| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TANG CAPITAL MANAGEMENT LLC | 500,000 | 1,200,000 | +700,000 | 0.27 | 0.42 | +0.15 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 596,108 | +596,108 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 44,577 | 530,859 | +486,282 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 59,991 | 523,363 | +463,372 | 0.00 | 0.00 | +0.00 | buy |
| 683 Capital Management, LLC | 1,025,000 | 1,445,000 | +420,000 | 0.82 | 0.92 | +0.10 | buy |
| UBS Group AG | 465,616 | 707,578 | +241,962 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 98,068 | 314,873 | +216,805 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 966,400 | 1,131,032 | +164,632 | 0.00 | 0.00 | -0.00 | buy |
| Propel Bio Management, LLC | 989,927 | 1,134,927 | +145,000 | 7.98 | 8.27 | +0.28 | buy |
| WASATCH ADVISORS LP | 1,558,928 | 1,701,627 | +142,699 | 0.06 | 0.06 | -0.00 | buy |
| CITADEL ADVISORS LLC | 72,007 | 179,721 | +107,714 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 463,340 | 568,630 | +105,290 | 0.01 | 0.01 | -0.00 | buy |
| Simplify Asset Management Inc. | 581,935 | 681,935 | +100,000 | 0.33 | 0.20 | -0.13 | buy |
| XTX Topco Ltd | 0 | 90,191 | +90,191 | 0.00 | 0.03 | +0.03 | buy |
| AQR CAPITAL MANAGEMENT LLC | 17,658 | 107,399 | +89,741 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 79,311 | +79,311 | 0.00 | 0.01 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 135,995 | 200,690 | +64,695 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 45,831 | +45,831 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 44,964 | +44,964 | 0.00 | 0.08 | +0.08 | buy |
| Russell Investments Group, Ltd. | 0 | 41,799 | +41,799 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 21,070 | 60,056 | +38,986 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 23,243 | 59,937 | +36,694 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 33,297 | +33,297 | 0.00 | 0.00 | +0.00 | buy |
| SHERBROOKE PARK ADVISERS LLC | 0 | 26,307 | +26,307 | 0.00 | 0.08 | +0.08 | buy |
| Trexquant Investment LP | 378,637 | 398,751 | +20,114 | 0.04 | 0.03 | -0.01 | buy |
| Corton Capital Inc. | 0 | 18,384 | +18,384 | 0.00 | 0.38 | +0.38 | buy |
| STIFEL FINANCIAL CORP | 0 | 17,398 | +17,398 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 5,395 | 22,474 | +17,079 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 6,826 | 23,763 | +16,937 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 102,748 | 114,535 | +11,787 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 11,473 | +11,473 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 0 | 11,250 | +11,250 | 0.00 | 0.00 | +0.00 | buy |
| FIDUCIARY TRUST CO | 0 | 10,905 | +10,905 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 0 | 10,394 | +10,394 | 0.00 | 0.01 | +0.01 | buy |
| Nebula Research & Development LLC | 20,963 | 28,821 | +7,858 | 0.02 | 0.02 | -0.00 | buy |
| CWM, LLC | 0 | 7,384 | +7,384 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 17,424 | 21,484 | +4,060 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 166,505 | 170,281 | +3,776 | 0.00 | 0.00 | -0.00 | buy |
| Brooklyn Investment Group | 0 | 3,456 | +3,456 | 0.00 | 0.00 | +0.00 | buy |
| Kera Capital Partners, Inc. | 26,849 | 29,849 | +3,000 | 0.06 | 0.06 | -0.01 | buy |
| WELLS FARGO & COMPANY/MN | 25,516 | 28,425 | +2,909 | 0.00 | 0.00 | -0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 2,404 | +2,404 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 50,772 | 52,431 | +1,659 | 0.00 | 0.00 | -0.00 | buy |
| GW&K Investment Management, LLC | 1,102,805 | 1,104,308 | +1,503 | 0.08 | 0.06 | -0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 25,641 | 27,013 | +1,372 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 22,149 | 23,163 | +1,014 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 55,968 | 56,739 | +771 | 0.00 | 0.00 | -0.00 | buy |
| Farther Finance Advisors, LLC | 17 | 683 | +666 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 136,907 | 137,393 | +486 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 13,990 | 14,462 | +472 | 0.00 | 0.00 | -0.00 | buy |
