| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| WASATCH ADVISORS LP | 246,942 | 1,558,928 | +1,311,986 | 0.02 | 0.06 | +0.04 | buy |
| JENNISON ASSOCIATES LLC | 5,866,389 | 7,062,507 | +1,196,118 | 0.07 | 0.03 | -0.03 | buy |
| Checkpoint Capital L.P. | 1,504,307 | 2,274,157 | +769,850 | 13.49 | 9.40 | -4.09 | buy |
| MORGAN STANLEY | 439,490 | 966,400 | +526,910 | 0.00 | 0.00 | -0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 0 | 500,000 | +500,000 | 0.00 | 0.27 | +0.27 | buy |
| UBS Group AG | 71,941 | 465,616 | +393,675 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 3,122,570 | 3,502,375 | +379,805 | 0.00 | 0.00 | -0.00 | buy |
| Trexquant Investment LP | 0 | 378,637 | +378,637 | 0.00 | 0.04 | +0.04 | buy |
| TWO SIGMA INVESTMENTS, LP | 154,030 | 485,790 | +331,760 | 0.01 | 0.01 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 282,553 | +282,553 | 0.00 | 0.04 | +0.04 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 862,918 | 1,018,495 | +155,577 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 133,700 | +133,700 | 0.00 | 0.00 | +0.00 | buy |
| Propel Bio Management, LLC | 869,927 | 989,927 | +120,000 | 9.12 | 7.98 | -1.14 | buy |
| STATE STREET CORP | 922,788 | 1,039,936 | +117,148 | 0.00 | 0.00 | -0.00 | buy |
| MARSHALL WACE, LLP | 0 | 98,068 | +98,068 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 2,696,323 | 2,779,561 | +83,238 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 320,775 | 397,964 | +77,189 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 103,779 | 166,505 | +62,726 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 292,860 | 353,038 | +60,178 | 0.00 | 0.00 | -0.00 | buy |
| Simplify Asset Management Inc. | 521,935 | 581,935 | +60,000 | 0.65 | 0.33 | -0.32 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 178,670 | 235,404 | +56,734 | 0.01 | 0.00 | -0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 55,973 | +55,973 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 200 | 55,400 | +55,200 | 0.00 | 0.09 | +0.09 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 81,770 | 132,269 | +50,499 | 0.00 | 0.00 | -0.00 | buy |
| JANE STREET GROUP, LLC | 27,842 | 77,869 | +50,027 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 415,340 | 463,340 | +48,000 | 0.01 | 0.01 | -0.01 | buy |
| Catalys Pacific, LLC | 1,122,572 | 1,167,114 | +44,542 | 16.19 | 8.18 | -8.01 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 10,410 | 50,772 | +40,362 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 39,532 | +39,532 | 0.00 | 0.00 | +0.00 | buy |
| Summit Financial Wealth Advisors, LLC | 29,032 | 68,125 | +39,093 | 0.10 | 0.08 | -0.02 | buy |
| Engineers Gate Manager LP | 0 | 32,500 | +32,500 | 0.00 | 0.00 | +0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 32,029 | +32,029 | 0.00 | 0.04 | +0.04 | buy |
| MILLENNIUM MANAGEMENT LLC | 32,928 | 59,991 | +27,063 | 0.00 | 0.00 | -0.00 | buy |
| Aristides Capital LLC | 0 | 25,200 | +25,200 | 0.00 | 0.06 | +0.06 | buy |
| Brevan Howard Capital Management LP | 0 | 22,845 | +22,845 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 21,070 | +21,070 | 0.00 | 0.00 | +0.00 | buy |
| Nebula Research & Development LLC | 0 | 20,963 | +20,963 | 0.00 | 0.02 | +0.02 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 98,025 | 117,803 | +19,778 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 57,807 | 76,463 | +18,656 | 0.00 | 0.00 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 17,658 | +17,658 | 0.00 | 0.00 | +0.00 | buy |
| Capula Management Ltd | 0 | 16,083 | +16,083 | 0.00 | 0.00 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 15,400 | +15,400 | 0.00 | 0.00 | +0.00 | buy |
| 683 Capital Management, LLC | 1,010,000 | 1,025,000 | +15,000 | 1.86 | 0.82 | -1.04 | buy |
| Bayesian Capital Management, LP | 0 | 14,900 | +14,900 | 0.00 | 0.01 | +0.01 | buy |
| VIRTUS ADVISERS, LLC | 30,078 | 43,789 | +13,711 | 0.25 | 0.15 | -0.11 | buy |
| Virtu Financial LLC | 0 | 13,424 | +13,424 | 0.00 | 0.01 | +0.01 | buy |
| PROFUND ADVISORS LLC | 0 | 13,310 | +13,310 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 31,521 | 44,577 | +13,056 | 0.00 | 0.00 | -0.00 | buy |
