| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BVF INC/IL | 2,989,474 | 4,889,474 | +1,900,000 | 0.31 | 0.28 | -0.03 | buy |
| TANG CAPITAL MANAGEMENT LLC | 117,847 | 600,000 | +482,153 | 0.02 | 0.05 | +0.02 | buy |
| Checkpoint Capital L.P. | 1,755,987 | 2,017,650 | +261,663 | 2.72 | 1.53 | -1.19 | buy |
| LETKO, BROSSEAU & ASSOCIATES INC | 36,200 | 77,100 | +40,900 | 0.00 | 0.00 | +0.00 | buy |
| Troluce Capital Advisors LLC | 52,914 | 83,758 | +30,844 | 0.02 | 0.11 | +0.09 | buy |
| Aberdeen Group plc | 883,704 | 891,448 | +7,744 | 0.01 | 0.00 | -0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 105,900 | 113,300 | +7,400 | 0.01 | 0.00 | 0.00 | buy |
| Pale Fire Capital SE | 43,723 | 47,734 | +4,011 | 0.03 | 0.01 | -0.02 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,031 | 1,218 | +187 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 10,410 | 9,847 | -563 | 0.00 | 0.00 | -0.00 | sell |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | 260,870 | 27,000 | -233,870 | 0.01 | 0.00 | -0.01 | sell |
| EcoR1 Capital, LLC | 5,000,000 | 662,833 | -4,337,167 | 0.57 | 0.05 | -0.52 | sell |