| SIGNATUREFD, LLC | 0 | 463 | +463 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 0 | 329 | +329 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,436 | 1,751 | +315 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 1,090 | 1,354 | +264 | 0.00 | 0.00 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 19 | 268 | +249 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 508 | 727 | +219 | 0.00 | 0.00 | -0.00 | buy |
| Versant Capital Management, Inc | 0 | 197 | +197 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 1,334 | 1,446 | +112 | 0.00 | 0.00 | -0.00 | buy |
| COLDSTREAM CAPITAL MANAGEMENT INC | 0 | 109 | +109 | 0.00 | 0.00 | +0.00 | buy |
| Parkside Financial Bank & Trust | 0 | 85 | +85 | 0.00 | 0.00 | +0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 0 | 84 | +84 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 0 | 50 | +50 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 20,448 | 20,478 | +30 | 0.00 | 0.00 | -0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 10 | 35 | +25 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 19,508 | 19,532 | +24 | 0.00 | 0.00 | -0.00 | buy |
| EverSource Wealth Advisors, LLC | 21 | 37 | +16 | 0.00 | 0.00 | +0.00 | buy |
| True Wealth Design, LLC | 0 | 16 | +16 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,279 | 2,288 | +9 | 0.00 | 0.00 | -0.00 | buy |
| CANADA LIFE ASSURANCE Co | 2,839 | 2,839 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ameritas Investment Partners, Inc. | 3,095 | 3,095 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 35,262 | 35,262 | 0 | 0.00 | 0.00 | -0.00 | hold |
| KEYBANK NATIONAL ASSOCIATION/OH | 25,512 | 25,512 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STALEY CAPITAL ADVISERS INC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 45,590 | 45,590 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Amundi | 42 | 42 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 15,710 | 15,710 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 260 | 260 | 0 | 0.00 | 0.00 | -0.00 | hold |
| StepStone Group LP | 422,085 | 422,085 | 0 | 3.00 | 2.72 | -0.28 | hold |
| NEA Management Company, LLC | 1,960,169 | 1,960,169 | 0 | 0.90 | 0.95 | +0.05 | hold |
| Carlyle Group Inc. | 3,496,808 | 3,496,808 | 0 | 0.68 | 0.58 | -0.11 | hold |
| MetLife Investment Management, LLC | 24,366 | 24,366 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Swiss National Bank | 73,300 | 73,300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| IFP Advisors, Inc | 2 | 2 | 0 | 0.00 | 0.00 | -0.00 | hold |
| KESTRA PRIVATE WEALTH SERVICES, LLC | 15,500 | 15,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Medicxi Ventures Management (Jersey) Ltd | 7,464,572 | 7,464,572 | 0 | 11.46 | 10.69 | -0.76 | hold |
| KLP KAPITALFORVALTNING AS | 9,100 | 9,100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Occidental Asset Management, LLC | 29,672 | 29,672 | 0 | 0.04 | 0.03 | -0.01 | hold |
| Frazier Life Sciences Management, L.P. | 10,109,279 | 10,109,279 | 0 | 3.41 | 2.90 | -0.51 | hold |
| Covestor Ltd | 7 | 7 | 0 | 0.00 | 0.00 | 0.00 | hold |
| ELEVATION WEALTH PARTNERS, LLC | 20 | 20 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Bear Mountain Capital, Inc. | 1,000 | 1,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Catalys Pacific, LLC | 1,167,114 | 1,167,114 | 0 | 8.18 | 4.92 | -3.26 | hold |
| Police & Firemen's Retirement System of New Jersey | 8,251 | 8,251 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 840 | 840 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 36,438 | 36,438 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 10,770 | 10,770 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Penn Mutual Asset Management | 62,802 | 62,802 | 0 | 0.92 | 0.76 | -0.16 | hold |
| Aster Capital Management (DIFC) Ltd | 15 | 0 | -15 | 0.00 | 0.00 | -0.00 | sell |
| GILDER GAGNON HOWE & CO LLC | 41,610 | 41,566 | -44 | 0.00 | 0.00 | -0.00 | sell |
| Caitong International Asset Management Co., Ltd | 179 | 113 | -66 | 0.00 | 0.00 | -0.00 | sell |