| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Invesco Ltd. | 0 | 488,415 | +488,415 | 0.00 | 0.00 | +0.00 | buy |
| Laurion Capital Management LP | 60,400 | 362,484 | +302,084 | 0.01 | 0.08 | +0.07 | buy |
| MILLENNIUM MANAGEMENT LLC | 99,082 | 392,115 | +293,033 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 30,285 | 260,148 | +229,863 | 0.00 | 0.00 | +0.00 | buy |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | 0 | 212,200 | +212,200 | 0.00 | 0.03 | +0.03 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 103,948 | 297,902 | +193,954 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 110,551 | 191,171 | +80,620 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 61,100 | 135,000 | +73,900 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 83,622 | 153,133 | +69,511 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 79,989 | 143,536 | +63,547 | 0.00 | 0.00 | +0.00 | buy |
| Marathon Trading Investment Management LLC | 0 | 51,000 | +51,000 | 0.00 | 0.16 | +0.16 | buy |
| CITIGROUP INC | 73,163 | 116,921 | +43,758 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 37,747 | +37,747 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 34,789 | +34,789 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 17,777 | 52,478 | +34,701 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 34,578 | +34,578 | 0.00 | 0.02 | +0.02 | buy |
| JPMORGAN CHASE & CO | 33,230 | 67,013 | +33,783 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 30,179 | +30,179 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 50,410 | 77,339 | +26,929 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 21,700 | 47,000 | +25,300 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 391,646 | 413,779 | +22,133 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,788,152 | 1,808,152 | +20,000 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 19,736 | +19,736 | 0.00 | 0.04 | +0.04 | buy |
| Cubist Systematic Strategies, LLC | 26,245 | 44,308 | +18,063 | 0.00 | 0.00 | +0.00 | buy |
| Cannon Global Investment Management, LLC | 0 | 17,500 | +17,500 | 0.00 | 0.37 | +0.37 | buy |
| OMERS ADMINISTRATION Corp | 0 | 14,200 | +14,200 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 0 | 12,200 | +12,200 | 0.00 | 0.00 | +0.00 | buy |
| CTC Alternative Strategies, Ltd. | 0 | 11,000 | +11,000 | 0.00 | 0.05 | +0.05 | buy |
| AMERICAN CENTURY COMPANIES INC | 21,315 | 31,885 | +10,570 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 10,291 | +10,291 | 0.00 | 0.00 | +0.00 | buy |
| Cambridge Investment Research Advisors, Inc. | 0 | 10,061 | +10,061 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 15,005 | 24,446 | +9,441 | 0.01 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 71,611 | 76,960 | +5,349 | 0.00 | 0.00 | +0.00 | buy |
| MACQUARIE GROUP LTD | 0 | 1,618 | +1,618 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 0 | 56 | +56 | 0.00 | 0.00 | +0.00 | buy |
| BVF INC/IL | 2,989,474 | 2,989,474 | 0 | 0.44 | 0.65 | +0.22 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,900,000 | 3,900,000 | 0 | 0.05 | 0.06 | +0.01 | hold |
| BAKER BROS. ADVISORS LP | 2,784,792 | 2,784,792 | 0 | 0.18 | 0.28 | +0.09 | hold |
| LETKO, BROSSEAU & ASSOCIATES INC | 20,700 | 20,700 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DC Investments Management, LLC | 35,563 | 35,563 | 0 | 0.21 | 0.24 | +0.03 | hold |
| EcoR1 Capital, LLC | 5,000,000 | 5,000,000 | 0 | 0.76 | 1.01 | +0.25 | hold |
| Waldron Private Wealth LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Alphabet Inc. | 1,077,080 | 1,077,080 | 0 | 0.29 | 0.34 | +0.05 | hold |
| Aberdeen Group plc | 200,000 | 200,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Aries Wealth Management | 10,000 | 10,000 | 0 | 0.02 | 0.03 | +0.00 | hold |
| Privium Fund Management (UK) Ltd | 15,825 | 15,825 | 0 | 0.06 | 0.06 | +0.00 | hold |
| Simplify Asset Management Inc. | 1,046,916 | 1,046,916 | 0 | 0.95 | 0.80 | -0.15 | hold |
| NewEdge Wealth, LLC | 91,463 | 91,463 | 0 | 0.01 | 0.02 | +0.00 | hold |
| DC Funds, LP | 630,000 | 630,000 | 0 | 44.16 | 48.34 | +4.18 | hold |
| Lynx1 Capital Management LP | 5,224,600 | 5,224,600 | 0 | 11.98 | 10.68 | -1.29 | hold |
| Pale Fire Capital SE | 21,573 | 21,573 | 0 | 0.02 | 0.02 | +0.00 | hold |
| Propel Bio Management, LLC | 2,087,139 | 2,087,139 | 0 | 10.09 | 9.65 | -0.44 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 22,104 | 22,104 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Deer Management Co. LLC | 1,245,505 | 1,245,504 | -1 | 0.94 | 1.79 | +0.85 | sell |
| ATLAS CAPITAL ADVISORS INC. | 896 | 18 | -878 | 0.00 | 0.00 | -0.00 | sell |
| LAZARD ASSET MANAGEMENT LLC | 3,983 | 2,551 | -1,432 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 45,986 | 41,942 | -4,044 | 0.00 | 0.00 | +0.00 | sell |
| MORGAN STANLEY | 234,703 | 223,894 | -10,809 | 0.00 | 0.00 | +0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 13,293 | 0 | -13,293 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 16,670 | 0 | -16,670 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 18,418 | 0 | -18,418 | 0.01 | 0.00 | -0.01 | sell |
| STIFEL FINANCIAL CORP | 120,400 | 101,400 | -19,000 | 0.00 | 0.00 | +0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 88,300 | 63,300 | -25,000 | 0.01 | 0.01 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 63,778 | 35,661 | -28,117 | 0.00 | 0.00 | -0.00 | sell |
| 683 Capital Management, LLC | 43,198 | 0 | -43,198 | 0.03 | 0.00 | -0.03 | sell |