, LLC | 561,490 | 568,026 | +6,536 | 0.05 | 0.05 | +0.01 | buy |
| Woodline Partners LP | 1,096,121 | 566,439 | -529,682 | 0.11 | 0.06 | -0.05 | sell |
| Simplify Asset Management Inc. | 237,935 | 521,935 | +284,000 | 0.34 | 0.53 | +0.19 | buy |
| Saturn V Capital Management LP | 160,075 | 500,987 | +340,912 | 0.56 | 2.13 | +1.57 | buy |
| TWO SIGMA INVESTMENTS, LP | 266,857 | 467,448 | +200,591 | 0.01 | 0.01 | +0.01 | buy |
| Octagon Capital Advisors LP | 50,000 | 455,000 | +405,000 | 0.07 | 0.59 | +0.51 | buy |
| Checkpoint Capital L.P. | 359,446 | 445,161 | +85,715 | 2.29 | 3.16 | +0.87 | buy |
| StepStone Group LP | 422,085 | 422,085 | 0 | 0.69 | 0.95 | +0.26 | hold |
| NORTHERN TRUST CORP | 289,819 | 283,200 | -6,619 | 0.00 | 0.00 | +0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 262,524 | 264,494 | +1,970 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 124,551 | 237,160 | +112,609 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 170,044 | 225,024 | +54,980 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 154,391 | 223,390 | +68,999 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 210,211 | 207,372 | -2,839 | 0.00 | 0.00 | +0.00 | sell |
| Newtyn Management, LLC | 646,760 | 165,000 | -481,760 | 1.16 | 0.35 | -0.81 | sell |
| Schonfeld Strategic Advisors LLC | 61,000 | 144,700 | +83,700 | 0.00 | 0.01 | +0.01 | buy |
| JPMORGAN CHASE & CO | 146,037 | 138,452 | -7,585 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 11,533 | 125,645 | +114,112 | 0.00 | 0.00 | +0.00 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 100,000 | 120,000 | +20,000 | 0.02 | 0.03 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 81,793 | 105,855 | +24,062 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 106,319 | 95,221 | -11,098 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 129,389 | 64,138 | -65,251 | 0.00 | 0.00 | -0.00 | sell |
| Penn Mutual Asset Management | 62,802 | 62,802 | 0 | 0.44 | 1.42 | +0.98 | hold |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 52,313 | 59,437 | +7,124 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 47,314 | 59,186 | +11,872 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 56,000 | 56,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TWO SIGMA ADVISERS, LP | 22,700 | 51,600 | +28,900 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 39,432 | 49,923 | +10,491 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 48,502 | 47,103 | -1,399 | 0.00 | 0.00 | +0.00 | sell |
| INSPIRION WEALTH ADVISORS, LLC | 35,134 | 35,134 | 0 | 0.06 | 0.06 | +0.00 | hold |
| Legal & General Group Plc | 34,253 | 34,102 | -151 | 0.00 | 0.00 | +0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 37,700 | 32,290 | -5,410 | 0.00 | 0.00 | -0.00 | sell |
| Creative Planning | 21,352 | 32,102 | +10,750 | 0.00 | 0.00 | +0.00 | buy |
| Occidental Asset Management, LLC | 29,672 | 29,672 | 0 | 0.06 | 0.06 | +0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 30,590 | 28,947 | -1,643 | 0.00 | 0.00 | +0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 43,209 | 28,583 | -14,626 | 0.01 | 0.01 | -0.00 | sell |
| BARCLAYS PLC | 49,672 | 28,199 | -21,473 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 65,254 | 25,021 | -40,233 | 0.00 | 0.00 | -0.00 | sell |
| FULTON BREAKEFIELD BROENNIMAN LLC | 23,579 | 23,579 | 0 | 0.02 | 0.02 | +0.00 | hold |
| Allworth Financial LP | 22,580 | 22,580 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 22,044 | +22,044 | 0.00 | 0.02 | +0.02 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 593,751 | 20,987 | -572,764 | 0.03 | 0.00 | -0.03 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 17,401 | 19,573 | +2,172 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 0 | 19,380 | +19,380 | 0.00 | 0.18 | +0.18 | buy |
| SG Americas Securities, LLC | 18,070 | 18,873 | +803 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 16,471 | 16,471 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMERICAN INTERNATIONAL GROUP, INC. | 15,938 | 15,802 | -136 | 0.00 | 0.00 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 17,699 | 14,262 | -3,437 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 0 | 14,174 | +14,174 | 0.00 | 0.01 | +0.01 | buy |
| Mirae Asset Global Investments Co., Ltd. | 13,636 | 13,906 | +270 | 0.00 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 12,893 | 12,893 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 12,250 | 12,602 | +352 | 0.00 | 0.00 | +0.00 | buy |
| Stratos Wealth Advisors, LLC | 12,500 | 12,500 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Entropy Technologies, LP | 14,590 | 12,138 | -2,452 | 0.02 | 0.01 | -0.01 | sell |
| WELLS FARGO & COMPANY/MN | 10,890 | 11,605 | +715 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 0 | 11,228 | +11,228 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 12,843 | 11,019 | -1,824 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 6,626 | 10,989 | +4,363 | 0.01 | 0.01 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 11,585 | 10,783 | -802 | 0.00 | 0.00 | -0.00 | sell |
| Klingman & Associates, LLC | 0 | 10,376 | +10,376 | 0.00 | 0.01 | +0.01 | buy |
| STALEY CAPITAL ADVISERS INC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| KESTRA PRIVATE WEALTH SERVICES, LLC | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| DAVENPORT & Co LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| VIRTUS ADVISERS, LLC | 10,367 | 9,701 | -666 | 0.06 | 0.05 | -0.01 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 8,271 | 7,084 | -1,187 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 5,649 | 6,045 | +396 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 5,787 | 5,924 | +137 | 0.00 | 0.00 | +0.00 | buy |
| FNY Investment Advisers, LLC | 0 | 5,000 | +5,000 | 0.00 | 0.03 | +0.03 | buy |
| US BANCORP \DE\ | 0 | 3,450 | +3,450 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 3,095 | 3,095 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CANADA LIFE ASSURANCE Co | 2,839 | 2,839 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FMR LLC | 3,333 | 2,084 | -1,249 | 0.00 | 0.00 | -0.00 | sell |
| METROPOLITAN LIFE INSURANCE CO/NY | 1,818 | 1,818 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 2,824 | 1,090 | -1,734 | 0.00 | 0.00 | -0.00 | sell |
| HUNTINGTON NATIONAL BANK | 960 | 978 | +18 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 9,861 | 580 | -9,281 | 0.00 | 0.00 | -0.00 | sell |
| Vestcor Inc | 915 | 548 | -367 | 0.00 | 0.00 | -0.00 | sell |
| BFSG, LLC | 300 | 300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Bear Mountain Capital, Inc. | 200 | 200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Daiwa Securities Group Inc. | 167 | 167 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Riggs Asset Managment Co. Inc. | 0 | 69 | +69 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 7 | 23 | +16 | 0.00 | 0.00 | +0.00 | buy |