| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | 12,466,489 | 12,466,489 | 0 | 3.56 | 2.95 | -0.62 | hold |
| Medicxi Ventures Management (Jersey) Ltd | 7,464,572 | 7,464,572 | 0 | 8.45 | 45.65 | +37.20 | hold |
| BlackRock, Inc. | 4,061,996 | 4,525,129 | +463,133 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 4,322,060 | 4,029,731 | -292,329 | 0.01 | 0.00 | -0.00 | sell |
| Carlyle Group Inc. | 3,496,808 | 3,496,808 | 0 | 0.37 | 0.38 | +0.01 | hold |
| MILLENNIUM MANAGEMENT LLC | 4,022,909 | 3,375,834 | -647,075 | 0.03 | 0.02 | -0.01 | sell |
| GW&K Investment Management, LLC | 1,421,109 | 2,166,838 | +745,729 | 0.14 | 0.18 | +0.04 | buy |
| FRANKLIN RESOURCES INC | 994,504 | 1,970,828 | +976,324 | 0.00 | 0.00 | +0.00 | buy |
| NEA Management Company, LLC | 1,960,169 | 1,960,169 | 0 | 1.24 | 1.34 | +0.10 | hold |
| 683 Capital Management, LLC | 1,850,000 | 1,850,000 | 0 | 1.91 | 1.85 | -0.06 | hold |
| GOLDMAN SACHS GROUP INC | 626,196 | 1,778,032 | +1,151,836 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 1,386,890 | 1,586,323 | +199,433 | 0.00 | 0.00 | -0.00 | buy |
| Catalys Pacific, LLC | 1,493,854 | 1,493,854 | 0 | 7.19 | 7.06 | -0.13 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 1,328,045 | 1,315,687 | -12,358 | 0.00 | 0.00 | -0.00 | sell |
| WASATCH ADVISORS LP | 1,340,916 | 1,307,247 | -33,669 | 0.10 | 0.09 | -0.01 | sell |
| Ensign Peak Advisors, Inc | 1,627,806 | 1,051,913 | -575,893 | 0.03 | 0.02 | -0.01 | sell |
| Propel Bio Management, LLC | 841,272 | 1,050,358 | +209,086 | 5.90 | 5.96 | +0.07 | buy |
| Point72 Asset Management, L.P. | 0 | 1,022,193 | +1,022,193 | 0.00 | 0.02 | +0.02 | buy |
| SummitTX Capital, L.P. | 995,885 | 789,550 | -206,335 | 0.35 | 0.23 | -0.13 | sell |
| HSBC HOLDINGS PLC | 0 | 709,695 | +709,695 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 860,692 | 666,090 | -194,602 | 0.01 | 0.01 | -0.00 | sell |
| EcoR1 Capital, LLC | 625,000 | 625,000 | 0 | 0.30 | 0.34 | +0.04 | hold |
| PERCEPTIVE ADVISORS LLC | 925,000 | 532,000 | -393,000 | 0.20 | 0.09 | -0.11 | sell |
| TWO SIGMA INVESTMENTS, LP | 482,136 | 519,076 | +36,940 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 414,956 | 458,301 | +43,345 | 0.00 | 0.00 | -0.00 | buy |
| StepStone Group LP | 422,085 | 422,085 | 0 | 2.26 | 0.21 | -2.05 | hold |
| Sixth Street Partners Management Company, L.P. | 0 | 419,094 | +419,094 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 409,015 | 419,094 | +10,079 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 369,052 | 369,052 | 0 | 0.02 | 0.01 | -0.00 | hold |
| Hennion & Walsh Asset Management, Inc. | 145,932 | 327,278 | +181,346 | 0.05 | 0.10 | +0.05 | buy |
| AMERIPRISE FINANCIAL INC | 254,219 | 293,979 | +39,760 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 287,430 | 275,251 | -12,179 | 0.00 | 0.00 | -0.00 | sell |
| Simplify Asset Management Inc. | 262,386 | 249,267 | -13,119 | 0.04 | 0.04 | -0.01 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 305,800 | 226,400 | -79,400 | 0.01 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 0 | 212,706 | +212,706 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 360,371 | 204,573 | -155,798 | 0.00 | 0.00 | -0.00 | sell |
| NewEdge Advisors, LLC | 183,000 | 203,962 | +20,962 | 0.01 | 0.01 | -0.00 | buy |
| Avidity Partners Management LP | 249,390 | 200,000 | -49,390 | 0.56 | 0.35 | -0.21 | sell |
| MORGAN STANLEY | 0 | 199,909 | +199,909 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 26,445 | 191,866 | +165,421 | 0.00 | 0.02 | +0.01 | buy |
| Opaleye Management Inc. | 0 | 185,589 | +185,589 | 0.00 | 0.18 | +0.18 | buy |
| CITADEL ADVISORS LLC | 383,058 | 184,901 | -198,157 | 0.00 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 293,305 | 173,884 | -119,421 | 0.02 | 0.01 | -0.01 | sell |
| Bank of New York Mellon Corp | 124,018 | 152,313 | +28,295 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 46,113 | 152,002 | +105,889 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 208,115 | 151,015 | -57,100 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 160,501 | 135,832 | -24,669 | 0.03 | 0.02 | -0.01 | sell |
| AQR CAPITAL MANAGEMENT LLC | 55,468 | 134,901 | +79,433 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 111,752 | 132,284 | +20,532 | 0.00 | 0.00 | +0.00 | buy |
