| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| NEA Management Company, LLC | 1,276,595 | 1,960,169 | +683,574 | 0.95 | 1.19 | +0.25 | buy |
| Ensign Peak Advisors, Inc | 1,732,172 | 2,280,000 | +547,828 | 0.04 | 0.04 | +0.00 | buy |
| Woodline Partners LP | 740,021 | 1,096,121 | +356,100 | 0.09 | 0.11 | +0.02 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 280,932 | 593,751 | +312,819 | 0.02 | 0.03 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 84,063 | 266,857 | +182,794 | 0.00 | 0.01 | +0.00 | buy |
| 683 Capital Management, LLC | 1,100,000 | 1,280,000 | +180,000 | 1.16 | 1.17 | +0.01 | buy |
| Saturn V Capital Management LP | 0 | 160,075 | +160,075 | 0.00 | 0.56 | +0.56 | buy |
| Newtyn Management, LLC | 500,000 | 646,760 | +146,760 | 1.28 | 1.16 | -0.12 | buy |
| GILDER GAGNON HOWE & CO LLC | 1,310,048 | 1,455,132 | +145,084 | 0.21 | 0.18 | -0.02 | buy |
| Walleye Capital LLC | 85,372 | 202,154 | +116,782 | 0.01 | 0.03 | +0.01 | buy |
| Avidity Partners Management LP | 1,617,300 | 1,721,580 | +104,280 | 0.68 | 0.60 | -0.07 | buy |
| GOLDMAN SACHS GROUP INC | 138,500 | 210,211 | +71,711 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 11,402 | 82,244 | +70,842 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 65,600 | +65,600 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 99,810 | 154,391 | +54,581 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 682,570 | 735,273 | +52,703 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 52,313 | +52,313 | 0.00 | 0.00 | +0.00 | buy |
| Octagon Capital Advisors LP | 0 | 50,000 | +50,000 | 0.00 | 0.07 | +0.07 | buy |
| MORGAN STANLEY | 78,244 | 124,551 | +46,307 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 13,235 | 49,672 | +36,437 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,922,662 | 1,956,429 | +33,767 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 139,348 | 170,044 | +30,696 | 0.00 | 0.00 | -0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 8,900 | 38,569 | +29,669 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 53,558 | 81,793 | +28,235 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 14,120 | 39,292 | +25,172 | 0.00 | 0.00 | +0.00 | buy |
| FULTON BREAKEFIELD BROENNIMAN LLC | 0 | 23,579 | +23,579 | 0.00 | 0.02 | +0.02 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 22,700 | +22,700 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 38,744 | 61,000 | +22,256 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 268,776 | 289,819 | +21,043 | 0.00 | 0.00 | -0.00 | buy |
| Graham Capital Management, L.P. | 0 | 20,619 | +20,619 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 667,596 | 687,837 | +20,241 | 0.00 | 0.00 | -0.00 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 80,000 | 100,000 | +20,000 | 0.02 | 0.02 | -0.00 | buy |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | 0 | 18,100 | +18,100 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 246,681 | 262,524 | +15,843 | 0.00 | 0.00 | -0.00 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 15,000 | +15,000 | 0.00 | 0.01 | +0.01 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 0 | 14,940 | +14,940 | 0.00 | 0.01 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 12,893 | +12,893 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 95,065 | 106,319 | +11,254 | 0.00 | 0.00 | -0.00 | buy |
| DAVENPORT & Co LLC | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 12,164 | 18,070 | +5,906 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 33,700 | 39,432 | +5,732 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 1,455 | 6,626 | +5,171 | 0.00 | 0.01 | +0.01 | buy |
| INSPIRION WEALTH ADVISORS, LLC | 30,134 | 35,134 | +5,000 | 0.06 | 0.06 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 12,829 | 17,699 | +4,870 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 13,394 | 17,401 | +4,007 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 7,274 | 10,890 | +3,616 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 19,580 | 22,580 | +3,000 | 0.00 | 0.00 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 7,744 | 10,367 | +2,623 | 0.05 | 0.06 | +0.01 | buy |
