| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BVF INC/IL | 2,989,474 | 4,889,474 | +1,900,000 | 0.31 | 0.28 | -0.03 | buy |
| TANG CAPITAL MANAGEMENT LLC | 117,847 | 600,000 | +482,153 | 0.02 | 0.05 | +0.02 | buy |
| Checkpoint Capital L.P. | 1,755,987 | 2,017,650 | +261,663 | 2.72 | 1.53 | -1.19 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 231,175 | +231,175 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 66,756 | 265,101 | +198,345 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 10,600 | 169,706 | +159,106 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 90,201 | +90,201 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 963,257 | 1,015,090 | +51,833 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 49,000 | +49,000 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 41,817 | +41,817 | 0.00 | 0.01 | +0.01 | buy |
| LETKO, BROSSEAU & ASSOCIATES INC | 36,200 | 77,100 | +40,900 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 35,042 | +35,042 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 21,078 | 52,559 | +31,481 | 0.00 | 0.00 | +0.00 | buy |
| Troluce Capital Advisors LLC | 52,914 | 83,758 | +30,844 | 0.02 | 0.11 | +0.09 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 24,992 | +24,992 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 1,450 | 21,878 | +20,428 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 17,782 | +17,782 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 800,948 | 817,248 | +16,300 | 0.00 | 0.00 | -0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 16,242 | +16,242 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 0 | 14,580 | +14,580 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 19,216 | 33,683 | +14,467 | 0.00 | 0.00 | -0.00 | buy |
| Virtu Financial LLC | 0 | 11,023 | +11,023 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 160,673 | 170,349 | +9,676 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 322,096 | 330,024 | +7,928 | 0.00 | 0.00 | -0.00 | buy |
| Aberdeen Group plc | 883,704 | 891,448 | +7,744 | 0.01 | 0.00 | -0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 105,900 | 113,300 | +7,400 | 0.01 | 0.00 | -0.00 | buy |
| STIFEL FINANCIAL CORP | 109,700 | 116,452 | +6,752 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 6,160 | 10,709 | +4,549 | 0.00 | 0.00 | +0.00 | buy |
| Pale Fire Capital SE | 43,723 | 47,734 | +4,011 | 0.03 | 0.01 | -0.02 | buy |
| RHUMBLINE ADVISERS | 46,807 | 50,019 | +3,212 | 0.00 | 0.00 | -0.00 | buy |
| FEDERATED HERMES, INC. | 0 | 2,182 | +2,182 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 22,214 | 23,238 | +1,024 | 0.00 | 0.00 | -0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 10,415 | 10,995 | +580 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 16 | 582 | +566 | 0.00 | 0.00 | +0.00 | buy |
| COLDSTREAM CAPITAL MANAGEMENT INC | 0 | 555 | +555 | 0.00 | 0.00 | +0.00 | buy |
| Point72 (DIFC) Ltd | 0 | 492 | +492 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 60 | 352 | +292 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,031 | 1,218 | +187 | 0.00 | 0.00 | -0.00 | buy |
| CoreCap Advisors, LLC | 0 | 166 | +166 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 61 | 211 | +150 | 0.00 | 0.00 | +0.00 | buy |
| True Wealth Design, LLC | 0 | 33 | +33 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 21 | +21 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 105 | 110 | +5 | 0.00 | 0.00 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 3,762 | 3,762 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,782 | 2,782 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,500,000 | 3,500,000 | 0 | 0.02 | 0.01 | -0.01 | hold |
| BAKER BROS. ADVISORS LP | 2,784,792 | 2,784,792 | 0 | 0.09 | 0.04 | -0.05 | hold |
| ATLAS CAPITAL ADVISORS INC. | 18 | 18 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BROWN BROTHERS HARRIMAN & CO | 143,051 | 143,051 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Deer Management Co. LLC | 1,245,504 | 1,245,504 | 0 | 0.30 | 0.16 | -0.14 | hold |
