| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | 10,109,279 | 10,109,279 | 0 | 4.53 | 4.87 | +0.34 | hold |
| Medicxi Ventures Management (Jersey) Ltd | 7,464,572 | 7,464,572 | 0 | 17.65 | 22.93 | +5.29 | hold |
| Carlyle Group Inc. | 3,496,808 | 3,496,808 | 0 | 2.34 | 3.40 | +1.07 | hold |
| Invesco Ltd. | 3,159,789 | 3,143,452 | -16,337 | 0.01 | 0.01 | -0.00 | sell |
| JENNISON ASSOCIATES LLC | 1,647,697 | 2,757,579 | +1,109,882 | 0.01 | 0.02 | +0.01 | buy |
| Ensign Peak Advisors, Inc | 2,280,000 | 2,244,828 | -35,172 | 0.04 | 0.04 | -0.00 | sell |
| VANGUARD GROUP INC | 1,979,113 | 2,211,755 | +232,642 | 0.00 | 0.00 | +0.00 | buy |
| NEA Management Company, LLC | 1,960,169 | 1,960,169 | 0 | 1.29 | 1.52 | +0.23 | hold |
| Avidity Partners Management LP | 1,735,000 | 1,620,000 | -115,000 | 0.65 | 0.71 | +0.05 | sell |
| TAKEDA PHARMACEUTICAL CO LTD | 3,153,217 | 1,557,063 | -1,596,154 | 11.59 | 6.90 | -4.68 | sell |
| GILDER GAGNON HOWE & CO LLC | 1,017,617 | 1,472,259 | +454,642 | 0.14 | 0.19 | +0.05 | buy |
| 683 Capital Management, LLC | 1,650,000 | 1,400,000 | -250,000 | 1.79 | 1.51 | -0.27 | sell |
| Portolan Capital Management, LLC | 0 | 1,130,089 | +1,130,089 | 0.00 | 0.96 | +0.96 | buy |
| Checkpoint Capital L.P. | 445,161 | 875,000 | +429,839 | 3.16 | 5.43 | +2.27 | buy |
| Propel Bio Management, LLC | 869,927 | 869,927 | 0 | 5.38 | 5.81 | +0.43 | hold |
| Decheng Capital LLC | 850,000 | 850,000 | 0 | 1.21 | 2.68 | +1.47 | hold |
| KENNEDY CAPITAL MANAGEMENT LLC | 572,336 | 830,906 | +258,570 | 0.13 | 0.18 | +0.06 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 751,379 | 806,047 | +54,668 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 566,439 | 785,990 | +219,551 | 0.06 | 0.08 | +0.02 | buy |
| STATE STREET CORP | 717,201 | 785,249 | +68,048 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 237,160 | 762,597 | +525,437 | 0.00 | 0.00 | +0.00 | buy |
| Catalys Pacific, LLC | 721,962 | 721,962 | 0 | 5.18 | 5.61 | +0.44 | hold |
| GW&K Investment Management, LLC | 568,026 | 600,443 | +32,417 | 0.05 | 0.06 | +0.00 | buy |
| Saturn V Capital Management LP | 500,987 | 593,306 | +92,319 | 2.13 | 2.31 | +0.18 | buy |
| Simplify Asset Management Inc. | 521,935 | 521,935 | 0 | 0.53 | 0.47 | -0.06 | hold |
| StepStone Group LP | 422,085 | 422,085 | 0 | 0.95 | 0.88 | -0.07 | hold |
| GOLDMAN SACHS GROUP INC | 207,372 | 417,284 | +209,912 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 352,340 | +352,340 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 467,448 | 303,431 | -164,017 | 0.01 | 0.01 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 264,494 | 285,870 | +21,376 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 283,200 | 276,660 | -6,540 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 223,390 | 226,641 | +3,251 | 0.00 | 0.00 | -0.00 | buy |
| ORACLE INVESTMENT MANAGEMENT INC | 0 | 225,000 | +225,000 | 0.00 | 2.49 | +2.49 | buy |
| Schonfeld Strategic Advisors LLC | 144,700 | 168,323 | +23,623 | 0.01 | 0.01 | +0.00 | buy |
| JPMORGAN CHASE & CO | 138,452 | 134,357 | -4,095 | 0.00 | 0.00 | -0.00 | sell |
| MOORE CAPITAL MANAGEMENT, LP | 120,000 | 120,000 | 0 | 0.03 | 0.03 | +0.00 | hold |
| Bank of New York Mellon Corp | 95,221 | 114,721 | +19,500 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 59,186 | 113,592 | +54,406 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 112,691 | +112,691 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 105,855 | 98,032 | -7,823 | 0.00 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 12,893 | 93,154 | +80,261 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 125,645 | 78,816 | -46,829 | 0.00 | 0.00 | -0.00 | sell |
| Penn Mutual Asset Management | 62,802 | 62,802 | 0 | 1.42 | 1.37 | -0.05 | hold |
| Swiss National Bank | 56,000 | 56,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JANE STREET GROUP, LLC | 25,021 | 55,848 | +30,827 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 47,103 | 55,178 | +8,075 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 32,290 | 50,110 | +17,820 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 49,923 | 43,086 | -6,837 | 0.00 | 0.00 | -0.00 | sell |