| CITIGROUP INC | 3,828 | 5,649 | +1,821 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 1,545 | +1,545 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 1,889 | 3,333 | +1,444 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 144,756 | 146,037 | +1,281 | 0.00 | 0.00 | -0.00 | buy |
| Creative Planning | 20,475 | 21,352 | +877 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 9,311 | 9,861 | +550 | 0.00 | 0.00 | -0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 15,409 | 15,938 | +529 | 0.00 | 0.00 | -0.00 | buy |
| BFSG, LLC | 0 | 300 | +300 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 34,002 | 34,253 | +251 | 0.00 | 0.00 | -0.00 | buy |
| AMALGAMATED BANK | 2,575 | 2,824 | +249 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 13,541 | 13,636 | +95 | 0.00 | 0.00 | -0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 19 | +19 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 20 | 30 | +10 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 2,839 | 2,839 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ameritas Investment Partners, Inc. | 3,095 | 3,095 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 12,843 | 12,843 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STALEY CAPITAL ADVISERS INC | 10,000 | 10,000 | 0 | 0.01 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 37,700 | 37,700 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 167 | 167 | 0 | 0.00 | 0.00 | -0.00 | hold |
| StepStone Group LP | 422,085 | 422,085 | 0 | 0.98 | 0.69 | -0.28 | hold |
| Carlyle Group Inc. | 3,496,808 | 3,496,808 | 0 | 1.57 | 1.54 | -0.03 | hold |
| MetLife Investment Management, LLC | 16,471 | 16,471 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Vestcor Inc | 915 | 915 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Stratos Wealth Advisors, LLC | 12,500 | 12,500 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Medicxi Ventures Management (Jersey) Ltd | 3,760,869 | 3,760,869 | 0 | 12.45 | 11.59 | -0.86 | hold |
| Occidental Asset Management, LLC | 29,672 | 29,672 | 0 | 0.07 | 0.06 | -0.02 | hold |
| Tradition Wealth Management, LLC | 500 | 500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Simplify Asset Management Inc. | 237,935 | 237,935 | 0 | 0.41 | 0.34 | -0.07 | hold |
| Frazier Life Sciences Management, L.P. | 10,109,279 | 10,109,279 | 0 | 6.97 | 4.93 | -2.04 | hold |
| ELEVATION WEALTH PARTNERS, LLC | 20 | 20 | 0 | 0.00 | 0.00 | -0.00 | hold |
| METROPOLITAN LIFE INSURANCE CO/NY | 1,818 | 1,818 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Penn Mutual Asset Management | 62,802 | 62,802 | 0 | 0.61 | 0.44 | -0.17 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 12,250 | 12,250 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Newbridge Financial Services Group, Inc. | 35 | 0 | -35 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 5,825 | 5,787 | -38 | 0.00 | 0.00 | -0.00 | sell |
| HUNTINGTON NATIONAL BANK | 1,051 | 960 | -91 | 0.00 | 0.00 | -0.00 | sell |
| US BANCORP \DE\ | 113 | 0 | -113 | 0.00 | 0.00 | -0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 8,429 | 8,271 | -158 | 0.00 | 0.00 | -0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 11,801 | 11,585 | -216 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 30,986 | 30,590 | -396 | 0.00 | 0.00 | -0.00 | sell |
| HEADINVEST, LLC | 882 | 0 | -882 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 130,564 | 129,389 | -1,175 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 2,120 | 0 | -2,120 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 60,200 | 56,000 | -4,200 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 22,835 | 18,427 | -4,408 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 70,784 | 65,254 | -5,530 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 56,537 | 48,502 | -8,035 | 0.00 | 0.00 | -0.00 | sell |
| Centiva Capital, LP | 10,962 | 0 | -10,962 | 0.01 | 0.00 | -0.01 | sell |
| Engineers Gate Manager LP | 12,888 | 0 | -12,888 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 14,847 | 0 | -14,847 | 0.03 | 0.00 | -0.03 | sell |
| GW&K Investment Management, LLC | 577,450 | 561,490 | -15,960 | 0.06 | 0.05 | -0.01 | sell |
| ExodusPoint Capital Management, LP | 17,008 | 0 | -17,008 | 0.00 | 0.00 | -0.00 | sell |