| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | 12,466,489 | 12,466,489 | 0 | 5.55 | 3.56 | -1.99 | hold |
| Medicxi Ventures Management (Jersey) Ltd | 7,464,572 | 7,464,572 | 0 | 14.83 | 8.45 | -6.38 | hold |
| Invesco Ltd. | 3,920,446 | 4,322,060 | +401,614 | 0.01 | 0.01 | -0.00 | buy |
| BlackRock, Inc. | 3,555,548 | 4,061,996 | +506,448 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 2,082,180 | 4,022,909 | +1,940,729 | 0.02 | 0.03 | +0.01 | buy |
| Carlyle Group Inc. | 3,496,808 | 3,496,808 | 0 | 0.43 | 0.37 | -0.06 | hold |
| NEA Management Company, LLC | 1,960,169 | 1,960,169 | 0 | 1.66 | 1.24 | -0.42 | hold |
| 683 Capital Management, LLC | 1,785,000 | 1,850,000 | +65,000 | 2.46 | 1.91 | -0.56 | buy |
| Ensign Peak Advisors, Inc | 2,352,020 | 1,627,806 | -724,214 | 0.07 | 0.03 | -0.04 | sell |
| Catalys Pacific, LLC | 1,429,014 | 1,493,854 | +64,840 | 7.63 | 7.19 | -0.44 | buy |
| GW&K Investment Management, LLC | 1,306,678 | 1,421,109 | +114,431 | 0.19 | 0.14 | -0.05 | buy |
| STATE STREET CORP | 1,149,536 | 1,386,890 | +237,354 | 0.00 | 0.00 | -0.00 | buy |
| WASATCH ADVISORS LP | 1,331,669 | 1,340,916 | +9,247 | 0.13 | 0.10 | -0.03 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,073,434 | 1,328,045 | +254,611 | 0.00 | 0.00 | -0.00 | buy |
| SummitTX Capital, L.P. | 517,820 | 995,885 | +478,065 | 0.26 | 0.35 | +0.09 | buy |
| FRANKLIN RESOURCES INC | 0 | 994,504 | +994,504 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 925,000 | +925,000 | 0.00 | 0.20 | +0.20 | buy |
| MARSHALL WACE, LLP | 0 | 860,692 | +860,692 | 0.00 | 0.01 | +0.01 | buy |
| Propel Bio Management, LLC | 740,918 | 841,272 | +100,354 | 10.49 | 5.90 | -4.60 | buy |
| GOLDMAN SACHS GROUP INC | 392,045 | 626,196 | +234,151 | 0.00 | 0.00 | -0.00 | buy |
| EcoR1 Capital, LLC | 0 | 625,000 | +625,000 | 0.00 | 0.30 | +0.30 | buy |
| TWO SIGMA INVESTMENTS, LP | 57,783 | 482,136 | +424,353 | 0.00 | 0.00 | +0.00 | buy |
| StepStone Group LP | 422,085 | 422,085 | 0 | 2.66 | 2.26 | -0.40 | hold |
| NORTHERN TRUST CORP | 356,466 | 414,956 | +58,490 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 397,910 | 409,015 | +11,105 | 0.00 | 0.00 | -0.00 | buy |
| CITADEL ADVISORS LLC | 311,315 | 383,058 | +71,743 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 187,291 | 369,052 | +181,761 | 0.01 | 0.02 | +0.00 | buy |
| UBS Group AG | 304,383 | 360,371 | +55,988 | 0.00 | 0.00 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 305,800 | +305,800 | 0.00 | 0.01 | +0.01 | buy |
| Trexquant Investment LP | 136,824 | 293,305 | +156,481 | 0.02 | 0.02 | +0.00 | buy |
| JPMORGAN CHASE & CO | 296,684 | 287,430 | -9,254 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 0 | 275,161 | +275,161 | 0.00 | 0.01 | +0.01 | buy |
| Susquehanna Portfolio Strategies, LLC | 267,962 | 267,962 | 0 | 0.07 | 0.04 | -0.02 | hold |
| Simplify Asset Management Inc. | 321,935 | 262,386 | -59,549 | 0.09 | 0.04 | -0.04 | sell |
| AMERIPRISE FINANCIAL INC | 185,744 | 254,219 | +68,475 | 0.00 | 0.00 | -0.00 | buy |
| Avidity Partners Management LP | 206,076 | 249,390 | +43,314 | 0.99 | 0.56 | -0.43 | buy |
| Catalio Capital Management, LP | 698,996 | 247,767 | -451,229 | 2.05 | 0.58 | -1.47 | sell |
| BANK OF AMERICA CORP /DE/ | 258,996 | 208,115 | -50,881 | 0.00 | 0.00 | -0.00 | sell |
| Birchview Capital, LP | 195,000 | 195,000 | 0 | 1.89 | 1.23 | -0.66 | hold |
| NewEdge Advisors, LLC | 200,823 | 183,000 | -17,823 | 0.01 | 0.01 | -0.00 | sell |
| XTX Topco Ltd | 39,400 | 160,501 | +121,101 | 0.02 | 0.03 | +0.01 | buy |
| Hennion & Walsh Asset Management, Inc. | 114,981 | 145,932 | +30,951 | 0.07 | 0.05 | -0.01 | buy |
| GILDER GAGNON HOWE & CO LLC | 145,174 | 139,889 | -5,285 | 0.03 | 0.02 | -0.01 | sell |
| D. E. Shaw & Co., Inc. | 261,068 | 132,457 | -128,611 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 122,967 | 124,018 | +1,051 | 0.00 | 0.00 | -0.00 | buy |
| Nuveen, LLC | 108,846 | 117,301 | +8,455 | 0.00 | 0.00 | -0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 134,546 | 111,752 | -22,794 | 0.00 | 0.00 | -0.00 | sell |
| Stratos Wealth Partners, LTD. | 50,300 | 100,000 | +49,700 | 0.01 | 0.01 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 82,624 | 97,068 | +14,444 | 0.12 | 0.07 | -0.05 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 207,085 | 95,301 | -111,784 | 0.01 | 0.00 | -0.00 | sell |
