| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | 12,466,489 | 12,466,489 | 0 | 4.40 | 5.55 | +1.16 | hold |
| Medicxi Ventures Management (Jersey) Ltd | 7,464,572 | 7,464,572 | 0 | 11.80 | 14.83 | +3.03 | hold |
| Invesco Ltd. | 3,864,971 | 3,920,446 | +55,475 | 0.01 | 0.01 | +0.00 | buy |
| BlackRock, Inc. | 3,402,324 | 3,555,548 | +153,224 | 0.00 | 0.00 | +0.00 | buy |
| Carlyle Group Inc. | 3,496,808 | 3,496,808 | 0 | 0.95 | 0.43 | -0.52 | hold |
| VANGUARD GROUP INC | 3,215,572 | 3,177,211 | -38,361 | 0.00 | 0.00 | +0.00 | sell |
| Ensign Peak Advisors, Inc | 2,503,344 | 2,352,020 | -151,324 | 0.05 | 0.07 | +0.02 | sell |
| MILLENNIUM MANAGEMENT LLC | 5,081,451 | 2,082,180 | -2,999,271 | 0.05 | 0.02 | -0.02 | sell |
| NEA Management Company, LLC | 1,960,169 | 1,960,169 | 0 | 1.27 | 1.66 | +0.39 | hold |
| 683 Capital Management, LLC | 1,820,380 | 1,785,000 | -35,380 | 1.95 | 2.46 | +0.52 | sell |
| Catalys Pacific, LLC | 1,167,114 | 1,429,014 | +261,900 | 3.91 | 7.63 | +3.72 | buy |
| WASATCH ADVISORS LP | 1,537,218 | 1,331,669 | -205,549 | 0.10 | 0.13 | +0.03 | sell |
| GW&K Investment Management, LLC | 1,144,330 | 1,306,678 | +162,348 | 0.12 | 0.19 | +0.07 | buy |
| STATE STREET CORP | 1,053,591 | 1,149,536 | +95,945 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,088,910 | 1,073,434 | -15,476 | 0.00 | 0.00 | +0.00 | sell |
| Propel Bio Management, LLC | 552,927 | 740,918 | +187,991 | 6.51 | 10.49 | +3.98 | buy |
| Catalio Capital Management, LP | 1,128,521 | 698,996 | -429,525 | 2.46 | 2.05 | -0.41 | sell |
| Divisadero Street Capital Management, LP | 0 | 662,312 | +662,312 | 0.00 | 0.63 | +0.63 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 600,000 | 600,000 | 0 | 0.14 | 0.20 | +0.06 | hold |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 154,277 | 549,171 | +394,894 | 0.00 | 0.01 | +0.01 | buy |
| SummitTX Capital, L.P. | 385,968 | 517,820 | +131,852 | 0.19 | 0.26 | +0.07 | buy |
| StepStone Group LP | 422,085 | 422,085 | 0 | 2.34 | 2.66 | +0.32 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 365,904 | 397,910 | +32,006 | 0.00 | 0.00 | +0.00 | buy |
| NEXT CENTURY GROWTH INVESTORS LLC | 0 | 393,774 | +393,774 | 0.00 | 0.45 | +0.45 | buy |
| GOLDMAN SACHS GROUP INC | 152,032 | 392,045 | +240,013 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 107,262 | 384,770 | +277,508 | 0.00 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 357,578 | 356,466 | -1,112 | 0.00 | 0.00 | +0.00 | sell |
| Simplify Asset Management Inc. | 321,935 | 321,935 | 0 | 0.08 | 0.09 | +0.01 | hold |
| CITADEL ADVISORS LLC | 508,720 | 311,315 | -197,405 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 338,360 | 304,383 | -33,977 | 0.00 | 0.00 | +0.00 | sell |
| JPMORGAN CHASE & CO | 136,948 | 296,684 | +159,736 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 58,097 | 276,989 | +218,892 | 0.01 | 0.09 | +0.08 | buy |
| Susquehanna Portfolio Strategies, LLC | 267,962 | 267,962 | 0 | 0.05 | 0.07 | +0.02 | hold |
| D. E. Shaw & Co., Inc. | 0 | 261,068 | +261,068 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 249,094 | 258,996 | +9,902 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 295,161 | 207,085 | -88,076 | 0.01 | 0.01 | -0.00 | sell |
| Avidity Partners Management LP | 306,000 | 206,076 | -99,924 | 0.82 | 0.99 | +0.17 | sell |
| NewEdge Advisors, LLC | 201,523 | 200,823 | -700 | 0.01 | 0.01 | +0.00 | sell |
| Birchview Capital, LP | 85,000 | 195,000 | +110,000 | 0.76 | 1.89 | +1.14 | buy |
| Woodline Partners LP | 187,291 | 187,291 | 0 | 0.01 | 0.01 | +0.00 | hold |
| AMERIPRISE FINANCIAL INC | 554,590 | 185,744 | -368,846 | 0.00 | 0.00 | -0.00 | sell |
| CAXTON ASSOCIATES LLP | 38,570 | 181,968 | +143,398 | 0.01 | 0.06 | +0.05 | buy |
| HUSSMAN STRATEGIC ADVISORS, INC. | 0 | 147,000 | +147,000 | 0.00 | 0.59 | +0.59 | buy |
| GILDER GAGNON HOWE & CO LLC | 88,542 | 145,174 | +56,632 | 0.01 | 0.03 | +0.01 | buy |
| Trexquant Investment LP | 78,183 | 136,824 | +58,641 | 0.01 | 0.02 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 146,459 | 134,546 | -11,913 | 0.00 | 0.00 | +0.00 | sell |
| Bank of New York Mellon Corp | 127,382 | 122,967 | -4,415 | 0.00 | 0.00 | +0.00 | sell |
| MORGAN STANLEY | 255,573 | 117,781 | -137,792 | 0.00 | 0.00 | -0.00 | sell |
| Campbell & CO Investment Adviser LLC | 0 | 115,284 | +115,284 | 0.00 | 0.09 | +0.09 | buy |