| DC Investments Management, LLC | 35,563 | 35,563 | 0 | 0.07 | 0.03 | -0.05 | hold |
| Waldron Private Wealth LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| IFP Advisors, Inc | 7 | 7 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Alphabet Inc. | 1,077,080 | 1,077,080 | 0 | 0.19 | 0.09 | -0.10 | hold |
| Aries Wealth Management | 10,000 | 10,000 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Simplify Asset Management Inc. | 1,046,916 | 1,046,916 | 0 | 0.22 | 0.07 | -0.15 | hold |
| NewEdge Wealth, LLC | 91,463 | 91,463 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DC Funds, LP | 630,000 | 630,000 | 0 | 53.75 | 42.07 | -11.69 | hold |
| Lynx1 Capital Management LP | 5,357,347 | 5,357,347 | 0 | 6.11 | 2.65 | -3.46 | hold |
| Propel Bio Management, LLC | 2,087,139 | 2,087,139 | 0 | 6.30 | 3.35 | -2.96 | hold |
| Police & Firemen's Retirement System of New Jersey | 7,720 | 7,720 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 3,937 | 3,937 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 15,479 | 15,479 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 6,169 | 6,169 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 112,941 | 112,941 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 1,329 | 1,329 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Invesco Ltd. | 20,628 | 20,590 | -38 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 19,090 | 19,031 | -59 | 0.00 | 0.00 | -0.00 | sell |
| LAZARD ASSET MANAGEMENT LLC | 70 | 0 | -70 | 0.00 | 0.00 | 0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 1,636 | 1,556 | -80 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 88,314 | 88,142 | -172 | 0.00 | 0.00 | -0.00 | sell |
| Sterling Capital Management LLC | 480 | 259 | -221 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 10,410 | 9,847 | -563 | 0.00 | 0.00 | -0.00 | sell |
| US BANCORP \DE\ | 2,265 | 0 | -2,265 | 0.00 | 0.00 | -0.00 | sell |
| ProShare Advisors LLC | 13,140 | 10,626 | -2,514 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 67,508 | 61,850 | -5,658 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 20,415 | 13,581 | -6,834 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 280,028 | 270,099 | -9,929 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 40,243 | 28,146 | -12,097 | 0.00 | 0.00 | -0.00 | sell |
| OSAIC HOLDINGS, INC. | 12,245 | 0 | -12,245 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 12,786 | 0 | -12,786 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 65,139 | 51,841 | -13,298 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 14,508 | 0 | -14,508 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 14,715 | 0 | -14,715 | 0.00 | 0.00 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 18,951 | 0 | -18,951 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 19,461 | 0 | -19,461 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 19,540 | 0 | -19,540 | 0.00 | 0.00 | -0.00 | sell |
| Heck Capital Advisors, LLC | 20,120 | 0 | -20,120 | 0.01 | 0.00 | -0.01 | sell |
| Shay Capital LLC | 21,363 | 0 | -21,363 | 0.02 | 0.00 | -0.02 | sell |
| VANGUARD GROUP INC | 2,382,533 | 2,356,746 | -25,787 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 63,095 | 20,840 | -42,255 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 43,969 | 0 | -43,969 | 0.00 | 0.00 | -0.00 | sell |
| LMR Partners LLP | 71,800 | 0 | -71,800 | 0.00 | 0.00 | -0.00 | sell |
| BlackRock, Inc. | 4,961,700 | 4,878,833 | -82,867 | 0.00 | 0.00 | -0.00 | sell |
| Dauntless Investment Group, LLC | 110,345 | 0 | -110,345 | 1.42 | 0.00 | -1.42 | sell |
| Woodline Partners LP | 115,866 | 0 | -115,866 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 132,895 | 0 | -132,895 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 142,617 | 0 | -142,617 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 150,114 | 0 | -150,114 | 0.00 | 0.00 | -0.00 | sell |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | 260,870 | 27,000 | -233,870 | 0.01 | 0.00 | -0.01 | sell |