| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JENNISON ASSOCIATES LLC | 2,757,579 | 5,866,389 | +3,108,810 | 0.02 | 0.07 | +0.05 | buy |
| Woodline Partners LP | 785,990 | 2,573,412 | +1,787,422 | 0.08 | 0.39 | +0.32 | buy |
| ORBIMED ADVISORS LLC | 0 | 1,449,073 | +1,449,073 | 0.00 | 0.48 | +0.48 | buy |
| FEDERATED HERMES, INC. | 0 | 1,403,638 | +1,403,638 | 0.00 | 0.06 | +0.06 | buy |
| FMR LLC | 2,656 | 1,304,114 | +1,301,458 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 3,143,452 | 4,096,762 | +953,310 | 0.01 | 0.01 | +0.01 | buy |
| Checkpoint Capital L.P. | 875,000 | 1,504,307 | +629,307 | 5.43 | 13.49 | +8.06 | buy |
| Portolan Capital Management, LLC | 1,130,089 | 1,699,918 | +569,829 | 0.96 | 2.23 | +1.27 | buy |
| GW&K Investment Management, LLC | 600,443 | 1,126,083 | +525,640 | 0.06 | 0.17 | +0.12 | buy |
| ORACLE INVESTMENT MANAGEMENT INC | 225,000 | 749,487 | +524,487 | 2.49 | 10.83 | +8.34 | buy |
| VANGUARD GROUP INC | 2,211,755 | 2,696,323 | +484,568 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 439,816 | +439,816 | 0.00 | 0.03 | +0.03 | buy |
| Catalys Pacific, LLC | 721,962 | 1,122,572 | +400,610 | 5.61 | 16.19 | +10.57 | buy |
| Decheng Capital LLC | 850,000 | 1,250,000 | +400,000 | 2.68 | 5.35 | +2.67 | buy |
| Ensign Peak Advisors, Inc | 2,244,828 | 2,581,388 | +336,560 | 0.04 | 0.08 | +0.04 | buy |
| Saturn V Capital Management LP | 593,306 | 874,590 | +281,284 | 2.31 | 5.65 | +3.34 | buy |
| WASATCH ADVISORS LP | 0 | 246,942 | +246,942 | 0.00 | 0.02 | +0.02 | buy |
| Informed Momentum Co LLC | 0 | 216,448 | +216,448 | 0.00 | 0.59 | +0.59 | buy |
| Avidity Partners Management LP | 1,620,000 | 1,804,493 | +184,493 | 0.71 | 1.66 | +0.96 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 178,670 | +178,670 | 0.00 | 0.01 | +0.01 | buy |
| GILDER GAGNON HOWE & CO LLC | 1,472,259 | 1,622,883 | +150,624 | 0.19 | 0.35 | +0.16 | buy |
| D. E. Shaw & Co., Inc. | 0 | 143,707 | +143,707 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 78,816 | 220,403 | +141,587 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 785,249 | 922,788 | +137,539 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 69,282 | +69,282 | 0.00 | 0.01 | +0.01 | buy |
| PRUDENTIAL FINANCIAL INC | 352,340 | 415,340 | +63,000 | 0.01 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 806,047 | 862,918 | +56,871 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 15,006 | 65,659 | +50,653 | 0.00 | 0.00 | +0.00 | buy |
| Numerai GP LLC | 0 | 49,327 | +49,327 | 0.00 | 0.24 | +0.24 | buy |
| BARCLAYS PLC | 12,405 | 57,807 | +45,402 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 276,660 | 320,775 | +44,115 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 168,323 | 208,640 | +40,317 | 0.01 | 0.03 | +0.02 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 36,383 | +36,383 | 0.00 | 0.01 | +0.01 | buy |
| SEI INVESTMENTS CO | 0 | 33,898 | +33,898 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 32,928 | +32,928 | 0.00 | 0.00 | +0.00 | buy |
| Summit Financial Wealth Advisors, LLC | 0 | 29,032 | +29,032 | 0.00 | 0.10 | +0.10 | buy |
| UBS Group AG | 43,086 | 71,941 | +28,855 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 8,856 | 31,521 | +22,665 | 0.00 | 0.00 | +0.00 | buy |
| KEYBANK NATIONAL ASSOCIATION/OH | 0 | 18,043 | +18,043 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 56,000 | 73,300 | +17,300 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 417,284 | 434,221 | +16,937 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 15,698 | +15,698 | 0.00 | 0.01 | +0.01 | buy |
| MML INVESTORS SERVICES, LLC | 19,600 | 33,860 | +14,260 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 13,483 | +13,483 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 11,443 | +11,443 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 0 | 10,918 | +10,918 | 0.00 | 0.02 | +0.02 | buy |
| Arizona State Retirement System | 0 | 10,814 | +10,814 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 0 | 10,485 | +10,485 | 0.00 | 0.00 | +0.00 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 120,000 | 130,000 | +10,000 | 0.03 | 0.07 | +0.04 | buy |