| Hennion & Walsh Asset Management, Inc. | 0 | 114,981 | +114,981 | 0.00 | 0.07 | +0.07 | buy |
| Nuveen, LLC | 110,110 | 108,846 | -1,264 | 0.00 | 0.00 | +0.00 | sell |
| GROUP ONE TRADING LLC | 4,248 | 103,684 | +99,436 | 0.00 | 0.05 | +0.05 | buy |
| BARCLAYS PLC | 128,356 | 84,859 | -43,497 | 0.00 | 0.00 | +0.00 | sell |
| Swiss National Bank | 0 | 84,000 | +84,000 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 70,258 | 82,624 | +12,366 | 0.07 | 0.12 | +0.05 | buy |
| Creative Planning | 78,058 | 80,766 | +2,708 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 53,648 | 68,016 | +14,368 | 0.00 | 0.00 | +0.00 | buy |
| Penn Mutual Asset Management | 62,802 | 62,802 | 0 | 1.44 | 0.62 | -0.81 | hold |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 62,248 | +62,248 | 0.00 | 0.05 | +0.05 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 57,783 | +57,783 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 52,629 | 54,448 | +1,819 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 61,713 | 52,093 | -9,620 | 0.00 | 0.00 | +0.00 | sell |
| STIFEL FINANCIAL CORP | 19,867 | 51,661 | +31,794 | 0.00 | 0.00 | +0.00 | buy |
| Stratos Wealth Partners, LTD. | 0 | 50,300 | +50,300 | 0.00 | 0.01 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 45,590 | 49,390 | +3,800 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 44,306 | 46,937 | +2,631 | 0.15 | 0.21 | +0.06 | buy |
| Engineers Gate Manager LP | 0 | 44,258 | +44,258 | 0.00 | 0.01 | +0.01 | buy |
| ADAR1 Capital Management, LLC | 42,900 | 42,900 | 0 | 0.05 | 0.05 | +0.00 | hold |
| Southeast Asset Advisors, LLC | 0 | 42,874 | +42,874 | 0.00 | 0.07 | +0.07 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 10,770 | 41,756 | +30,986 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,891 | 40,143 | +37,252 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 54,587 | 39,400 | -15,187 | 0.03 | 0.02 | -0.02 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 31,919 | 37,071 | +5,152 | 0.00 | 0.00 | +0.00 | buy |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | 24,700 | 34,700 | +10,000 | 0.00 | 0.01 | +0.00 | buy |
| Legal & General Group Plc | 4,087 | 34,249 | +30,162 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 33,425 | +33,425 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 29,572 | 33,380 | +3,808 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 30,944 | +30,944 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 30,616 | 30,940 | +324 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 30,631 | +30,631 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 30,488 | +30,488 | 0.00 | 0.01 | +0.01 | buy |
| Occidental Asset Management, LLC | 29,672 | 29,919 | +247 | 0.04 | 0.06 | +0.02 | buy |
| TUDOR INVESTMENT CORP ET AL | 34,090 | 28,554 | -5,536 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 13,635 | 28,459 | +14,824 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 54,594 | 28,250 | -26,344 | 0.04 | 0.03 | -0.02 | sell |
| HRT FINANCIAL LP | 22,521 | 27,010 | +4,489 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 25,845 | 25,845 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RAYMOND JAMES FINANCIAL INC | 13,394 | 24,390 | +10,996 | 0.00 | 0.00 | +0.00 | buy |
| Kera Capital Partners, Inc. | 30,059 | 24,255 | -5,804 | 0.05 | 0.04 | -0.01 | sell |
| ROYAL BANK OF CANADA | 162,443 | 22,554 | -139,889 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 71,275 | 22,401 | -48,874 | 0.01 | 0.00 | -0.01 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 22,185 | +22,185 | 0.00 | 0.00 | +0.00 | buy |
| Summit Financial Wealth Advisors, LLC | 22,143 | 22,143 | 0 | 0.04 | 0.05 | +0.01 | hold |
| Jain Global LLC | 0 | 21,737 | +21,737 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 21,500 | +21,500 | 0.00 | 0.00 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 20,487 | +20,487 | 0.00 | 0.05 | +0.05 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 19,890 | +19,890 | 0.00 | 0.00 | +0.00 | buy |
| INSPIRION WEALTH ADVISORS, LLC | 36,634 | 19,814 | -16,820 | 0.09 | 0.04 | -0.05 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 21,541 | 19,051 | -2,490 | 0.00 | 0.00 | +0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 19,402 | 18,460 | -942 | 0.00 | 0.00 | +0.00 | sell |