| DIADEMA PARTNERS LP | 54,650 | 129,950 | +75,300 | 0.25 | 0.50 | +0.25 | buy |
| Nuveen, LLC | 117,301 | 127,127 | +9,826 | 0.00 | 0.00 | -0.00 | buy |
| Engineers Gate Manager LP | 73,848 | 118,257 | +44,409 | 0.01 | 0.02 | +0.01 | buy |
| Virtus Investment Advisers, LLC | 57,986 | 112,139 | +54,153 | 0.18 | 0.28 | +0.11 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 101,745 | +101,745 | 0.00 | 0.00 | +0.00 | buy |
| Stratos Wealth Partners, LTD. | 100,000 | 100,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Russell Investments Group, Ltd. | 85,683 | 98,923 | +13,240 | 0.00 | 0.00 | -0.00 | buy |
| Swiss National Bank | 92,600 | 98,800 | +6,200 | 0.00 | 0.00 | -0.00 | buy |
| D. E. Shaw & Co., Inc. | 132,457 | 95,660 | -36,797 | 0.00 | 0.00 | -0.00 | sell |
| GILDER GAGNON HOWE & CO LLC | 139,889 | 88,134 | -51,755 | 0.02 | 0.01 | -0.01 | sell |
| Stonepine Capital Management, LLC | 50,010 | 85,010 | +35,000 | 0.49 | 0.70 | +0.21 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 77,316 | +77,316 | 0.00 | 0.00 | +0.00 | buy |
| KBC Group NV | 77,139 | 77,139 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Campbell & CO Investment Adviser LLC | 62,023 | 68,759 | +6,736 | 0.04 | 0.04 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 52,453 | 65,722 | +13,269 | 0.00 | 0.00 | +0.00 | buy |
| Penn Mutual Asset Management | 62,802 | 62,802 | 0 | 3.57 | 3.50 | -0.08 | hold |
| STATE OF WISCONSIN INVESTMENT BOARD | 44,004 | 62,283 | +18,279 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 55,439 | 60,346 | +4,907 | 0.00 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 55,788 | 55,788 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Birchview Capital, LP | 195,000 | 55,000 | -140,000 | 1.23 | 0.28 | -0.95 | sell |
| CITIGROUP INC | 29,369 | 52,945 | +23,576 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 54,039 | 52,832 | -1,207 | 0.00 | 0.00 | -0.00 | sell |
| Creative Planning | 70,193 | 52,750 | -17,443 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 40,222 | 51,787 | +11,565 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 36,459 | 50,205 | +13,746 | 0.00 | 0.00 | +0.00 | buy |
| Pale Fire Capital SE | 0 | 49,713 | +49,713 | 0.00 | 0.04 | +0.04 | buy |
| ALLIANCEBERNSTEIN L.P. | 49,390 | 49,290 | -100 | 0.00 | 0.00 | -0.00 | sell |
| Man Group plc | 30,352 | 48,679 | +18,327 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 26,328 | 48,024 | +21,696 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 26,766 | 47,663 | +20,897 | 0.12 | 0.16 | +0.05 | buy |
| ADAR1 Capital Management, LLC | 42,900 | 42,900 | 0 | 0.03 | 0.02 | -0.01 | hold |
| Quantbot Technologies LP | 0 | 42,755 | +42,755 | 0.00 | 0.02 | +0.02 | buy |
| BARCLAYS PLC | 25,357 | 41,777 | +16,420 | 0.00 | 0.00 | +0.00 | buy |
| NOMURA HOLDINGS INC | 0 | 40,000 | +40,000 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 39,845 | +39,845 | 0.00 | 0.01 | +0.01 | buy |
| FIDUCIARY TRUST CO | 18,067 | 35,731 | +17,664 | 0.00 | 0.00 | +0.00 | buy |
| ALLSTATE CORP | 32,687 | 32,875 | +188 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 32,037 | 32,738 | +701 | 0.00 | 0.00 | -0.00 | buy |
| Squarepoint Ops LLC | 275,161 | 31,595 | -243,566 | 0.01 | 0.00 | -0.01 | sell |
| GSA CAPITAL PARTNERS LLP | 97,068 | 30,138 | -66,930 | 0.07 | 0.02 | -0.05 | sell |
| MetLife Investment Management, LLC | 25,845 | 28,107 | +2,262 | 0.00 | 0.00 | -0.00 | buy |
| Kera Capital Partners, Inc. | 26,826 | 26,826 | 0 | 0.04 | 0.03 | -0.01 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 24,992 | 25,838 | +846 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 21,732 | 22,647 | +915 | 0.00 | 0.00 | -0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 32,230 | 22,535 | -9,695 | 0.00 | 0.00 | -0.00 | sell |
| Summit Financial Wealth Advisors, LLC | 22,143 | 22,143 | 0 | 0.03 | 0.03 | -0.00 | hold |
| INSPIRION WEALTH ADVISORS, LLC | 19,914 | 19,914 | 0 | 0.03 | 0.02 | -0.00 | hold |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 0 | 18,731 | +18,731 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 4,936 | 17,639 | +12,703 | 0.01 | 0.02 | +0.01 | buy |
| PROFUND ADVISORS LLC | 16,484 | 17,277 | +793 | 0.01 | 0.01 | -0.00 | buy |
| Jain Global LLC | 18,262 | 16,437 | -1,825 | 0.00 | 0.00 | -0.00 | sell |