| INSPIRION WEALTH ADVISORS, LLC | 35,134 | 36,634 | +1,500 | 0.06 | 0.06 | -0.00 | buy |
| Legal & General Group Plc | 34,102 | 34,325 | +223 | 0.00 | 0.00 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 9,701 | 30,078 | +20,377 | 0.05 | 0.15 | +0.10 | buy |
| Occidental Asset Management, LLC | 29,672 | 29,672 | 0 | 0.06 | 0.05 | -0.01 | hold |
| GSA CAPITAL PARTNERS LLP | 14,174 | 29,406 | +15,232 | 0.01 | 0.02 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 28,947 | 29,051 | +104 | 0.00 | 0.00 | -0.00 | buy |
| Creative Planning | 32,102 | 26,951 | -5,151 | 0.00 | 0.00 | -0.00 | sell |
| FULTON BREAKEFIELD BROENNIMAN LLC | 23,579 | 23,579 | 0 | 0.02 | 0.02 | -0.00 | hold |
| Allworth Financial LP | 22,580 | 22,580 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 19,573 | 20,575 | +1,002 | 0.00 | 0.00 | -0.00 | buy |
| MML INVESTORS SERVICES, LLC | 0 | 19,600 | +19,600 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 18,792 | +18,792 | 0.00 | 0.01 | +0.01 | buy |
| MetLife Investment Management, LLC | 16,471 | 18,289 | +1,818 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 11,605 | 17,315 | +5,710 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 51,600 | 16,300 | -35,300 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 14,262 | 15,071 | +809 | 0.00 | 0.00 | -0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 15,006 | +15,006 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 12,602 | 13,941 | +1,339 | 0.00 | 0.00 | +0.00 | buy |
| Stratos Wealth Advisors, LLC | 12,500 | 13,438 | +938 | 0.01 | 0.01 | -0.00 | buy |
| LVW Advisors, LLC | 0 | 12,909 | +12,909 | 0.00 | 0.02 | +0.02 | buy |
| BARCLAYS PLC | 28,199 | 12,405 | -15,794 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 11,019 | 11,691 | +672 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 0 | 11,596 | +11,596 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 5,924 | 10,770 | +4,846 | 0.00 | 0.00 | +0.00 | buy |
| Klingman & Associates, LLC | 10,376 | 10,376 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 7,084 | 10,071 | +2,987 | 0.00 | 0.00 | +0.00 | buy |
| STALEY CAPITAL ADVISERS INC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| KESTRA PRIVATE WEALTH SERVICES, LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DAVENPORT & Co LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CITIGROUP INC | 6,045 | 8,856 | +2,811 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 19,380 | 8,503 | -10,877 | 0.18 | 0.04 | -0.14 | sell |
| GROUP ONE TRADING LLC | 0 | 7,368 | +7,368 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 10,989 | 6,877 | -4,112 | 0.01 | 0.01 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 580 | 5,813 | +5,233 | 0.00 | 0.00 | +0.00 | buy |
| FNY Investment Advisers, LLC | 5,000 | 5,000 | 0 | 0.03 | 0.03 | +0.00 | hold |
| US BANCORP \DE\ | 3,450 | 4,082 | +632 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 3,095 | 3,095 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CANADA LIFE ASSURANCE Co | 2,839 | 2,839 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FMR LLC | 2,084 | 2,656 | +572 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 13,906 | 1,748 | -12,158 | 0.00 | 0.00 | -0.00 | sell |
| AMALGAMATED BANK | 1,090 | 1,090 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Bear Mountain Capital, Inc. | 200 | 1,000 | +800 | 0.00 | 0.00 | +0.00 | buy |
| HUNTINGTON NATIONAL BANK | 978 | 907 | -71 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 0 | 520 | +520 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 0 | 500 | +500 | 0.00 | 0.00 | +0.00 | buy |
| BESSEMER GROUP INC | 0 | 325 | +325 | 0.00 | 0.00 | +0.00 | buy |
| BFSG, LLC | 300 | 300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 167 | 167 | 0 | 0.00 | 0.00 | -0.00 | hold |
| COMERICA BANK | 0 | 129 | +129 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 20 | 84 | +64 | 0.00 | 0.00 | +0.00 | buy |
| Riggs Asset Managment Co. Inc. | 69 | 69 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Farther Finance Advisors, LLC | 17 | 27 | +10 | 0.00 | 0.00 | +0.00 | buy |