| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | 10,109,279 | 12,466,489 | +2,357,210 | 2.90 | 4.78 | +1.88 | buy |
| Medicxi Ventures Management (Jersey) Ltd | 7,464,572 | 7,464,572 | 0 | 10.69 | 16.75 | +6.06 | hold |
| Invesco Ltd. | 3,650,812 | 4,140,072 | +489,260 | 0.00 | 0.01 | +0.00 | buy |
| Carlyle Group Inc. | 3,496,808 | 3,496,808 | 0 | 0.58 | 0.67 | +0.09 | hold |
| BlackRock, Inc. | 3,323,603 | 3,315,348 | -8,255 | 0.00 | 0.00 | +0.00 | sell |
| VANGUARD GROUP INC | 2,778,687 | 2,787,311 | +8,624 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 2,514,284 | 2,519,972 | +5,688 | 0.03 | 0.04 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 523,363 | 2,250,497 | +1,727,134 | 0.00 | 0.02 | +0.02 | buy |
| 683 Capital Management, LLC | 1,445,000 | 2,105,000 | +660,000 | 0.92 | 2.05 | +1.13 | buy |
| NEA Management Company, LLC | 1,960,169 | 1,960,169 | 0 | 0.95 | 1.42 | +0.47 | hold |
| WASATCH ADVISORS LP | 1,701,627 | 1,461,895 | -239,732 | 0.06 | 0.07 | +0.01 | sell |
| Catalys Pacific, LLC | 1,167,114 | 1,167,114 | 0 | 4.92 | 8.50 | +3.58 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 1,016,423 | 1,069,927 | +53,504 | 0.00 | 0.00 | +0.00 | buy |
| Avidity Partners Management LP | 800,000 | 1,064,500 | +264,500 | 1.03 | 2.05 | +1.01 | buy |
| GW&K Investment Management, LLC | 1,104,308 | 1,048,472 | -55,836 | 0.06 | 0.09 | +0.03 | sell |
| Propel Bio Management, LLC | 1,134,927 | 922,927 | -212,000 | 8.27 | 10.74 | +2.48 | sell |
| STATE STREET CORP | 901,354 | 849,424 | -51,930 | 0.00 | 0.00 | +0.00 | sell |
| Catalio Capital Management, LP | 0 | 672,290 | +672,290 | 0.00 | 1.35 | +1.35 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 0 | 600,000 | +600,000 | 0.00 | 0.11 | +0.11 | buy |
| Simplify Asset Management Inc. | 681,935 | 521,935 | -160,000 | 0.20 | 0.30 | +0.10 | sell |
| CITIGROUP INC | 530,859 | 517,247 | -13,612 | 0.00 | 0.00 | +0.00 | sell |
| StepStone Group LP | 422,085 | 422,085 | 0 | 2.72 | 8.03 | +5.31 | hold |
| UBS Group AG | 707,578 | 419,473 | -288,105 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 348,035 | 360,160 | +12,125 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 386,623 | 359,324 | -27,299 | 0.00 | 0.00 | +0.00 | sell |
| Schonfeld Strategic Advisors LLC | 0 | 306,399 | +306,399 | 0.00 | 0.02 | +0.02 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 267,962 | +267,962 | 0.00 | 0.06 | +0.06 | buy |
| GOLDMAN SACHS GROUP INC | 187,874 | 192,526 | +4,652 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 751,692 | 187,291 | -564,401 | 0.03 | 0.01 | -0.02 | sell |
| AMERIPRISE FINANCIAL INC | 0 | 180,851 | +180,851 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 157,941 | +157,941 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 1,131,032 | 154,928 | -976,104 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 137,393 | 138,516 | +1,123 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 161,138 | 134,208 | -26,930 | 0.00 | 0.00 | +0.00 | sell |
| Bank of New York Mellon Corp | 114,535 | 121,166 | +6,631 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 101,520 | 110,110 | +8,590 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 170,281 | 96,080 | -74,201 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 99,776 | 90,781 | -8,995 | 0.00 | 0.00 | +0.00 | sell |
| BARCLAYS PLC | 54,902 | 82,170 | +27,268 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 56,739 | 64,557 | +7,818 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 42,800 | 63,424 | +20,624 | 0.05 | 0.10 | +0.05 | buy |
| Penn Mutual Asset Management | 62,802 | 62,802 | 0 | 0.76 | 1.06 | +0.31 | hold |
| Creative Planning | 59,937 | 57,264 | -2,673 | 0.00 | 0.00 | +0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 45,590 | 50,590 | +5,000 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 107,399 | 49,924 | -57,475 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 28,425 | 46,678 | +18,253 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 44,964 | 44,306 | -658 | 0.08 | 0.14 | +0.07 | sell |
| DIADEMA PARTNERS LP | 0 | 40,294 | +40,294 | 0.00 | 0.24 | +0.24 | buy |
| Nebula Research & Development LLC | 28,821 | 37,937 | +9,116 | 0.02 | 0.03 | +0.01 | buy |