| Brevan Howard Capital Management LP | 276,989 | 94,638 | -182,351 | 0.09 | 0.01 | -0.08 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 549,171 | 92,979 | -456,192 | 0.01 | 0.00 | -0.01 | sell |
| Swiss National Bank | 84,000 | 92,600 | +8,600 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 6,644 | 85,683 | +79,039 | 0.00 | 0.00 | +0.00 | buy |
| Freestone Grove Partners LP | 0 | 84,573 | +84,573 | 0.00 | 0.01 | +0.01 | buy |
| HUSSMAN STRATEGIC ADVISORS, INC. | 147,000 | 84,000 | -63,000 | 0.59 | 0.20 | -0.39 | sell |
| KBC Group NV | 0 | 77,139 | +77,139 | 0.00 | 0.00 | +0.00 | buy |
| Burkehill Global Management, LP | 0 | 75,000 | +75,000 | 0.00 | 0.04 | +0.04 | buy |
| Engineers Gate Manager LP | 44,258 | 73,848 | +29,590 | 0.01 | 0.01 | +0.00 | buy |
| Creative Planning | 80,766 | 70,193 | -10,573 | 0.00 | 0.00 | -0.00 | sell |
| Penn Mutual Asset Management | 62,802 | 62,802 | 0 | 0.62 | 3.57 | +2.95 | hold |
| Campbell & CO Investment Adviser LLC | 115,284 | 62,023 | -53,261 | 0.09 | 0.04 | -0.05 | sell |
| Virtus Investment Advisers, LLC | 46,937 | 57,986 | +11,049 | 0.21 | 0.18 | -0.03 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 30,631 | 55,788 | +25,157 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 54,448 | 55,468 | +1,020 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 52,093 | 55,439 | +3,346 | 0.00 | 0.00 | -0.00 | buy |
| DIADEMA PARTNERS LP | 0 | 54,650 | +54,650 | 0.00 | 0.25 | +0.25 | buy |
| STIFEL FINANCIAL CORP | 51,661 | 54,039 | +2,378 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 37,071 | 52,453 | +15,382 | 0.00 | 0.00 | +0.00 | buy |
| Stonepine Capital Management, LLC | 0 | 50,010 | +50,010 | 0.00 | 0.49 | +0.49 | buy |
| ALLIANCEBERNSTEIN L.P. | 49,390 | 49,390 | 0 | 0.00 | 0.00 | +0.00 | hold |
| WELLS FARGO & COMPANY/MN | 68,016 | 46,113 | -21,903 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 15,285 | 44,004 | +28,719 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 42,900 | 42,900 | 0 | 0.05 | 0.03 | -0.02 | hold |
| Aquatic Capital Management LLC | 0 | 40,852 | +40,852 | 0.00 | 0.01 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 40,143 | 40,222 | +79 | 0.00 | 0.00 | -0.00 | buy |
| ALGERT GLOBAL LLC | 0 | 39,420 | +39,420 | 0.00 | 0.01 | +0.01 | buy |
| TUDOR INVESTMENT CORP ET AL | 28,554 | 38,225 | +9,671 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 33,380 | 36,459 | +3,079 | 0.00 | 0.00 | -0.00 | buy |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | 34,700 | 35,200 | +500 | 0.01 | 0.01 | -0.00 | buy |
| ALLSTATE CORP | 0 | 32,687 | +32,687 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 30,940 | 32,230 | +1,290 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 34,249 | 32,037 | -2,212 | 0.00 | 0.00 | -0.00 | sell |
| Man Group plc | 0 | 30,352 | +30,352 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 28,459 | 29,369 | +910 | 0.00 | 0.00 | -0.00 | buy |
| Kera Capital Partners, Inc. | 24,255 | 26,826 | +2,571 | 0.04 | 0.04 | -0.00 | buy |
| Persistent Asset Partners Ltd | 12,916 | 26,766 | +13,850 | 0.10 | 0.12 | +0.01 | buy |
| Jump Financial, LLC | 17,408 | 26,445 | +9,037 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 24,390 | 26,328 | +1,938 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 25,845 | 25,845 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BARCLAYS PLC | 84,859 | 25,357 | -59,502 | 0.00 | 0.00 | -0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 19,890 | 24,992 | +5,102 | 0.00 | 0.00 | -0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 33,425 | 24,676 | -8,749 | 0.00 | 0.00 | -0.00 | sell |
| Summit Financial Wealth Advisors, LLC | 22,143 | 22,143 | 0 | 0.05 | 0.03 | -0.02 | hold |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 18,460 | 21,732 | +3,272 | 0.00 | 0.00 | -0.00 | buy |
| JANUS HENDERSON GROUP PLC | 21,500 | 21,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| INSPIRION WEALTH ADVISORS, LLC | 19,814 | 19,914 | +100 | 0.04 | 0.03 | -0.01 | buy |
| Jain Global LLC | 21,737 | 18,262 | -3,475 | 0.00 | 0.00 | -0.00 | sell |
| FIDUCIARY TRUST CO | 16,040 | 18,067 | +2,027 | 0.00 | 0.00 | -0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 62,248 | 17,460 | -44,788 | 0.05 | 0.02 | -0.03 | sell |