| GROUP ONE TRADING LLC | 7,368 | 15,130 | +7,762 | 0.00 | 0.01 | +0.01 | buy |
| ROYAL BANK OF CANADA | 0 | 7,006 | +7,006 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 285,870 | 292,860 | +6,990 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 26,951 | 33,884 | +6,933 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 6,877 | 13,134 | +6,257 | 0.01 | 0.03 | +0.02 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 29,051 | 35,261 | +6,210 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 98,032 | 103,779 | +5,747 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 15,071 | 20,227 | +5,156 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 93,154 | 98,025 | +4,871 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 16,270 | 18,741 | +2,471 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 4,082 | 5,248 | +1,166 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 134,357 | 135,431 | +1,074 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 0 | 840 | +840 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 18,289 | 19,029 | +740 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 17,315 | 18,054 | +739 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,748 | 2,470 | +722 | 0.00 | 0.00 | +0.00 | buy |
| Larson Financial Group LLC | 0 | 647 | +647 | 0.00 | 0.00 | +0.00 | buy |
| HUNTINGTON NATIONAL BANK | 907 | 1,471 | +564 | 0.00 | 0.00 | +0.00 | buy |
| LVW Advisors, LLC | 12,909 | 13,440 | +531 | 0.02 | 0.03 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 20,575 | 21,049 | +474 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 200 | +200 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 7 | 154 | +147 | 0.00 | 0.00 | +0.00 | buy |
| Daiwa Securities Group Inc. | 167 | 260 | +93 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 34,325 | 34,378 | +53 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 20 | 65 | +45 | 0.00 | 0.00 | +0.00 | buy |
| EARNED WEALTH ADVISORS, LLC | 0 | 29 | +29 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 84 | 112 | +28 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 8 | 32 | +24 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 22,580 | 22,594 | +14 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 2,839 | 2,839 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ameritas Investment Partners, Inc. | 3,095 | 3,095 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STALEY CAPITAL ADVISERS INC | 10,000 | 10,000 | 0 | 0.00 | 0.01 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 50,110 | 50,110 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 10,071 | 10,071 | 0 | 0.00 | 0.00 | +0.00 | hold |
| StepStone Group LP | 422,085 | 422,085 | 0 | 0.88 | 2.78 | +1.90 | hold |
| NEA Management Company, LLC | 1,960,169 | 1,960,169 | 0 | 1.52 | 1.93 | +0.41 | hold |
| Carlyle Group Inc. | 3,496,808 | 3,496,808 | 0 | 3.40 | 6.62 | +3.22 | hold |
| Arax Advisory Partners | 17 | 17 | 0 | 0.00 | 0.00 | +0.00 | hold |
| VIRTUS ADVISERS, LLC | 30,078 | 30,078 | 0 | 0.15 | 0.25 | +0.10 | hold |
| Riggs Asset Managment Co. Inc. | 69 | 69 | 0 | 0.00 | 0.00 | +0.00 | hold |
| INSPIRION WEALTH ADVISORS, LLC | 36,634 | 36,634 | 0 | 0.06 | 0.09 | +0.03 | hold |
| KESTRA PRIVATE WEALTH SERVICES, LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Klingman & Associates, LLC | 10,376 | 10,376 | 0 | 0.01 | 0.01 | +0.00 | hold |
| BFSG, LLC | 300 | 300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Stratos Wealth Advisors, LLC | 13,438 | 13,438 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Medicxi Ventures Management (Jersey) Ltd | 7,464,572 | 7,464,572 | 0 | 22.93 | 25.52 | +2.58 | hold |
| Occidental Asset Management, LLC | 29,672 | 29,672 | 0 | 0.05 | 0.09 | +0.03 | hold |
| Simplify Asset Management Inc. | 521,935 | 521,935 | 0 | 0.47 | 0.65 | +0.18 | hold |
| Frazier Life Sciences Management, L.P. | 10,109,279 | 10,109,279 | 0 | 4.87 | 7.33 | +2.45 | hold |
| Propel Bio Management, LLC | 869,927 | 869,927 | 0 | 5.81 | 9.12 | +3.31 | hold |
| ELEVATION WEALTH PARTNERS, LLC | 20 | 20 | 0 | 0.00 | 0.00 | +0.00 | hold |