| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | 12,466,489 | 12,466,489 | 0 | 4.78 | 4.40 | -0.38 | hold |
| Medicxi Ventures Management (Jersey) Ltd | 7,464,572 | 7,464,572 | 0 | 16.75 | 11.80 | -4.95 | hold |
| MILLENNIUM MANAGEMENT LLC | 2,250,497 | 5,081,451 | +2,830,954 | 0.02 | 0.05 | +0.03 | buy |
| Invesco Ltd. | 4,140,072 | 3,864,971 | -275,101 | 0.01 | 0.01 | +0.00 | sell |
| Carlyle Group Inc. | 3,496,808 | 3,496,808 | 0 | 0.67 | 0.95 | +0.28 | hold |
| BlackRock, Inc. | 3,315,348 | 3,402,324 | +86,976 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 2,787,311 | 3,215,572 | +428,261 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 2,519,972 | 2,503,344 | -16,628 | 0.04 | 0.05 | +0.01 | sell |
| NEA Management Company, LLC | 1,960,169 | 1,960,169 | 0 | 1.42 | 1.27 | -0.15 | hold |
| 683 Capital Management, LLC | 2,105,000 | 1,820,380 | -284,620 | 2.05 | 1.95 | -0.10 | sell |
| WASATCH ADVISORS LP | 1,461,895 | 1,537,218 | +75,323 | 0.07 | 0.10 | +0.02 | buy |
| Catalys Pacific, LLC | 1,167,114 | 1,167,114 | 0 | 8.50 | 3.91 | -4.59 | hold |
| GW&K Investment Management, LLC | 1,048,472 | 1,144,330 | +95,858 | 0.09 | 0.12 | +0.03 | buy |
| Catalio Capital Management, LP | 672,290 | 1,128,521 | +456,231 | 1.35 | 2.46 | +1.10 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,069,927 | 1,088,910 | +18,983 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 849,424 | 1,053,591 | +204,167 | 0.00 | 0.00 | +0.00 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 600,000 | 600,000 | 0 | 0.11 | 0.14 | +0.03 | hold |
| AMERIPRISE FINANCIAL INC | 180,851 | 554,590 | +373,739 | 0.00 | 0.00 | +0.00 | buy |
| Propel Bio Management, LLC | 922,927 | 552,927 | -370,000 | 10.74 | 6.51 | -4.23 | sell |
| CITADEL ADVISORS LLC | 0 | 508,720 | +508,720 | 0.00 | 0.00 | +0.00 | buy |
| AIGH Capital Management LLC | 0 | 429,000 | +429,000 | 0.00 | 1.77 | +1.77 | buy |
| StepStone Group LP | 422,085 | 422,085 | 0 | 8.03 | 2.34 | -5.69 | hold |
| SummitTX Capital, L.P. | 0 | 385,968 | +385,968 | 0.00 | 0.19 | +0.19 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 360,160 | 365,904 | +5,744 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 359,324 | 357,578 | -1,746 | 0.00 | 0.00 | +0.00 | sell |
| UBS Group AG | 419,473 | 338,360 | -81,113 | 0.00 | 0.00 | -0.00 | sell |
| Simplify Asset Management Inc. | 521,935 | 321,935 | -200,000 | 0.30 | 0.08 | -0.23 | sell |
| Avidity Partners Management LP | 1,064,500 | 306,000 | -758,500 | 2.05 | 0.82 | -1.23 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 13,182 | 295,161 | +281,979 | 0.00 | 0.01 | +0.01 | buy |
| Walleye Capital LLC | 0 | 290,467 | +290,467 | 0.00 | 0.03 | +0.03 | buy |
| Susquehanna Portfolio Strategies, LLC | 267,962 | 267,962 | 0 | 0.06 | 0.05 | -0.01 | hold |
| MORGAN STANLEY | 154,928 | 255,573 | +100,645 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 96,080 | 249,094 | +153,014 | 0.00 | 0.00 | +0.00 | buy |
| NewEdge Advisors, LLC | 0 | 201,523 | +201,523 | 0.00 | 0.01 | +0.01 | buy |
| Woodline Partners LP | 187,291 | 187,291 | 0 | 0.01 | 0.01 | +0.00 | hold |
| ROYAL BANK OF CANADA | 157,941 | 162,443 | +4,502 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 134,208 | 154,277 | +20,069 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 192,526 | 152,032 | -40,494 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 146,459 | +146,459 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 138,516 | 136,948 | -1,568 | 0.00 | 0.00 | +0.00 | sell |
| BARCLAYS PLC | 82,170 | 128,356 | +46,186 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 121,166 | 127,382 | +6,216 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 110,110 | 110,110 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JANE STREET GROUP, LLC | 0 | 107,262 | +107,262 | 0.00 | 0.00 | +0.00 | buy |
| GILDER GAGNON HOWE & CO LLC | 31,358 | 88,542 | +57,184 | 0.00 | 0.01 | +0.01 | buy |
| Birchview Capital, LP | 25,000 | 85,000 | +60,000 | 0.24 | 0.76 | +0.52 | buy |
| Trexquant Investment LP | 0 | 78,183 | +78,183 | 0.00 | 0.01 | +0.01 | buy |
