| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MILLENNIUM MANAGEMENT LLC | 2,082,180 | 4,022,909 | +1,940,729 | 0.02 | 0.03 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 0 | 994,504 | +994,504 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 925,000 | +925,000 | 0.00 | 0.20 | +0.20 | buy |
| MARSHALL WACE, LLP | 0 | 860,692 | +860,692 | 0.00 | 0.01 | +0.01 | buy |
| EcoR1 Capital, LLC | 0 | 625,000 | +625,000 | 0.00 | 0.30 | +0.30 | buy |
| BlackRock, Inc. | 3,555,548 | 4,061,996 | +506,448 | 0.00 | 0.00 | -0.00 | buy |
| SummitTX Capital, L.P. | 517,820 | 995,885 | +478,065 | 0.26 | 0.35 | +0.09 | buy |
| TWO SIGMA INVESTMENTS, LP | 57,783 | 482,136 | +424,353 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 3,920,446 | 4,322,060 | +401,614 | 0.01 | 0.01 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 305,800 | +305,800 | 0.00 | 0.01 | +0.01 | buy |
| Squarepoint Ops LLC | 0 | 275,161 | +275,161 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,073,434 | 1,328,045 | +254,611 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 1,149,536 | 1,386,890 | +237,354 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 392,045 | 626,196 | +234,151 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 187,291 | 369,052 | +181,761 | 0.01 | 0.02 | +0.00 | buy |
| Trexquant Investment LP | 136,824 | 293,305 | +156,481 | 0.02 | 0.02 | +0.00 | buy |
| XTX Topco Ltd | 39,400 | 160,501 | +121,101 | 0.02 | 0.03 | +0.01 | buy |
| GW&K Investment Management, LLC | 1,306,678 | 1,421,109 | +114,431 | 0.19 | 0.14 | -0.05 | buy |
| Propel Bio Management, LLC | 740,918 | 841,272 | +100,354 | 10.49 | 5.90 | -4.60 | buy |
| Freestone Grove Partners LP | 0 | 84,573 | +84,573 | 0.00 | 0.01 | +0.01 | buy |
| Russell Investments Group, Ltd. | 6,644 | 85,683 | +79,039 | 0.00 | 0.00 | +0.00 | buy |
| KBC Group NV | 0 | 77,139 | +77,139 | 0.00 | 0.00 | +0.00 | buy |
| Burkehill Global Management, LP | 0 | 75,000 | +75,000 | 0.00 | 0.04 | +0.04 | buy |
| CITADEL ADVISORS LLC | 311,315 | 383,058 | +71,743 | 0.00 | 0.00 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 185,744 | 254,219 | +68,475 | 0.00 | 0.00 | -0.00 | buy |
| 683 Capital Management, LLC | 1,785,000 | 1,850,000 | +65,000 | 2.46 | 1.91 | -0.56 | buy |
| Catalys Pacific, LLC | 1,429,014 | 1,493,854 | +64,840 | 7.63 | 7.19 | -0.44 | buy |
| NORTHERN TRUST CORP | 356,466 | 414,956 | +58,490 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 304,383 | 360,371 | +55,988 | 0.00 | 0.00 | -0.00 | buy |
| DIADEMA PARTNERS LP | 0 | 54,650 | +54,650 | 0.00 | 0.25 | +0.25 | buy |
| Stonepine Capital Management, LLC | 0 | 50,010 | +50,010 | 0.00 | 0.49 | +0.49 | buy |
| Stratos Wealth Partners, LTD. | 50,300 | 100,000 | +49,700 | 0.01 | 0.01 | +0.00 | buy |
| Avidity Partners Management LP | 206,076 | 249,390 | +43,314 | 0.99 | 0.56 | -0.43 | buy |
| Aquatic Capital Management LLC | 0 | 40,852 | +40,852 | 0.00 | 0.01 | +0.01 | buy |
| ALGERT GLOBAL LLC | 0 | 39,420 | +39,420 | 0.00 | 0.01 | +0.01 | buy |
| ALLSTATE CORP | 0 | 32,687 | +32,687 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 114,981 | 145,932 | +30,951 | 0.07 | 0.05 | -0.01 | buy |
| Man Group plc | 0 | 30,352 | +30,352 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 44,258 | 73,848 | +29,590 | 0.01 | 0.01 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 15,285 | 44,004 | +28,719 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 30,631 | 55,788 | +25,157 | 0.00 | 0.00 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 0 | 15,997 | +15,997 | 0.00 | 0.00 | +0.00 | buy |
| DRW Securities, LLC | 0 | 15,921 | +15,921 | 0.00 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 37,071 | 52,453 | +15,382 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 0 | 14,671 | +14,671 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 82,624 | 97,068 | +14,444 | 0.12 | 0.07 | -0.05 | buy |
| Persistent Asset Partners Ltd | 12,916 | 26,766 | +13,850 | 0.10 | 0.12 | +0.01 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 12,111 | +12,111 | 0.00 | 0.02 | +0.02 | buy |
| Quadrature Capital Ltd | 0 | 12,078 | +12,078 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 0 | 11,536 | +11,536 | 0.00 | 0.00 | +0.00 | buy |