| Versor Investments LP | 0 | 12,400 | +12,400 | 0.00 | 0.02 | +0.02 | buy |
| Rafferty Asset Management, LLC | 0 | 11,113 | +11,113 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 0 | 11,065 | +11,065 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 20,227 | 30,213 | +9,986 | 0.00 | 0.00 | -0.00 | buy |
| KEYBANK NATIONAL ASSOCIATION/OH | 18,043 | 25,512 | +7,469 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 18,054 | 25,516 | +7,462 | 0.00 | 0.00 | -0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 11,443 | 17,424 | +5,981 | 0.00 | 0.00 | -0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 10,071 | 15,710 | +5,639 | 0.00 | 0.00 | -0.00 | buy |
| KESTRA PRIVATE WEALTH SERVICES, LLC | 10,000 | 15,500 | +5,500 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 19,029 | 24,366 | +5,337 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 50,858 | 55,968 | +5,110 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 21,049 | 25,641 | +4,592 | 0.00 | 0.00 | -0.00 | buy |
| ROYAL BANK OF CANADA | 7,006 | 11,587 | +4,581 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 98,191 | 102,748 | +4,557 | 0.00 | 0.00 | -0.00 | buy |
| ProShare Advisors LLC | 10,485 | 14,289 | +3,804 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 18,741 | 22,149 | +3,408 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 34,378 | 36,438 | +2,060 | 0.00 | 0.00 | -0.00 | buy |
| Point72 (DIFC) Ltd | 0 | 1,951 | +1,951 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 5,248 | 6,826 | +1,578 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 135,431 | 136,907 | +1,476 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 13,134 | 14,499 | +1,365 | 0.03 | 0.01 | -0.02 | buy |
| Corebridge Financial, Inc. | 18,245 | 19,508 | +1,263 | 0.00 | 0.00 | -0.00 | buy |
| Sterling Capital Management LLC | 106 | 867 | +761 | 0.00 | 0.00 | +0.00 | buy |
| Greenline Partners, LLC | 0 | 500 | +500 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 13,594 | 13,990 | +396 | 0.00 | 0.00 | -0.00 | buy |
| GAMMA Investing LLC | 154 | 508 | +354 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 11,364 | 11,689 | +325 | 0.00 | 0.00 | -0.00 | buy |
| Larson Financial Group LLC | 647 | 797 | +150 | 0.00 | 0.00 | -0.00 | buy |
| Klingman & Associates, LLC | 10,376 | 10,517 | +141 | 0.01 | 0.01 | -0.01 | buy |
| GSA CAPITAL PARTNERS LLP | 15,083 | 15,173 | +90 | 0.02 | 0.01 | -0.01 | buy |
| Arizona State Retirement System | 10,814 | 10,900 | +86 | 0.00 | 0.00 | -0.00 | buy |
| Amundi | 0 | 42 | +42 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 4,387 | 4,414 | +27 | 0.00 | 0.00 | -0.00 | buy |
| HUNTINGTON NATIONAL BANK | 1,471 | 1,497 | +26 | 0.00 | 0.00 | -0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 21 | +21 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 0 | 7 | +7 | 0.00 | 0.00 | 0.00 | buy |
| IFP Advisors, Inc | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 35,261 | 35,262 | +1 | 0.00 | 0.00 | -0.00 | buy |
| CANADA LIFE ASSURANCE Co | 2,839 | 2,839 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ameritas Investment Partners, Inc. | 3,095 | 3,095 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STALEY CAPITAL ADVISERS INC | 10,000 | 10,000 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 260 | 260 | 0 | 0.00 | 0.00 | -0.00 | hold |
| StepStone Group LP | 422,085 | 422,085 | 0 | 2.78 | 3.00 | +0.21 | hold |
| NEA Management Company, LLC | 1,960,169 | 1,960,169 | 0 | 1.93 | 0.90 | -1.03 | hold |
| Carlyle Group Inc. | 3,496,808 | 3,496,808 | 0 | 6.62 | 0.68 | -5.94 | hold |
| Swiss National Bank | 73,300 | 73,300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Riggs Asset Managment Co. Inc. | 69 | 69 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BFSG, LLC | 300 | 300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Stratos Wealth Advisors, LLC | 13,438 | 13,438 | 0 | 0.01 | 0.01 | -0.01 | hold |
| Medicxi Ventures Management (Jersey) Ltd | 7,464,572 | 7,464,572 | 0 | 25.52 | 11.46 | -14.06 | hold |
| Occidental Asset Management, LLC | 29,672 | 29,672 | 0 | 0.09 | 0.04 | -0.05 | hold |
| Frazier Life Sciences Management, L.P. | 10,109,279 | 10,109,279 | 0 | 7.33 | 3.41 | -3.92 | hold |