| AlphaQuest LLC | 1,446 | 32,206 | +30,760 | 0.00 | 0.03 | +0.03 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 52,431 | 31,556 | -20,875 | 0.00 | 0.00 | -0.00 | sell |
| GILDER GAGNON HOWE & CO LLC | 41,566 | 31,358 | -10,208 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 27,013 | 30,104 | +3,091 | 0.00 | 0.00 | +0.00 | buy |
| Kera Capital Partners, Inc. | 29,849 | 30,059 | +210 | 0.06 | 0.06 | +0.00 | buy |
| Occidental Asset Management, LLC | 29,672 | 29,672 | 0 | 0.03 | 0.04 | +0.01 | hold |
| INTECH INVESTMENT MANAGEMENT LLC | 21,484 | 28,192 | +6,708 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 27,834 | +27,834 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 27,172 | 26,079 | -1,093 | 0.00 | 0.00 | +0.00 | sell |
| MetLife Investment Management, LLC | 24,366 | 25,845 | +1,479 | 0.00 | 0.00 | +0.00 | buy |
| Birchview Capital, LP | 0 | 25,000 | +25,000 | 0.00 | 0.24 | +0.24 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 23,163 | 23,334 | +171 | 0.00 | 0.00 | +0.00 | buy |
| Summit Financial Wealth Advisors, LLC | 31,143 | 22,143 | -9,000 | 0.04 | 0.04 | -0.00 | sell |
| STIFEL FINANCIAL CORP | 17,398 | 20,467 | +3,069 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 20,478 | 20,448 | -30 | 0.00 | 0.00 | +0.00 | sell |
| INSPIRION WEALTH ADVISORS, LLC | 19,864 | 19,814 | -50 | 0.02 | 0.03 | +0.01 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 14,462 | 15,826 | +1,364 | 0.00 | 0.00 | +0.00 | buy |
| KESTRA PRIVATE WEALTH SERVICES, LLC | 15,500 | 15,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ExodusPoint Capital Management, LP | 79,311 | 15,146 | -64,165 | 0.01 | 0.00 | -0.00 | sell |
| Private Advisor Group, LLC | 0 | 14,580 | +14,580 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 90,191 | 14,330 | -75,861 | 0.03 | 0.01 | -0.02 | sell |
| China Universal Asset Management Co., Ltd. | 13,715 | 14,022 | +307 | 0.01 | 0.01 | +0.00 | buy |
| AXQ CAPITAL, LP | 0 | 13,620 | +13,620 | 0.00 | 0.04 | +0.04 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 45,831 | 13,182 | -32,649 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 11,070 | 11,823 | +753 | 0.00 | 0.00 | +0.00 | buy |
| Savant Capital, LLC | 0 | 11,771 | +11,771 | 0.00 | 0.00 | +0.00 | buy |
| Entropy Technologies, LP | 0 | 11,600 | +11,600 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 11,473 | 11,473 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ProShare Advisors LLC | 11,714 | 11,265 | -449 | 0.00 | 0.00 | +0.00 | sell |
| OSAIC HOLDINGS, INC. | 11,250 | 11,250 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FIDUCIARY TRUST CO | 10,905 | 10,905 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 10,770 | 10,770 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STALEY CAPITAL ADVISERS INC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Persistent Asset Partners Ltd | 0 | 9,421 | +9,421 | 0.00 | 0.08 | +0.08 | buy |
| Police & Firemen's Retirement System of New Jersey | 8,251 | 8,251 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FMR LLC | 509,582 | 5,881 | -503,701 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 3,608 | 5,710 | +2,102 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 2,950 | 5,072 | +2,122 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 3,095 | 4,311 | +1,216 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 36,438 | 4,087 | -32,351 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 35,262 | 2,889 | -32,373 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 41,799 | 2,736 | -39,063 | 0.00 | 0.00 | -0.00 | sell |
| Brooklyn Investment Group | 3,456 | 2,718 | -738 | 0.00 | 0.00 | -0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 2,288 | 2,697 | +409 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 7,384 | 2,093 | -5,291 | 0.00 | 0.00 | -0.00 | sell |
| GF FUND MANAGEMENT CO. LTD. | 1,751 | 1,751 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HUNTINGTON NATIONAL BANK | 1,386 | 1,588 | +202 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 1,354 | 1,354 | 0 | 0.00 | 0.00 | +0.00 | hold |
| C M BIDWELL & ASSOCIATES LTD | 0 | 1,122 | +1,122 | 0.00 | 0.01 | +0.01 | buy |
| NISA INVESTMENT ADVISORS, LLC | 268 | 1,058 | +790 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 1,024 | +1,024 | 0.00 | 0.00 | +0.00 | buy |