| PRIMORIS WEALTH ADVISORS, LLC | 0 | 11,449 | +11,449 | 0.00 | 0.09 | +0.09 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 397,910 | 409,015 | +11,105 | 0.00 | 0.00 | -0.00 | buy |
| Virtus Investment Advisers, LLC | 46,937 | 57,986 | +11,049 | 0.21 | 0.18 | -0.03 | buy |
| TUDOR INVESTMENT CORP ET AL | 28,554 | 38,225 | +9,671 | 0.00 | 0.00 | -0.00 | buy |
| WASATCH ADVISORS LP | 1,331,669 | 1,340,916 | +9,247 | 0.13 | 0.10 | -0.03 | buy |
| Jump Financial, LLC | 17,408 | 26,445 | +9,037 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 84,000 | 92,600 | +8,600 | 0.00 | 0.00 | -0.00 | buy |
| Nuveen, LLC | 108,846 | 117,301 | +8,455 | 0.00 | 0.00 | -0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 19,890 | 24,992 | +5,102 | 0.00 | 0.00 | -0.00 | buy |
| State of Wyoming | 0 | 4,936 | +4,936 | 0.00 | 0.01 | +0.01 | buy |
| Rockefeller Capital Management L.P. | 155 | 4,095 | +3,940 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 52,093 | 55,439 | +3,346 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 18,460 | 21,732 | +3,272 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 33,380 | 36,459 | +3,079 | 0.00 | 0.00 | -0.00 | buy |
| SUMMIT SECURITIES GROUP LLC | 0 | 3,048 | +3,048 | 0.00 | 0.02 | +0.02 | buy |
| Kera Capital Partners, Inc. | 24,255 | 26,826 | +2,571 | 0.04 | 0.04 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 11,592 | 13,983 | +2,391 | 0.01 | 0.01 | -0.00 | buy |
| STIFEL FINANCIAL CORP | 51,661 | 54,039 | +2,378 | 0.00 | 0.00 | -0.00 | buy |
| FIDUCIARY TRUST CO | 16,040 | 18,067 | +2,027 | 0.00 | 0.00 | -0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 24,390 | 26,328 | +1,938 | 0.00 | 0.00 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 568 | 2,288 | +1,720 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 9,790 | 11,332 | +1,542 | 0.00 | 0.00 | -0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 30,940 | 32,230 | +1,290 | 0.00 | 0.00 | -0.00 | buy |
| Larson Financial Group LLC | 647 | 1,767 | +1,120 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 122,967 | 124,018 | +1,051 | 0.00 | 0.00 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 54,448 | 55,468 | +1,020 | 0.00 | 0.00 | -0.00 | buy |
| Arizona State Retirement System | 11,867 | 12,857 | +990 | 0.00 | 0.00 | -0.00 | buy |
| PROFUND ADVISORS LLC | 15,562 | 16,484 | +922 | 0.01 | 0.01 | -0.00 | buy |
| CITIGROUP INC | 28,459 | 29,369 | +910 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,097 | 1,941 | +844 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 2,871 | 3,526 | +655 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 3,457 | 4,110 | +653 | 0.00 | 0.00 | -0.00 | buy |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | 34,700 | 35,200 | +500 | 0.01 | 0.01 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 12,438 | 12,908 | +470 | 0.00 | 0.00 | -0.00 | buy |
| HUNTINGTON NATIONAL BANK | 1,986 | 2,304 | +318 | 0.00 | 0.00 | -0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 604 | 889 | +285 | 0.00 | 0.00 | -0.00 | buy |
| Truvestments Capital LLC | 0 | 225 | +225 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 40 | 239 | +199 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,397 | 1,588 | +191 | 0.00 | 0.00 | -0.00 | buy |
| MassMutual Private Wealth & Trust, FSB | 320 | 459 | +139 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 303 | 438 | +135 | 0.00 | 0.00 | -0.00 | buy |
| INSPIRION WEALTH ADVISORS, LLC | 19,814 | 19,914 | +100 | 0.04 | 0.03 | -0.01 | buy |
| Pathstone Holdings, LLC | 14,900 | 15,000 | +100 | 0.00 | 0.00 | -0.00 | buy |
| Allworth Financial LP | 10,450 | 10,540 | +90 | 0.00 | 0.00 | -0.00 | buy |
| Optiver Holding B.V. | 198 | 282 | +84 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 40,143 | 40,222 | +79 | 0.00 | 0.00 | -0.00 | buy |
| MAI Capital Management | 0 | 23 | +23 | 0.00 | 0.00 | +0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 1,073 | 1,091 | +18 | 0.00 | 0.00 | -0.00 | buy |
| US BANCORP \DE\ | 277 | 295 | +18 | 0.00 | 0.00 | -0.00 | buy |
| Root Financial Partners, LLC | 0 | 11 | +11 | 0.00 | 0.00 | +0.00 | buy |