| Creative Planning | 57,264 | 78,058 | +20,794 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 15,146 | 71,275 | +56,129 | 0.00 | 0.01 | +0.01 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 70,258 | +70,258 | 0.00 | 0.07 | +0.07 | buy |
| Penn Mutual Asset Management | 62,802 | 62,802 | 0 | 1.06 | 1.44 | +0.37 | hold |
| RHUMBLINE ADVISERS | 64,557 | 61,713 | -2,844 | 0.00 | 0.00 | +0.00 | sell |
| Brevan Howard Capital Management LP | 27,834 | 58,097 | +30,263 | 0.00 | 0.01 | +0.01 | buy |
| AlphaQuest LLC | 32,206 | 54,594 | +22,388 | 0.03 | 0.04 | +0.01 | buy |
| XTX Topco Ltd | 14,330 | 54,587 | +40,257 | 0.01 | 0.03 | +0.03 | buy |
| WELLS FARGO & COMPANY/MN | 46,678 | 53,648 | +6,970 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 49,924 | 52,629 | +2,705 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 50,590 | 45,590 | -5,000 | 0.00 | 0.00 | +0.00 | sell |
| Virtus Investment Advisers, LLC | 44,306 | 44,306 | 0 | 0.14 | 0.15 | +0.01 | hold |
| ADAR1 Capital Management, LLC | 63,424 | 42,900 | -20,524 | 0.10 | 0.05 | -0.05 | sell |
| CAXTON ASSOCIATES LLP | 0 | 38,570 | +38,570 | 0.00 | 0.01 | +0.01 | buy |
| INSPIRION WEALTH ADVISORS, LLC | 19,814 | 36,634 | +16,820 | 0.03 | 0.09 | +0.07 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 34,090 | +34,090 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 30,104 | 31,919 | +1,815 | 0.00 | 0.00 | +0.00 | buy |
| PharVision Advisers, LLC | 0 | 30,968 | +30,968 | 0.00 | 0.21 | +0.21 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 31,556 | 30,616 | -940 | 0.00 | 0.00 | +0.00 | sell |
| Quadrature Capital Ltd | 0 | 30,272 | +30,272 | 0.00 | 0.00 | +0.00 | buy |
| Kera Capital Partners, Inc. | 30,059 | 30,059 | 0 | 0.06 | 0.05 | -0.00 | hold |
| Occidental Asset Management, LLC | 29,672 | 29,672 | 0 | 0.04 | 0.04 | +0.00 | hold |
| DEUTSCHE BANK AG\ | 26,079 | 29,572 | +3,493 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 25,845 | 25,845 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | 0 | 24,700 | +24,700 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 22,521 | +22,521 | 0.00 | 0.00 | +0.00 | buy |
| Summit Financial Wealth Advisors, LLC | 22,143 | 22,143 | 0 | 0.04 | 0.04 | +0.00 | hold |
| INTECH INVESTMENT MANAGEMENT LLC | 28,192 | 21,541 | -6,651 | 0.00 | 0.00 | -0.00 | sell |
| Allworth Financial LP | 20,448 | 20,448 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SIMPLEX TRADING, LLC | 0 | 19,960 | +19,960 | 0.00 | 0.01 | +0.01 | buy |
| STIFEL FINANCIAL CORP | 20,467 | 19,867 | -600 | 0.00 | 0.00 | +0.00 | sell |
| AXQ CAPITAL, LP | 13,620 | 19,862 | +6,242 | 0.04 | 0.09 | +0.05 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 23,334 | 19,402 | -3,932 | 0.00 | 0.00 | -0.00 | sell |
| OMERS ADMINISTRATION Corp | 0 | 16,500 | +16,500 | 0.00 | 0.00 | +0.00 | buy |
| FIDUCIARY TRUST CO | 10,905 | 16,115 | +5,210 | 0.00 | 0.00 | +0.00 | buy |
| KESTRA PRIVATE WEALTH SERVICES, LLC | 15,500 | 15,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 15,826 | 14,612 | -1,214 | 0.00 | 0.00 | +0.00 | sell |
| Private Advisor Group, LLC | 14,580 | 14,580 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CITIGROUP INC | 517,247 | 13,635 | -503,612 | 0.00 | 0.00 | -0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 0 | 13,394 | +13,394 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 14,022 | 12,435 | -1,587 | 0.01 | 0.01 | -0.00 | sell |
| PROFUND ADVISORS LLC | 0 | 12,170 | +12,170 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 8,251 | 11,925 | +3,674 | 0.00 | 0.00 | +0.00 | buy |
| Savant Capital, LLC | 11,771 | 11,771 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 11,473 | 11,473 | 0 | 0.00 | 0.01 | +0.00 | hold |
| OSAIC HOLDINGS, INC. | 11,250 | 10,952 | -298 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 10,770 | 10,770 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Pathstone Holdings, LLC | 0 | 10,322 | +10,322 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 0 | 9,797 | +9,797 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 5,072 | 8,828 | +3,756 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 277 | 7,277 | +7,000 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 1,024 | 7,007 | +5,983 | 0.00 | 0.02 | +0.02 | buy |
| FMR LLC | 5,881 | 6,999 | +1,118 | 0.00 | 0.00 | +0.00 | buy |